LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Toronto, ON
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Dr. Andrew Huberman opened his live Q&A session in Toronto by addressing a series of episodes with psychiatrist Paul Conti, which aimed to bridge clinical expertise on trauma and the unconscious mind with accessible self-help tools. While many listeners initially assumed that understanding the subconscious required expensive talk therapy, Dr. Huberman explained that Dr. Conti's work utilizes simple practices like mirror work—staring into one's reflection while awake—to access deep psychological insights without cost or dependency on a therapist. A particularly significant revelation from this series concerned relationship dynamics; rather than focusing on superficial traits like profession or hobbies, the balance of three fundamental drives—the aggressive drive, pleasure drive, and generative drive—is what truly predicts compatibility in both romantic and non-romantic relationships. When asked about fostering emotional resilience during triggering situations, Dr. Huberman emphasized that real-time control is limited compared to long-term preparation through self-care. He argued that the threshold for a stress response can be elevated by consistently taking care of one's nervous system outside of crisis moments, starting with sleep and morning routines. While he acknowledged techniques like physiological sighs as immediate tools, his primary advice was preventative: building a robust foundation so that when triggered events occur, an individual is less reactive. He also touched upon the importance of understanding one's own psychology to avoid losing control in online environments where people often say things they would not do face-to-face due to physical distancing. To cultivate inspiration and new ideas, Dr. Huberman introduced "Strummer's Law," stating that there can be no output without input; therefore, creativity relies on collecting raw sensory materials before allowing the mind time to process them unconsciously. He advocates for weekly periods of wordlessness—such as walking or hiking without earphones—to let stored information from the unconscious "geyser up" into new concepts. This state is often characterized by a feeling of delight rather than awe, where an external event links directly to one's internal narrative and personal history, prompting action. He noted that while we do not fully understand the neural mechanism behind this inspiration in the brain, it represents a crucial link between our emotional wiring and creative output. Addressing seasonal depression common in northern latitudes like Toronto, Dr. Huberman explained how circannual rhythms are regulated by melatonin secretion from the pineal gland, which is suppressed by sunlight exposure. The key to combating winter blues is not just total light duration but extending bright light exposure slightly as days shorten, effectively tricking the brain's slow-integrating clock into thinking it is later in spring or early summer than reality dictates. He recommended using inexpensive 900-lux drawing tablets or bright incandescent bulbs for five to ten minutes of morning viewing before leaving home, rather than relying on expensive SAD lamps. This artificial light mimics the natural shift from shorter autumn days to longer winter ones, helping to regulate mood and energy levels without causing eye damage if viewed at a low solar angle equivalent intensity. Finally, Dr. Huberman discussed increasing neuroplasticity through various means, ranging from high-dose psychedelics like psilocybin or MDMA—which increase serotonin connectivity—to non-pharmacological methods such as learning to play an instrument in childhood. He stressed that while drugs can open windows for plasticity via neuromodulators like dopamine and acetylcholine, they should not be the primary entry point; instead, activities like playing music mimic the brain's natural ability to create broad connectivity found during psychedelic experiences. For those working from home all day, he suggested specific movement protocols including zone-two cardio, resistance training three times a week, and "soleus push-ups"—repeated heel raises while seated—to improve glucose utilization and insulin sensitivity without leaving one's desk. He concluded by describing his own morning perceptual exercise of shifting between different time domains to train the nervous system in task switching and broaden perspective beyond immediate stressors.
Read the full video transcript
Welcome to the Huberman Lab podcast,
where we discuss science and
science-based tools for everyday life.
Recently, the Huberman Lab hosted a live
event at the Meridian Theater in
Toronto, Ontario. The event consisted of
a lecture entitled The Brain-Body
Contract, followed by a question and
answer session. We wanted to make sure
that the question and answer session was
available to everybody, regardless of
who could attend in person. I also want
to make sure to thank the sponsors of
that event, which were Eight Sleep One
and Eight Sleep. Eight Sleep makes smart
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If you'd like to try Eight Sleep, you
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to save $150 off their Pod 3 cover.
Eight Sleep currently ships to the USA,
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AG1 is an all-in-one vitamin, mineral,
probiotic drink. I've been taking AG1
since 2012, so I'm delighted that they
sponsored the live event.
The reason I started taking AG1 and the
reason I still drink AG1 once or twice a
day is that it provides all of my
foundational nutritional needs. That is,
it provides insurance that I get the
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that's drinkAG1.com/huberman
to claim that special offer. And now,
without further ado, the question and
answer session from our live event at
the Meridian Theatre in Toronto,
Ontario.
