Video summary
Dr. Lisa Feldman Barrett challenges the traditional view of emotions as universal, fixed categories like anger or joy, arguing instead that these are variable populations of instances tied to specific situations and actions. She explains that our brains do not passively receive sensory signals from the world; rather, they solve an "inverse problem" by guessing causes based on outcomes received through a dark skull box. Because the brain lacks direct access to external causes, it prepares motor plans for action first, using copies of these predictions as sensations to construct meaning. Consequently, emotions are not inherent properties in objects or faces but relational realities created when the brain makes sense of signals like heart rate changes or facial expressions based on past experiences and current goals. This process means that a scowl does not objectively signal anger; it is merely one possible interpretation among thousands, dependent entirely on what the observer's brain predicts will happen next. The discussion highlights how language functions as an invitation to learn concepts rather than simply labeling feelings, with vocabulary size correlating to emotional richness through increased conceptual flexibility. Barrett illustrates that meaning-making relies heavily on memory and prediction: every experience is a combination of remembered past patterns and current sensory input. She debunks the idea that new experiences overwrite old ones or that memories are stored like files in a drawer; instead, memories are reconstructed from ensembles of neurons where individual cells participate in hundreds of different recollections. This reconstruction mechanism explains why we retain traumatic or significant memories even as other neural connections change over time, while also noting that humans have lost the ability to birth new neurons in most brain regions except the hippocampus, which may limit our capacity for memory storage as we age due to a lack of fresh neuronal real estate. A significant portion of the conversation addresses anxiety and chronic stress within modern life, framing them largely as metabolic issues rather than purely psychological failures. Barrett describes uncertainty as metabolically expensive because it forces the brain to prepare multiple motor plans simultaneously without knowing which is correct, leading to high arousal states often mislabeled as anxiety. She shares an anecdote about her daughter's karate training, where a sensei reframed nervous energy not as fear but as "butterflies flying in formation," demonstrating how changing one's meaning of physiological signals can alter the resulting experience without suppressing the underlying biology. Furthermore, she explains that chronic stress leads to metabolic dysregulation, such as cortisol resistance, where cells become insensitive to glucose mobilization because they are constantly flooded with it during false alarms. This state drains the body's energy reserves and damages immune function over time, linking conditions like depression and diabetes directly to prolonged uncertainty and poor lifestyle choices like insufficient sleep or consumption of "pseudo food." To mitigate these effects, Barrett emphasizes that while we cannot simply snap our fingers to change a mood or erase intrusive thoughts through willpower alone, we possess significant agency by changing the context in which those habits occur. She suggests that rumination is essentially an automatic behavior driven by predictions shaped by one's environment; therefore, shifting contexts—such as going for a walk, engaging in immersive activities like birdwatching, or reading neuroanatomy books—can disrupt negative prediction loops more effectively than trying to suppress thoughts directly. The transcript also touches on the profound impact of social connection and toxic relationships on health, noting that loneliness acts as a chronic stressor that shortens lifespan just as much as smoking does. Ultimately, Barrett concludes that while we are not solely responsible for every emotion or biological reaction, understanding how our brains construct reality empowers us to take responsibility for our actions and seek necessary help, whether through social support, medication, or lifestyle adjustments like rest and healthy eating, thereby reclaiming agency over our lived experiences.
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How unique is the way that we all
experience emotions? Is your experience
of anxiety or anger or joy the same as
mine or different?
>> Well, I think the proper question to
start with is your experience of joy on
one occasion exactly the same as your
experience of joy on another occasion?
And I think what we know is the answer
is no. It isn't. that joy or anger or
any other word for emotion really refers
to a population of instances that are
variable. Not infinitely variable, but
variable and tied to the situation that
you're in. So sometimes anger is
pleasant and sometimes it's unpleasant.
Sometimes it's, you know, you're full of
energy during anger and other times
you're not. Sometimes your blood
pressure goes up, sometimes it goes
down, sometimes it stays the same
depending on what actions you're taking.
And your actions differ in anger, right?
People scowl in anger about 35% of the
time, which is more than chance. But
that means 65% of the time people
express anger in this culture, in
western cultures, actually I should say
in urban cultures because it's in the
east and the west. Um that this is um
metaanalytic evidence. Um 65% of the
time you're doing something else with
your face in anger. You know, you might
smile in anger, you might cry in anger,
you might sit silently implant the
demise of your enemy in anger. And half
the time when you scowl, you're not
angry, you're feeling something else. So
the point being that, you know, all this
variation is not random, but it's not um
but it's not, you know, anger isn't one
thing, joy isn't one thing. So when you
ask the question, is your experience of
joy the same as mine? I think what you
mean is to say is um your vocabulary of
joy the same as mine? Is your
distribution of joy? Is your population
of instances the same as mine? And um
probably not. But there there has to be
enough overlap that we can communicate
about it or else we wouldn't be
communicating.
>> Right. that suggests that the breadth of
language that you have to be able to
describe the things that you're feeling
unlocks in some way or enables you to
have a deeper or richer emotional
experience.
>> Yeah, I think the the you know the focus
on words on language is there but it's
language isn't really the point. The
point is your ability to um your
concepts or your knowledge. So that
tends to be linked to words, but words
aren't really necessary. I think this is
a constant confusion that people have
that if you just label your experience
differently, you know, you'll have a
richer experience. And that's not true
at all. Um but it does tend to be the
case that words are invitations to learn
concepts. They're invitations for
knowledge. That's how they work. And the
more vocab, the larger your vocabulary
is, the more concepts you probably have.
And that's what's going to lead to a
richer emotional life.
>> What's a better way to think about
emotional richness beyond just the
words?
Well, really what's happening under the
hood is that your brain is
receiving signals from the sensory
surfaces of your body, from your eyes,
from your ears, from your nose, and all
the surfaces inside your body for
glucose and oxygen and you know the
stretching of muscles or the contraction
muscles and so on. So your brain is
being flooded really with these signals
and it has to make sense of these
signals and the way that it does is by
calling on instances or reinstating
instances from the past that are similar
to the present.
A group of things which are similar to
one another is called a category and a
representation of a category is a
concept. So basically your brain is
making meaning out of signals. Your
brain doesn't know what an increase in
heart rate means in some there is no
objective meaning psychologically
speaking of a raise and of a increase in
heart rate. Your brain has to make sense
of that. And the more
varied experiences you have in the past,
the more words or concepts that you the
more words you know, the more concepts
you've learned
gives you more flexibility for making
meaning. So in the same way that um you
know a basket can be something to carry
vegetables in or it could be a weapon or
it could be a door prop or you know you
could use it as a chair if you needed
to. That is the structure. You could
make meaning of it in a lot of different
ways by acting on it in different ways
in different situations to suit your
goals. The same is true for an increase
in heart rate, right? or a flash of
light or a loud sound.
You have some you don't have infinite
flexibility but you have some
flexibility in how you create meaning
and that is ultimately what your
emotional life derives from.
>> What's the role of meaning here? How how
does that slot in in amongst sensation,
emotion, story? Why does it
>> Well, you know, well, I think the the
way to understand this is it's a little
counterintuitive, but basically your
brain is trapped inside a dark silent
box
called your skull.
And it's receiving these sensory signals
which are the outcomes or the effects of
some set of causes
in the world or in your own body. But
your brain doesn't have access to the
causes. It only has access to the
outcomes, to the effects. This is what
philosophers call an inverse problem.
You have to guess at what the what
caused some outcome. You only know what
the outcome is. You don't know what the
cause is. So, for example, you hear a
loud bang. That loud bang could be a
door slamming or it could be thunder or
it could be a gunshot.
what how you make sense of it is first
and foremost by preparing an action.
