Is It Ethical To Hand-Pick Your Child’s Genes? - Dr Jonathan Anomaly
Watch on YouTubeVideo summary
Dr. Jonathan Anomaly opens his discussion on genetic enhancement by addressing the historical stigma surrounding IQ tests, noting how they were misused in the 1920s and 30s to justify restrictive immigration policies and eugenics before being banned under Nazi rule after Hitler discovered Jews scored higher than Gentiles. He clarifies that intelligence is broadly defined as the ability to creatively solve problems rather than just memory or recall, a trait with strong genetic limits similar to height or athletic speed. While acknowledging early cultural biases in testing have been largely corrected over 80 years of reliable data, Anomaly emphasizes that IQ tests measure a general factor known as "G," which correlates strongly with educational attainment, income, and even marital stability. He argues that lower IQ is inversely correlated with criminality not merely due to socioeconomic status but because intelligence relates to self-control and long-term planning; however, he warns against conflating cognitive ability directly with moral worth or social value, noting the dangers of both overplaying IQ differences and denying their genetic reality. The conversation shifts to the emerging technology of embryo selection via in vitro fertilization (IVF), which allows parents to screen embryos for polygenic risk scores related to health conditions like diabetes, heart disease, schizophrenia, autism, and bipolar disorder before implantation. Anomaly highlights that while gene editing with CRISPR is still a decade or two away, selecting among naturally occurring genetic diversity in IVF embryos is already available. He points out that religious groups engaging in cousin marriage, such as certain communities in the Middle East or Ashkenazi Jews facing Tay-Sachs risks, might be early adopters of this technology to reduce disease burdens and counteract the expression of rare deleterious alleles common in smaller genetic pools. Furthermore, he discusses how selecting for traits like height could lead to a self-equilibrating arms race where parents stop gaining relative advantages once everyone becomes taller, potentially introducing health risks associated with extreme stature without providing further social benefits. Anomaly also explores the ethical complexities of selecting for personality traits and morality, referencing Julian Savulescu's argument in *Unfit for the Future* that we should make people "nicer" to solve collective action problems like climate change. He counters this by invoking game theory, suggesting that unconditional cooperation is vulnerable to exploitation; instead, individuals need a balance between being cooperative with normal types and possessing the firmness to punish psychopathic or parasitic personalities. This concept of moral flexibility allows for both empathy and necessary boundaries. Public opinion data from surveys conducted by Remy Furman reveals significant variation in approval levels depending on how traits are framed: while screening against diseases like cancer enjoys near-universal support, selecting against intelligence is viewed more skeptically due to misconceptions about its link to mental health issues, whereas skin color remains the most strongly disapproved trait. Interestingly, people show low enthusiasm for enhancing openness or extraversion and even life satisfaction itself, perhaps fearing that high agreeableness might lead to accepting an unjust status quo rather than striving for improvement. Looking toward the future adoption of these technologies, Anomaly predicts a rapid uptake within five years as ideological resistance melts away once companies publicly offer cognitive enhancement services, despite inevitable media backlash labeling them "Nazis." He anticipates that governments in countries with declining birth rates or small populations, such as South Korea and Israel, may subsidize embryo selection to counteract dysgenic trends where highly intelligent individuals have fewer children. Beyond health improvements, he foresees a reduction in disease burdens globally, particularly for regions practicing cousin marriage, though he raises the dystopian possibility that heritable traits like religiosity or political orientation could eventually be selected for by parents wishing to preserve their specific cultural identities across generations. Ultimately, Anomaly concludes that while culture currently swamps genetic influences on things like politics and religion in the short term, long-term evolutionary forces will inevitably shape these demographics unless countered by technological intervention, making the coming decade a pivotal moment for defining how humanity shapes its own future offspring.
Read the full video transcript
Why do people really dislike
conversations about IQ?
I think it's pretty straightforward and
that is norms that followed the end of
the Second World War. So, what ends up
happening in the 1920s and 30s is IQ
tests were already pretty decent by
then. They did have some bias back back
in the day when they were invented, but
they were relatively good at gauging
cognitive ability, but what ended what
ended up happening is some people
misused IQ to justify, for example, uh
restrictive immigration policies in the
United States first. And then, you know,
after World War II, actually,
interestingly, a quick divergence here,
Hitler had Jews and and non-Jews,
Gentiles, cognitively tested and he
found that Jews consistently scored
higher on IQ tests than Germans did and
he banned IQ tests um in Germany.
Wow.
So, actually being anti-IQ is a Nazi
policy.
It's pro-Nazi. That's right, right,
right. So,
But But at least according to the lore,
and and some of this lore is true, some
of the some of the hardcore coercive
eugenicists in the 1920s and 30s did
notice cognitive differences between
populations and even though Hitler found
the reverse between, you know, Jews and
and Gentiles what than what he wanted to
find, it became stigmatized after the
Second World War because at least some
people, even if not Hitler, were using
cognitive differences to justify
restrictive immigration policies and
also potentially supremacy over other
groups. So, you can think of the British
Empire and, you know, why should the
French have colonies? Why should the
British have colonies? Well, we're
smarter. We're better than them. That
sort of thing. I I'm not French or or
British, by the way, but, you know,
there's at least the sense that they
could be misused for these things and
and and sometimes they were. And so, I
think what happened after the Second
World War is not just that IQ was
shunned and the genetics of IQ, but
really genetic explanations for any
group differences and even for
individual differences because it became
part of a dangerous package whereby you
could use this research to mistreat
groups of people.
Can you just explain group differences
and individual differences, what that
means in the genetic context, how it's
different? Sure. I mean, look, we all
understand first of all what
intelligence is broadly speaking. I
should just say that.
Intelligence is roughly the ability to
creatively solve problems. It's not just
memory, it's not just recall. It's the
ability to kind of draw conclusions from
evidence and so on. And we recognize it
in in dogs, we recognize it in
cuttlefish. Cuttlefish are some of the
brightest animals on Earth, which is why
I don't eat them, by the way.
That's a kind of species of octopus.
And so we we all know that there are
individual differences in intelligence.
We see it in our dogs, we see it in
cuttlefish, we see it in people.
And obviously the genetics of this is
just such that you know, there there are
genetic explanations for why people
differ in height, in weight, in muscle
mass, and in intelligence. And that's
not to say that the environment doesn't
matter, that you can't get better, for
example, at taking IQ tests or solving
cognitive problems. But there are pretty
strict genetic limits on that, right?
You're not going to train your way into
becoming Einstein.
And so that that's individual
differences in IQ. There's clearly a
mostly genetic basis. It's true across
the animal kingdom.
And it's probably going to be true
across groups, too, whether we want to
talk about that or not. I mean, it seems
obvious, just like height. There are
height differences, there are speed
differences. Right now, we're all
watching the Olympics, and you do see
patterns, right? Ethiopians tend to be
really good at long-distance running.
And West Africans tend to be really good
at short-distance running. And so there
are going to be these differences
between
individuals and groups, and genes are
going to have something to do with it.
What I've I've heard a lot of criticism
about the
accuracy of IQ tests. IQ actually
doesn't predict anything at all. The
tests don't
test what they say that they're going
to.
Uh they're easily gamified. What's the
How much legitimacy is there to the
skepticism around IQ? And
what is that? Is that coming from sort
of people that have done rigorous
science? Is that coming from people that
are motivated for sort of social justice
reasons?
Look, the tests have been going on for
over a century now, and I think it's
pretty clear some of the early versions
of the test had some cultural biases. Um
so, for example, if you gave the test to
someone who is illiterate or who wasn't
uh familiar with some of the common
concepts like, you know, show pictures
of a rabbit and then show a rabbit
without ears or with ears and ask
people, "What's wrong with this
picture?" with the rabbit without ears.
Well, some people are going to get that
wrong if they've never seen a rabbit or
if they've never heard the word rabbit
or something like that.
Those kinds of biases were pretty
quickly fixed, however, and for the last
80 or so years, IQ tests have been
pretty reliable. I would never ever take
too seriously one gauge of anything,
right? Other than maybe height.
Actually, height is going to be pretty
accurate. We can still measure it in
inches or in centimeters, but probably
cognitive tests, IQ tests are going to
leave some important things off.
Nevertheless, one reason to think that
they're pretty good at gauging general
cognitive ability is they test a whole
wide variety of different abilities. So,
yes, there's some mathematical stuff,
really simple math though, not calculus.
There's some spatial reasoning
abilities, there's verbal reasoning,
there's inferential reasoning, where
you've got a set of premises, what
follows from the premises, really basic
logic.
And so, I think it's pretty clear that
the results from IQ tests can be well
replicated, and there's something called
Spearman's hypothesis, which goes way
back, almost 100 years,
and the basic idea is something like
this. Anytime you try to to measure any
kind of cognitive ability,
you end up getting this general factor
whereby different tests um correlate
with each other, so that there is some
general factor of intelligence, often
called G or general cognitive ability.
And IQ tests have gotten better at sort
of gauging that, even if they leave
certain things out.
And um yeah, we're we're studying the
genetics of this pretty well now.
There's There's of course many years of
behavioral genetics research, where you
separate identical twins and
non-identical twins at birth, and then
gauge their cognitive ability across the
lifetime. And of course,
you know, genetic twins, identical
twins, tend to score almost exactly the
same, and fraternal twins score very
differently.
And so there is something going on with
IQ, even if it's not everything we care
about.
What are the holes in the uh assessment
of IQ, of IQ as a a concept or G or
whatever you want to call it? Well, I
think it's just that like first of all,
unless you're taking IQ tests many, many
times across your life, which most of us
aren't doing, right? There going to be
certain things that you know, you do
better or worse on just based on the
test itself or on how well you slept or
whatever the night before. There going
to be little little holes like that. And
probably there are some people with
really good memories and poor spatial
reasoning and vice versa and so on.
And so I just think you have to be
really careful with
just sort of saying like, "Look, here's
your IQ test score. Here's how smart you
are." Nevertheless,
um we know there's a whole bunch of
traits that that that are highly
correlative with IQ. And these are
things like educational attainment, not
surprising. You know, people who score
better on IQ tests, especially on G, the
general factor of intelligence. They
tend to make more money. They tend to
get more educational attainment, and
especially in more difficult fields,
like physics or chemistry. My IQ is
probably not high enough to do
especially well in either of those.
Um but here are some of the more
interesting things that that I think
most people don't know about. IQ is a
pretty decent predictor of things like
marital stability, addictive behavior,
and this is after you've corrected for
socioeconomic status. Here's another one
that might shock you.
IQ is a decent predictor at predicting
criminality.
And you might ask, well,
why? Why would that be the case,
especially after you correct for
socioeconomic status? I mean, an obvious
thing is
if you have low socioeconomic status,
you might think, okay, you're both going
to have a lower IQ, and you're more
prone to criminality, but that's just
because you're poor. You need to steal
things in order to stay alive. Again,
once you correct for socioeconomic
status, you still get these
correlations, and IQ is inversely
um correlated with certain things, and
positively correlated with others. So,
smarter people tend to
tend to engage in less criminality. Now,
why is that? That's an interesting
question.
You might have a story where it goes in
one of two directions. It may be that
you know, there's some trait that's
correlated with intelligence, like um
long-term planning, self-control. So,
it's actually not IQ at all that's
causing more criminality. It's something
like that is low IQ causing criminality.
It's something like lower IQ people tend
to have
uh shorter time horizons and less
self-control, and that is true. And so,
they're going to be more prone to
criminality.
Couple of interesting things there.
First, that you say sort of uh
competence in one area seems to
correlate with competence in another.