Okay, um what motivated me to do the
guest series with Paul Conti? Okay, so
first of all, for those of you that
don't know, Paul Conti is a
psychiatrist. He's a Stanford and
Harvard-trained psychiatrist. Um
and I wanted to do the series with Paul
for several reasons. Um and we we
initiated that series uh first of all,
um he's incredibly talented as a
clinician.
And yet, um despite having written an
excellent book about trauma,
I felt that
uh two things were true for sure. One is
that most people won't get the
opportunity to work with Paul, sadly, is
he's time limited. And second, that um
his expertise is incredibly vast, not
just restricted to trauma. Trauma's, if
understood, can be transmuted into, you
know, deep sources of knowledge that
other people can benefit from. And
indeed, um what I found in Paul as I got
to know him is that he has just profound
insight into the unconscious mind. And
people had long asked me, uh you know,
around in and around the podcast, "What
about the subconscious? What about the
unconscious?" And
I was of the mind that the supercomputer
of the human brain is the forebrain, the
thinking, planning, context setting
piece right behind our forehead. So,
there you know, it's the reason that
we're not the house cats. That the house
cats are the house cats and that's the
reason. We're the curators of the
planet. But, Paul said, "Oh, no, no, no,
no, no. No, no, no, no, no. The
unconscious mind is the supercomputer of
the mind." I'm like, "Well, that sounds
great. But, how do we understand the
unconscious mind?" And, he has a really
biological and psychological and
psychiatric understanding of the
unconscious. And, in that series, he
talks about these so-called cupboards
that we can look
into in order to better understand our
own conscious unconscious mind in order
to allow our unconscious mind to teach
us things about ourselves that are
useful. And,
there are three main places where our
unconscious teaches us useful things
that allow us to be more conscious of
the way that our brain is working in
useful ways.
Um, the first is in these liminal states
between waking and sleep.
It really does seem to be the case that
when
surprise, surprise, we're completely
still, and we're emerging
from where we're dropping into states of
reduced autonomic arousal, but our level
of
thought, if you will, is still active
enough that we are aware, maybe even
lucid dreams. And, also in dreams, our
unconscious mind uses, as I think Young
and Freud pretty well understood,
symbols to teach us things. But,
everything's flipped in there. Gender's
flipped. Like like the like just cuz
you're you're having a conflict with
somebody in your life who's a a man
doesn't mean that that person shows up
as a man. They could show up as an
animal. So, species are flipped. The
symbols become mishmashed. But, Paul
made it very clear that all this can be
parsed if you do a certain kind of
introspective work. And, I thought that
would mean a lot of talk therapy, that
people would And, how are we going to
get people to learn how to do talk
therapy by themselves? We want to keep
things as much you know,
independent of cost and things like
that. And, the practices he started
talking about were incredibly simple.
Things like mirror work. This Some of
the psychologists in the room will be
familiar with this. I thought mirror
work, what is that? He said literally
people trying to
activate their unconscious
you know or excuse me access their
unconscious in sleep by a practice of
staring into the mirror for some period
of time while awake and reflecting on
self and aspirations and the idea of the
body as a container. All this stuff even
for a kid from Northern California sound
really woo new agey.
But here it's scripted by Paul into a
formal structure that one can use to
parse your own mental health and enhance
mental health. So that was the reason
for for doing the series and especially
that the episode on relationships not
just romantic relationships I found
hasn't come out yet incredibly
interesting because
he talked about how in his clinical
experience
all virtually all the stuff that people
pay attention to in relational stuff is
are they a narcissist? Are they
obsessive? Is this person a musician
versus whether or not I'm an accountant?
Would are we compatible? That none of
that stuff predicts anything as well as
the balance of these three drives, the
aggressive drive, the pleasure drive and
the so-called generative drive. And I
found it to be fascinating and I'm
excited for that episode and the other
episodes to come out but basically
because Paul's brilliant and he makes
the what I consider pretty obscure and
opaque very clear and concrete and there
are a bunch of worksheets. Again, all
available at zero cost and none of them
requiring that you do therapy with
anybody if that if you choose not to.
This is all the kind of work one could
do on oneself. And the last thing I'll
say about this is that and I should have
said this first is that the primary
motivation was we did a series of Dr.