You'll do different things if it's windy
or if it's about to rain um or if you or
if there's, you know, somebody's firing
a gun near you. Um, your brain first
makes a plan for action
and
the literal copies of those signals
become your brain's guesses for what
your what you will hear ne next, what
you will see next, what you will feel
next. So sensation
doesn't lead to action. Preparation for
action leads to sensation.
Right? You don't you don't react you
don't detect things in the world and
then react to them. Your brain is making
a guess about what's going to happen
next. That guess begins as an action as
a preparation for motor movements in
your body to support the movements of
your skeletal motor system, your arms,
your legs, your eyes, you know, and
the copies, the electrical copies of
those signals.
It's literally neurons are going down to
the body to spraying motor signals and
the cop and then then collaterals off
those axons
other they are sent to the other
different parts of your brain to um
prepare
for those incoming signals from the body
and from the sensory services of the
body. So meaning it means is really
about what you take
the signal scape that is around you to
mean what it what is it what does it
demand of you um metabolically what does
it demand of you in terms of action
that's what determines your experience
your lived experience of yourself in the
world
>> okay so things happen blackbox detects
what has occurred to us from those
things that are happening Well, your
your brain isn't a black box. It's in a
dark box. Your brain is has intrinsic
signaling going on all the time. It's
Yeah.
>> brain inside of blackbox. Uh we have
experiences from the past because of
those experiences. We use those to say,
hey, this kind of thing happened
previously. Therefore, I can infer, I
can predict that looking forward, it
also means this thing. The last time
that that thing happened, the last time
that a big dog came up to me, uh, I got
bit. Therefore, this is the appropriate
sort of response.
>> Yes. And you prepare. So, you're
predicting that the that the dog might
bite you. So, you prepare for a set of
changes inside your body to support the
movements of your body. And you also
prepare your your brain starts to
prepare the experience that corresponded
to those actions last time. Every action
that you take, every experience that you
have is a combination of what's in your
head, the remembered past that we, you
know, are prediction signals basically
and the sensory present. the signals
that are um informing you about the
state of the of your own body and the
state of the world. Every experience is
a combination of the remembered past and
the sensory present. And in an in in a
in an instance, it could be a little
more of one or a little more of the
other or a lot of one or a lot of the
other. Um, but the point is that the
remembered past, what's happened to you
in the past is fundamentally what your
brain is using your experiences from the
past to make sense of to predict the
future which will become your immediate
present.
>> Well, if our brain is constantly
predicting, how much of our life is
actually experienced versus just
anticipated?
>> Well, you're making a distinction. I'll
sort of pick at the premise of your
question there, which is that there's a
distinction between anticipating and
experiencing. And all experience is
partly anticipation.
That's a good Okay, maybe I could put it
a different way. Is there any such thing
as sort of true objective perception
then? Do we are we always seeing things?
>> Well, you really get right to the point,
you know, like that's like usually
people, you know, they ease into that.
That's a big metaphysical question. They
kind of ease into it, right? So, um,
well, are you asking me for my opinion
or are you asking me for what I think
the brain what neuroscience says or do
you want me to lay out the whole
metaphysical like landscape for you?
>> No, your your opinion. We've I think I
think that the obvious place that people
arrive at at the moment is wow I I
really sort of molest the present moment
a lot between it happening and then me I
it being a part of me. Um
>> I thought I thought that I saw things
the way they were. I thought that I felt
things that were appropriate given the
situation that I'm in. And this doctor
lady
has said that doesn't seem to really be
the case. So I wonder
>> Well, I think I think people definitely
feel things that are appropriate to the
situation that they're in, but the
assumption therefore is that you're
making or that somebody might make maybe
not you, but you're just, you know,
you're the you're the messenger, right?
>> Yeah. Um the assumption that therefore
it's there's some objective accuracy, I
think that's where things break down. So
in the history of philosophy and also
pundits and I don't know people who
consider themselves to be you know
public intellectuals there's a debate
you know that's gone on for really
thousands of years like is reality out
there objective separate from you and
you just perceive it and react to it or
is reality like all in your head um you
know I this is called idealism that that
the um other view is what I would call a
traditional traditional realism that
that you know there's an objective
reality out there. Um and that's been
the debate for thousands of years. And I
think that when a debate goes on for
thousands of years, it's probably
somebody's asking the wrong question.
And so the way I think of it is the
following.
Reality is relational meaning there is a
reality but the reality is partly
you're involved in creating that reality
right so you know this object is solid
because we have the kind of bodies that
we have and if we were subatomic
creatures this would not be solid it
would be mostly empty space
and there are other I think more
compelling that one's that That's a hard
one to to kind of wrap your head around.
Like, are you telling me that the world,
you know, that that like a desk isn't
solid? Well, it is solid. It's solid for
you and for other, you know, animals
like you that have the kind of body that
you have. But there conceivably could be
other sorts of animals or other
organisms or creatures that don't have
those features and therefore their
reality would be different. And so
again, it it doesn't mean that well I'm
saying is there a reality out there
separate from you? No. Is that is does
objectivity exist in that way? Not as
far as I can tell. That's not what the
neuroscience would suggest.
But does it mean it's all in your head?
No. Because you need those sensory
signals to wire your brain in the first
place. They just don't have an inherent
meaning. So, what this means for you in
I mean there are some really fun things
that it could mean which we could talk
about, but in the practical sense, what
does it mean? It means that when
somebody scowls at you, you aren't
reading anger.
You're guessing that that is an
expression of anger. But that movement
could have multiple meanings. And the
meaning is not inherent in the signal.
It's relational.
Right? I I think that's so this here's
the example I think that's the best that
sort of really usually communicates the
point well. So I don't know let's hope
usually
that you know there your retina has
different kinds of receptors in it in
your eye different kinds of receptors in
it
and there are you need three kinds of
receptors in order to for a wavelength
of light which will hit your retina and
travel the the wavelength of light gets
translated into electrical signals and
it goes up to your brain.
You need three kinds of receptors in
your eye in order for you to experience
a wavelength of light around 620
nanometers as red.
Most humans neurotypically have three
neurotrans have three cones, three types
of receptors. So we say that that light
at that wavelength is red.
The rose is red. The the sports car is
red. The lipstick is red. The shoes are
red. But red is not really a property of
an object. It's not in the wavelength of
light.
Red is a property of the relation
between that wavelength and what's in
your eye and what's in your brain. We
say, well, somebody who only has two
cones,
they can't they don't see that
wavelength of light as red. they see it
as kind of a greenish brown. So we say,
"Oh, that person is colorblind
because it implies that the the light is
objectively red."
>> Mhm.
>> But that's only because humans have
three cones, three receptors
neurotypically.
There are humans who have four cones,
four types of receptors, and they don't
see that light as red either. They see
it as a different color. And if all
humans had four cones,
then objectively that wavelength of
light would not be red. It would be some
other color. And those of us with three
cones would be colorblind to that color.
So the point being that what we call
objective is really we are elevating a
human consent. We're elevating the, you
know, certain experiences of certain
humans as to be objective and other
people's to be something else. And so
we're prioritizing
our own ourselves, our own biology
essentially, and we're calling it
objective. And that's pretty much what
we do on a large scale like as humans.
>> Yeah. I I think functionally we need
some way could be if if it was there's a
scowl over there. Well, that could mean
one of 50,000 different things. It would
take a long time to get through my day,
you know. I
>> It doesn't but it doesn't. That's that's
the amazing thing about the brain is it
is this is the business problem. The
business problem is there's a lot of
variation and your brain has to make
sense of it. Your brain has to figure
out which signals mean something, which
signals are noise, can be ignored. And
your brain isn't just taking in a scowl.
It's taking in an entire ensemble of
signals and it's making sense of those
based on patterns from the past. So the
really amazing thing is that we are
equipped to deal with that kind of
variation. And it's just that we
categorize so automatically. We make
meanings so automatically that we think
the meaning is inherent in the world.