So, the shape rotator word cell
dichotomy uh isn't sort of necessarily
true, that people are kind of they tend
to the rising tide of of intelligence
seems to lift sort of everybody's
capacity within that although you do get
some stuff skewed around. I wonder as
well if
a little bit of it is that because all
of these other benefits kind of come
along for the ride as a byproduct with
IQ, it becomes increasingly
more slippery to say well these people
are worth more. They're worth more to
society. They're less likely to be a
criminal. They're more likely to have a
job. They're more likely to be in a
stable relationship and not hurt you
know that those emotionally around them.
It's you know, just keep on scaling this
up. We review people that have got
education. We review people that have
got a higher
job title. We review people that have
got a nicer car which is downstream from
the earning potential which is from
their job which is from their education
which is from their IQ. And all of these
things sort of come along for the ride
to make
an image of a desirable person. You you
know, it'd be very rare for you to say,
"Would you like to have a child or would
you like for one of your friends to be
in some accident and after this they
were more likely to be a criminal or
they were more likely to
struggle in school or they were less
likely to get a promotion at work or
they were less you know, less
self-control etc. etc." And I think that
it it kind of gets into the topic that
we spoke about last time we're going to
talk about today sort of genetic
enhancement, the virtue of sort of
philosophical underpinnings of it.
that
it it's perilously close and this is the
you know, the criticisms of better or
worse
people That's right.
preferable or less preferable traits.
But even that you know, the moral it's a
sort of messy line between moral
equivalence. How much does this person
actually have value? Are they equal? Are
they better? And I think that because IQ
is kind of this
epicenter of it all and so much stuff is
downstream from it. Arguably, maybe as
you know, height might have some more or
it'll be probably not too far off.
Um
I you know,
would someone trade one standard
deviation of height for one standard
deviation of IQ? I don't know, but it
would you know, it'd be an interesting
experiment to run in a virtual reality.
But yeah, I just think um you know, it
it really gets to the point of better or
worse, more valuable or less valuable.
Yeah, let me say something about that
before we turn to sort of embryo
selection and the genetics of this
stuff.
I think that that is true, that there is
a real risk, and among my friends who
are IQ realists, I actually think some
of them
tend to overplay IQ relative for example
to personality traits. You mentioned a
superficial one like height, but you
mentioned it of course because it's
true. Um taller people tend to make more
income, women tend to prefer taller men
on the mating market, and there are
psychological studies we talked about
last time showing that
not only that taller people tend to be
regarded as more authoritative,
but people who are regarded as more
authoritative or attractive, who you've
never seen in person before, are often
thought to be taller than they are. So I
mentioned Tom Cruise last time as a as a
typical example of that, and that shows
you it is a bias, and that also shows
you we should be careful to
succumb to that bias. So for example, we
do tend to make these value judgments.
Um
more attractive people are in some sense
better, which is why they're on
television, right? Which is why people
tend to want to watch them on soap
operas rather than less attractive
people. And I think this is an actual
real problem. In politics, we want to be
sure that we have, for example,
anti-discrimination laws so that you
know, if someone basically an employer
preferentially hires someone simply
because they're attractive, if we really
did have good evidence that that was
true, I do think they have a case for a
lawsuit. And I think we should structure
our society in that way so that we don't
necessarily just value people based on
how attractive or smart they are.
Nevertheless, there are actually moral
risks to denying IQ and its importance
in everyday life because
if you don't understand that this is a
real phenomenon and that some people
have more of it than others, then what
you're going to end up saying is, "Look,
there's a class of people who are just
privileged." You know, you hear these
terms all the time like um
you know, whether it's toxic masculinity
or male privilege or white privilege or
Asian Asian privilege or whatever.
And and the same thing goes for, you
know, again, aesthetic privilege
actually. People don't use that term
very much, but they should.
There is actually a worry that um if you
don't acknowledge that some people are
smarter than others for largely genetic
reasons, then you're going to think that
their income is undeserved and you're
going to become envious of them and
you're going to create social policies
that basically say, "Look,
let's punish the high IQ people and
reward, you know, the others." And now
that's fine if if you have a theory of
fairness that says you should do that
because maybe IQ is largely unearned
because your genetics are unearned.
Fine, I can deal with that. That's
called luck egalitarianism in philosophy
and there are good arguments for that.
But there are also purely envy-based
arguments that are destructive of any
kind of political order that says,
"Let's punish the smart people and
reward those at the other end of the
bell curve." Um there's a of course a
parable for this that many people have
read from Kurt Vonnegut. It's a little
three-page story about a Handicapper
General and it takes place in the future
where everyone is finally equal in terms
of resources, income, you know, the size
of your house, etc., but some people are
smarter than others. So, what do they
do? They come up with a brain implant
and they zap them every 20 seconds so
they can't string thoughts together and
come up with the kind of innovations,
the kind of medical innovations that
that benefit all of us. And so,
just as there's a risk to overplaying
and to conflating it with moral value,
um I think there's also a risk to
denying the reality of IQ and the
genetic basis of it. And that risk is
designing political institutions so that
you punish the people who are actually
creating a lot of the value in the
world.
Getting into genetic enhancement and the
sort of selection
effectiveness,
this is something that you're absolutely
knee-deep in. I think this is going to
be
the big area of conversation for the
next decade. I I I can't I mean AI
yes, um
it is going to make
changes on the surface and it's going to
be more immediate, but this the
potential for gene embryo selection for
you to be able to fertilize with your
partner 10 harvested eggs and then be
able to do your polygenic risk scores
and look at a whole host of traits.
I think that is the big new technology
over the next few decades and I think
it's going to probably be the biggest
change that we're going to see. May but
between that and AI I think are the two
things that are neck and neck. Where
where's your sort of money lie on that?
I think that's right and I have a lot of
uncertainty over AI. So it's it's fairly
obvious that weak AI, in contrast to
strong AI, it's already here. Weak AI is
just basically algorithms that can
substitute for human thinking.
Self-driving cars, um programs that
solve math problems, that's weak AI or
you know, IBM's program Big Blue that
can beat every chess player in the world
handily. Okay, fine. That's here. That's
going to be very disruptive and I think
actually very good overall, but it's
going to be disruptive to certain jobs.
Strong AI, where you've actually got a
conscious being that is that has a
theory of mind that's conscious and so
on, however you however you define that.
I really have no idea if or when it's
coming. I assume at some point in the
future it will,
but I really don't know. One thing I do
know that's coming though, and that's
already here, is
the capacity to select genes for
intelligence and make our kids slightly
brighter. And here I'm not talking about
CRISPR. Um I'm not talking about gene
editing, which is almost certainly
coming, probably a decade or two away.
Um AI will actually facilitate that if
we get if we get AGI.
Um but I'm talking about using in vitro
fertilization, generating a bunch of
embryos, and then selecting among those
embryos. Everybody produces quite a bit
of genetic diversity. If you have, let's
say, 8 10 15 embryos, you know, you you
might get 20 25 IQ points difference
between the highest and the lowest
scoring. And right now, I actually know
there are companies, of course, that
will let you select for health traits,
polygenic health traits like diabetes,
heart disease, schizophrenia.
These have enormous value for future
people in in terms of health, longevity,
and so on.
But there's at least one company that
that I actually work with, um hasn't
publicly launched yet, but that can
select for cognitive ability. And
you know, if you're if you're doing IVF
anyway, why not select among the
brightest embryos? I don't think it's
the only thing you should select. You
should probably look at health traits
and what runs in your family.
And eventually we're going to be able to
select for personality. Like I said, a
lot of a lot of my friends who
you know, who sort of understand the
reality of IQ and its importance, still
often overplay it relative to, let's
say, conscientiousness or openness,
which to me actually have a lot of
value, because I want my kids
to, you know, to to respect other
people, to compete not only to compete,
but to compete fairly in the business
world, um and to be able to sort of set
tasks and goals and complete them on
time. That's conscientiousness.
So, basically, that's going to come very
soon. IQ is already here if you want to
select for it. Certainly, anyone can
contact me if they're interested in
that. And I think in the coming years,
you know, there going to be many other
companies that end up doing this. And
there's going to be almost an arms race
for who can offer which traits.
And this is going to become not just a
reality, but I think it'll become
widespread.
It leads to a very interesting
situation, which is that
you kind of have an arms race. Well, if
other families are able to do this and
I'm not able to do this, you end up with
sort of two classes of people, those
that can select and those that can't.
Yeah, I think it's going to be in the
same way that there's not just going to
be two classes genetically as as
pictured in Gattaca, there's going to be
thousands or millions of of ways in
which we diverge. There's going to be a
kind of spectrum.
So, too, with access. It's not going to
be like you have it or you don't. Um,
you know, we've talked about before and
you talked many times about mate
selection, which is clearly the most
important thing, right? If if you have a
sperm or egg donor or your husband or
wife just happens to be really bright or
conscientious,
that's already going to stack the
genetic deck in favor of your kids being
That that would be something I think
important to put in, which is, you know,
for anybody and even me before I became
friends with you, before we started
having these conversations more deeply,
there's just this
post-1943
ick around anything that gets kind of
close to selection, traits, preference,
reproduction, who is, who isn't, why do
we want this one and not the other, all
of that. Um, but everybody is a
eugenicist in some form because why did
you pick your partner? Why did you
choose that partner over another one?
Oh, it's because they're attractive and
because they were this and because they
were that. But when you get down to the
absolute root of it,
why is it that we're attracted to
symmetrical faces and not
non-symmetrical faces? Well, it's
because of mutational load and how how
resilient you've been to the
uh perturbments that you've had thus far
in your life. Why is it that we prefer
people that are tall? Well, sexy son
hypothesis. You know, we know that the
partner that we're with is going to pass
traits on to our children. It it the the
most interesting thing is what happens
when you allow um women to choose sperm
donors. Because what you get there is a
woman that is purely choosing genetic
material detached from their attraction
to the person that
deposits or supplies them with the
genetic material. And
it's it's evident. It's evident what
people they want somebody that's kind.
Right, okay. Well, that's going to be a
kind child, right? A smart child. They
don't want somebody that's unhealthy.
They don't want somebody that's full of
disease. So, yeah, I just
the the the fact that you already do a
proxy rough-hewn version of this where
you just roll the dice with which sperm
gets to which egg fastest. Like it's all
it's we're already there. We've been
there since the beginning of time, since
you know,
uh reproduction through sex started.
Yeah, I think that's right. And so,
you're you're you're already stacking
the genetic deck in favor in a certain
direction. We're all trying to find the
best mate we can. I mean, I don't want
to put it in terms of, you know, a
spreadsheet mentality. We're not ticking
boxes necessarily, but as you put it,
the kinds of traits that were adapted to
be attracted to obviously are cues of of
social success. And think of Think of
how much weight women place not just on
achievement, but you know, achievement
in a social context, right? Like you can
you could be on a on a date and and I
listened to your episode um a few days
ago that launched uh dating advice for
men, which was really interesting.
You know, and and the guest, I forget
her name, Blaine, yeah. Blaine, yeah.
She was sort of saying, you know, one
mistake men make is they kind of like
they talk too much and they kind of list
off their traits like it's a resume. And
that might all be true, but women want
to see you in action. Are you socially
dominant in a group? And not just
dominant in some sadistic sense, but
dominant in the sense that you
command the attention of other people.
They listen to you because they trust
you. Why do they trust you? Well,
there's information there. They trust
you probably because they have
experience of you solving problems well,
of you coordinating other people in a
kind of altruistic way. Like, here's the
plan. Here's how we're going to succeed
as a group.
And here's how we're going to beat the
other group, etc. And so, yeah, women
are already looking for proxies of these
men are too, of course. They're slightly
different proxies. But then when you get
into embryo selection or, you know,
again, before that even, sperm or egg
selection, if you're doing that, that's
what's really revealing the things that
you care about most. And
I mean, I might add, like, when I used
to teach this stuff at university,
you know, this is before I used I I
wrote about the topic, but I'd teach
other people's writings.