Andy Galpin on
physical fitness. Why isn't there a
series on mental fitness? Right? Like
what is that? Why do we talk so much
about mental health when we're and it's
usually a conversation about mental
illness. What people should have tools
and practices that are zero cost, I
believe, to be able to introspect in a
structured way and enhance their mental
health
independent of, you know, their level of
income. And I think Paul was the guy to
do it. And we'll do more of that with
other people as well because no single
episode about any topic or series can
exhaustively cover any topic, although
Lord knows we we will try.
Okay, next question. What are the
recommended protocols and best practices
to enhance emotional resilience and
develop effective responses during
highly triggering situations? You're
asking the wrong guy.
Yeah.
I mean, I don't snap. I don't snap. I
was a wild teenager, but I don't snap.
I'm not the aggressor, but I do have a
snap button and it's been pushed uh
before and I have to say when that
happens, it's really kind of a scary
thing. Not to me, right? Um and it's
been many years, but I think anyone
who's who's hit that threshold where you
just you try not to say something, you
say it anyway. You You know, that that's
usually how how it shows up for people.
Um
I think
we hear
the statements like be responsive, not
reactive. Okay, that's why I became a
biologist cuz stuff like that makes no
sense to me.
Like in that moment, how are you
responsive, not reactive? So, to me it
was like, what are the tools? Clearly,
as you go up that continuum of autonomic
arousal, it becomes much harder to do
whatever that means,
right?
So, that hence the the tools for
reducing stress in real time. I I think
the one that we haven't emphasized so
much on the podcast,
um
and by the way, thanks to some great
therapy and that was not voluntary. I I
was able to, you know, I was a wild kid,
a wild wild kid, hung around wild kids
and
things were pretty different then and we
we
worked it out, you know, but I think
nowadays it's wonderful because I think
people are more conscious of um the need
to understand their nervous system,
their own psychology. That wasn't as
common back then. Um in fact, I I hid
the fact that I had to do therapy for a
long time thinking, "Wow, like
everyone's going to think I'm crazy."
They did call me crazy. You know, I
think things have really changed. I
think the last 20 years have brought
about a profound shift in the way that
we think about our own species and what
what are useful tools and practices. And
I think that
one of the things that is abundantly
clear
is that
that threshold for a stress response
really is
different for different people,
different in different situations, but
that it is something that can be um
practiced and elevated. And um
it in terms of not getting near that
trigger point uh through the types of
practices I talked about earlier,
getting more comfortable with adrenaline
circulating in your system is what it's
really about, frankly. But of course, it
all starts with a good night's sleep,
right? It's going to make you far less
reactive. But of course, when you're
stressed, that's
often when you're not getting good
sleep. So, I think that ultimately that
our ability to
as you know,
more emotional resilience and effective
responses during triggering situations
is really the consequence of practices
of taking good care outside of those
situations. And then of course,
inevitably there will be situations
where people get triggered. And uh it's
actually interesting to see the way that
people behave online and the fact that,
you know, many people, in fact, in
science as well, have literally lost
their jobs for having, you know, not
being able to control their thumbs.
It's kind of we're in an odd time where
there's the the the distancing of doing
things online as opposed to in person
where people somehow engage in saying
things and doing things that they
wouldn't in person. But I think that
ultimately it's the consequence of
good self-care. And this gets actually
back to some of the things that are
covered in the Contemplative Series. You
know, we hear about self-care as we
think that means massages, which are
great, by the way, and we think that
that is about exercise, and that's
wonderful. But, much of self-care is
about really making sure that our
nervous system is in the state that we
need it to be in in order to go about
our day. And I think this is why morning
routines and practices are so vital. I
think that those set the stage for the
emotional resilience. Those set the
stage for avoiding getting triggered, so
to speak. I don't think there's a lot
that one can do in real time, except
perhaps physiological sighs.
So, sorry to give you a sort of empty
answer. I'm not a pessimist on this
front, but it's I think that ultimately,
it's like saying, "Well, what if you
have to scale the side of a building to
get in?" You locked yourself out. You
know, what can you do to prepare for
that? Well, you can buy a ladder, but if
you don't have a ladder, you know, what
cuz what you probably should do is be
able to climb up a railing or something
like that, and know how to pick a lock
or something like that. So,
I think ultimately, that it's the
consequence of stuff that's done away
from those triggering situations.
Next question, please.
How would you describe the brain
activity of somebody when they're
suddenly inspired, and how to foster
inspiration in your life? Well, I talked
a little bit about this, but I I will
say that that the best way to foster
inspiration is, in the words of the
great Joe Strummer, they actually call
it Strummer's Law, no joke.