That the categories are in the world.
But they're not in the world. They're
also not only in our heads. They are
relationally real.
>> And no matter how confident you are like
you know I'm I am also someone who's
pretty confident about my you know I but
I am tempered by the fact that the
neuroscience is very clear. We don't
read people. Movements aren't, you know,
can't be read. The emotional meaning of
them can't be read like words on a page.
No matter how confident you are, your
feeling of confidence is not an
indicator of the validity of your
perception.
>> Yeah, that's great. It's a really lovely
way to sort of bring that into land. I
think um the it means a couple of things
at least to me. Uh, one would be, wow, I
can I really have a good bit of agency
over
how I see the world, what things mean to
me. Um, the way that an experience can
be interpreted and encoded by myself,
>> the way that a way that signals can be
experienced.
It's not that you're interpreting your
experience. I mean you we may do that
also but the formation of experience out
of these these signals that we that
we're constantly um processing. The
other thing it makes me think is how
often are people who are in a bad mood
mistaking their bad mood for mistaking
dehydration or low blood sugar or a lack
of sleep or or I remember you saying
some story about you you got a stomach
bug on a first date and and and and muck
miss m um like butterflies for something
else that was happening in your stomach.
And um
>> yeah,
>> I
>> I wish I wish that were not true. I wish
I just made that story up, but
unfortunately I didn't. It it actually
happened. I I was surprised and I
thought, well, I must be really lusting
after this person when really what I had
was the beginnings of the flu.
>> But yeah, we are um at the mercy of the
signals, right? Both internal and
external. and in some not at the mercy.
>> Well, yes and no. I think this is why I
think it's really useful to know
something about how brains work. Listen,
when I'm at the end of the day and I
have no spoons left and I'm exhausted
and to me it feels like the world is
ending and it really does happen
sometimes where I feel like the world is
ending. Like I just can't deal with one
more thing and everything is awful. I
just have to grab a hold of myself and
say, "Okay, you're metabolically
depleted.
Go to bed. Get some sleep. Tomorrow will
be a better day." But it doesn't feel
like that. It's not like I can I mean I
it's I feel like, you know, everything
is horrible. And um but but I I'm aware
of the evidence, right? The evidence is
that everything that you experience is
partly
um every the way that you experience the
outside world is partly due to what's
going on in your body as it is relayed
to your brain. And and so because I'm
aware of that, I do have more agency
um than I would otherwise. It still
automatically happens that I will feel
like sometimes.
>> Mhm.
>> Um more often than I would like to uh
admit maybe. Um but but I'm also aware
the agency I think looks different than
than what we imagine agency to be like.
You know,
getting control over your um your
experience
doesn't look exactly the way we imagine
it to. It's much harder to do than we
would like. Um, it takes a lot longer, a
lot more practice than anybody would
wish. Some people have more options than
others, but everybody has the
opportunity for a little more agency
that begins with understanding a little
bit about
um what's happening under the hood.
How do you come to think about that
relationship between the
experiencing self and the one that steps
in the one the How do you think about
the difference between apocalyptic Lisa
at the end of the day
and
uh gently reassuring Lisa saying you
probably just need to have a cup of tea
and go to bed. What What is that
relationship? What is it about tea that
is so
>> Well, I'm British, so
>> No, but I'm Well, I'm Canadian and so
maybe that we have tea in common, but I
do actually find a cup of tea just I
don't know what it is about tea, but it
could just be the whole mythology around
tea like in all the all of the
paraphernalia
>> you tell yourself.
>> Yeah. I don't know. But there is Yeah. I
mean, I'm tempted to say there is
something objective about tea, but maybe
it's only in relation to, you know,
>> Mhm. into our based on our experience.
>> Bifificate that away from the sacred
ritual of making the tea and smelling it
brew.
>> Yeah. Yeah. Yeah. And pulling out your
favorite mug and whatever. Yeah. So, um
I but what I would say is you don't have
multiple selves, you know, you have one
brain
and your brain in conversation
constantly with your body and the s you
know, I mean, we like to say with the
world too, but you only know the world
through the sensory surfaces of your
body. So your brain is really modeling
your body. That constant conversation
which is informing the brain also on the
conditions of the world
that is your mind. That's that is the
manifestation of that is your mind. So
we, you know, we have a um like I use a
cartisian cr uh crutch, you know, like
uh Daycart famously was a philosopher
who famously um bifurcated you know the
body and the mind and um uh
you know the physical and the mental as
if they're separate things and they're
really not separate things. Every
feeling you have, every perception,
every every mental thing that occurs has
some physical basis.
But there it's a useful device
linguistically to talk about the things
that your brain does automatically
as happening in your brain and the
things that your brain does with
valition
as happening in your mind. So I will
sometimes say well your brain does this
versus you have control but really it's
all your brain. So why does your brain
make itself aware of some things and not
others? Nobody knows the answer to that
question. And there are lots of ideas
like how is it that this automatic stuff
can go on but yet sometimes we can
sometimes use attention to kind of shift
um the signaling. Nobody understands
they might understand a little bit about
how it happens, but nobody understands
why it's happening that way. So, um it's
not like I have an apocalyptic self and
a um my some my husband sometimes will
when I'm, you know, I'll just be like, I
I need to complain to you. I need to
complain about this. Or sometimes I
won't even ask. I'll just start to
complain and he'll be like, are there
any other dwarves visiting you? like
you've got sleepy and grumpy and you
know hungry and you know chilly you know
just like is there any are there any
other dwarves
you
>> you know
>> the thing is it's all you
in in the same way that um you know
right now
>> um you know Chris I can focus on your
face or I can focus on that pink light
that's kind of in the background or I
could focus on I can hear the air
conditioning blowing a little bit in
background here that is I'm foreground
with attention I'm foregrounding certain
features and I'm backgrounding other
features and so at any given moment you
you can do that you can practice doing
that and for a human those features
aren't always in the moment they can
also be features that you predict will
be occurring later right so I may feel
exhausted now and it may feel like the
world is ending now or that everything
is terrible now but I'm aware of the
fact I can focus on the fact that
probably tomorrow morning based on my
long history of experience if I just can
get some sleep, have a hot bath, have a
nice cup of tea, get some sleep, I won't
feel this way in the morning. And I
think the thing that's really to me
profound about this is
I know this to be true. I mean, I know
this as a as a neuroscientist. I know
that my experience in the moment is a
combination of what's in here and you
know
>> what's out here,
>> but that doesn't change my experience of
everything feeling like the world like
the world is closing in on me. And it
really does feel that way. And it
requires I can pretty automatically now
remember that it it's just it it you
know this is a construction of the
sensory present and the remembered past
and that there are other possible
experiences in the moment that I could
be having.
And that's why I think like I can't
remember the person who said this but
it's this is not my quote. It's actually
in my I think in the footer of my email,
but um my my email signature, but um
like hope is a practice. You know, hope
is a practice. What does that mean? It
means that if meaning ultimately is
grounded in metabolism and movement, you
always begin a prediction. The brain
begins with a predicting a a set of
behaviors, a set of actions that then
gives rise to your lived experience.
Then you can practice.
You can deliberately engage in
experiences. You can deliberately
cultivate experiences for yourself in
the present with effort
that if you do it frequently enough
become automatic
and available. They become available
automatically for your brain to use as
predictions in the future.
>> Uhhuh. So if you want to change your if
you want to change who you are,
you can you can't really go back into
the past and change what happened. You
can try. That's what therapy is for in
part, but um but what you can do is
change the present
which will equip the brain, your brain
to predict differently in the future.
And as a consequence, you will do
different things and experience yourself
differently in the world. And that's
where the real agency is, I think.