And a common distinction that people
will make, and I've seen it among
ordinary people too, is between
treating diseases that already exist and
enhancing existing capacities. There
seems to be a conceptual and moral line
that people want to draw. Or in the
context of embryo selection, we might
say, "Look, it's okay to prevent certain
known diseases.
So, you can select an embryo that
doesn't have Down syndrome,
that doesn't have a single gene or
monogenic condition like Tay-Sachs.
But that's very different than selecting
an embryo that's a little bit higher
than average on height or IQ or on
longevity, right? We can we can predict
longevity by putting a bunch of diseases
together and then having a kind of
disease-adjusted life year metric. And,
you know, choosing on the right-hand
side of that bell curve.
And I understand the the kind of
motivation behind this. You might think
like, "Look, it's one thing to kind of
say, yeah, diseases are bad. We know
that for sure, right? We can see them
manifest themselves. But,
what are we going to get when we select
in favor of these traits, you know, when
we select on the right side of the
bellcurve, so to speak, of intelligence
of a
And, you know, you might worry that
there's some unknown there. Now, I
actually think this line breaks down
pretty quickly. Um let me pick on
British people because they're British.
Um for whatever reason, Brits seem to
have on average worse teeth than
Chinese. Maybe that's not true,
actually. Let me pick a different group.
No, they need a different group. Uh
let's say Arabs. I don't know. I've
lived in the Middle East, you know.
Arabs don't seem to have as crooked a
teeth as Brits do in their kids, you
know. Um
Um and, you know, Brits get braces. We
all get braces these days, you know. I
was just in South America and it's a
little poorer down there, and you see a
lot of 30, 40-year-olds getting braces
for the first time.
And you think, "What's going on here?
This is an enhancement. Crooked teeth
are normal for our species.
They're especially normal for Brits, for
whatever reason.
And yet, we think it's perfectly fine to
enhance crooked teeth by putting braces
on. Similarly, it's perfectly normal for
our species to with age, over the age of
40, lose muscle mass, which is relevant
for your audience, you know, the people
who are listening for for workout
advice, you know.
Um it's perfectly normal to lose
eyesight. I'm 48 now,
and I'm from a family of pilots. We have
just perfect vision, or I should say
had, until this year, and I have my
goddamn glasses right in front of me
here. For the first time,
I started having difficulty seeing small
text, and it's blurry to me.
Now, is that normal? Yes, it is. If we
could select in in favor of having
eyesight, better eyesight longer, more
muscle mass later in life, would we do
it? I sure as hell know I would do it. I
think you would do it. And so,
you know, we have these intuitive lines.
It sort of makes sense from an
evolutionary standpoint to have these
stark distinctions. Look, we know these
diseases, they're bad. Let's let's
select against them, right? We've seen
them manifest. But, there's this unknown
territory of genetically enhancing
ourselves. And that seems scary and
mysterious. But, in a way it's not. You
know, we know what causes bad eyesight.
It's just like the the micro muscles
around your eyes just kind of getting
worse. We know that we're in some sense
programmed to die.
Um and we're more and more prone to
cancer as we get older.
So, is it an enhancement to select an
embryo at lower risk of adult cancer? In
a way, the answer is yes, but I also
think it's morally fine. So, the the the
treatment enhancement distinction is
it's conceptually interesting. I I
understand why people make it, but I
don't think it's either morally or very
conceptually coherent or significant.
Well, it definitely leads to some
difficult situations that you get into.
Okay, so if we got rid of all of the
potential risks for disease, that's a
longevity increase, but you're only
allowed to do it up to some kind of
arbitrary waterline ceiling thing, and
then beyond that that's I I I do think
even from our last conversation where we
spoke about the sort of difference
between selecting between different
offspring, so genetic selection, and
modifying the same offspring, which
would be enhancement, like actually
getting in and tinkering with the with
genes, which we're not not at the stage
to be able to do. Um
it does to me
feel
like
a fundamental difference between the
two. Uh given that you can't you know,
one of the things that you could be
concerned about if you were enhancing an
existing embryo with but going in and
tinkering with the genetic material is
that that embryo didn't ask
for them to have to be uh taller than
they were going to be or for them to be
smarter than they were going to be or
whatever. But when it comes to selecting
between different embryos, it's like,
"Well, the only way that you were going
to be born was if you were selected."
And you are the way that you are. You
are the way that you were always going
to be. So, I I feel like this sort of
first stage of
embryo selection is uh going to
encounter some challenges. And then when
we get to the next stage of genetic
enhancement, that's going to encounter
new philosophical challenges morally.
Yeah, I think that's right. And a couple
of things that he said. First is
consent, you know, so typically in
medical ethics, what's the foundational
principle? It's informed consent. You
know, your doctor doesn't have the right
to act paternalistic toward you, to tell
you, "You should select this embryo.
Why? Because I like it." Or you should
take this cancer treatment because it's
going to cure you. You're allowed to
say, "Look, I know it's more likely to
cure me, but I'm a Jehovah's Witness,
let's say,
and I don't want it." You know, you're
allowed to do that. And so, you know,
that that I think is the right principle
to to act from. Informed consent should
be the bedrock of medical ethics. It
certainly is in legal ethics.
Um
but it really doesn't apply when it
comes to children because no children
asked to be born, right? It's
impossible. So, whether it's you just,
you know, having sex with your wife and
the sperm that happens to join, you
know, you could have done it the night
before or the night after and it would
have been a different sperm
It was a sorry, that
uh Brian Klass told me about the fact
that um you know, when you're having
sex, especially if you're trying to have
children, that because of the way that
your physiology moves, the difference
between this thrust and the next thrust
it is the difference between a different
child being born. And I was like, "Well,
just in case any men weren't suffering
with enough performance anxiety already,
the knowledge that the amount of
duration that they they last for during
sex is going to be massively and it's
going to completely change our entire
future based on whether it's now or is
it now or is it now?
Totally.
Exactly. Yeah, so kids kids never
consent to being born, but you might ask
yourself this is kind of philosophical
principle.
Um you know, and it has to do with
hypothetical consent. Like if you were
to consent to something or if some being
could, it would be something like what
are the traits that it would consent to
having if it had a choice. Now it will
it never will in the case of a child
being born, but it would probably be
things like generally having a healthy
immune system,
being reasonably bright, not necessarily
a genius, um
because those are the the kind of
all-purpose goods that that lead to a
variety of different good lives. There
are there are so many different ways in
which you could have a good life, but
the last thing it would select in favor
of is severe disability or extremely low
intelligence or something like that or
poor self-control. Um and so it's
obvious like the things that people
would select for in general if they were
the ones doing the selecting, you know,
if they were choosing their parents.
But they can't and so I think, you know,
as long as your life is reasonably worth
living, which is almost all lives,
right? There are very few cases to the
contrary,
um you should be happy with your life
and and and parents, you know, I would
trust parents to do this rather than I
don't know the government or something
like that.
Now, to your other point though about
why do we have this treatment
enhancement distinction, you sort of
said, "Yeah, I can't kind of shake the
idea that maybe it is it is a a
worthwhile distinction." I do think in
some context it is. So think about
socialized health care.
Um to some extent we all live in a
system of socialized health care because
we have insurance pools.
And as soon as we're in an insurance
pool,
we're forced to share the costs and
benefits of one another's choices. And
in England it's just one giant forced
insurance pool, right?
And in cases like this, you know, you
have to allocate scarce resources. And
what we wouldn't want, you know, we
would want the government to say, "Look,
if you're doing IVF, maybe we should
also subsidize the ability to select
against severe disease." It's totally
uncontroversial, right? Or at least,
yeah, I think for most people, you'd
want to prioritize that, but you
wouldn't want to have subsidies for like
aesthetic enhancements, where it's like
all you're doing is you're spending
state resources, meaning my tax money,
Mhm. to, I don't know, give your kid a
slight advantage, which actually may
have a slight negative effect on
everyone else, because if your kid is
taller than everyone else, that means
mine is relatively shorter. And so,
actually, in the allocation of scarce
resources, where we're a kind of forced
um
a situation of forced allocation,
um where we're sharing each other's
resources, in those situations, I think
it's worth prioritizing treatment of
existing disease or prevention of
disease over, let's say, aesthetic
enhancement. It alleviates a potential
future burden. Exactly. A burden on
everyone in that case, right? Yeah.
Talk to me about this sort of gene
erosion and this increasing mutation
load. This I read a a very spicy short
article uh taken from something John
Tooby wrote a while ago, and I I kind of
can't stop seeing it now. That's right.
Yeah, I I briefly mentioned on your show
last time, actually, about a year and a
half ago, and uh Louise Perry is now
talking about it, too. So, I see that as
a victory for not so much enhancement as
science. I think this is something
everyone should know about. Um it's
something Darwin wrote about in 1871 in
The Descent of Man, although indirectly,
because the word gene didn't even exist
back then.
But the idea is something like this. Um
you know, we have in nature a set of
forces that uh you know, purify the
population, not in the kind of Nazi
sense of purification, not racial
purification, but purification in the
sense that,
you know, evolutionary biology works
like this. You know, we've we've got a
set of people, they have children, they
mix their genes, there are a bunch of
random mutations that accumulate in your
lifetime. You know, the most obvious
cases of those are like freckles on your
skin, you know, that's a mutation from
the sun. But here we're talking about
mutations that you pass on to your
children.
Most of those mutations are going to be
bad. They just have to be, right? By
definition, they're either neutral or
bad. And then rarely those mutations are
good and lead to to to some new
innovation at a genetic level.
Well, when we have a kind of
civilization with advanced health care,
and um nursing homes for the elderly and
so on, but what we're really talking
about is health care for children.
If you have diseases um when you're a
kid or during your reproductive years,
uh that we can now treat. So I mentioned
poor eyesight that we can treat with
glasses or LASIK surgery, childhood
cancers that we can often treat with
chemotherapy. There's a whole range of
diseases that we can treat now
by adjusting the environment to make it
easier for you to survive and reproduce,
or by actually just giving you medical
care if you can't afford it. Those are
going to imply, almost by definition,
that we're going to be passing along
uh genes and traits that are unfavorable
from the standpoint of genetic fitness
or from the standpoint of human welfare.
And again, Darwin understood it in the
point uh in terms of just certain human
welfare, but we can put it in terms of
genetic fitness as well. So we're we're
almost certainly accumulating
deleterious mutations in civilized
societies and passing those along. Those
are going to be accumulating.
Now, I think what's interesting about
this is I actually want to give a
metaphor which Louise Perry uh
introduced when when I was doing an
interview with her last year. And I I
should have put this in the first
edition of my book. I did put it in the
second edition, Thanks to you and her.
And the metaphor is something a lot of
people have heard of. It's Chesterton's
fence. So, G.K. Chesterton is a famous
uh British conservative, religious
conservative, and and just a brilliant
writer.
And the metaphor of Chesterton's fence
is something like this.
In the context of social reform, many of
the kind of socialists of the early 20th
century, they were they were a little
too eager to tear down existing
structures, you know, social norms,
legal institutions, and so on,
without thinking about why those things
were there to begin with and what is
going to replace them. And I think this
is just obviously a great metaphor for a
lot of things. And so, when you think
about Chesterton's fence in the context
of genetics, you might think
we should be cautious before we Forget
about gene editing. That's obvious. We
should be cautious there. But even with
embryo selection or I guess even mate
selection, maybe we should be cautious
with what we do, you know, before we, I
don't know, radically influence the
genetics of our children. And I think
that's a that's a really good point. But
what I want to bring up now is um a term
I guess I I coined it, but it's really
Chesterton's idea. I call it
Chesterton's post, and it's from an
earlier essay in 1908 that he wrote. Um
and actually, let me see if I can quote
it. Yeah, I do have it here from my
book.