No input, no output. I think one of the
things that I've observed over and over
again is that
as much as we need to dedicate ourselves
to our craft, to our families, to our
friends, that ultimately, our
best ideas come from disparate
experiences, when we're not seeking a
particular kind of input to get ideas.
Now, maybe this practice of being
completely still while being alert
fosters a lot of
I I I think the way I understand it is
more of a geysering up of
of stored information in the
unconscious.
That's how I think Rick would talk about
it or Paul Conti would talk about it as
geysering up from the unconscious
because when we are
focused on the outside world, we're
taking in sensory information or
exteroception as opposed to
interoception.
And
of course, that external inform-
sensory information, that no input, no
output, is that those are the raw
materials that our nervous system uses
to construct ideas about anything. So,
my
belief, and this is a practice I do
every week, is I make sure that at least
once a week I either walk or hike or run
without any earphones, and I'm trying to
get into states of wordlessness, states
where I'm not
digesting a podcast, where I'm not
reading a book, where I'm not listening
to a lecture, where I'm not in
conversation, and essentially trying to
turn off the the linguistic narrative.
All right, we are a a storytelling
species.
We tend to take all our all of our
internal and external experience and
construct things around language, but
language is not spoken language is not
the language of the nervous system.
The language of the nervous system still
remains to be identified. It's something
else. For people that think in feels, it
will certainly incorporate that. Spoken
language, which of course is important,
and we have some core structures to
spoken language. We covered this in the
podcast episode with my friend Eddie
Chang.
But, ultimately
the
the way to come up with
new ideas or inspiration is going to be
to collect the raw materials of
experience and then give ourselves these
periods, maybe even just 5, 10 minutes.
You don't have to lay around half the
day doing nothing, still wide awake, and
give that
those raw materials the opportunity to
to marinate and combine in whatever ways
that are unique to you and then to
geyser up.
What inspiration looks like in the brain
we don't really know.
There's awe. There's some studies about
awe, but that's different. I the the
word that better comes to mind is
delight. Awe ten in my mind is something
that we we witness that sort of
overwhelms our attention. Like wow.
Delight is when it somehow links up with
our own internal narrative. Like I have
something to do with what's happening.
I'm not just here to witness it. You
know, a firework show, really impressive
firework show is like awe. But there's
nothing to do about it.
It doesn't relate to anything about you
really. You're a purely a spectator.
Whereas delight is when you see
something and it somehow links to
something in your emotional or personal
history or
how you're wired. But now there's
something to do about it. That's
inspiration. And we don't understand
where that exists in the brain or what
that looks like. But I think we all
recognize that feeling when it happens
and it's oh so wonderful.
Okay. Next question, please. How can
Canadians fight the seasonal depression?
Winters are too long here.
Okay.
Okay. Well,
Well, this gives me an opportunity to
share with you what I think is one of
the coolest things about our species.
Um notice I say that about many things.
Um so we've talked about circadian
rhythms, right? Sun rises, sun sets. And
we get that information transmitted into
our nervous system by looking at the
sunrise. By the way, you don't have to
watch the sun cross the horizon. It just
needs to be low solar angle.
Low in the sky. Once it's overhead, it's
a different signal. So low solar angle.
That's what it's about. It's not
necessarily about seeing the sun cross
the horizon. By the way, someone the
other day on my team said, "Wait, won't
you get cataracts if you look at the
sun?" Low solar angle sunlight is very
unlikely to cause cataracts, especially
if you're just doing it 10 to 30
minutes. That solar, you know, the sun
overhead is when it's quite bright. Yes,
indeed, some people are going to be at
risk for cataracts. So,
um ophthalmologists in the audience can
attack me for that one, but it was our
chair of ophthalmology at Stanford that
said it, so I'm going to trust him.
Okay.
That's circadian 24-hour rhythms, but
there's also these circannual rhythms.
So, if you're at a fairly northern
location on the planet,
nights get very long, days get short in
winter.
What happens then? Well, melatonin, the
hormone of darkness, right, is
essentially obliterated by light, by
sunlight. So, what's happening when days
are, you know, 12 hours long,
you have very little melatonin. The
duration of the melatonin signal is very
short. Then as you proceed into the
fall, days are getting shorter, nights
are getting longer, the duration of the
melatonin signal is getting longer and
longer.
Then is, of course, in winter, there's a
lot more darkness.
Melatonin signals are very long.