>> Which do you think is a more powerful
practice between the two? going back to
try and change your retrospective
story meaning of the past, revisiting
things that have occurred or creating
this new investment to then be uh paid
down a memory dividend for you to
withdraw from in future by changing what
you're doing right now.
Well,
maybe every therapist will hate me for
saying this, but um I I think that
there's
varied success with going back into your
past and trying to change the meaning of
what's happened. It's not futile,
but it's I think much harder
than
investing in the present.
You know, it's like exercise. You you're
exercise. You invest literally invest
energy in the present. Sometimes you
make yourself really uncomfortable in
the present in order to equip yourself
to be better in the future. you know,
you're building a better, healthier, you
know, future you. And that's a little
bit like what I'm saying. You can do it
not just with, you know, building bigger
muscles or, you know, a more robust
cardiovascular system, but you can also
do it. It also works with the brain that
you can. So I think that
probably both are useful but
investing in experiences now changing
your situation for example you can you
can literally get up and move go for a
walk like literally move your body that
will change your lived experience but
you can also
um just change what you're focusing on
in you cannot even move um a muscle
and stay put in the present room um but
um but change what features you're
focusing on and that can that is
functionally like a change in
environment that can change your
experience. M
>> um and so what is useful I think is the
flexibility to um to equip yourself with
the flexibility to have a choice later
about how you experience things. I so I
don't think one is necessarily better
than the other, but I think they're both
probably have a role to play, but
I think the utility I think we
I don't know. I'm I'm I'm hesitant, as
you can see, to say that trying to
tell a different story about your past
is not useful because I do think it has
a it does have a a role to play. I think
>> you're being diplomatic, which I think
is is fair. Uh I have to assume because
we'll have a recency bias. Everybody's
got one. Um that experiences that you
had. Oh, this is get an interesting
question. Um attachment theory, uh the
the way that your nervous system has
encoded what this means to be close to
someone or far away, for them to this
person to approach you in a dark alley
or not, for you to be in a closed space
or whatever. Um, I would have assumed
that newer experiences would have
overwritten older experiences. That this
thing that we've done a couple of times
most recently, I've been in a small
space and it was okay. Uh, why does that
not get rid of claustrophobia, let's
say, that I had previously?
>> Yeah. So, surprisingly, that's not how
it works. And um the evidence suggests
that
um the original meaning and the new
meaning are both there, but you never
lose the old meaning
>> and it can and it can be reinstated
really easily.
So, um,
the only way to get rid of an old
meaning is to lose the neurons
that that manifest it.
Um, you know, there's an interesting
scient I think that's an interesting
scientific kind of story about this that
um a number of years ago like decades
maybe I don't know 40 50 years ago maybe
more now
some guy in Rockefeller University in
New York was studying why it is that
song birds
ch the size of the um clusters of
neurons in their um brains called um the
song nuclei. The like so a nucleus is
just like a clump of neurons that um
work together. The in in song birds they
these nuclei grow in size. They they
like new new neurons are there at some
parts of the year and then they get
smaller at other parts of the year. And
this scientist was like super interested
in like how does what is this what is
this about? This was the birth of the
science of plasticity. He discovered
that brains can birth new neurons
and then it was discovered that other
animals can do it and even humans can do
it but humans can only do it in some
parts of the brain in in exactly I think
one part there's some evidence maybe two
but one part of the brain called the
hippocampus can birth new neuron new
neurons
and then people start asking the
question well why how did this happen
that you know um the hippocampus can can
can birth new neurons. But they were
asking the wrong question because it
turns out that in vertebrate brains,
most animals, most vertebrates can they
they birth new neurons all over the
brain. Humans have lost that capacity.
We've only retained it in one part of
the brain, but it's been lost everywhere
else. And like why would that be? And
the one potential answer that scientists
think about is that we are long lived.
And when if you replace one neuron with
another neuron, you've lost the memories
that that neuron participated in
or you lose part of the memory that the
neuron particip. What is a memory? A
memory isn't like a file. It's a pattern
of electrical and chemical and maybe
magnetic. We don't know but definitely
electrical and chemical activity that is
remanifesting itself.
So memories aren't,
you know, retrieved, even though that's
the word we use. They're not really
retrieved like you would retrieve a file
from a file drawer. They are
reconstituted, re-implemented. they are
constructed reconstructed
um patterns of electrical activity with
electrical electrochemical activity
and if you lose the neurons that are
part of the I mean a given memory
doesn't just have one neuron it doesn't
just have one um you know one assembly
of neurons there are neurons that are
constantly switching out to maintain the
memory
um
um you know like like um I don't know,
like players on a baseball team or
something, you know, like they're
they're constantly switching out. But if
you lose some of those, the memory is is
lost.
So we don't lose our memories.
We remember things for 50, 60, 70, 80,
90 years, right? So we and we have a
limited capacity for memory. Meaning at
some point, and this is something that,
you know, scientists now talk about,
like maybe our inability to remember
things as we get much older is because
like we're we're getting filled up
because we don't have new neurons.
There's no place for those memories to
to to go essentially. Like there's no
there's no there no new neurons that are
like freed up the you know, so one
neuron doesn't participate in one
memory. It can participate in hundreds
or thousands of memory because it's it's
in an ensem a larger ensemble that
create the memory. But our the limited
nature of our of our memories or well
let's put it this way the expansive
nature of our memories comes from the
fact that we keep our neurons for a
really long time and we don't birth new
ones in most places in the brain. But
that also puts a limit on what we can
remember as we age.
I remember seeing something written a
while ago about
there is no such thing as sort of
getting rid of
myelin sheets that have been laid down.
You can simply lay down ones that are
more
easy to access, more commonly accessed
over the top. So basically there's no
such thing as not driving a habit. there
is simply choosing between which habit
you want to drive here or which one you
want to encode. Yeah. How much how much
truth is in that?
>> Well, yeah. I mean I there is some truth
in what you're saying, but it's the
devil's in the details, right? So, first
of all, a myelin sheath is the fatty
sheath that goes around the axon. It's
not responsible for content of your
experience. It's responsible for
transmission speed. So if you have an
axon that is well wrapped.
So an axon does everyone who I mean you
don't know what everyone who listens to
this knows but you know an axon is a is
um a like a a protrusion from the cell
body of a neuron that carries an
electrical signal that is part of how
neurons talk to each other and create
you know your movements and your lived
experience.
The speed with which the electrical
signal moves down the axon is directly
related to the thickness of the neuron
and the amount of myelin on the neuron
that wraps it for like conductive
purposes. It's also there are other
things which affect transmission speed
too that aren't aren't the myelin like
there are gal cells other cells uh that
wrap themselves around the junctures
between where neurons talk to each other
called a syninnapse and that also
affects the transmission speed of
signaling. But the point being that you
can you can lose myelin there that
happens. Um for example in intractable
depression you your um the myelin starts
to to um in on certain tracks in your
brain certain um
certain groups of axons lose some of
their mileination. And when you do deep
brain stimulation, that grows the myelin
back. That's partly why that treatment
is really useful.
But um
but it is the case that
once you have a memory, if you've
if you've consolidated that memory,
which means that your neurons have grown
new little receptors
um that are important for making an
ensemble of signals That is the memory.
If you've consolidated that memory,
you will have a hard time un remembering
it unless there is physical change to
your neurons.
>> What would that be?
>> Dementia like you lose you lose neurons.
>> Spike through the head.
>> Spike through the head. Yeah. However,
if you can prevent research suggest I
think that's accurate what I just said.
I'm pretty sure that's accurate.
I don't know of any other way that you
would
I guess you might have a hard time
remembering something, you know, like
you have tip of the tongue or something
like that. If the um if you get if
you're getting old like me um or you
haven't used the memory in a while um
then some of the
there could be you know
>> but there's no sort of real pruning
going on or like atrophy to this sort of
stuff.