So, Chesterton says in 1908,
"Conservatism is based on the idea that
if you leave things alone, you leave
them as they are. But you do not. If you
leave a thing alone, you leave it to a
torrent of change." And again, think
about this mutation accumulation thing
here. Evolution doesn't stop. "If you
leave a white post alone, it will soon
be a black post.
Um if you particularly want it to be
white, you must always be painting it
over and over again. Broadly, he says,
if you want the old white post, you must
have a new white post." And let me
extend the metaphor to an old Greek
metaphor um of a boat where, you know,
everyone who owns a boat, I certainly
don't have the money to own a boat, but
we all know that you have to constantly
maintain it because the salt water
erodes it. So, you're changing planks
one at a time, so to speak, right? And
at some point, it's basically a new
boat, but you still call it your boat.
And the metaphor here is conservatives,
of which GK GK Chesterton is a
conservative,
they often make the mistake that if you
want to stay where you are now, you can
just kind of take a snapshot and freeze
everything. But, in fact, entropy is
this universal force that dissolves
boats in the water, that dissolves
molecules in the universe, and that
degrades our genome over time. And so,
I've actually argued that just
Chesterton, who is a a vehement opponent
of eugenics,
but, by which he meant state-sponsored
coercive eugenics, Chesterton himself
should probably endorse voluntary
eugenics or genetic enhancement because
if you like where we are now, well,
you'd probably want to do one of two
things.
You either want to select in favor of a
low disease burden and low genetic load,
or reintroduce the really harsh mistress
that is purifying selection. That is, go
back to the Middle Ages, stop taking
your antibiotics and vaccines, and just
allow people basically to have a huge
number of kids, most of whom die before
reproductive age. So, I actually think
that
this is an essay everyone should read.
It's called the the race between
germline gene editing and genetic
meltdown.
Um and we don't necessarily need gene
editing, but we could use embryo
selection to minimize overall disease
burden, and therefore stay where we are
now. That's super interesting. I I I
hadn't thought I I've
learned about this sort of gene erosion
thing, and there's slow dwindling
towards us all becoming aliens with big
heads and skinny bodies.
Um
Yeah. But I I didn't consider that a
countervailing force would just be even
without the enhancement just straight up
Okay, well, if we continue to select a
uh disproportionately
uh
optimal um set of embryos across the
board, and if that becomes more
democratized, more democratized Um it's
kind of interesting, you know, I I had a
Malcolm Collins on the show last year.
Really interesting. I I, you know,
unique guy, and the fact that he's at
the forefront of talking about birth
rate decline is is is pretty cool.
One of the things I've been considering
is kind of the intersection of
declining birth rates with this
soon-to-come online reproductive
technology, especially given that some
of the groups that have the highest
birth rates are religious groups for
whom I imagine genetic selection because
of IVG and the potential for you having
unused embryos left over at the end of
this reproductive span for your wife uh
that they're not going to do that. So,
it's the the groups that are reproducing
more highly at the moment are going to
be the ones that are potentially unable
to use this technology or unwilling
because of some ethical consideration
that they have as part of their sort of
religion. Have you considered all of
these different things together?
Yeah, and and let me go back that one of
those feeds into your previous point.
Some people will be unable to use this.
I actually think like one solution to
this is going to be governments um
subsidizing IVF. China and Israel are
already doing this to boost their birth
rate. And I think it's actually a decent
idea because if you're older
um it is going to be harder to
reproduce, and so So you have crashing
birth rates, one way to to to boost it a
bit is to subsidize IVF, but once you do
that, it's a short step between
selecting among those embryos, because
when you do IVF, you have multiple
embryos, you're either going to select
at random or you're going to select the
one with the better genetic profile
according to you, not according to the
government, hopefully. And generally
that's going to be the one with the
lower disease burden and so on. So I
actually think
there's two things that are going to
follow from this
um
this initial unequal access. Governments
will see IVF and then eventually, you
know, companies that do genetic
selection on top of IVF as a thing to
promote not only to prevent big
inequalities, but also to
to promote birth rates. And so I see
this as incredibly optimistic actually.
I think it'll start in China and Israel
and it'll go from there to other parts
of the world.
Now you mentioned religious groups that
are unable or unwilling. Um so yeah,
again, government subsidies might help
for this for IVF um or insurance
subsidies. I know Tesla, you know, uh
right down the street from us has of
course Tesla and Elon Musk companies and
Elon of course has used IVF and embryo
selection. Tesla offers um IVF and
frozen eggs and that sort of thing. And
I think this is, you know, going to be
more and more common.
Now with religious groups, I do worry
that some are going to have a
prohibition against this and their kids
not in the first generation, but over
two or three or 10 generations could
suffer serious
um
genetic disadvantages because of the
choices their parents made. Some of them
are going to adapt and endorse um using
IVF and embryo selection and so on,
others won't.
But I don't endorse the government
coming in and forcing them to do it. Um
I think the risk
opposite of forced sterilization is,
forced selection reproduction.
Forced using of it. Yeah, exactly. I
don't think governments are specially
competent to do that. But I will say one
more thing. Um
and this goes to the point of what you
mentioned with uh
deleterious mutations accumulating in
the absence of embryo selection. That is
a fact. So, if we want to stay where we
are now and simply not deteriorate, here
is an example where
religious groups should endorse and
actually use embryo selection. So, in
Islam for a long, long time, maybe a
thousand years, it's been common to
engage in cousin marriage. And in fact,
that is the norm around the world, but
especially in Islam, and it's not in
Europe for one really interesting
reason. And there's a paper on this,
actually. It's called intensive kinship
connect
intensive kinship selection, the
Catholic Church, and global
psychological variation. That's the name
of the paper. This is from 2019. And
what it argued is that the Catholic
Church had prohibitions on first and
even second cousin marriage for more
than a thousand years. And this actually
had an effect on the European
population. Not only did they have lower
disease burdens, but they were selected
for various kinds of norms, and you see
this in every European society,
including their offshoots like Canada,
Australia, the United States. Higher
trust,
more of a sense of an impersonal set of
fairness rules,
and less corruption in the sense of
favoring your kin over non-kin. And
these authors have argued that that is
actually partly result of an inadvertent
ban on cousin marriage by the Catholic
Church. Now, I don't know if this is
true. These are two of the best scholars
in the world, Joseph Henrich at Harvard
and Jonathan Schulz,
who's an economist and statistician at
George Mason.
Um this has been replicated by a few
teams, but this is wild. So, when you
think about what what banning cousin
marriage can do, just doing that, right?
That can have tremendous genetic
effects. And in the Middle East, I'll
just put some meat on this bone. I
actually think the people that are going
to take up embryo selection first as it
becomes more out in the open and more
popular are Arabs in the Middle East,
Bangladeshis, and Africans in East
Africa. Why? Because they engage in more
cousin marriage. And as you know, I
mean, as everybody knows, right?
European kings who were doing sibling
and cousin marriage ended up with all
kinds of crazy deformities, low
cognitive ability. I mean, it toppled
entire regimes, right? And what you have
in the Middle East is the expression of
rare alleles, where if both parents have
them, you got you have this devastating
disease. You get cognitive impairments,
and you get all kinds of deformities
including heart disease and all of these
things at much higher rates in those
places that engage in cousin marriage
than those that don't. And this is a
religious practice. This is within Islam
or certain branches of it. So, I
actually think, interestingly, the
people who should use genetic selection
the most are going to be religious
groups, and some of them will, and
others won't, and they're going to put
their kids at all kinds of
disadvantages. That is so fascinating.
The fact that you have certain religious
groups which have got smaller genetic
pools. What how would you refer to that?
Less genetic variation?
Yeah, exactly. And that includes, you
know, my pool. I mean, I'm half
Ashkenazi Jew, and Ashkenazis were down
to a tiny bottleneck of only a few
hundred people in the Middle Ages. And
then they expanded quite a bit in
medieval Europe. And this is why
Ashkenazis have have a big disease
burden, right? This is why every
Ashkenazi, including the most extreme
religious person, the kind of crazy
Orthodox people you see in Brooklyn or
Israel, they all get the Tay-Sachs test
before they go on a first date. Um this
is straight-up eugenics, and it's
straight-up genetic selection. They know
they're at risk of these things, and so
it's better to marry someone who doesn't
have that deleterious allele.
So
Well, actually that's one point. Does
that mean that as a uh Ashkenazi Jew who
does have that allele,
it's super difficult for you to date?
Yeah, you have to you have to find
someone who doesn't etc. So um
yeah, you have to worry about it being
expressed if you're both carriers. Um if
you're not, it's not a problem. As if
the mating crisis wasn't hard enough as
it is, cut out 50% of So yeah, I mean
it's dude, that's so interesting. You've
got this this sort of smaller genetic
pool
and from that one of the ways that these
religious groups could uh combat uh the
downstream effects is to
sort of offset the entropy or off-
offset that sort of deleterious nature
by going in and ensure okay, we're okay
here, we're okay there. And then after a
period of time, maybe that gets you to
such a robust uh genetic uh standpoint.
Yeah, what are
what are some of the other What are some
of the other reasons to be worried about
genetic selection? What else have you
got concerns about?
Um let's see. I mean, look,
one of the reasons I wrote a book about
this long before I was involved kind of
in the industry, so to speak, um is
I don't know, you know, I studied
economics and philosophy and so I think
in terms of
what are the situations in which
individually rational choices, these
micro-level choices we make every day,
can sum up to an overall pattern that's
either better than our individual choice
or much worse from a social standpoint.
So the better case is the Adam Smith
case about trade, right? So each of us,
the the butcher, the brewer, and the
baker is just trying to get a good deal,
right? The end result is lower prices,
higher quality products. That's
that's the economic case for free trade,
right? Um that doesn't mean infinitely
free trade, but other things equal,
better off to leave people free to own
their own property, specialize in what
they're good at, and then exchange with
one another on mutually agreeable terms.
The overall social product is better for
everyone, right? We end up with these
rich societies. Um of course, you see
that, right? It starts in Britain in the
Industrial Revolution, it spreads from
there, and every society that has
private property and market exposure
ends up much richer than it was. So,
that's like the classic economic case
where it's positive sum.
But, economists often focus on these
negative sum games where it's like,
yeah, I buy gas, or let's say I buy
energy from a coal company.
That coal company
produces energy in a way that's really
dirty. They're putting um all kinds of
pollution in the atmosphere. Let's take
the case of China, for example.
Uh you know, it could contribute to
global warming. Even if you're not
worried about global warming, it's a
fact, it produces pollution that is bad
for your lungs, right? It can reduce
lifespan, increase cancer.
So,
those are cases where economists sort of
study them cuz it's just kind of a an
intellectual puzzle. It's fun to try to
solve them. What's producing this
overall pattern, and then how can we
how can we incentivize people
to act in ways that would be better for
everyone rather than worse? It could be
a tax on pollution, it could be,
you know, some kind of control on how
people produce energy, et cetera. And
then I thought, what is the ultimate
collective action problem
across societies, across countries, and
across generations? And it's genetic
selection. What'll happen when everyone
has the ability to select embryos or
edit those embryos eventually? Is it
going to be collectively a good thing or
a bad thing? Um and so, I wrote a book
about this, and I thought, you know,
each chapter was on a different topic,
like cognitive enhancement, aesthetic
enhancement, immuno-enhancement,
et cetera. And and then moral
enhancement, which I think is the most
interesting one. Maybe we can talk about
it, but
you know, basically, um
I think that the risk is there are some
arms races that can be collectively
self-defeating. Again, take a case like
male height.
If we each selected an embryo for the
tallest possible boy, we we ignored
everything else, so we just get tall
boys.
Well, now you've got a situation where
populations are taller, but there's no
relative advantage if everyone else is
equally tall.