Daylight signals are very short because
the days are short. So, you could say,
"Okay, well, that's obvious. Thank
goodness."
But,
what that means is incredible. What that
means is that you have a hormone,
melatonin, that's secreted from your
pineal gland, which Descartes called the
seat of the soul,
cuz there's only one of them in the
brain.
I don't know how he came up with that
one, but
the pineal secretes melatonin, and it
sec- and it you suppress melatonin
secretion with sunlight viewing. There's
a couple of synapses in between the eye
and the pineal, but it gets there, up
through the neck, basically, the
cervical ganglia.
What's wild,
therefore, is that the location of the
Earth around the Sun and the tilt of the
Earth is translated
into a neural and then a hormonal signal
in your brain, which to me is amazing.
That literally means that that the
position of the Earth around the Sun and
its tilt
are translated into a physiological
signal that's working unconsciously to
tell your
brain and body what time of year it is,
but it doesn't care what time of year it
is. It cares about where you are in this
orbit about the Sun.
So,
if you think about when days are say 8
hours long
in the fall
versus 8 hours long in the spring,
what's different?
What's different is how long the signal
was the day before. So, the seasonal
depression we now know is the
consequence of the melatonin signal
getting longer, not an absolute duration
of the melatonin signal. In other words,
in
the spring when a day is 8 hours long,
but yesterday the day was 7 hours and 48
minutes long,
your brain has a memory of how much
melatonin was released the day before,
much more than that particular day. So,
it's a slow integrating clock. So, this
is a very roundabout way for me to teach
you about the melatonin seasonal rhythm
cycle and answer the question directly
by saying, if you want to offset
seasonal depression, what you want to do
is extend the amount of bright light
that you're getting in the morning
slightly as days get shorter. But, it's
the extension of the bright light
exposure, and if you can't do that with
sunlight because there's no sunlight cuz
you live in Toronto, not Toronto,
what you want to do is find some
artificial source that you can look at
in the morning before you leave your
home. And I haven't talked too much
about this on the podcast because our
listeners are extended around the globe
and not just in
um
northern locations, but what this
essentially means is getting maybe
two to three minutes of bright light
exposure as you're heading from fall
into winter. Bright light from an
artificial source. You do not need to
purchase a so-called SAD lamp, one of
these very expensive seasonal affect
depression
lamps. You can what I did was I
purchased because I'm very sensitive to
seasonal changes in light even though I
don't live very far north is you can get
a 900 lux drawing tablet. These are
quite inexpensive. They're not zero cost
but quite inexpensive and just put that
on your desk or on your wherever you
make your coffee in the morning 90
minutes after you wake up.
This sort of thing and just get five or
so minutes before you leave the house.
And then as you extend into the winter,
you don't have to be neurotic about
increasing the duration every day.
You could actually the way these these
slow integrating clocks work, you could
actually even just hold it a little bit
closer each day. Don't burn your
eyeballs out.
Um a little bit closer each day, but
essentially if you just dose yourself
with a little bit more bright light
early in the day as you extend into
winter, that will essentially trick the
the melatonin system into thinking that
you're going from 8 hours into 10 hours
of light as opposed to 8 hours into 6
hours of light. Okay? Very simple and if
you can't get one of these 900 lux
tablets or something off a website, then
you could do this with any bright
incandescent bulb
should work.
Again, just be careful not to put it
directly against your eyeball.
Okay, next question, please.
How do you increase neuroplasticity?
Well, this this is an opportunity to
talk about something
I should have said earlier, which is
that ultimately whether or not you are
triggering neuroplasticity through
elevated focus or whether or not you're
taking high-dose psilocybin,
your business, not mine.
Um and we can talk about psychedelics if
you want.
Um, just decriminalized in California or
soon to be decriminalized.
Cool. People are enthusiastic. Yeah, the
one thing
I've I've been pretty um vocal about my
belief that the data are really
interesting, to say the least, about um,
not microdosing. By the way, there
there's not a lot of evidence that
microdosing is useful. I'm not saying
it's not, but there are not a lot of
clinical trials so showing that. But the
two macrodose with with effective
therapeutic support um,
trials are very encouraging not just for
major depression, but also for various
eating disorders, alcohol uh, use
disorder, which is by the way that the
term that people are starting to shift
to as opposed to alcoholism or alcoholic
is now alcohol use disorder.
Um,
which is not to be politically correct,
but just so you understand what they're
talking about when they're talking about
alcohol use disorder.