>> Well there is pruning
but I don't think
I mean pruning it happen if you don't
use it you lose it. I mean for sure
pruning happens very intensely in
children's brains. It happens also in
adult brains but slower. Everything
happens slower. You know, all the tuning
and pruning happens much sl more slowly
in adult brains but and and much slower
the older you get. But I don't think
that there's pruning
for really intense memories or memories
that have um we would call them
stressful maybe or threatening or what
have you. But I would say, you know,
that have a strong metabolic demand. Um
that they require, you know, that they
are um they're
they have a strong impact on your
metabolic state. Those memories
typically are not pruned as far as I
know. What what you can what can be done
though is certain chemicals. You can
take certain drugs that will prevent you
from consolidating the memory in the
first place. And I think I think there
is research going on that attempts to
prevent
certain memories from really taking hold
physically for certain experiences
taking hold physically in the brain.
>> Is this like the equivalent of taking
Narcan for an overdose on a traumatic
experience?
>> A little bit. A little bit. Yeah.
>> You've had something bad happen to you.
that's hit you with this whatever like
anticolinergic or some some something
>> right I mean the thing is it's a very
complex process right that involves like
hundreds of chemicals and so if you
knock out a couple of the chemicals you
know the likelihood is that you'll have
a harder time consolidating the memory
um and therefore you you won't you won't
be able to remember
>> fascinating that's so fascinating that
you can but yeah sorry go ahead
>> just you could have an acute
intervention for for something that
happens. I've heard that women uh post
childbirth are given a flood of hormones
or a flood of neurochemicals that give
them a a sort of uh retrospective pain
amnesia about the discomfort that they
went through.
>> That is such that is like a myth.
>> Oh, my friend Daniel Sloth put it in his
standup special. I'm gonna have to tell
him
>> that is a myth. I can listen
I can remember
>> scientific myth or personal myth.
>> Well, I'm telling you that I can
remember how painful it was and my
husband can confirm that I can remember
how painful it was. But but what I would
say is
um
what's interesting about pain, right,
is that if I said to you, Chris, I want
you to keep your eyes open and in your
mind's eye, I want you to imagine a red
Macintosh apple of the sort that you
would eat. Can you see the ghost of a
red apple in your mind's eye?
>> Kind of.
>> Yeah. Right. And if I or if I asked you
to um are you you know if I asked you
what's your what's your what's your
favorite band like your favorite musical
band?
>> Sleep Token.
>> Oh gosh. I don't even know them.
>> Yeah. Well,
>> that's how old I am.
>> Okay. Well, can you can you hear one of
their songs in your head?
>> Mhm.
>> Right. But pretty pretty vividly
probably. Right.
>> Yep.
>> Yeah. Okay. But if I said,
"What's the most painful thing that ever
happened to you?"
>> Mhm.
>> Pick pick a painful thing that's
happened to you. Now try to actually
embody that pain. Like imagine it. Can
you
>> kind of
>> not really though?
>> Uh with difficulty. Yeah.
>> You have an awareness that you were in
pain.
>> Yes.
But you aren't feeling the pain the way
that you're hearing the song.
>> That's correct. That's correct.
>> Yeah. So, that's a really interesting
thing about what we would call
interceptive signaling. Signaling from
the the sensory um conditions of the
body. We can't
exactly
simulate it. We can't the predictions
our that our brains are making
don't reinstate the experience in the
same way that it will with vision or
with hearing or sometimes with taste.
Um
which is interesting and I you know
don't know
that anyone knows why that's the case
but it does seem to be the case. So,
>> um I mean a lot of really funky things
do happen in pregnancy and um in
childbirth
hormonally speaking. I mean when I was
pregnant with my daughter right before I
delivered her, my husband could open a
box of Cheerios in the kitchen and I
could be
four rooms away and I could smell it,
you know? I could I mean I could tell
the difference between Cheerios and Rice
Krispies or whatever, you know, like I
my sense of smell was really quite um
alarmingly and interestingly uh uh
intense, but
I don't know about I I think the most
women I know completely remember how
painful child birth was. I'll have to
inform my friend who pushed fake news to
theaters of people around the United
States.
>> Well, it's a probably a funny it's
probably a funny joke.
>> It's a very funny joke. It's a very
funny joke. It might just be a useful a
useful dramatic tool. Um, I want to talk
about I want to talk about anxiety
sort of emotion dour of the modern world
it seems. What do you wish more people
knew about anxiety and how it works?
Well, I don't think there's one cause of
anxiety exactly, but I do think that,
you know, your brain is making sense of
signals and there are other ways to make
sense of those signals. So
anxiety usually is a sit, you know, it's
usually occurring in situations where
there's a lot of uncertainty and there's
a lot of arousal, meaning there's a lot
of chemicals
um uh there's a more a higher
concentration of chemicals that um are
involved in your brain attempting to
learn that has taken new it take in
signals because it's not predicting
particularly well. there's a lot of
that's what it means when there's a lot
of uncertainty. Your brain can't prepare
one motor plan. It's preparing many and
it doesn't know which one is the one the
right one to choose.
>> That's such a great definition. That's
such a lovely way to to think about it,
especially what we've said previously
about the importance of prediction for
future events.
>> Yeah. So, um the go-to meaning doesn't
have to be anxiety. I if you if you
experience heightened arousal as
uncertainty, you do different things
than if you experience it as anxiety.
And you're not just labeling. It's not
labeling. It's you're embodying a
different meaning.
And um you know, what do you do when
you're uncertain about something? You
you forage for for for information.
>> You could get curious. You could be
interested.
>> Yeah. Yeah. Um what do you do? you know,
when you're anxious, you usually
withdraw.
Um,
and sometimes there's probably utility
in um in experiencing a high arousal
unpleasant state as uncertainty. There's
research, not my research, but research
by um a guy named Jeremy Jameson who um
trained people to recategorize or make
meaning of their um high arousal states
as um determination.
And uh he was able to in these studies
train people to overcome their test
anxiety by dissolving it. Basically,
their high arousal states remained high,
but
um they experienced it differently
because they made a different meaning of
it. And
there's great utility to getting rid of
test anxiety. Um it can be the
difference between mean the difference
between hundreds of thousands of dollars
over your lifetime in earning capacity.
Um,
my personal ex, you know, example that I
love that I've used in my book and I
talk about sometimes because I love this
example. It's an example of my daughter
when she was 12. When my daughter was
12, she was barely 5t tall and she was
testing for her black belt in karate.
Her sensei was a 10th degree black belt.
So, this guy, you know, could break a
board by looking at it, right? He was
just like really massively strong guy.
And she had to spar these like 15, 16,
17 year old boys who were like a foot
taller than her
um in order to um over two days to to
achieve this black belt. And her her
sensei, you know, kind of saunters up to
her and he just says, "Get your
butterflies flying in formation."
And I was like, "Oh my god, that is
amazing." He didn't say, "Calm down,
little girl." Because actually, calming
down would be the wrong thing to do when
you are in a motivated performance
situation. You don't want to be calm.
You want that arousal.
But if you experience it as anxiety,
the motor plans that come with that are
very different than if you experience it
as determination or as getting your
butterflies in formation.
And I personally have used that
particular concept multiple times in my
life when I've been faced in a motivate
like before I gave my TED talk you know
when I before I gave my TED talk in
front of a thousand people I could feel
my heartbeats in my fingertips like
that's how much arousal was in my body I
was like if somebody brought a flame
near me I probably would have combusted
like I was just wired
But
you know I just and I had to say to
myself like out loud you know this is
not anxiety. Get your butterflies flying
in formation because under those
circumstances
what comes to you I is the really is the
thing that has been ingrained in you.
The most automatic thing and in our
culture the most automatic thing is to
make sense of those experiences
as arous as um anxiety. But you do have
choices, you know. You do have choices.