And at some point there actually may be
health risks to being really tall, like
cardiac disorders and so on, right? If
you look at NBA players, these are not
the longest-lived people, right? They
live shorter lives and worse lives in in
old age than gymnasts do. Why? Because
there's a greater burden on their
on their joints, on their heart, etc.
And so there's actually benefits to
being shorter, not taller. So, are we
going to have this collectively
self-defeating arms race? I think just
on that point there a couple of
interesting pieces of insight, at least
when it comes to mate selection, it
seems like the height uh differential is
based, at least in part, it's anchored
to the height of the woman, not just the
relative height of other men around
them. So, on average women say they want
a partner that's 21 cm taller than they
are. Uh now, if we get to the stage
where the parents of women, uh females,
start to increase their height, yes,
then we have a true arms race on our
hands. Uh and also, I know that there's
some really interesting data around
whatever it is, like only three times in
history the shorter presidential
candidate has won. Uh there definitely
are some big big advantages to height,
but when you kind of really take the
reins off, uh
I
would guess that that's going to be
self-limiting before we get to a a
physiological kind of problem.
Exactly. And I like the word that you
use, self-limiting. I would say
self-equilibrating, just using a more
technical game-theoretic term, but it's
the same thing.
Um first of all, men tend to prefer
short women, not tall women. Um and and
and vice versa, so it's not clear you're
going to get
Imagine if we end up with this fee, fie,
foe, fum [ __ ] group of guys and a
bunch of four foot 11 women. Exactly.
Yeah, exactly. That's right. Um but
yeah, I mean at the you know, the
serious point is like this arms race is
probably self-equilibrating also because
even if you didn't have that, you know,
short women, tall men and they cancel
each other out
when when parents are selecting an
embryo, let's say or or or whatever, you
know, a sperm or egg as we said at the
sperm or egg bank. Not not that
everyone's doing that. That's the
minority, of course, but
the ones that are doing that, you know,
they're thinking about what makes for a
good life and they're going to know that
being extremely tall, like way outside
of the mean, is going to have these
health effects. So, it's going to be
self-equilibrating. There's you know,
people know that above say 6'4, 6'5,
there's not a big advantage in terms of
attractiveness. Unless you want to get
into the NBA. Exactly. Unless you just
want that. Yeah. I- I- interesting bit
of basketball trivia for you. For every
inch in height that you grow, it doubles
the chance of you being in the NBA and
that's just that keeps going. So, 6'1 is
twice as likely as 6, 6'2 is twice as
likely as 6'1. It goes all the way up.
And less likely to be a gymnast, right?
I'm sure it's the same the same scale.
yourself in half. Um what about a sex
ratio imbalance? You know, this is maybe
the most basic, I would guess, of
genetic selection that okay, well, we
can pick between boys and girls. We
don't know what sort of a boy, we don't
know what sort of a girl, but we can
pick the sex that we want our child to
be.
Have you looked at any data around Do
humans modern humans just have some
discriminatory preference over for boys
over girls?
Yeah, I mean I think we touched on this
a little last time. I mean the
I have a hunch that I actually don't
have evidence for this directly, but I
have a hunch that women will be slightly
preferred in advanced or rich societies
and men preferred in poor ones. Why?
Because the sheer value of just muscle
mass, right? That sort of thing. Or the
the tiny advantage that men have in
spatial reasoning just on average.
That's going to be really important when
you're working with your hands and tools
and in poorer societies. In richer
societies, the ability to sit still, you
know, this is why like guys, I hated
school, you know, and a lot of guys have
ADHD, which
uh at the extremes, that's probably a
real disease, but I think some of it's a
bit fake, you know, like boys are
diagnosed with it more because boys are
programmed more to to be fidgety, right?
To to use their hands and run around and
compete.
And so I think actually in the modern
environment, women are a safer bet and
there may be a slight preference for
them. I don't know. I don't think
there's definitive evidence yet, but
again, I do think there are some worries
that this could be out of hand a bit in
the far future. However,
self-equilibration again, because if the
current population is trending toward
females, well, hell man, my son is going
to have a pretty good pretty good odds,
you know.
Exactly. So you've talked about it in
the context of like dating apps and this
sort of thing, but like yeah, I mean, in
terms of the overall population, big
benefits to being a Global sex ratio
imbalance. Exactly.
moral enhancement, certainly one of the
things that most people probably
wouldn't be thinking about when it comes
to embryo selection. Oh, maybe maybe you
can select for height, maybe would
people choose sort of eye color or
something because your blue-eyed boy
would be pretty or something. Maybe they
can but morality, I I I think we sort of
I don't know where we think it comes
from. It's sort of born out of the
things that we learn, the culture we're
in, our socialization, our values, our
virtues, um what what does genetics have
to say about morality and moral
enhancement?
Yeah. Yeah, clearly a lot of our values
come from our culture, obviously, you
know, religious cultures tend to be in
particular, Christianity, Islam. There
are secular versions of morality. I
mean, actually the woke left is, you
know, it's often called a religion. It
is a set of moral rules, you know,
whether you like it or not, you know,
it's got a it's got a strict set of
rules and so on. So, we don't seem to be
able to escape either religion in some
sense and certainly not morality. And
the two are often tied together for good
reason. Darwin speculated, and I think
he's right, that the two co-evolved to
get us to solve collective action
problems, right? Where we're of course
naturally a little bit selfish, maybe a
lot selfish, and then through kin
selection, we tend to we tend to favor
our close relatives. That that's true in
general.
But then what do we do when we're in
groups of 100, 200 in a tribal scenario?
There are always incentives to favor
ourselves and our and our small group,
our family over the overall group, let
alone a group of 10,000 or 300 million
in the modern United States. How do we
get people to cooperate? And some of
that is kind of social technology called
morality or social norms, which embody
various kinds of practices and
information. You know, we line up in
front of a bus and that makes it better
for all of us. You know, this time I
could do better if I, you know, clobber
the old lady and get to the front,
right? But overall, if we have norms
that say respect older people and
respect the line, we're all going to
sort of have a way to coordinate our
actions and achieve mutually beneficial
goals. That's what morality is.
But a big part of it, of course, is you
can't get people to behave according to
social norms unless they're inclined to
do so, right? This is why psychopaths
will follow the norms when people are
watching and they won't do it when
they're not watching. Um and the more
you are in the direction, this is not a
binary thing, like you either are a
psychopath or not. You have dark triad
traits or you don't. These are all um
these are all degrees to which we, you
know, have propensities like this. And
as with everything else, you know,
there's a a big genetic influence on it.
So, it's both in terms of influencing
our our overall like affective empathy,
which is to say like when we see someone
in trouble, are we inclined to want to
help them? Just naturally. That's
affective empathy. Some of us are more
inclined than others toward that.
But also personality traits. So, for
example, the big five. If you are higher
in openness and in conscientiousness,
which I think are generally good things,
you tend to be a team player more. And
you tend to pay attention to other
people's needs and respond
appropriately. And so, in terms of moral
enhancement, what would you do? It would
be something like increasing affective
empathy or conscientiousness or
whatever. Now, I don't think you should
infinitely do this. And one of the
reasons I wrote this book is I was
annoyed by one of my colleagues back
when I was in academic. And I actually
wrote with this colleague. I like him a
lot. His name is Julian Savulescu. Um
he's head of the Centre for Practical
Ethics at Oxford. And he wrote a book
called Unfit for the Future. And he was
really worried about these collective
action problems on a global scale like
climate change, nuclear war. You know,
Toby Ord has written this book, The
Precipice, on this as
well. I love it. It's one of my top five
books ever.
Yeah, it's a good work. Um but, you
know,
one of the ways that they say we should
respond to this is let's just make
people nicer and then they'll cooperate
more and we'll have fewer existential
risks. And my response to this, thinking
in game theoretic terms, is
first of all, if a lot of people are
making their kids just unconditional
cooperators, there going to be some that
see, you know, either they're selecting
intentionally or they're not and their
kids are more selfish than average.
They're going to take advantage of those
kids. And in game theory, as in biology,
we have these terms.
You don't want to be an unconditional
cooperator. You want to be a reciprocal
altruist or a conditional cooperator.
And in fact, by doing that, you not only
make the world better for yourself
because when you find a kind of
parasitic kind of personality, you know,
you stay away from them, right? The
actual psychopath, shun them, right?
Mhm. And when you If you someone who's
nice and cooperative, you cooperate with
them.
And a lot of people are in between that.
And so, what you really want to do is be
disposed on the one hand to meet out
severe punishment, even at a personal
cost to yourself, to the psychopathic
types,
but extend actually quite a bit of
decency to normal types and and really
even amp up cooperation.
you kind of want uh
the wrong term, moral flexibility is not
is not the right thing, but you want a
range within which you can understand.
You want to be able to be firm and be
gentle. And the more firm and the more
gentle that you can be, probably the
better. Exactly. And in fact, um I don't
want to get into the details of game
theory, but but when you do these um
they're called prisoner's dilemma
tournaments, and you can iterate it many
times over or public goods games, you
know, we could get into that, but maybe
it'll bore your audience, I don't know.
Um either way, what you find in those
games is the best outcome is be is to
cooperate with people when you identify
them and amp up cooperation, right? To
get active enjoyment in finding the
cooperators. You know, kind of like what
we do in team sports when you find
someone who's willing to pass,
even when they might have taken credit
for the goal, but you had a slightly
better odds or ability to get the goal.
And the people who are willing to do
that, we really enjoy being around them
for good reason. They they make it
better for the team.
But you want to also be the kind of
person who will actually be willing to
lose a game to punish that [ __ ] who
simply won't pass.
I like to use this as a as a metaphor.
Think of the World Cup in it was circa
2010
when Germany just absolutely destroyed
Brazil in the World Cup 7 to 1. It
should have been like 12 to nothing. It
almost was, but in the last minute there
was a pity goal for Brazil.
And it was because these individual
Brazilian players were probably better
than the individual Germans, but they
were just show-offs. And the Germans
were engaged in this like precision
passing, you know, I'm going to
sacrifice a a of my welfare and a bit of
camera time so that I can make sure my
team won. And they destroyed them.
Um and in fact E.O. Wilson has this
great, you know, the the great
evolutionary biologist recently passed
away.
He has a a really great line which is
when we think about groups of people, um
selfishness actually wins within a
group, but groups of selfish people lose
to groups of altruistic people. And so
when we're thinking about when we're
thinking about moral enhancement, we
should think about evolutionary
psychology which I know you know a lot
about and think a lot about and think
about what
what kinds of problems did our moral
conscience and our moral practices
evolve to solve? And that is collective
action problems where there individual
benefits to defecting from this overall
group goal.
Um but there are big benefits over time
if you can program yourself to kind of
cooperate, whether it's hunting, whether
it's warfare, whether it's sports, in
accordance with those group goals. And
how do we do that?
We find the cooperators and we have
these emotions that positively respond
to cooperators. And uh not only
negatively treat the non-cooperators,
but give us joy in [ __ ] killing those
people, right? Finding them and just
slaughtering them. And so we have this
weird set of dispositions where
it's called moralistic aggression
actually. And moralistic aggression is a
good thing because it leads to
cooperative outcomes being more likely
to materialize.
Yes. You positive reinforcement for the
good things, negative reinforcement for
the bad things. Exactly. Didn't I learn
from you that IQ also plays a role in
cooperation, collaboration, intergroup
stuff?
Yeah, there's it's it's interesting. Um
I actually don't think it's IQ per se,
but what we found, um my colleague
Garrett Jones has done a lot of tests,
actually prisoners' dilemmas
tasks. So, he gets his groups of his
students to play these games where there
are individual benefits to
to going your own way, but but
collective benefits to cooperating with
the group. And what he found is that,
again, corrected for socioeconomic
status, smarter people tend to be more
cooperative in these kinds of collective
action problems or prisoners' dilemma
games. Now, I think it's not
intelligence per se. I could be wrong
about this. And it's certainly not that
that smarter people are nicer.