Uh,
whether or not psilocybin, whether or
not it's MDMA, whether or not it's
frustration brought about by your
inability to play an an instrument and,
you know, your determination to to do
so, it's in the end it's all about
deployment of these neuromodulators.
Neuromodulators being some combination
of dopamine, serotonin,
uh, acetylcholine, or epinephrine.
Again, usually in combination. What's
very clear is that the neuroplastic
effects of MDMA, the neuroplastic
effects of psilocybin are brought about
by huge increases in serotonin.
This is also can help us understand why
for some years, and to some extent still
now, it was thought that the SSRIs, the
selective serotonin reuptake inhibitors,
would be good treatments for depression.
I think some people, by the way, have
experienced tremendous relief from the
SSRIs. We don't want to demonize them.
Uh, at the same time, it's very clear
that depression is not simply low levels
of serotonin. That's also not true.
Um, hence why there are effective
in some people antidepressants like
bupropion that increase
dopamine and epinephrine and and not
serotonin. The point here is that these
neuromodulators, as they're called,
allow for what? They allow for
modulation of synapses, which
effectively allows for neuroplasticity.
I mean, ultimately, whether or not it's
through talk therapy, Kundalini
breathing,
uh
you know, high-dose psilocybin, MDMA, or
the combination, which I think is called
a hippie flip. Um
Never done them together. I confess,
never done them together.
Um
but have done them.
Um it with a clinician, by the way, in
legal circumstances, and not a lot, um
not not often, that is. Um
it it's very clear that it's opening
windows for plasticity. Now, what's
intriguing, if we're going to just talk
about psychedelics for a second, is why
a drug like MDMA, which increases
dopamine, which by the way, MDMA is
methylenedioxy-methamphetamine.
Don't let anybody tell you it's
something there. It's meth.
It's meth, but it's meth with a lot of
serotonin thrown in there, too.
But it's meth.
And it's clear that for the treatment of
PTSD, it holds promise. It's not
absolutely safe, uh especially for
people with cardiac conditions. And you
If you're going to go down that path,
you want and need a a skilled guide, and
this is where I think the laws are
really going to have to
um pay careful attention to what who and
what is a skilled guide. Okay? Um and
when it comes to psilocybin,
the serotonin increase is what
effectively causes broader connectivity
in the brain. And what's interesting is
that both of those drugs increase
plasticity mainly through increases in
serotonin, but working on very different
receptors. So, they have different types
and outputs of plasticity. What's
interesting to me is that, because I'm a
strong believer that children should not
be doing psychedelics, nor should we be
giving children psychedelics is that the
the increases in connectivity in the
brain that are the consequence of
playing a musical instrument or ideally
an instrument with others as a child
mimic a lot of the broader scale
connectivity sort of called so-called
resting network connectivity that occurs
when people take psychedelics as adults.
In other words, and I can't emphasize
this enough, and again, I failed at
music miserably. I'll tell you the story
about that in a second. But so
getting kids to play an instrument
is it's very clear and improves their
ability to learn all sorts of things for
their entire life. It's just so so
important. I don't really know what to
do about this or who to shout out or
talk to about keeping the arts active in
in schools as and physical education,
but the idea that we would just train
kids in math is just frightening because
if you want them to be truly good at
math and science, you'd also have them
play instruments. By the way, when I was
a kid, I played the violin. My parents
made me.
It was not the instrument I wanted to
play, and we have only one picture, and
it was a they taught me the Suzuki
method. You're supposed to learn by ear,
and there's one picture, and all the
other kids have their bows up, and my
bow is down, and I'm standing here on
the stage, and my fly is down.
And I And that and literally the
neighbor's dog howled, and I quit after
that concert. So, I was traumatized by
They showed me the picture. My sister
teased me relentlessly.
Um so, neuroplasticity
figure out your choice way to increase a
neuromodulator like serotonin or
epinephrine acetylcholine or dopamine. I
honestly would not encourage
pharmacologic
or psychedelic approaches as your
primary entry point. I really don't. I
think that there's a place for that in
certain circumstances, but that would
not be the primary entry point.
Next question, please.
What type of movement protocol do you
recommend for somebody who's working
from home, sitting behind the computer
from 8:00 a.m. to 5:00 p.m.? Oh. Um
okay, well, a couple things.