>> I'm thinking about that uncertainty and
ambiguity
point. I'm wondering what it is about
the modern world which is providing us
with such potent fuel for anxiety to to
come through.
>> You mean such potent fuel for uncert
Yeah. So I would say what is I would say
there's a lot of uncertainty
and um
>> well there's a lot of anxiety where is
the where is the uncertainty ambiguity
how is that being borne through if
that's one of the key drivers of that
emotion.
>> Yeah. So what I would say is there's a
lot of uncertainty and there's a lot of
metabolic um demand. There's a lot of
well I mean we haven't talked about you
know your brain's most important job is
regulating your body and and all of that
but you know people are walking around
basically metabolically encumbered all
the time and partly that's the case
because there's so much uncertainty.
Uncertainty is very expensive for a
nervous system to manage and as a
consequence there's a lot of arousal and
and people are the go-to kind of
knee-jerk uh way of making sense of that
and experiencing it is anxiety. So
I think that
we've,
you know, engineered for ourselves like
the perfect environment basically to
bankrupt a human nervous system.
>> And um I think that I wrote about this
in my book and I continue to to
>> think that this is the case. you know
that um that
if you think about all of the moments
where in all of the things that could be
potentially
demanding um
you know making it hard for you to
predict well it you could just start to
enumerate them you know I mean most
people don't get a sufficient amount of
sleep we actually now you know there's A
lot of discussion now about getting
enough sleep but still we have um modern
life is not designed really for sleeping
well. We have computers, we have phones,
we have a lot of screens. Those screens
have um you know light in them that
stimulates our ganglen cells in our
retina that screws up our circadian
rhythm. Um
that's not trivial actually. That's a
really substantially important thing.
Um, we um, you know, we we eat pseudo
food that isn't really, you know, like
isn't necessarily really healthy and can
really screw up your predictions. You
know, if you're eating something with or
drinking soda or eating things with like
artificial sweeteners, the taste no
longer is a good predictor of the of the
um glucose concentration. Um uh you know
um we have
social media where I mean human the
biggest one of the biggest sources of
uncertainty for humans is other humans.
You know the best thing for your nervous
system is another human. The worst thing
for your nervous system is also another
human. And um
we um
you know our ways of interacting with
each other now you you know are also
somewhat uncertain. You know like
somebody walks up to you and goes hey
like well is that hi nice to see
you or is that you know like somebody
calling you a not a not nice name like
what you know. And then there's also
economic uncertainty. there's um climate
change and you wouldn't think climate
change you know you wouldn't think that
that really necessarily I mean it
doesn't matter whether you believe in
climate change or not the thing is that
climate change climate change is
happening and um you cannot believe it
but the impact of the change will still
impact your nervous system whether you
believe it or not climate change means
that one of the consequences is that
there are small changes in carbon
dioxide concentrations in the air And
very very small changes in carbon
dioxide concentrations actually have a
profound impact on vertebrate nervous
systems. Actually I think it may also
impact a non-vertebrate nervous systems
too.
>> Okay. So you're saying that the parts
per million increase is maybe as much of
a concern for our emotional system as
our climate system.
>> Well, you don't have an emotional
system, but I would say it's it's as
much of a
>> No. Well, you know.
>> Yeah. Yeah. Yeah. A mental system,
should we say? No, for your brain, for
your brain's ability to control your
body.
>> Okay.
>> And you know, you may think of that as
um that distinction as kind of like
splitting hairs, but you invited me on
your
>> Hey, you're you are the you you're the
specialist and you're here for a reason
and keeping me in line is one of them.
This is very important for today. But
yes, it turns out that very small
changes in carbon dioxide actually in
actually has an impact on a measurable
impact on nervous systems
>> and um um
so you know I mean and then in the
United States there are also other
issues you know like
there are school shootings there are you
know which happen at alarming
frequencies right um and then you also
have like political uncertainty and
um
doesn't really matter whether you're on
the left or on the right, you know,
whether you're a liberal or
conservative. There's a lot of
uncertainty for everybody.
>> So these your nervous system doesn't
your brain doesn't really like parse
these things and go well this is one
kind of uncertainty and that's another
kind and no it just it just they
compound each other. They just make it
harder for your brain to do its job.
>> And the result is increases in chemicals
that will you will experience as arousal
and you will make sense of
>> as anxiety
all other things being equal.
>> It's kind of inescapable. It seems like
a a pretty sort of perfect cocktail to
to create a an environment that this
this would be a common experience for a
lot of people in. Well, I think it is a
common experience for a lot of people,
but they make sense of it as, you know,
like, oh, my fight and flight circuits
are like overworked or whatever. But you
don't have fight orflight circuits.
There are no fight orflight circuits in
your brain. And I think people do things
to try to
um
reduce
their discomfort. Some of which are
this is just my speculation now, but
there's no evidence that this is the
case. But basically,
we know here's what we do know. We know
that from mathematical modeling using
using intelligent agents, it seems to be
the case that if you the evidence
suggests that if I make myself
predictable to you,
you will be more predictable to me.
And that's a benefit to both of our
nervous systems.
We'll like each other more.
And if we like each other more, we'll be
influenced by each other more.
So
if you wanted to reduce uncertainty in
your like or not even if you wanted to
you don't even have to know this right
like if you just if you feel better when
you're around people who are like who
are similar to you who you can predict
better
you're going to be around them more
because it feels better. The suggestion
here is as well that if you want them to
regulate you more, behaving in a
consistent and predictable manner
yourself is going to influence them
which will influence you which will
>> Right. Exactly. Exactly. And um I think
that this might be one of the reasons
why people are in their own little echo
chambers right now where they're out of
all of the out of all the information
that people and experiences people can
expose themselves to. What we see is
this
um you know self
um selection into
information bubbles and social bubbles
that are
where where viewpoints are are being
the the diversity of viewpoints is
decreasing and
>> unchallenged largely
>> unchallenged and I think it it my
speculation right is that it might
because um people are really encumbered.
They're really encumbered. I mean, we
haven't even talked about the fact that,
you know, like I said, okay, well, you
know, you're you're eating pseudo food
and you know, you might wonder, well,
what is that? Why does that matter?
Well, it matters because um what you
eat, how much you sleep, these things
actually matter to your brain's ability
to properly metabolically regulate your
body in an efficient way. And
if you know you
if that if the inability to do so
happens in in a given moment, nothing
bad's going to happen to you, but you'll
pay maybe a little tax, right? Like
evidence suggests for example that um if
you're engaged if you have if you're
exposed to social stress that means a
stressful situation involving another
person within 2 hours of eating your
metabolism becomes less efficient to the
tune of 104 calories. So it's like you
ate 104 more calories than you actually
ate. If you add that up over a year of
meals that's 11 pounds. So, it's almost
exactly a pound a month. Yeah.
>> Yeah. So, that means that you could eat
the exact same thing. You could even be
eating like super healthy.
>> But if you're exposed within 2 hours,
the research suggests that's, you know,
11 pounds in a year. So, the point is
that these like little metabolic
efficiencies that inefficiencies that
happen from these little moments of
uncertainty or little moments of stress,
they add up over time. and they um leave
you vulnerable to metabolic illnesses.
Well, what are metabolic illnesses?
Metabolic illnesses are well, we know
diabetes, heart disease, depression,
anxiety. These are illnesses that have a
very strong metabolic basis. And so my
point is that um that there isn't one
cause of anxiety. There are all these
little nudges.
Enough little nudges in the in the same
direction produce a big shove.
It seems to me, it's an interesting
point to bring up how other people can
impact us. There's a lot of conversation
at the moment about the impact of
loneliness too much. It's not even
necessarily solitude. It's people
feeling like they don't have anyone
around them. The most common answer to
the question, how many friends can you
call on in an emergency is zero. It's
not the mean, but it is the most et.
