Video summary
The speaker identifies as an "AI realist," arguing that while artificial intelligence offers remarkable capabilities, it is not magic nor a cure-all that functions independently of human involvement. A central concern raised throughout the discussion is the tendency for people to blindly trust AI-generated answers without applying critical scrutiny, effectively outsourcing their cognitive processing to machines or the cloud. This behavior creates a dangerous paradox where individuals feel smarter and more informed simply because they receive quick, easy solutions from an algorithm, leading them to stop engaging in deep thinking. Over time, this reliance on fast, effortless answers can atrophy slow cognitive systems, potentially impacting long-term brain health by reducing activity in critical areas like the prefrontal cortex and hippocampus, which are essential for complex reasoning and memory retention.
To illustrate how human cognition works best, the speaker draws parallels between biological growth and mental exercise, using metaphors such as plant roots strengthening under stress or baby owls learning to adapt their brains when forced to see an upside-down world. These examples highlight a concept called "arborization," where challenging experiences force dendrites in the brain to form richer connections, thereby enhancing cognitive resilience against decline later in life. The speaker warns that if society allows AI to provide all answers without effort, we risk creating a generation of individuals who act merely as expensive copy-paste functions rather than active thinkers. Consequently, there is a genuine fear that widespread reliance on easy AI solutions could accelerate early cognitive aging and diminish the unique value humans bring to problem-solving, turning complex professions into mere administrative tasks for less skilled workers while elite professionals continue to benefit from these tools.
Despite these risks, the speaker emphasizes that the optimal path forward involves a symbiotic relationship between human intelligence and modestly intelligent AI systems rather than replacing one with the other entirely. Research cited suggests that teams combining smart humans with capable but not overly advanced models often outperform both pure AIs and top-tier experts alone in predicting outcomes. The key lies in maintaining "human-in-the-loop" dynamics where professionals actively challenge, verify, and refine AI outputs instead of passively accepting them. In medicine specifically, this means doctors should use AI as a diagnostic aid that highlights unique patient details rather than letting it dictate treatment plans or eroding professional expertise. Patients are encouraged to educate themselves on their conditions using AI as a tutor to build genuine understanding before consulting with healthcare providers, ensuring they enter appointments well-prepared and able to ask informed questions about specific concerns.
Ultimately, the goal is not to fear technology but to cultivate an environment where humans remain engaged in deep thinking while leveraging AI's speed for data synthesis and pattern recognition. The speaker advocates for a cultural shift where individuals challenge themselves with difficult problems—whether solving math puzzles or analyzing complex texts—to keep their cognitive "gym" active throughout life. By adopting this mindset, society can harness the power of AI to augment human capabilities without falling into the trap of intellectual laziness or de-professionalization. The future envisioned is one where a thoughtful person paired with a smart tool achieves superhuman results, ensuring that medicine and other critical fields continue to benefit from both technological efficiency and irreplaceable human insight tailored to unique individual needs.
Read the full video transcript
I just happen to be an AI realist. It's
not magic, it's not going to cure all
diseases without our involvement, it's
not going to destroy us all. What it can
do is amazing, but what it can do isn't
always what we need it to do.
>> [music]
>> Now, from where you sit as a
neuroscientist who has actually built
health AI,
what is AI genuinely good at when it
comes to medicine and where does it fall
dangerously short? Kind of what your
book is all about.
>> Our conversation or what I'm about to
say about health and medicine, we can
probably generalize. I've built
companies in education and workforce.
You see a lot of commonalities across
all of these domains.
And the one that most might be the most
alarming about health is essentially AI
gives you what seems like a great answer
and you don't question it at all. You
just dive in and do what it says. And as
smart as AI may seem sometimes, it isn't
a a magic genie. In fact, there was a
a great paper. I hope I'll have a chance
to talk about some of my research, but
in this specific instance, let's say
diagnostics,
there was a great paper in the journal
Nature.
And they found that it turns out doctors
and cutting-edge AIs, but you know, what
we call large language models, they
gentle AI, they make different kinds of
errors. May sound scary that either of
they're making any errors at all when
they have your life in their hands, but
the way these scientists put it is they
make complementary errors. They kind of,
you know, fit together like LEGOs. And
it ends up they were better together
than either one was alone. And so, one
of the first things I see a lot
is people looking for answers about
health and then just blindly doing
whatever the AI tells them. Or, you
know, in other domains, students asking
AI tutors for answers
and then never learning anything cuz
they're never really thinking about it.