I mean, I can make all sorts of
recommendations like get up early and,
you know, move and if you can take
breaks and walk, this sort of thing. But
but let's let's assume that all of that
is is kind of an understood that there
are certain forms of exercise that we
should all be doing. Three I think now
it's very clear based on the beautiful
work of Peter Attia, whose brother is in
the audience, by the way, tonight. Yeah.
Yeah. He's got a younger brother.
He's got a younger brother. Can you
imagine Peter Attia was your older
brother?
Can you imagine?
Be pretty cool. The um
I sort of adopt people as siblings. They
don't know it, but I do it. But I just
assumed Peter was my older brother, but
it turns out he has a younger brother
already. Um and Peter has essentially um
hammered home the truth, which is that
we should all be getting somewhere
between 150 to 200 minutes of so-called
zone two cardio, where we're walking a
lot and or moving about where we can
just barely hold a conversation.
I notice people in Toronto seem to walk
a lot, so that's great. Um
and then 3 days a week or so resistance
training and there are a bunch of other
mobility things that we should all do so
that we don't fall and break our hips,
cuz that's where another bone cuz that's
another way that people really limit
their health span and life span and so
on and so forth. But
two things that can make
being at a desk, which I loathe, even
though I like to learn, I hate sitting
still. Um you can do the standing desk
thing. I do that by stacking boxes. The
other thing that was interesting, did
anyone see this study out of the
University of Texas, I think it was in
Houston, this last year about the soleus
push-up? Did anyone see this? This is
pretty interesting. So, the soleus,
this, you know, wider, flat muscle below
the gastrocnemius of the calf, is a
really unique muscle in the human body.
It's 1% of the total human musculature,
but it has an ability
what
will soon be for obvious reasons,
to um dramatically shift fuel
utilization in the body. What they did
in this study was they had people who
were sitting for, you know, 3 or 4 hours
a day just simply raise their heel.
Seems almost silly, right? They called
it soleus push-up. When I called it that
online, I literally got attacked by the
gym bros telling me that's a seated calf
raise.
Okay? You know, I mean, I
like, "Okay." No wonder they, you know,
this whole bro science thing gets kind
of, you know, people get really
aggressive.
They lift their heel and they put
they're pushing their toe down, and some
people think of it as bouncing the knee,
but it's really about pushing the toe
down and lifting the heel. So, they just
simply had these sedentary people do
this heel raise. And what they saw was
that there was a dramatic
highly statistically significant
increase in blood glucose utilization
and reduction in in both
insulin levels during that activity and
around the clock. Really interesting.
What they were doing was mimicking some
aspect of walking. Now, is it as good as
walking? No. But if you are stuck behind
a, you know, working from home, sitting
behind the computer from 8:00 a.m. to
5:00 p.m., get it What they found was
that people getting into this
unconscious pattern of lifting their
heel over and over and shifting back and
forth mimicked a lot of the effects of
walking. It's not a replacement for
exercise, but the shifts in glucose and
insulin
output and utilization, excuse me,
utilization and output, respectively, uh
were were very impressive. And this uh
group down at the University of Houston
uh University of Texas in Houston is
starting to incorporate this into people
who have limited mobility.
Uh
and it doesn't seem like other limb
movements can do this. There's something
special about the soleus. It was
designed,
in air quotes, um
to be a muscle that's used repeatedly
over, you know, extended hours of time,
and it has this unique pathway of fuel
utilization. So, is it going to cure
obesity? No. But if you're stuck behind
a desk, that would be something useful.
I have this little fidget thing. Um I
was too lazy to build one, but I I found
one online for a couple bucks where you
just when you stand at your desk, it
just you kind of kick it back and forth.
Anyone seen these? They're kind of cool.
Then you just got to kick them back and
forth. And then some people will
treadmill at the desk. I can't do that.
I can't do that many things, but I also
I'm still like working on this one. I
can't can't quite do that. Uh next
question, please.
My morning meditation consists of Okay,
and then I think we're about out of
time, but the um yeah, so my morning uh
meditation is not really a meditation.
It's a perceptual exercise. And um that
perceptual exercise is has a weird name
cuz I gave it a weird name. Um I and I
didn't intend to sound mystical, and I
don't want credit for it, but I call it
space-time bridging, but it's not that.
What it really is is that the To me, one
of the most interesting things about the
nervous system is our ability to orient
in different time domains. This gets a
little bit abstract, but we know from
states of high stress that we start fine
slicing time.