What I think is going on
is that, and and he does, too, smarter
people tend to have longer time
horizons. And so, they see the advantage
over long periods of time
of taking the
taking the decision now to give up some
benefits in the short term in order to
foster group benefits in the long term.
And this is again probably why
smarter people tend to stay out of
prison more. It's because they tend to,
even if they're actually not very good
people, they tend to see the individual
benefits of doing the thing that's
socially beneficial. It has positive
externalities. So great. So, sort of
selfishness is short-sightedness in many
ways. It's this sort of thing.
Yeah, this this not exclusively, but
it's this sort of
one of the ways that you can arrive at
selfishness is by being short-sighted.
Maybe that would be better to say. And
if you're not able to accurately predict
the long long-term repercussions of you
[ __ ] this person over or you saying
that particular thing
or maybe it doesn't even appear in your
mind. You know, we we we look at a lot
of people, and I think this is one of
the problems with the world being run by
at least moderately well-educated people
that have got you probably IQs at
standard or above. The problem of that
is that they often look to the behavior
of people who maybe don't have that same
sort of computing power and assume that
well the only way that you could elect
to go and rob this particular store or
go and do this particular sort of
reprehensible thing is if you fully
understood he knew, they knew the what
was going to happen, he knew what he was
doing. It's like, did he?
Did he? Like if this is someone that's
in the bottom, you know, 10% of IQ
distribution or whatever or this is
someone that's got some unbelievable
psychopathic pathology or whatever. I'm
not saying that, you know, these are
good people they, you know, deserve like
to be let off the hook or whatever, but
I think that it it gives a more nuanced
explanation of why people do the things
that they do and using your theory of
mind and saying what situation would I
need to be in in order for me to do that
doesn't take into account and this is
the problem with [ __ ] blank slateism
because it does flatten that playing
field.
Yeah. Yeah, good. Yeah, let me put a
couple of points together there. I I
like that. Um
first of all, yeah, I mean morality is
complicated. It's a set of norms where
we fear violating those norms because we
just fear being punished selfishly.
But also it's a set of moral
dispositions where, you know, most of us
enjoy treating other people with
kindness, you know, you don't just help
the person who's in a wheelchair through
the door when other people are looking.
You you do it even when no one's
looking. And that's that's of course you
deserve more moral credit when you do
that. But the the reality is like moral
behavior is super complicated. It's a
mixture of selfishness and long-term
thinking and and genuine altruism and
it's hard to detect what's what in any
particular case, but but the smarter
person with a good theory of mind who's
not necessarily consciously thinking
about it, but kind of instinctively
understands there are benefits to
long-term cooperation. They tend to
follow these mutually beneficial rules.
And therefore there are these like
positive externalities. In fact, going
back to Garrett Jones, he and I have a
paper on this um called cognitive
enhancement and network effects. How
individual traits influence social
welfare, and we gave an argument, this
is back in 2020, for why voluntary
embryo selection for IQ would actually
be a prosocial thing. Um not just
because it's making people nicer, it's
probably not. You should have other
reasons to make them nicer maybe. Mhm.
But because it has these effects and and
it also produces, you know, smarter
people produce more wealth in the world,
more innovations, etc. And so what does
that do? It enables us to create a
society where we're so wealthy, we don't
have to worry about should I commit
crime or not. You can just get a job and
you're fine. Like you can actually, you
know, wealthier societies can can afford
to treat strangers with kindness rather
than hostility because you're not
constantly worried about how to put a
meal on the table or something. So it's
interesting, these things interact um
moral behavior and intelligence in ways
that are really kind of counterintuitive
to be honest, but but they seem
ability the ability to work out the
repercussions of your actions to you
know, again it's
it it I understand why many people
that are maybe first being introduced to
this, people who don't like the idea of
individual differences from genetic
factors or group differences due to
genetic factors, can understand why it
feels so icky. Every time that you say
the word genetic or genetics, I've just
got this Yeah. Pavlovian [ __ ] itch
response to it. Which I still, after
thinking about this for you know, 18
months, I still haven't really actually
been able to get myself past, which you
know, maybe shows just how ingrained
that is. You know, eugenics and and sort
of the horrors of Nazi Germany and and
that period just did so much to really
cloud any discussion that even veers in
the remote sort of region of that
direction. Um but if you were to say to
someone um do you think it would be
better for there to be less crime in
future because the very people that many
of the
uh, I guess skeptics or critics of
genetic enhancement, people from the
left, well, one of the reasons that
you're trying to do this, at least
originally, was that you wanted to raise
up the working class. You wanted to
improve the situations of poverty, uh,
of strife and struggle for the sort of
normal working man, the proletariat. And
you go, okay, well, you can this is
something that can be quite it can be
achieved. Um, but
if you assume or if your worldview is
that the only reason that you get
different outcomes is because of
different opportunities, because of
exclusively structural, systemic,
societal factors, this is not something
this is not an opportunity to
uh, that presents itself. And I think we
both said last time that a lot of the
people who do have this sort of blank
slate view of humans are going to be
faced with a very difficult um, like
literally an unlimited conveyor belt of
difficult decisions. First off, what are
you going to do with your child? If this
technology is on the table and you can
afford it and your right-leaning
colleague at work has decided that
they're going to get it because they
don't have the same ick factor that you
and your particular group do, then okay,
well, that's fine, but your children are
maybe going to have a less robust immune
system or they're maybe going to need
glasses at 5 years old or, you know,
maybe their risk for autism's higher or
maybe they're going to be into more
externalizing behavior and they're more
likely to go to jail. That doesn't seem
very good. So, okay, so put your money
where your mouth is personally. Then
when it comes to what happens more
socially, too, you think, well, if we
can show that this kind of intervention,
that these kinds of genetic selections
actually do make for less crime,
actually do make for this, you go, well,
where's that effect coming from? Because
it's still the same racist, bigoted,
transphobic, homophobic uh, environment,
uh, for the first time ever,
we're actually able to manipulate the
genetic environment, not just the
post-womb environment, or we're able to
select before the
before the womb. Um Yeah, because up
until now the only the only if you deny
the genetic reality, the only acceptable
explanation was environment because
that's the only thing that ever sort of
oscillates. Whereas now we actually can
we can get in there and you know, who
knows? Maybe there is a country. Maybe
in 50 years we look back and we go,
"Wow, China,
their crime rates declined by you know,
50% over and they didn't do what the guy
in El Salvador did." Um and
Bukele. Yeah, and we we don't we have
the opportunity to do that. It's
fascinating. You know, by the way, that
there is a very naughty paper written
about uh it was in the 1990s
uh and the idea behind this paper is an
economist was that the abortion ban in
certain American states in the 1970s
being lifted because of Roe v. Wade
resulted in a much lower crime rate in
the 1990s. And the way that happened is
children unwanted children
who weren't born but otherwise would
have been forced to be born because now
there was the opportunity for abortion
actually ended up resulting in fewer of
those children and therefore less crime.
And the way that they tested that
hypothesis is look at the states in
which abortion was legal before Roe v.
Wade versus those in which it was
illegal. And what you see is dropping
crime rates 20 years later in the states
in which it was illegal and became
legal. Surely that would be Surely that
would be more of an environmental
uh insight than a genetic one unless
people that get abortions happen to have
some particular genetic predisposition
that then gets passed down to their
kids. It could be it could be either or
both. And of course the kind of people
who wanted an abortion but couldn't
afford to go to another state to do it
might be a certain kind of person or
unwilling to do it or whatever.
I don't want to weigh in on that. I'm
just saying that that argument has been
made. It's it's an interesting one. It
was in the book Freakonomics as well.
So, it's a very mainstream economist who
did it named Steven Levitt.
But in terms of the point that you made
on blank slatism and the kind of
cognitive dissonance that elites have,
well, there's this phrase, you know,
blank slatist in the streets, hereditary
in between
You know, we all see this. I was in
academia where, you know,
maybe I don't care that much about IQ,
although we're talking about it right
now. I mean, I'm just telling you,
putting my cards on the table, I don't
want to be an IQ maximizer for my own
kids. I know some people who would be. I
care more about personality traits and
health,
even though I think IQ matters a bit.
But my colleagues who would denounce me
for even talking about IQ, I mean,
they're the ultimate IQ realists. Again,
because they're obsessed with it in
selecting their spouse,
in thinking about I want the smartest
grad students. I want to appear to be
smart, um and I want to please my
colleagues. So, they have a lot of
cognitive dissonance. In fact, blank
slatism has always been selective. They
don't really believe it in their private
lives, which is why I said blank slatist
in the streets, hereditary in between
the sheets, but they also don't even
fully apply this
um
consistently. So, a very famous and
widely read book is Guns, Germs, and
Steel by Jared Diamond. And he argued in
this book, the point of this book is
actually pretty interesting in in many
ways, showing like history is partly
determined by like what diseases happen
to be near your tribe at the time, or
did climate change, you know, happen
really dramatically in Iceland at this
time? And that's going to have effects
on, you know, who lives and who dies,
who succeeds. That that's all true.
But he says he's he's so obsessed with
being a blank slatist and showing like
it's all just arbitrary. Like why is
England, you know, richer than whatever
Somalia or something?
Um and so he says on page 22,
"It's always struck me that the New
Guineans that I work with are on average
much smarter than the than Europeans and
Americans." So he throws that in there
like as if we're supposed to just go,
"Wait, you're a blank slatist, but
you're actively saying this group that
has stone age technology is obviously
smarter than Brits or Americans or
whatever." It's like, "Okay, I get it.
This is This is a political game you're
playing. You're not even a blank
slatist. You're a selective blank
slatist." So, again, this is stuff that
we inherited from the war. I understand
why we inherited it. We inherited it
because there were claims made,
especially by Germans, like "We're
racially superior to other groups. This
is a justification for, you know,
colonialism, hegemony, and war." And so
what happened is this overreaction. Or
we're supposed to think there are just
no differences. And people make even
this absurd claim while we're watching
the Olympics that Africans are not
faster runners than, let's say,
Europeans. That is [ __ ] crazy, right?
Like it's just so obvious that for
short-term sprinting events, you know,
people from Jamaica on average are
poorer. Yeah, sure, they practice more,
maybe. But why do they practice more?
Because they're better at it, right? I
mean, you have to deny so much reality
to sort of get you there. Or men and
women, right? We just saw this like
transgender boxer or whatever.
Dude, I need to We We need to talk about
this. So for the people that don't know,
"Italian boxer quits bout sparking furor
over gender at Olympics. The Italian
Angela Carini stopped fighting only 46
seconds into a match-up against Imane
Khelif of Algeria, who had been barred
from a women's event last year. An
Italian boxer abandoned her bout. The
Italian boxer withdrew after she had the
[ __ ] kicked out of her. Khelif, 25, was
permitted to compete at the Olympics
even though she had been barred last
year after boxing officials said she did
not meet eligibility requirements to
compete in a women's event. Another
athlete also barred from last year last
year's championship under similar
circumstances Lin Yu Ting has also been
cleared to fight in Paris. The presence
in the women's competition of being the
latest flash point in the politically
charged debate over gender and fair play
in sports. There was
the IOC doesn't use quite the same set
of criteria to judge
sex gender that this particular previous
competition did, but it seems like you
have two biological males
competing in the one sport that you
shouldn't have biological males
competing against women in which is the
one where they literally punch each
other in the face. Yeah, I mean I would
go further and say other sports. I was a
professor at Penn when the transgender
swimmer Lia Thomas switched teams and
one of my students actually has now come
out you know finally and over the last
year or so and said not only did I
oppose this from the beginning and I'm
talking about it now now that I've
graduated, but our coach told us not to
talk about it. We're going to get in
trouble if we even question this
person's gender. I mean this is wild.