So, using it as a way to inform yourself
and come in with some ideas to talk to
your doctor, I think is great.
Using it, unfortunately, as like a
magical oracle that will give you all of
the right answers
is where my research starts to come in
and we see that that is the mistake most
people end up making.
>> You talk a lot about this in the book.
Why
why are we kind of downloading our
critical thought processing
to a machine or to the cloud?
>> My instinct is always to get as nerdy as
possible and get messy with the data,
but we have all of these interesting
things going on inside of our heads.
Some of them are really helpful, some of
them are not, but they're all there for
good reasons. If you had to think hard
about every single problem,
it would be exhausting and you'd never
really get anywhere. And so, even the
most genius
hard-working person ever
is doing a lot of what in the famous
book Thinking, Fast and Slow, they're
doing a lot of that fast thinking. And
that's actually a perfectly reasonable
thing for you to do. You don't need to
think about this all the time. There's a
very rare disorder in which people can't
feel where their body parts are, a
phenomenon known as proprioception that
we all have, we never have to think
about it. And you'd think, "Well, gosh,
that wouldn't be so bad if I didn't have
to think about my body but if I did, so
what?" Turns out it's totally disabling.
If you had to think about every movement
you made was effortful and conscious,
it would be exhausting. You'd spend all
day in bed because that's what ends up
happening. So,
we have this really strong system for
doing that.
And when you can get an easy answer
off of your phone or
uh from your computer, or let's just say
you got a really smart friend and they
can answer all the questions for you,
then it actually turns out it feels
really good. And I mean that almost
literally. It You begin to think what
the phone can do, what your friend can
do, is you. You're answering the
questions. We see this a lot in
students, where they actually hide their
misconceptions from themselves, and they
feel like they figured everything out
because they just are sitting back in
class and letting it kind of wash over
them. And the opposite, that slow,
effortful thinking,
for most of us, it actually feels like
we've learned less.
If AI gives you a really quick, pretty
good answer,
but let's say that there's actually a
better one out there,
well, that exploration to find the
better one, to most people,
feels actually like you're getting less
informed rather than more.
So, this is this kind of paradox, where
most of us are built to really go after
these quick, easy answers. Students
going to see the doctor,
working, let's say writing code if that
was your job, and and instead the AI can
write it for you, the real paradox is it
isn't simply that you're being lazy. You
actually feel like you know more when
you get those quick, easy answers. And
so, that then leaves us down,
unfortunately, a slippery slope, where
we start looking to AI
for the next answer and the next answer.
So, in terms of the question you
originally asked, obviously pretty
quickly that leaves us to just ask GPT
or Claude or Gemini for that quick easy
answer, feel really good about it, and
you act on it.
So, that could have problems if it's not
the right answer.
But, here's the next part of my answer
to your question.
The more you're relying on these AIs to
make the decision for you, the less
you're using your own slow cognitive
systems. You know, the less we're seeing
activity in your prefrontal cortex, in
your dorsolateral medial prefrontal
cortex, in your hippocampus.
You play that out over a lifetime,
especially if someone starts doing this
early,
and now
I start to get worried about what
happens to your long-term cognitive
health. Then, very much including issues
like Alzheimer's. So, no, AI is not
giving us Alzheimer's just because you
ask it a question.
But, that dynamic, that quick easy
answer, making you feel smarter,
then leading to a long-term
uh process by which you're always
looking for the quick easy answer, and
you're never really thinking for
yourself.
You know, if you're a bit of a drag to
your doctor sometimes because you show
up as a know-it-all, well,
we meet people like that all the time.
That longer process is the one that
actually worries me, that we're truly
outsourcing our cognition to a machine
and robbing ourselves
of what turns out to be incredibly
important daily exercise in cognitive
health.
>> That's a great way to look at it. I had
Dr. David Perlmutter on my program last
week.
And I'm interested in
uh plants suffering
uh to
to produce more of what are called
polyphenols and the harder a plant
struggles
to find water or to fight off heat or
insects,
the more it uses these compounds called
polyphenols to protect itself and
it was first discovered in growing
grapes and people rapidly found out that
the more the grape vine struggles,
the deeper the roots go, the harder the
plant works and the more of these
wonderful polyphenols you make.