We know this, right? The world becomes
like a slow-motion video because frame
rate has increased. We know As a visual
vision neuroscientist, I can tell you
that in my laboratory, we were doing
studies with virtual reality where we
can crank up people's level of stress by
giving them certain visual stimuli, and
then their ability to parse
information is clearly increasing in the
time domain. They're fine slicing, much
in the same way that when you look at a
slow-motion video somebody dunking a
basketball or something of that sort is
because the frame rate went up, right?
So, when we are in high alertness
states, our frame rate
increases. When we're very relaxed, our
frame rate decreases. So, if you're Rick
Rubining and you're lying there looking
at the sky, you your frame rate is
probably slower than if you're
hyper-focused on Oh my goodness, you
know,
um like you said like imagine a dreadful
situation where somebody sends you a
text message. Well, let's make it
positive. Somebody's having a child in
your family and you're like, you know,
is it a healthy Are mom and baby okay?
Dot dot dot.
It I mean, seconds feel like minutes.
Minutes feel like hours because you're
fine-slicing time. Okay? And then, mom
and baby are fine. Okay, great. Happy
story ending. Great. So, when we're very
relaxed, we tend to bend time more
broadly. Now, it's also true that your
visual system and your perception of
time are inextricably linked.
So, that if you close your eyes and you
focused on your internal state,
you are fine-slicing time and the second
hand, if you will, is more or less that
the metronome, rather, is your
breathing.
Or your and your heart rate from
combined.
When you open your eyes and you look at
something in your immediate environment,
when you move from so-called
interoception to exteroception, you
start your perception of time shifts
fairly dramatically.
And you now perceive time according to,
believe it or not, the speed of images
moving in your environment relative to
you. And then, as you look out further
onto, say, the horizon, you extend the
time domain even more. If you then
imagine yourself kind of in the whole
globe,
you extend your time domain even more.
So,
my morning meditation, if you will, it's
more of a perceptual exercise, is to
step through these different time
domains
to close my eyes and focus on my
internal state, open my eyes and focus
on something close by,
look a little bit further, look a bit
further, think about sort of myself on a
on the globe, the whole world moving, so
you're really extending your space
domain, and then the time domain expands
with it. You know, and this is comes up
when you see these little memes of, you
know, anytime you're worried, just
remember you're a little dot on a little
blue dot spinning in the universe. You
know, this kind of thing. But you don't
think that way when you're stressed.
You're thinking, I'm the blue dot.
You're the problem, whatever, you know,
or I want that, you know, you're not
thinking. So, this perceptual exercise
is a way of training the nervous system
my nervous system to shift deliberately
between these different time domains.
And for me, it's been very useful for
improving task switching. Something
that, as you probably have noticed, I'm
not very good at. I go into the trench,
I don't leave the trench very easily.
Um so, that's been very useful. And if
you are interested in this in more
detail, there's a wonderful book
um
called uh
The Secret Pulse of Time. And there's a
Hitchcock movie that's discussed in that
book, which the movie is about 75
minutes long. And during the course of
that movie, the background actually
includes rising and setting of the sun
and a bunch of different speeds of
movement and interplay between the
characters. And your perception at the
end of the movie is that a much, much
longer period of time occurred because
of sub unconsciously, your brain was
paying attention to these circadian
signals and these other signals. And
it's absolutely fascinating. Hitchcock,
not a huge Hitchcock fan, but now I
after seeing that, I was like, "Wow,
that's genius." He captured this
space-time thing. What you see out the
window is in one time domain, in the
room is a different time domain. I won't
tell you who killed who, but it's very,
very interesting. And so, the point
being that when your visual system is up
close, focusing on things up close or
internally, you're you're fine slicing.
When you focus on things further away,
you're more broadly focusing and so on
and so forth. So, that's a morning
meditation I do. It only perceptual
exercise, it only takes about a minute
or so.
And
the other thing is that on the monitors,
they're flashing out. That was your last
question. So, I I wanted to just say a
couple of things before we go. First of
all, thanks to all of you who um stood
out the night uh for the long duration.
I realize this stuff is like nerdy
detailed and there are a lot of other
things you could be doing with your
evening and your time.
And so, I'm very uh grateful that uh
you all came together tonight for this
uh
what I like to think was a discussion
and I also just want to thank everyone
for your interest in the podcast. I you
know it is a labor of love. I'm highly
dependent on my team for doing all of
it. I don't do it alone by any stretch,
but as much as it might seem like it's
me talking to all of you, it really is
about all of you. That's the reason I do
it and I'm ever so grateful and I'd
certainly be remiss if I didn't say
thank you for your interest in science.
Thank you.