And I mean just putting this all
together
denying you know you might say oh we're
obsessed with genetics cuz oh we're
talking about genetic influence on
things. I'm not. I actually just think
like we should acknowledge a genetic
role. We should acknowledge a social
role social norms matter parenting
matters all of it matters.
But by denying any role for genetics is
not taking the moral high ground. It's
causing women to be oppressed in the
name of women's liberation.
And it's causing as you said to to make
your previous point
if the best or most effective way of
advancing your children's prospects is
to if you're doing for example IVF and
embryo selection, just to take that
case, is to select one that has a low
disease burden and relatively high
cognitive ability. And you say, "Look,
we're going to deny that genetics
matters and we're going to make this
illegal or shun people for doing it."
You're actually oppressing the people
that you're currently claiming to defend
by saying, "Oh, you're structurally
oppressed and it's bad schools and you
know, whatever racism, xenophobia, you
know."
Wait a minute.
Why don't you just acknowledge reality
on its own terms? Schooling matters,
society matters, parenting matters, and
genetics sure as hell matters. And let
people make use of the best of available
technology to actually increase their
children's prospects. If you cared about
inequality, that would be the thing that
you'd really want to target.
Why do you think people don't?
I think they will soon. In fact, I have
an essay coming out and I'm giving some
talks on this lately called Breaking the
Blank Slate. And what I argue in this
is more or less the following. We have
this cognitive dissonance by the elites
we've talked about. We inherited it
again, post-World War II norms.
It's starting to break down already.
More people, of course, are pushing back
on the transgender stuff. I think
they're they're going to do the same for
the genetics in general.
And I think what's going to happen is
the following.
You know, companies come out
very very publicly in the coming years.
And they offer, for example, embryo
selection for various traits, including
personality, intelligence. It's going to
be harder and harder to deny that these
things are real, that they're influenced
by genes. Elites are going to publicly
condemn it while privately using it. I
can name some people. I won't do it, but
who are already doing this.
I've dealt with them actually, working
with companies that do this.
And what's going to happen is people
will eventually figure out, "Wait, the
elites are playing a game here.
They actually are taking advantage of
their inside knowledge that these things
are are highly heritable. They're using
it to the the best of their ability and
telling us like, "Oh, you know, we
shouldn't do this. It's wrong." And I
think this cognitive dissonance will
grow until we get elites. And by elites,
I mean often they're fake elites, but
journalists, professors, et cetera,
people in positions of power
whereby eventually they're just going to
come out and say it. Like I'm doing it.
I think it's fine. You should do it,
too. And then we're going to get a
preference cascade, right? Right now
we're in Let me give you an analogy.
It's It's like we're in East Germany in,
you know, 1988. And everyone knows
communism is [ __ ] And everyone
knows even the Stasi in East Germany
know it's [ __ ] It causes poverty
and misery. And it's just We're spending
more money on monitoring people to make
sure they affirm the official ideology.
Everyone knows it's fake. Um
And basically what's going to happen is
as people in positions of power come out
and say, "Look, this this is real. I'm
doing it.
Um it's fine." We're going to get a
massive preference cascade. What's that?
What's a preference cascade? It's a A
preference cascade is basically where,
you know, we've got these um
we've got these people publicly lying
about what they prob- publicly or
privately know.
And so they're they're
expressing false preferences, right?
This is called preference pal-
falsification. My old colleague Timur
Kuran at Duke University. Um we were
colleagues for about 7 years
um in the political science department.
He uh invented this term. And it was a
book called Private Truths, Public Lies.
He invents this term of preference
falsification.
What he basically said is a lot of
elites play this game, and it's
inter-elite competition. They have this
like ideology. All this gender stuff,
for example, ordinary people, they don't
care. They know it's [ __ ] It's the
elites in academia and journalism that
do it, you know, oh, we have to call
them she, her, and he, him, and all that
stuff.
But they know what's they know what the
reality is privately. And so what
happens is
once you get this like pressure cooker
and it's often not evidence and
arguments, right? I've given evidence
and arguments and people just brush it
off or, you know, call me a eugenesis or
something.
But when the technology comes out into
the open and people are actively doing
this and knowing
that they're doing it and other people
know they're doing it, then what happens
is you realize, oh,
okay, the real preference is actually to
do genetic enhancement and it's fine and
it works and lots of people are going to
do it and suddenly
you get this falsified preference
becoming the openly stated preference,
which is it's okay to do this,
heritability is real, blank slate is a
myth false, and then rapidly everyone
else adopts this in the same way rapidly
everyone sees through the lie of
communism.
They once the first person starts
breaking the wall and then the policeman
follows him, then everyone gets on the
wall, destroys it, and they're like, we
always knew communism was [ __ ] My
hope is, by the way, this week that
Venezuela follows suit. So, Venezuela is
very close to my heart. I know a lot of
Venezuelans because I worked in Ecuador.
And um I know how many smart and great
Venezuelans are in the world. I know a
lot of them in Austin here.
And um my great hope is that the
pressure put on by Elon Musk, by Bukele
in El Salvador, Milei in Argentina, and
maybe Trump or whoever wins the election
will basically cause the Venezuelan
people to rise up and people in the
military, once that first general says,
this is [ __ ] Maduro did not win
this election, we know he didn't, once
he defects everyone else defects and you
get this preference cascade. So, that's
what it is.
So interesting, dude. I think it's going
to be a
Just this this this odd sort of
cathartic fantasy I have of all of the
people who are claiming to not believe a
thing or that the thing doesn't actually
happen and just having to see that uh
that discordance sort of come out front.
It's going to be it's going to be
oddly satisfying and I wish that I wish
I was less petty. I wish I was less
petty.
Uh but it's but it's true. One of the uh
studies that I came across I really
wanted to speak to you about uh Remy
Furrer and colleagues, public attitudes,
interests, and concerns regarding
polygenic embryo screening. Um you must
have seen this. Yep, I sure have. I met
him last year in Cambridge, yeah.
Can can you uh how well do you know that
study? Could you give a an overview of
what was found? Uh he's been on at least
two relevant ones for our purposes. So
he's he's a bioethicist, really good
guy. I think he's either Swiss or French
but works at Harvard in Cambridge. Um
he's part of a team that studies
polygenic risk scores and we talked
about that last time but a polygenic
risk score is just this idea that you
can take these highly polygenic traits
like risk of diabetes or how tall you
are, whatever. These things are
influenced by thousands of small genetic
variants and
based on the kind of data we have from
biobanks, you can assess individuals'
risks of developing diabetes or being a
certain height or whatever, right? So
they study polygenic risk scores and
public attitudes toward them and
specifically in this context, I think
you have in mind public attitudes toward
using polygenic risk scores to select
between embryos if they're doing IVF.
So one of their studies that he's
actually on two but one of their
studies, I believe he was on the first
one, uh just compared, you know, would
you use tutoring to improve the the
prospects of your kids getting into an
elite university? The second question,
would you use embryo selection for it
and then would you use gene editing
assuming it was safe? They found almost
everyone would use tutoring. Um many
people even among Americans about half
would use embryo selection and slightly
less would do
gene editing. And then if you ask them
what if people around you were doing it
or people you respected were doing it?
And this is of course the secret of
human societies right? We we basically
copy the norms of high status people
right? So what if high status people are
doing it then everyone's like I I would
do it too.
But their second study
um this is more recent found something a
little bit different. A little bit of
dis- discordance there. Um they found
that like the vast majority I think it
was like 70 something percent. I I'd
have to look at the study. I've got I've
got the uh You've got it. Oh yeah, go
for it. Yeah, tell us what they found.
I've got the charts in front of me. So
basically the the sort of two
differences here. They looked at health
conditions on one side and sort of
traits on the other. Uh Remy Furman
colleagues surveyed Americans about the
risks and benefits of polygenic and
embryo screening. They found that a
large majority of respondents believed
that screening should be allowed.
However, the level of approval varies
substantially with the target trait. It
is high for diseases, moderate for
intelligence, and low for skin color. So
just having a look here uh sort of
cascading down from uh most highly
agreed with. So people could strongly
disapprove, disapprove, neither approve
or strongly approve. Uh cancer almost
you know what's that 50% of people
strongly approve and then 35% of people
approve. So almost very very high. I I
can't believe you know 5% of people
disapprove and 5% of people uh strongly
disapprove. Yeah, cancer maximizers.
Yeah, they honestly it's basically the
same for heart disease, nearly the same
for Alzheimer's, diabetes a little bit
less, schizophrenia a little bit less,
bipolar, autism. All of these are you
know combining approve and strongly
approve in the 70s. Blood pressure
instant interestingly actually doesn't
doesn't get quite so much OCD less ADHD
significantly less. I wonder if that's
because a lot of people know that they
have it. Um Or they know that it's over
diagnosed which I think.
interesting.
But but but anyway. Obesity
seen as a health condition rather than a
trait that could be controversial in and
of itself. Yeah. Uh what's that? 55%
between the top two. But then we get
into traits.
Intelligence is the most highly approved
overall.
Uh but
it's significantly lower. You're talking
about what's this?
35 40% of approval. Neuroticism the
same. BMI So obesity they
they're actually track the same thing.
Like the trait of BMI versus the health
condition of obesity. So that tells you
everything you need to know about
framing that you gain
Yeah. What do you gain by framing these
two things? You gain I don't need to
tell you Chris. You're probably
considered obese cuz you're a pretty
buff dude.
BMI is not good. Obesity is all right
though. Life satisfaction like selecting
for life satisfaction.
Height height the trait of height not
good. Educational attainment also the
same. Agreeableness baldness the
baldness maximizes 25% of people
strongly disapprove with selecting
against baldness.
Jealously. Those are the people with
good hair. Yeah. And they want to keep
their advantage. Openness to experience
really interesting. Openness to
experience and extraversion two of the
lowest. I mean I I well I
how much does the normal person know
what extraversion is? They just think
we're going to be surrounded by loads of
parties. I wonder about sort of the
education. And then skin color
really really really highly
strongly disapproved. But I mean some of
the most
sort of surprising ones in there to me,
extraversion, openness to experience,
life satisfaction. Why is life
satisfaction Why would you want to ever
select against that? Like, that's
literally the only thing that we're all
here for. All of these other things,
cancer, heart disease, ADHD,
intelligence, neuroticism, skin color,
all of these things presumably are in
service of some form of life
satisfaction. And me, even if that's
impossible, even if you can't select for
it, which I'm not sure that you can,
saying I don't think that we should go
directly to the source and then enhance
someone's [ __ ] life satisfaction.
Wild. Wild. Chris, I'm going to push
back on you here. I'm going to agree
with the crowd, maybe the first time in
my life, you know. I want to be the I'm
going to be the conformist. Let me give
you good arguments for this. I mean,
first of all, this is just interesting
data and
yeah, you got to take it with a grain of
salt because how many people even know
exactly what the big five are, the
personality traits, how heritable they
are.
Probably you'd want to prompt them first
to get good answers.
But, there seems a lot of wisdom in
these answers to me. So, first of all,
if people are
not very superficial, they really care
about the quality of their children's
lives,
skin color probably should be near the
bottom. You You shouldn't You wouldn't
want to emphasize it too much. Now, I
don't think it should be illegal, you
know, etc. I think that's stupid. And in
fact, I think most people would not
select for the whitest possible skin.
They'll skin select for a tan skin. My
skin looks really orange right now
because of this light in front of me,
but I've got like Homer Simpson skin
right now, but what I would want is like
a little bit tanner than I naturally am,
so you don't get too many, you know,
skin cancer, that sort of thing, right?
Sunburn.
So, I think a lot of people have a sense
like it's superficial and probably dumb
to like focus too much on
skin color, you know, something like
that.
But, health does seem to me it seems
right that you should focus that on that
the most.