And it occurred to me while you were
talking about this uh the learning
process as as you're the expert on this,
these dendritic processes have to
literally find other dendrites, other
synapses to make connections to
and in a way
the harder they have to work at that,
the better the root system becomes in
the brain. Is that a good way of
explaining that?
>> We talk about it as arborization. So now
now the visualization maybe goes the
other direction out into the branches,
but whether you're thinking of the root
system or the branches,
you know, there's this classic
experiment. It may sound a little silly
at first, but it leads into a broader
understanding. Uh this guy named Eric
Knudsen at Stanford run this experiment
with little baby owls. And what he did,
uh and it's very cute if you see the
pictures, is he put little goggles on
these owlets.
But the goggles were prisms, so they
flipped the world upside down.
Now if you're an owl, you have this
incredibly important brain system that
ties your hearing to your vision.
Otherwise, how do you catch your mice?
Um well, now the world's flipped upside
down, and he later looked at the
dendritic arborization. And in the owls,
later in life when they grow up, the
owls that had to learn both
how to do the regular world and the
world flipped upside down,
they had this big, rich branching
structure, so much more dense than the
other owls. And interestingly, later in
life, you could then put the goggles on
and off, and the ones that never grew up
with them could never learn the flipped
world. But the others could go back and
forth. Now, that again may feel like a a
silly little example, but it turns out
we kind of call this enrichment.
Uh enriched environments. So, kids and
animals in experiments, we can put them
into enriched environments.
This is why people say things like read
to your kids. Want to create this rich
language experiment. In fact, here's a
fun little if any of you are parents of
young kids,
uh tell them math stories. Cuz it turns
out now you're getting both of these
things going on, numeracy and literacy
at the same time.
Um
and sure enough, you see
uh in these enriched experiences
producing greater arborization,
and the evidence suggests that later in
life,
obviously, we can't just crack open
people's heads all the time to answer
these questions about humans, but
certainly in our um work with animals,
you can see later in life that that
actually both improves early life
cognitive ability, but also pushes out
later life cognitive decline. So,
you know, the the somewhat grim way of
putting it is if we all live long
enough,
uh eventually
we're going to lose the sharpness that
we had in our youth.
But these people, a combination of
absolutely some genetics plays a role,
but these enriched early environments
and then using it throughout your life
pushes that date farther and farther
out. So, my my grim little joke is
happily you get to die of something
else, but at least it isn't not
recognizing your own kids or remembering
who you are. And I'm really worried if
we steal that from our kids and then we
steal that preservation fact from our
adulthood, that we're going to end up
genuinely seeing substantially higher
rates of early cognitive decline uh kind
of across the board. So, that metaphor
of exercise of arborization
is is big. The real underlying biology
is very complex
um where certain kinds of activity that
we call gamma activity
uh is essentially used as like a cue by
your broader brain network for things
like called astrocytes.
And they use that as a cue to say, "Hey,
get busy. Uh clear the system out.
Engage in what's called glymphatic
perfusion." So, you're looking for your
at night when you're sleeping you get
these waves of clearance where your your
brain is literally pulsating and we can
measure that effect. And it happens more
and more healthily
if you're actively using your brain. I'm
using lots of metaphors here, but it's
essentially like i- if you're um you
know, not actively clearing out the
garbage and putting it out on your
stoop, then no one ever comes to pick it
up and pretty soon you're just
overloaded with garbage, and then
as your astrocytes aren't doing their
job, then later your immune system gets
involved, what are called microglia, and
they can become hyperactive. This is a
whole complex process.
But, it starts healthily
with you thinking. The simplest, easiest
medical advice I can give to you is
think regularly. Take a different route
to work every day. See if think about
it. Learn a new language. Do something
useful. Challenge yourself. But, uh
again, we can go back. It's this trap
with AI that it feels like thinking when
it gives you the answer, when really
it's taking that opportunity away from
you.
>> So,
the idea of doing uh multiplication
tables as as a kid
might be a good idea rather than knowing
how to punch it in on my cell phone?
>> There's certain things that like over
history, this comes up a lot. Like, oh,
Dr. Ming, you're so worried about AI.
But, to be clear,
I've had the true pleasure of building
six life-saving technologies around AI.
I'm all in. I drank the Kool-Aid. I just
happen to be an AI realist.
It's not magic. Uh it's not going to
cure all diseases without our
involvement. It's not going to destroy
us all.
What it can do is amazing, but what it
can do
isn't always what we need it to do.