I'm interested in what the impact is of
toxic relationships on our health that
as you said there, the best thing for
our nervous system is another human, but
the worst thing for our nervous system
is that too. What What is the impact of
toxic relationships on our health?
Well, I think you know the evidence I
think um
on loneliness and feeling alone and so
on. I think the evidence is clearer
there. Um just probably because more
research has been done on that topic.
But I mean all things being equal, you
will live years you will lose years off
your life if you are really alone. Not
if you're by yourself and you're fine
being by yourself, but if you're lonely,
if you really if you're if you don't
have a connected social, you know, if
you don't even have one person that you
can call on that you feel that you could
rely on. I think it's important to
understand that we are um we are social
animals and what that means is we don't
just we are the caretakers of each
other's nervous systems whether we like
it or not. Doesn't matter again what
your politics are. It does. It's
irrelevant what you believe. The fact is
that we aren't built, we didn't evolve
as creatures to regulate our own nervous
systems by ourselves. We need help. We
need other people to do to help to bear
that burden.
The problem I think is um that
um as I said before that other people
are also the largest source of
uncertainty in our lives.
And
um
you know I think there's pretty good
evidence to suggest that um well there's
definitely evidence to suggest that if
you're in a relationship that is
physically harmful to you or sexually
harmful to you um where where where
adverse circum adverse events are
happening that will take a toll on not
just your emotional health but your
physical health. And if you're a child
or an adolescent and this is happening,
it will actually there's almost a
parametric relationship between your
experience of those events and the
likelihood that you will develop
metabolic illness of some sort in in
adulthood or middle age.
So it's it's really pernitious.
That being said, there is also evidence
that
um
but I don't think this is not really
evidence about a toxic relationship. So
there's evidence that if adverse
circumstances happen to you like a one a
big oneshot thing,
>> your way of making meaning of that can
have a really big effect on its how it
impacts your biology.
>> It's very different to a a chronic
stress situation though.
>> Yes, it is. And I think
I think we would probably think of a
toxic relationship more like a chronic
stress situation. I mean stress is just
the definition of stress really in our
lab. The way we think about it is um
stress is um your brain predicting the
need for a big metabolic outlay.
And that could be for any number of
reasons.
Um but if it happens chronically
um and you're mispredicting it all
>> um then what happens is the your the
mechanisms
the healthy mechanisms that occur that
the that are engaged to prepare for that
metabolic outlay become disregulated and
then you know you're basically you have
this pervasive metabolic disregulation
that occurs and that's the problem with
chronic stress. The problem is that
um
you know you're basically you've drained
their gas tank and um
kind of damaged the mechanisms in the
process kind of thing. But I I think
probably
probably there's research on longer the
effects of longer term adverse
relationships. I'm just not
>> I don't I don't know that literature
super well.
>> What What are the um mechanisms that are
turned on in chronic stress? You
mentioned certain things get damaged,
certain things are sort of always on.
You can't switch them off. gas tank is
empty. What What does chronic stress
look like metabolically? What does it do
to the brain?
>> Well, what happens in So, if we think
about stress as just anytime your brain
is predicting a big metabolic outlay.
So, when you drag your ass out of bed in
the morning, your brain before as you're
waking up, your brain is um uh you know,
signaling the need for cortisol.
Um because cortisol is not a stress
hormone. It's a hormone that gets
glucose in, you know, it it basically
makes your it m it it allows your cells
to metabolize glucose more easily
basically. Um, and so
standing up is metabolically costly.
Like the most expensive thing that your
brain can do is move your body, learn
something new, deal with persistent
uncertainty, and deal with an immune
system that is um chronically active,
meaning um that you have some metabolic
um some immune um dysfunction like an
you know, which would lead to like like
say an autoimmune illness or something.
So like elevated
>> persistent infection
Right. Yeah. Exactly. Um,
so when you wake up, if you go to
exercise, you have a cortisol surge
because your brain is predicting a big
metabolic outlay. But what happens often
like let's say when you're sitting in a
boardroom at a business meeting or
you're you know you have to talk to your
friendmy or you're worried about you
know getting into a fight with your
girlfriend or whatever it is your brain
is preparing for a big metabolic outlay
and then you don't need that you don't
need that gl so you're flushed with
glucose and you don't need the glucose
you don't need the extra glucose
>> that's like a false alarm
if that happens happens frequently
enough, your cells become insensitive
to cortisol,
which means that they can't utilize that
signal anymore when they when you
actually need it.
So, cortisol dysregulation is an example
of um what happens in chronic stress.
>> But that sounds good. Oh, I'm not so
sensitive to cortisol anymore. I can
handle the cortisol more effectively.
>> Mm-m.
>> What it means is that your cells won't
when cortisol is in the blood,
the cells can't utilize it anymore.
They're they ignore it because it's a
signal that doesn't have any meaning
anymore. It's always there.
>> So, when you go to drag your ass out of
bed in the morning, there's a cortisol
increase, but your cells can't utilize
it. And so, how do you feel? you feel ex
you feel you feel exhausted like you
can't move,
>> right? Or you know when you you have to
prepare for a big meeting
and you need that cortisol to you need
your cells to be able to utilize that
cortisol. Well, now it can't. So, how do
you feel? Well, you feel fuzzyheaded.
Cortisol is one chemical of thousands of
chemicals that work like this, right? So
what happens is there's a disregulation
of the normal
um mechanisms for regulating the body
and eventually
um this results in vulnerability to
illness. Not the first time, not the
10th time, but eventually. And What's
interesting about this is that, you
know, research shows that a single
interaction
that is unp socially unpleasant, like
where somebody, you know, yells at you
or especially if you're a kid or an
adolescent, but even in adulthood
where somebody's rude to you or
whatever, you see an effect. Now, that
effect isn't going to persist
necessarily because it's just once,
right? it. These are like little effects
that take a long time to add up until
they become a problem, but eventually
they will become a problem.
>> How does chronic stress impact memory,
our ability to encode things, recall
them?
>> Well, it's a complicated relationship.
Um the evidence suggests that um there's
an optimum level. If something doesn't
matter to you at all, like it has no
your brain is predicting it will have no
metabolic impact. You won't even pay
attention to it. Like you won't remember
it. You It's like noise. It's just like
you won't remember it. If your stress
level is too high, meaning that there's
um
that there's too much demand on the
system, you also probably won't
remember. Well, there's an optimum level
of of stress. Actually, it's like a an
inverted U. That's what the research
suggests.
How would you advise someone to rebuild
their function after a period of of
prolonged stress? Someone's had a rough
period, they've been sort of getting
through it and they think, "Wow, that
that sort of tired but wide thing that
really sounds like me." Or I wake up on
a morning and I feel sluggish and that
does actually correlate with a period
where I was kind of eating it a little
bit emotionally. And that thing had to
deal with mom and had to deal with work
and had to deal with the
what is a a good way for that person to
bring themselves back into a state of
normality.
>> Well, a I would say a state of of
optimal optimal metabolism or optimal um
optimal energy um efficiency. I would
say first of all your mood is a pretty
good clue to
you know like a like a very simple
summary or like a very simple barometer
of your metabolic state. So if you're
feeling okay, you have enough energy,
you know, you perceive enough energy,
you feel pretty good, probably
everything is going pretty well
metabolically speaking. And if you're
feeling really distressed or really
dragged out, probably there's some
metabolic demand. And I would say the mo
I mean, it's so boring, Chris. What I
have to say about this is like here she
goes. She's going to be a mother. Eat
healthfully. Get enough sleep. Whatever
that means for you. Like eight hours
isn't for everybody. You just have to
get enough sleep that you eventually
will wake up feeling rested. And even
even just resting like I learned this. I
couldn't believe this actually. I I um I
I you know used to do yoga quite a bit.