Intelligence, I think people have an
excusable ignorance about this, right?
So, that was somewhere in the middle and
it's probably because people they're
often told that oh, you know, smart
people yeah, maybe they make more money
but they're actually much more prone to
depression and mental health disorders
and that's false. That's just obviously
and completely false. We know that from
just huge numbers of studies. There have
been one or two that allege that and
then they get debunked and there's a
million studies to contravert to the
contrary. So,
I think some of this is ignorance. Some
of it is actually correct.
And let me give you an argument for why
life satisfaction is good. You know, the
upside of depression um you know, here's
here's the argument. I mean,
maybe what people are thinking there,
some of them, is you wouldn't want a kid
who's overly satisfied with the existing
social order or their place in it. You
want someone who's like an achiever and
someone who's too easily satisfied, you
know, they break up with this this great
girl that that they were with for for a
couple years and they're not depressed
at all. They're like, let's get back on
it, man. I'm on Tinder tomorrow. And
it's like, no, actually you should
probably do some self-reflection, you
know, talk listen to some Chris
Williamson episodes and you know, Okay,
well so that you can you can
absorb some of my low life satisfaction.
No, no, I I I I don't I don't think that
that's too bad. I think that certainly
wallowing in reflection, moving slowly,
that kind of melancholy there's there's
lessons from it. So, probably what you
should do is select, I mean, should I
mean, what I would do anyway. I don't
want to give people advice but select
against like severe depression. That's
obvious, right? But overall life
satisfaction, do you really want to be
at a 10 all the time? Maybe some people
do but I actually think that might be
correlated with being all too easily
I don't know, manipulated or just like
accepting the status quo for what it is.
It's kind of like agreeableness. Do you
just want to maximize that? Like [ __ ]
no, you know, I
I I I want I want to push back on like
some of the popular wisdom which I think
is false. So, if there's like and that
requires a little bit of
disagreeability, so
Yeah, that is interesting to
to consider the sort of the advantages
of melancholy and Artistic advantages,
too, right?
Yeah, all of them. You're not going to
make You're not going to make a good
rock
acoustic guitar rock star if you if
you're not Your lyrics are going to
suck. You're going to outsource them to
some corporation. So [ __ ] happy. Shut
up.
Shut up.
I don't I don't need to hear about that.
So,
just one other interesting sort of
consideration What about um political
trends, uh group affiliation, ideology,
living setup? Um you know, we're talking
We've got so far to go, and I wonder how
quickly this is going to be adopted.
Actually, the two two separate points.
First off, how quickly is this going to
be adopted? Um obviously, we're at least
rate limited by the rollout of the
technology, by the
uh sort of
cost, the accessibility. Have I got a
[ __ ] facility within 100 miles of me
that I can do it with, blah blah. Um and
then we've got this kind of
I guess conceptual inertia thing which
is going on. Um but what's your
predicted uptake? How many kids are we
going to see in the Western world born
through using embryo selection over the
next few decades?
Well, I think really by the end of this
decade, there's going to be a lot of
uptake. But by a lot, I mean, you know,
whatever, couple percent or something.
Um look, infertility is on the rise.
People are having kids later. Um some of
which is good, you know, they build
their career.
Um some of which is bad because if you
wait too long, you accumulate mutations.
We know that, especially on on the male
line, which is why autism is on the
rise.
But um yeah, so more people are using
IVF anyway. I think more people are
going to use it who don't need to use it
um in order to select against family
disorders. I actually think that's a
good thing. Um
And um so I think once companies start
moving from disease traits to
non-disease traits, more will do it. And
there's going to be a kind of network
effect where once governments,
especially governments like South Korea,
Israel, etc. with small populations that
have enough money
and they worry about declining birth
rates, I think they're going to kind of
subsidize it and hasten it. And once
that happens, yeah, you're going to get
uh a much more rapid uptake of it. So,
you know, IVG, this thing we talked
about last time where you can take an
adult cell, turn it into a pluripotent
stem cell, which turns into an egg. If
that becomes feasible in 5, 10 years,
let's say, um and cheap enough and
accurate and all that, then you could of
course select among hundreds, thousands
of embryos, which is pretty wild.
I think if that became feasible, it
would be taken up really quickly because
it obviates the need to even do IVF,
right? You just take a a vial of blood
and do it.
Um so yeah, there's uncertainty about
this, but I think the ideological
resistance is going to melt away very
soon, like in the coming 5 years.
Uh you know, when some of these
companies come out into the open with
cognitive ability, personality, there's
going to be the New York Times, you
know, sling [ __ ] at them and calls them
Nazis. That's all predictable and
boring.
But what actual people will be doing is
sort of going, "Huh, is this real?" And
they'll start reading up a little bit
more about it because it is real.
And I think that's going to change the
incentives in ways that are hard to
predict. That's going to drive costs
down quite a bit. And I will say this, I
won't mention the technology per se, but
there will be ways for everyone to to
use this um very, very soon. Like within
a year or two, people around the world
because there are some innovations where
you're not going to necessarily need all
of the clinical equipment that is
currently needed to do this. Um I'll
just hint at that and not say much more
about it.
Mm. Very sexy. Okay. And then um
downstream, what what are we going to
see in terms of social setup, political
What's what's what's going to change if
this sort of technology starts to be
rolled out en masse?
I think for the most part, you know,
things will be quite good because as I
mentioned, I mean, one in eight people
in the world marry their cousin.
And in the Middle East, in parts of of
Egypt and Saudi Arabia, it's close to
half, like 50%. So, we're going to see a
dramatic reduction in disease burden in
in those parts of the world. And that's
going to lead to
you know, more flourishing for those
people. Imagine you're some Saudi kid
and you're born to a cousin marriage.
Like, what are your prospects versus not
born to a cousin marriage? So, we're
going to see a lot more
people taking um heredity into account
when they choose their their mates. And
then on top of that, because there's
been generations generations of cousin
marriage, I think selecting embryos to
minimize disease burden.
So, we're going to see a lot of people,
you know, a lot of countries with far
fewer diseases, both monogenic and
polygenic.
And then we're going to see some pretty
wild things. We're probably going to see
mild gains in cognitive ability, which
will counter
the kind of sterilizing dysgenic trends
of liberalism. Um you may have seen this
meme online of cities being IQ
shredders. What happens in the West now?
You know, the smartest people go to Ivy
League schools or Cambridge and Oxford.
They then take their talents to live in
a city and make a bunch of money as
bankers in London and New York and so
on. And they have, you know, 1.1 kids or
whatever at the age of 40.
You know, this is not great from the
standpoint of civilization across long
tracts of time, even if it's good in the
moment. And so, I think what you're
going to see is people, on the one hand,
making different kinds of decisions with
their lives, but you're also going to
see a countervailing force where a lot
of people are going to be gaining slight
amounts in IQ, as well as decreasing
disease burdens. And over a few
generations, that really makes a
difference. But here's a kind of dis-
dystopian scenario.
I don't think it's going to happen too
much, but I think it will a little bit.
It's possible that when people realize
that religiosity and political
orientation are about heritable. They're
moderately heritable conditions. You
don't inherit Christianity per se, but
the tendency to be religious and to seek
out that kind of community and set of
beliefs. That is heritable. And so is
again political orientation. The
tendency to score really high on
openness and some of these other traits
underlies that probably.
I can imagine a world where religious
people find this out and eventually use
embryo selection or possibly way down
the line using gene editing to select in
favor of religiosity or political
extremism.
It's kind of a wild thought, but
I don't know why wouldn't they? If if
what they wanted to do
my daughter to be a part of my church. I
want my daughter to come you know, if
you really care about your politics. If
you really think that, exactly.
Daniel Cox
uh did some really interesting research
about this stuff. And you know, you're
seeing huge swaths of Gen Z girls with
Republican fathers and mothers Yeah.
pivoting left and going to Democrats. So
you know, this the heritability that
there is for religious affiliation has
really been or there's something going
on that has managed to to sort of um
I think that's really interesting. That
shows two things. One, culture in the in
the short term culture swamps the
heritability of religiosity or political
orientation. No doubt about that, right?
That's the short term. But over long
tracks of time, you know, evolution is a
real thing. and the choices we make and
differential choices, differential birth
rates, you know, we we know we talked
about it last time both within countries
and across countries, religious
conservatives simply have more kids than
atheistic liberals. And Jonathan Haidt
and others have talked about this. I
know you've had him on the show. He
mentions this in his book The Righteous
Mind that has to have genetic
consequences over time. It just may take
a long time.
But it may also be when you think about
Yeah, Gen Z, you've got boys turning
more right-wing and girls turning much,
much more left-wing. That's obviously
because the institutions are left-wing.
I mean, I was a professor in these elite
schools, and you know, Duke was pretty
moderate, but it was still pretty
left-wing. Penn was off the charts
left-wing and and and pretty much
everywhere else I've been. So, they get
indoctrinated. Girls are also on average
more conformists, and they know like if
you want to climb in polite society, who
are the elites? They're obviously
left-wing, and so they they swing more
left-wing. But when you look at the
1970s in universities, women were more
conservative than men. And I think
that's because at that time in their
culture and given what their parents
were doing,
you know, religiosity, conservatism were
bigger cultural forces. Yeah, you had
the hippies, but they were the outliers.
And so I think what's going on here is
just there's women being more conformist
on average than men, the institutions
being completely captured on the left
for now, maybe that'll change.
And um you're not seeing like a a a huge
you know, deep down really felt change.
It's just more of them responding to the
environment. So,
so yeah, I think there are cultural
forces in the short term that simply
swamp those genetic forces.
Very interesting, man. I mean, the next
few years are just going to be so
fascinating, and the fact that you get
to be
commercially or academically close to
the front of this must be must be pretty
exciting. Where should people go if they
want to keep up to date with all of the
stuff that you've got going on?
Yeah, well, maybe we can leave some
links in the show notes. I mean, those
papers by by Remy, for example, on the
on the heritability of traits and, you
know, how people feel about that. That's
some pretty cool stuff. There's actually
a group called peer, p e e r, that it's
a collection of scientists and ethicists
that are sort of tackling these problems
and they're based at Harvard and
Cambridge. So, you know, the usual
biases apply, but they're really good. I
mean, the scientists in particular just
rock solid. Um but obviously, yeah, I I
have a new book on this. Uh it's Here it
is. Uh Creating Future People, the the
science and ethics of genetic
enhancement. And um
you can buy the paperback. That's always
um I I like to read physical books, but
there's also a free version, too, open
access. So, I can send that out to you
to to have the link, but I also have a
website. So, if you want to read sort of
I have a column for Psychology Today
called Sex and Civilization. And I kind
of go through like
what's happening, you know? First, it
starts with the birth control pill and
all these innovations, we separate more
and more sex and reproduction.
Some of that's good, some of it's bad,
but what are the big cultural
consequences? So,
yeah, I tried to outline some of that
stuff and uh listening to your show
actually is pretty damn good. I mean,
you have a lot of great guests, so.
That's what we need. I'm just looking at
your uh Psychology Today,
Technotraditionalism.
The label for view that we can embrace
traditional values whilst also endorsing
the use of reproductive technologies. I
am going to go and read that. Mate, I
really appreciate you. Uh I'm fired up
to see what you do next and uh yeah,
let's get you on We need to have a chat
about the sort of modern world of cancel
culture in academia from a
Oh, man. Yeah. front lines perspective.
I've had an online stalker for years and
some of my friends he's trying to take
down at Cambridge and other
universities. It's There's never been a
better time to be a psycho on the
internet who just [ __ ] posts all day and
cancels academics and other people. So,
yeah, maybe one of these days we'll talk
about that. Thank you. Appreciate you,
man. If you enjoyed that episode, you
will love a selection of the best clips
from the podcast over the last couple of
months, and it's available right here.
Go on.
Give them a watch.