It can quickly give us easy answers, so
we never have to think about anything,
or it can challenge you.
For example, I have a number of
recommendations in my book uh around
things that parents can do with kids, or
people can do for themselves, or even
organizational leaders can do inside
their organizations. And some examples
that I actually give in writing the book
itself was what I called the nemesis
prompt. You know, I said uh in this case
I was using Gemini a lot at the time,
"Hey Gemini, you are my nemesis, my
lifelong enemy. You found every mistake
I've ever made and pointed it out to the
world.
Here's the next chapter of my book,
which you have not helped with at all.
Read it and tell me why I'm wrong.
Explain to me in detail and then give me
some ideas of what I might do about it."
So, I didn't use it to make writing the
book easier. I used it to make writing
the book harder,
but in ways that challenged me to be
better, like a great editor ought to do.
And so, in that sense,
should you think about your
multiplication tables instead of just
doing the math,
you know, I'll take it in a different
direction. Yes, you should think about
all those math problems, those word
problems, the trains going in different
directions. Mix it up, you know, it
seems like it's a a train problem, but
really hidden in it is something
different. In other words, what's really
important is you're thinking deeply
about it.
Slow thinking, rather than thinking
shallowly and fast. Anything that gets
you thinking deep,
thinking about how you're getting to
work, uh but genuinely thinking about
it, thinking through uh little math
puzzles, any of these are good for you
and to be honest, our life is littered
with easy examples. All you have to do
is think about what you're already
doing.
Uh and now you're getting that thing
done and you're thinking about it, which
is great.
>> That's a good segue. Uh you talk about
the Jiffy Lube economy
uh
with AI. You want to I think what you're
saying is exactly that. Do you want to
build on that, particularly in medicine?
>> Yeah, you know, my dad was a
gastroenterologist
and it turns out back in the '70s, you
could get away with having a little kid
in the room while you're scoping
somebody. So, I would see him. Like, I'd
see the inside of these people's colon.
And he'd say, "See that little duck
there?" I don't see anything, you know,
he's an expert. I don't see anything,
but bloop, suddenly he's in a different
part. See this? That little thing,
that's probably a polyp. Let's grab a
bit of that. I don't see anything that
looks different. You know, the
7-year-old me watching this happen
doesn't know anything, but to him, that
was incredibly
powerful. Going in day after day, seeing
all of these. And so, that was his
experience as a doctor. A recent paper
found, uh, this is out of Europe, but
this is a really good paper. Not that we
should be skeptical, uh, of Europe, but
I assure you this study generalizes.
What they found is people doing
colonoscopies with AI assistance, if you
took it away,
they weren't just worse in terms of the
they didn't get the benefit of AI, they
were worse than where they started
before they ever used AI. And I
genuinely respect for this, released a
report, they're the makers of Claude,
and they released a report on Claude
code that showed the majority
of professional developers using Claude
code actually got worse the more they
relied on Claude code to write their
code for them.
So, one of my concerns, particular to
medicine, is what I called initially the
Jiffy Lube colonoscopy,
which is
if the AI is doing most of the
decision-making,
then do I really need a doctor in the
room? You know, wouldn't a well-trained
lab tech be good enough? And that might
honestly be worth us talking about, like
collectively as a society. What is the
right level of expertise necessary in
the room to make medicine efficient?
But right now we're not talking about
it. It's just kind of happening. And
that builds what I call on
de-professionalization.
Where the role of doctors and lawyers
and others, it isn't that these jobs
disappear. We still need doctors and
lawyers.
But the where AI is actually helping the
most
is with the best doctors. The most elite
lawyers and and software developers.
They're showing all the benefits. These
older, experienced, highly talented
individuals. Most people entering the
profession
uh are actually having those skills
eroded by AI. Not everyone.
But most. And so now
how do I become a great doctor
or lawyer or software developer
if the day I started medical school and
then my residency
and and on and on
a machine is handling a significant
portion of my decision-making and I'm
just doing it doing what it tells me to.
And again, there are right moments for
that. Like in the opening research paper
I I shared with you all
machines, AIs, and humans make
complementary errors. So there's real
value in having them help with the
colonoscopy or the radiology or
um helping surgeons with micro
surgeries. But
how do we make certain it's adding its
unique value on top of what humans can
do?
And honestly, in some ways, much like I
was talking about as an author,
challenging the doctors to still do the
uniquely human part as well as they can.