I had back surgery a couple years ago
and so it's curbed my ability to do yoga
a little bit but I used to do yoga every
like a lot like three times a week and
but shioasana was always like the
hardest thing for me like where you're
laying flat you know and some yoga
teachers chill out
>> yoga yoga instructors always like oh
this is my favorite part and I would be
like this is a living hell for me to lie
here like for six minutes whatever it
turns out there's actually evidence that
it's really good for you to just lie
down and have a rest for a minute.
>> Oh, interesting question on that. What
does it mean then that there's good
evidence lying down having a rest for a
minute is good for you, but your
experience of it was one of stress?
>> Well, it wasn't good for me. I mean,
like
you have to actually tune out the, you
know, oh, I've got to, you know, like
tune out the, you know, your inner troll
like, oh, I've got to do this and I've
got to do that and I've got to the
minute I as soon as I'm allowed to get
out of here, I've got to, you know, no,
you have to actually rest. Rest means,
you know, your mind isn't racing at a
100 miles an hour. Um, so, but I mean,
rest is good. Eating healthfully,
exercising, even if it means just going
for a walk, even if it's just a walk
around the block, it's a start, you
know. So, these things actually are like
50% of the I don't know if it's 50, but
it's like a lot of the equation here.
Um, and I would say, you know, be a
little gentler with yourself. um if
you're recovering from an illness or or
you've lived in a really you're live
you're just coming out of a really
stressful period you you have to
remember that you're just not as
resilient and you are not you you just
you're not as resilient as you will be
once you're so you just have to really I
think take care to um
uh get enough rest and
really do your best to not make more out
of it than that,
>> right? If you have the flu, what do you
do? You lie down, you watch TV, you
drink chicken soup, you take, you know,
maybe, you know, Tylenol or whatever.
You don't berate yourself for being a
horrible person. You have the flu. The
symptoms of prolonged stress are very
similar to the flu.
maybe no nausea, but definitely, you
know, the fatigue and the, you know, and
so you just have to be a little more
patient and um gentle with yourself
um as you recover.
>> You've said today our brains are are
pretty flexible. We have more of a
control over our emotional uh state than
we might think that we that we are able
to to step in. What's the limit? What
what can't we rewire ourselves to do?
What's the upper bound of our ability to
step into our our own brains?
Well, I think it's different for
different people. Um,
it depends on a lot of different
factors, but
I mean, you can't snap your fingers and
change your mood, for example. you if
you feel like you can change the
flavor of the that you're
experiencing, but you can't actually
turn it off um the way you would flip
off a light switch. It just doesn't work
like that. You have to tolerate it. You
have might you might tell yourself this
is noise. You know, you might experience
it as not relevant. Um
you know, kind of like chatter in a way.
I mean normally when we feel unpleasant
about something the first thing we do is
look to the world like what's wrong with
the world you know this is a clue or we
might look to ourselves what's wrong
with me but it could just be that you're
metabolically kind of like depleted and
so I think how you make sense of things
matters to a point but you can't if
you're feeling distress or fatigue you
can't just you know do a couple of Jedi
mind tricks and talk yourself out of it.
It doesn't work like that.
>> Mhm.
>> And if you're really ruminating, meaning
that you have intrusive thoughts or
thoughts that are you're going over and
over and over, you know, that are are
just turning around turning around in
your mind. It's very hard to turn those
off. I mean, you need to try. It's
really not healthy for you, but you're
just you're just giving those thoughts
essentially. You're you're sort of
juicing them up to be more easily uh
reinstated later. But it's very hard to
do that. And
sometimes, you know, you have to
literally change your context in order.
You have to think of them like mental
habits in a sense. And the way to change
a habit is not willpower. The way to
change a habit is to change your
context. Because a habit is nothing more
than automatic
behavior that is governed by predictions
which are influenced shaped by the
context that you're in. If you change
your context, you make it easier um to
shift into a different set of
predictions.
>> What would context consist of in the
rumination example? What would that look
like?
>> It depends on it depends. I mean, I
can't give you a specific recipe because
the conditions of human life are so
varied, but it could literally mean go
out for a walk,
immerse yourself in something, get
outside your head.
Um, you know, for me, honestly,
one thing that helps me a lot, it's not
going to help everybody, but it helps
me. I do neuroanatomy.
I I'll crack open a neuroanatomy book
and you know there are a couple of
anatomical problems I've been working on
for a while and I'll just read some
neuroanatomy. It absorbs
>> slightly niche solution. Yeah.
>> Yeah. But I also could do something like
I might watch television or watch a
movie. Well, I don't really watch
television but like I might watch a
movie or a cereal or something and knit,
>> right? Or I might go for a walk and I
might bird watch or I might work in the
garden.
>> Seems like you're trying to engage
yourself.
>> Yeah,
>> you're trying to engage your brain in a
different set of automatic predictions.
Willpower
like the kind of willpower that you
might use that we understand. we
understand this, you know, like um uh I
really want to eat that second piece of
chocolate cake and I have to tell myself
not to eat it. That's what we think of
as control.
That kind of control rarely works and
it's it's it's infrequent compared to
the other sources of control that are
automatically going on inside your brain
and you just have to figure out how to
harness those. So find something that
you find immersive and that isn't about
you
and that's a good recipe for um trying
to control these things that are really,
you know, really kind of hard to
control. Actually,
>> the thing that's I guess
interesting, reassuring, and a little
bit daunting that I've taken away from
this is the amount of responsibility
that we all can take over sort of what's
happening to us. Although it's very
disempowering to think, well, you know,
these emotions are just happening and
I'm I'm along for the ride. It's not
that doesn't feel particularly great.
But in some ways, it kind of
relinquishes you of any of the
responsibility of having to step in and
and why there's nothing I could do.
There's nothing I can do about my
anxiety. There's nothing that I can do
about my chronic stress. There's nothing
I can do about my rumination.
>> Mhm. Well, well, welcome to the quandry
of of uh modern life. I mean, I think
the idea that you're not responsible for
your emotions and and or or better said
that you're not responsible for your
behavior when you're under the influence
of an emotion that you've just described
um a large part of um western um legal
theory,
you know, I mean, so um but but I think
that you've put your you put your finger
on exactly the quandry,
you know, the very thing that gives a
lot of people hope
is the thing that is the thing that mean
it what it means is that you you know
you have more responsibility for for how
you act and how you feel than you might
think you do. And
I think the important thing and I I'm
really really you know this is an
important thing to say. Sometimes we're
responsible for things not because we're
to blame for them, but because we're the
only ones who can change them.
So, you just have to figure out what you
want in your life and how how hard
you're willing to work for it. And
everybody always need everyone needs a
little help. Sometimes that help can be
another person. That help could be a
medication. That help could be um it
could come in many different forms. It
doesn't necessarily mean that you have
to do everything yourself, but you are
the architect of your life.
Not everybody has the same options. It's
a lot harder, as I said before, to sort
of to take take the reigns, you know,
than we would like. It's it's not as
it's it's harder. It takes more time.
It's not always as effective as we would
like. But everybody can have more
control over their experience and their
actions uh than they think they can. And
that means everybody has a little more
responsibility than they might realize.
>> And that's pressure. There is a degree
of pressure, but there's also a kind of
liberation that comes along with it. So,
it's a it's an interesting blend. Dr.
Lisa Felman Barrett, ladies and
gentlemen, you're fantastic. Lisa, I
think you're wonderful. I really enjoy
your work. Uh where should people go?
They're going to want to uh check out
everything you've got going on.
lisafeldenbarrett.com.
>> Easy as that. Two books that everybody
should read, including one that's like
the perfect holiday. I don't want to
just do true crime romance fiction stuff
and is an easy read and then something
else which is deeper too. Uh Lisa, I
appreciate you very much. Thank you.
>> Thank you so much.
>> Congratulations. You made it to the end
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