That aspect right now is not getting
enough attention, and I don't expect
medicine to change overnight. It isn't
like AIs will just make all the
decisions next week. In fact, this may
be one of the slower industries for some
obvious reasons.
Nonetheless,
what we see with AI in medicine is
either doctors just do exactly what the
AI tells them to
or they completely ignore it.
Neither of which is what we as patients
want.
We want them to take these great
diagnostic tools
and make an even better decision,
whether it's it's diagnosis or treatment
plan or application, a better decision
than they could have made on their own,
better than AI. Um, and I'm worried of
this bleeding into the broader economy.
That it isn't just the Jiffy Lube
colonoscopy, that it quickly becomes
Could a high school student, you know,
walk this tool around the room? Can't a
high school student feed your contract
into a lawyer AI? Can't a high school
student, you know, just be present while
an AI is writing all the code that runs
your website? All these things are
essentially debates that are happening
internally in companies right now. And
again, this is a decision I feel like we
should be making as a society. AI has a
role. I am not a skeptic of it. I spent
30 years here.
I believe in what it can do,
but here's maybe where I begin to get
into my own research,
uh, which I'll preview with the single
smartest thing on the planet today isn't
Terrence Tao, the famous mathematician.
Uh, I mean, obviously I am, but setting
myself aside,
uh, isn't the smartest human you can
think of. It It isn't the latest version
of Claude that the US government won't
let anyone use right now. It turns out
it's a modestly intelligent human being
combined with a modestly intelligent AI.
That's all.
A simple little, what we would call a
small open-source model compared with
compared with a smart person. In my
experiments, we find that they can
out-predict the best AIs. They can
out-predict the best humans about what's
going to happen in the future. And in
fact, compared to these websites called
Polymarket and Classy, these prediction
markets,
they're actually do as well as experts
betting millions of dollars on these
outcomes, which is really exciting and
hopeful for humanity. We have a unique
value add here. But, the unfortunate
thing in an experiment I haven't
described yet is
it's a tiny percentage of my
participants. At best, 5%
show this superhuman capability, and the
vast majority do exactly what I've
described to date. They say, "Hey, GPT,
what's the answer to this question?" And
then they submit it as their own. And
essentially, in that context, which we
saw in a 60 to 70% of all the
participants in my experiment,
essentially, you're just a very
expensive
copy-paste function, you know, that
needs health insurance. Um so, that's a
pretty dismal view of humanity. If we
could see more people doing, forgive me,
I'm a science fiction nerd, what we
called cyborg mode,
where you couldn't tell was it the AI
that made the decision? Was it the
human? They They did it together. The
best of what each could do produced
these superhuman capabilities. That as
as someone that cares a lot about that,
that's what I want out of my doctor.
That's what I want out of my lawyer. So,
this is my worry about, you know, the
Jiffy Lube economy, no offense to Jiffy
Lube. Um, but I want people
thinking, what do I know uniquely about
this problem?
Because the AI I'm using knows all the
rest of it. It It has all of the right
answers. That those easy immediate
answers, the value add now for my
doctor, my lawyer is
how do we do even better than that? How
do we treat this specific patient
different than any of my other patients?
Uh, and that's the real challenge, I
think, that sits in front of us.
>> Back in the good old days of computing,
the expression garbage in, garbage out.
Um,
one of the things I see, uh, my patients
doing and
and when I research, I'll use it.
But, at least in medical research, AI at
the moment can't discriminate
between a
paper, a published paper,
>> [snorts]
>> in a human or in a in a mouse or in a
Petri dish, in vitro,
and some blogger who has a YouTube,
who actually knows nothing about
anything,
and yet, at least what I see is AI can't
tell the difference.
And
is that How do we fix that?
>> So, the way people have been going about
fixing this so far is you start by
taking these large language models, what
are called pre-trained transformer
models, and in the pre-training, you
know, Google just gives it every piece
of information Google has ever
collected. That's what OpenAI and
Anthropic have done and all these other
organizations. And in that pre-training,
you get all sorts of bad behavior
emerging. Um you get
you know, every time I read a paper in
which people complain that AI is biased.
And let's say in the context of medicine
that it demonstrably does, for example,
less well
>> in underrepresented populations. So, if
you were from indigenous
ancestry from Central America,
it genuinely is likely that an AI isn't
going to be as good at doing your
diagnostic work because you are much
less well represented in the data for
wide variety of reasons. Um so, this
then plays out really big in that first
pass, which can include lots of spurious
claims from bloggers. It can include a
lot It can include intentional garbage.
Lots of interesting papers of people
intentionally injecting things into data
sets, and later the AI can be prompted
to recall it and do bad things.
All of this we should be worried about.
Um
but then the next phase, it's what's
called human in the loop fine-tuning.
You know, that AI won a couple of Nobel
Prizes 2 years ago, one for the original
work on deep neural networks, and the
other for protein folding. But the
underlying algorithm there is called
reinforcement learning, which by the way
was discovered
by neuroscientists studying how rats
solve mazes. So, take pride, our brains
produced artificial brains, almost
literally.
Um so, the goal here is take this
algorithm that allows AIs to learn
through playing games.
And then you put a human in the loop,
and
the algorithm produces a result, and
then the human says,
"That one wasn't very good. That one was
much better."
So, if I ask it a question,
and it pops out a bunch of bad pop
psychology because it it occurs a lot in
self-help books, but it isn't born out
in the experimental research, ideally,
the human in the loop for the
fine-tuning says, "Nope, that's a bad
answer."
Um unfortunately, they also say things
like, "Tell me how much of a genius I
am." So, that's why you get a lot of
sycophantic behaviors.
A lot of that get trained in at this
point. The problem is those two things
together.
While they have produced these amazing
tools that truly can answer incredibly
challenging problems astonishingly well,
it produces hallucinations.
In fact, it turns out
you can't get rid of hallucinations. For
complicated machine learning
mathematical reasons, but essentially,
they boil down to
if you are simultaneously asking it
questions about places where the data
there isn't a lot of data,
but you're also forcing it to give
answers, right? I'm going to penalize
you if you don't give a right answer, so
make something up.
Then, it turns out we
hallucinations become unavoidable.
Uh in these models,
if you're wondering, you know, there's
kind of nothing behind their eyes, they
are genuinely intelligent. They they're
kind of like the fast intelligence we've
been talking about, the fast thinking,
but they don't have the slow part, or
they have like a simulation of the slow
part. And so, it doesn't know right from
wrong. It doesn't know causality. It has
trouble knowing what is a good piece of
information.
is just generating the next word. And
what that allows us to do is
astonishing.
But we can end up with the mistaken
belief that oh, it understands me. It
understands my medical condition.
No, what is encoded is a mass of
knowledge pulling together facts from
broadly different areas in ways no human
being can do, which is amazing.
But it doesn't actually understand
any of it, which is also why you should
100% prep research, but be skeptical.
Part of your job is be skeptical of the
AI, challenge the AI, get the AI to
challenge you. That's where the best
stuff comes happening. Then go in
and um
bring that informed self in to your
doctor who has hopefully the benefit of
not getting misled, actually bringing
that slow understanding to the problem.
>> Certain physicians or uh health care
providers
uh have been raised
to be
the all-knowing God. And when patients
come in with
perhaps AI-generated answers and or
questions
uh a lot of them, and I hear this from
my patients to see other physicians. You
know, how dare you question my
authority?
And you know, and I've actually had
patients
thrown out of uh physicians' offices.
Uh cuz if you, you know, if you don't
trust what I'm saying,
uh
you leave. Okay, what do we do about
that?
>> One of the historical findings in AI in
medicine is
uh doctors of all the groups that exist
out there, doctors are the most likely
to ignore AI advice. You know, as
someone that
flirted with doing an MD PhD, part of
what I realized is
I'm not actually all that interested in
being a practicing doctor. Um
I like to go deep into a small set of
problems. You know, as though all
doctors could be House uh all the time.
One patient and you just get to lose
yourself in it. And although I I do in
my philanthropic work get actual
interesting medical questions brought to
me just because no one else is making
some progress on it.
Um
what I understood was the real job of a
doctor
is to make a large numbers, large as you
can, number of people more healthy than
they were before. The negative part of
that can be you start to treat people
like they are patient archetypes. Um you
look at three symptoms that appear on
this massive sheet and just based on
that you go. And instead of well, yes,
but you know, Vivian with her freckles
uh and pasty pasty skin like she's
almost certainly going to have a bigger
inflammation response than the
archetypal So, I'm going to adjust for
that. Our dream
for me in some of my work has been can
we build medical AI technologies
that very much don't replace what the
doctor can do.
But they're more like a pair of
you know, corrective lenses that allow
you to see this unique patient a little
bit different than the others. So, we
would build systems that would
highlight, for example,
here are a couple of facts about this
patient that might be salient to this
particular, let's say, diagnosis,
um that may not be as important for a
different patient.
And it turns out stuff like that has
been part of where people have seen real
value add of AI in medicine.
What that's saying is we need to do a
different kind of med school training.
In the exact same way where we have this
sort of human in the loop fine-tuning
for AI to give it feedback about where
it's giving good answers, we need a
little bit of that in in humans. When my
son was diagnosed with type 1 diabetes,
my wife and I were just told, "This is
just how it is.
Blood glucose, you can only control it
so much, so stop sweating the details."
And obviously in my head, it's
I build models of the brain. Are you
really telling me the pancreas is more
complex than the brain? Uh obviously
they're all equally complex because they
interact with one another, but
nonetheless,
in my hubris, in 2011, I start hacking
his medical equipment. No, don't do
that. But, um in this particular case,
uh like the rest of the at the end of
every episode of Jackass, don't do the
stupid thing these people just did. But,
in this case, I didn't do something
terribly revolutionary. I just happened
to be the first person to do it, which
was I took a very simple model and I
trained it on my son's blood glucose
history coming out of what's called his
continuous glucose monitor.
And it turns out there was a lot that
was predictable there, a lot of patterns
that had gotten missed because his
endocrinologist are the doctors for a
lot of patients, helping a lot of
families through this process, many of
whom were desperate for concrete advice.
Just tell me how it's going to be.
Don't make it complicated. Well, my wife
and I happen to both be scientists, and
I'm a computational scientist at that, I
wanted it to be complicated because I
make bottles already of
biology.
So, I just happen to be the right person
in this moment, not the world's greatest
genius. I do, of course, again, happen
to be that, but in this moment, I just
happen to be the mom who knew something
that understandably uh my son's
endocrinologist didn't know cuz in 2011,
who was thinking about artificial
intelligence? Not many. So, I hacked the
system and I put it together largely
because I was frustrated that I was
handwriting numbers on a sheet of paper.
That was still in 2011 how diabetes was
being treated even in the Bay Area. So,
I just was very frustrated and did
something different.
Now, I think we need to bring medicine
along on this AI-enabled journey. Train
doctors when to be skeptical, when to
challenge an AI,
but also train doctors now
to be aware of what it's saying and take
it as part of their diagnostics. You as
a doctor truly have something unique to
offer that the AIs are not going to be
capable of delivering. You're going to
see this as a unique patient rather than
just another pattern in a massive data.
That distinction between what humans are
uniquely good at and what machines are
uniquely good at
still hasn't filtered in not just into
medicine, it really hasn't filtered into
a lot of job domains. So, yeah, it's a
bit of an education problem, a
fundamental human problem, I I would
think.
And I and I do encourage patients not to
hack your medical equipment, please
don't,
but to be thoughtful. Um it's stressful.
When my son would go to bed every night,
I get up three or four times a night and
poke him.
Just to make certain. Which didn't
matter much to him, but it was terrible
for me to do that for months and months.
Just scared. Every morning you'd wake up
and, you know, having support that can
help you understand this process, help
you be more confident in your
decision-making, while not replacing
your doctor, that's our sweet spot that
we're really looking for.
>> If someone listening wants to use AI to
understand their health better, not just
get answers, but build real knowledge,
what is what does that actually look
like practically? You're not going to
build an AI model to manage your type 1
diabetes.
>> It is unlikely you will be as mad
scientist-y as I am, uh, but that's kind
of my day job, so of course I would live
my life that way. I think the starting
point is something that a number of
people talk about, which is something
that, you know, no no textbook can help
you with or or even a website.
Because what you can do here is walk
through the understanding.
Hey GPT, Claude, what whatever your
favorite, uh, tool is, imagine
I'm a fifth-grader.
Talk to me about diabetes.
I just was diagnosed. What should I be
thinking about? And after you feel like
you've got that,
um, say, "Okay,
now
I'm a high school student. Now I'm a,
uh, a graduate student." Walk through
I one of my recent companies, uh, we
launched is doing something amazing.
We've developed the first ever
biological test for postpartum
depression. Any moms or post-moms out
there and you've ever been told it's
just in your head, we can literally
literally see it in a blood sample. We
can see it in your epigenetics.
So, turns out I am a lot of things, but
I am not an epigenetics expert. It's
just I'm not a molecular neuroscientist.
I build models of brains. So, to help
launch this company,
I educated my dumb ass on epigenetics
and its application to mental health.
And I started with exactly what I said.
I you know, I I placed myself at the
undergraduate level first. Yes, I do
have a bunch of fancy degrees. And then
I went to grad student, and then
professor, and then some of the unique
work we were doing that my colleagues
understood, but as the brain and AI
expert were alluding me, and I got this
wonderful walk-through. And you know,
you can take it beyond medicine. I I
know this this is a nerdy pastime, but I
read lots of science and um economics
papers.
And even though my work has nothing to
do with quantum computing, I came across
a really interesting paper, and I said,
"You know, here's something I do
understand." Um Now, let's start there.
And slowly build an understanding of
what quantum computing is about. And you
know, it took about an hour, and
suddenly it just clicked, and I got it.
This is a great example, I think, in how
you can use AI to build up an
understanding. And I think one of the
things you should really do is as you
gain that new understanding,
tell Claude, Gemini, "Hey, give me a
paper to read." You know, maybe it
starts with a
a very understandable news article, and
then it moves to a slightly more
challenging tech reporting article, and
then it moves to an actual science
paper. So, you can actually see what
people are talking about. You you don't
get caught with a blogger who's just
making stuff up.
>> I love it when
I get referred to a something that's
kind of made up and
and right now AI can't quite
discriminate that.
Now, you know, in your book Robot Proof,
it you know, you get the sense
that and you talk about a lot of this
we don't want to become I don't want to
paraphrase you. We don't want to become
dependent on AI for our thinking.
Uh because that's going to
getting back to where we started, that's
going to really hurt
our neuro connections, our our
branching. Is is that
can I say that?
>> Yes. I mean, this is a long-term
process. I I certainly wouldn't want
people to think that just because they
asked AI for help that they were
damaging their brain,
but the the somewhat lazy way I put it
is too often AI gives us what we want
and not what we need.
Uh and and it's happy to do it. Really,
you're the one that needs to challenge
yourself. AI is the tool for doing that.
>> When we get this information from AI,
are there
the the consumer,
are there guardrails that we have to use
to decide
how how much do I trust this? Uh
do I
a lot of people go, "I don't need a
doctor anymore. Uh I got Dr. Google. Um
maybe if I'm sick, I'll go to the
emergency room, but I don't need anybody
checking on me anymore." Are we there
yet?
>> I will say this. Uh I'm not coming at
this problem from the perspective of
AI is a magical army of robotic minions
that will do whatever we want and we
never have to work again. Again, my
research shows
that a a smart person paired with an
even modestly smart AI
is amazing. Smarter than the smartest
AI, smarter than the smartest people.
That's what I'm advocating for. I mean,
we could just simply look at it as I'm
advocating for it because I want a
future for us, but I'm also advocating
because it turns out my research,
Anthropic's research, the paper I cited
earlier about doctors making
diagnostics, the best results are when
humans and machines work together.
And I think that even holds
when we're sort of non-experts.
So,
again, getting yourself educated and
ready
uh to go talk to your doctor
uh is smart. Let's be honest. There's a
lot of gatekeeping going on. And want to
go chat with my doctor, but I can't. I'm
being asked to submit an answer. Maybe
it's even going to an AI right now. I've
seen lots of companies, startups getting
funded to do just that. Can an AI answer
this or should it get sent to a
physician's assistant? And if not,
should it go to the physician
themselves? So, there's some real value
in understanding
where the easy answer might be the right
one and you could move forward with some
confidence there. If you're a doctor,
I would want to be bringing that unique
value-add. What could I have done here
that no other, even doctor, would have
done, much less any AI? What's my unique
approach to a patient like this?
And if I'm a patient, boy, do I still
want a chance to talk to my doctor.
But I can make the most of that time
if I can, for one thing address some of
my real concerns, um some of the things
that are scaring me. You know, the
simple reality is terrible things do
occasionally happen in diabetes uh with
my son with type 1,
but it's
our bodies are actually really robust,
and it's more of a long-term game for
most of us.
As long as you're you're being
thoughtful about lows, and in that
sense,
being able to put that understanding
every moment of every day is not a
disaster and emergency, but focus on the
things that are important and go talk to
your doctor about them. I think AI has a
huge role in helping us deal with that.