Why You Need To Protect Your Joints If You Want to Live to Be 100 | Peter Attia on Health Theory
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In this episode of Health Theory, host David Goggens interviews Dr. Peter Attia regarding the feasibility and definition of living to 100 years old with high physical function. Dr. Attia posits that while biological immortality is likely impossible within our current understanding of cellular respiration, achieving a "phase shift" in disease onset by two decades is necessary for longevity. He argues against viewing exercise merely as a sport or competition; instead, he proposes creating a new discipline aimed at becoming the most capable 100-year-old possible. This involves reverse-engineering functional capabilities required later in life—such as carrying heavy groceries, lifting children from the floor without assistance, and maintaining balance—and training specifically for these metrics rather than arbitrary athletic standards like running distances or swimming laps. A significant portion of the discussion focuses on joint health and movement mechanics as critical factors in preventing "slow death" through chronic orthopedic issues that lead to a diminished quality of life. Dr. Attia highlights how humans are poor at estimating risk, often engaging in behaviors with asymmetric risk-reward ratios, such as excessive alcohol consumption or driving while impaired by even small amounts of wine. He advocates for modifying exercise routines to minimize joint overload; for instance, he notes that deadlifting provides superior feedback on form and strengthens the posterior chain but carries higher risks compared to single-leg movements like lunges and courtesy squats which achieve similar benefits with less spinal loading. Furthermore, he challenges the obsession with VO2 max as a primary metric of health, explaining that it is largely determined by muscle efficiency rather than lung capacity, suggesting that training all energy systems—including explosive neuromuscular power—is essential for long-term performance optimization. The conversation also delves deeply into nutrition and psychological well-being, where Dr. Attia shifts his perspective from rigid caloric restriction to a more cyclical approach involving intermittent fasting and autophagy. He explains the biological difference between autophagy (cellular self-eating) and mitophagy (mitochondrial recycling), arguing that cycling through catabolic and anabolic states allows for better cellular repair than constant low-level dieting. Beyond physical health, Dr. Attia admits that his drive is fueled by insecurity rather than pure altruism, a realization he credits to therapy which identified three negative traits—emotional detachment, rage, and obsession—that once defined him but now require new tools to master emotional regulation. He emphasizes the importance of showing up as one's best self for loved ones like spouses and children, noting that this personal evolution is harder than managing heart disease or diabetes because it requires confronting uncomfortable truths about oneself rather than simply following a protocol. Ultimately, Dr. Attia concludes that while addressing sleep deprivation offers the most immediate impact on health due to its catastrophic consequences compared to poor nutrition or lack of exercise, true longevity also demands an examined life focused on minimizing suffering and maintaining cognitive function. He warns against the sunk cost fallacy in career choices, encouraging listeners to pivot toward what they find meaningful regardless of past investments if those paths no longer serve their future goals. The interview underscores that living a fulfilling century requires not just delaying death but actively cultivating resilience through functional movement, balanced nutrition, emotional intelligence, and an honest acknowledgment of one's limitations and motivations.
Read the full video transcript
out. All right, in this episode with my
boy Peter Attia, we discuss everything
you're doing right now to shorten your
life, why your insecurities are
definitely holding you back, how to live
a life worth living, and why nutrition
isn't everything.
Everybody, welcome to Health Theory.
Today's guest is Dr. Peter Attia, MD.
He's a former cancer surgeon and
researcher who got his MD from Stanford,
was the resident of the year at Johns
Hopkins Hospital where he trained for 5
years and authored a comprehensive
review of general surgery. He also spent
2 years at the NIH as a surgical
oncology fellow, and just because he
can, he also has a bachelor's of science
degree in mechanical engineering and
applied mathematics. And to round it all
out, he's also an ultra-long distance
swimmer who has completed such
ridiculously arduous journeys as
swimming from LA to Catalina Island in
shark-infested waters.
But what I want to know is, as somebody
whose practice now focuses on longevity,
is living forever possible? As you know,
that is a a goal of mine. And uh why
don't you want to live forever?
Well, I to your first question, I don't
think it is possible. I don't And I
don't see anything on the horizon that
makes it possible, at least not within
the way that we think of what it means
to be alive, meaning to be respiring
cellularly. It's very difficult to
imagine immortality when you untether
and uncouple the uh not dying part with
the preservation of health span, so
specifically
cognitive performance and physical
performance.
And
I think more about those things now than
I probably ever have before. I think a
lot about sort of the physical stuff, so
what does it really mean to be a hundred
but function like a
well-to-do 50 to 60-year-old.
And and even if you're alive, how happy
would you be? I mean, it would be I
think for many people it would be quite
frustrating. Or, you know, if you had
grandkids or great-grandkids and you
couldn't play with them. Or you couldn't
tie your shoe. I mean, we actually use
tying a shoe as one of the metrics to
evaluate sort of flexibility and and
certain physical performance. So, most
people our age don't think of tying
their shoe as a physical performance.
And yet, when you would start to lose
those things, I think you'd have a a
radically different view of
you know, what am I doing? But, how do
you get there and and look, perform, and
feel like the way we imagine a
60-year-old today? A fit 60-year-old.
Cuz I know some 60-year-olds that are
just amazing, right? So, how do you how
do you take that to 100? And what would
have to happen for us? Like, what do we
really need to figure out? Is this a
um
flexibility problem, joints burning out
problem, ATP problem? Like, what what's
the big
Um
so so far, my my exploration to this
topic has has suggested a couple of
things. So, one is we do tend to
disproportionately load joints over
muscles.
So, in an ideal world, you would want to
figure out a way to exercise where you
can maximally load the muscle while
minimally loading the joint. So, there
is a lot of joint failure that becomes
problematic. I mean, and I'm separating
the obvious, which is there's just too
many people who aren't exercising enough
or correctly at all. And so, they're
just sort of withering away. But, if you
come at this through the lens of okay,
well, what if we're dealing with a
subset of people who are committed to
figuring out how can they exercise best?
In many ways, it's just a lack of
specificity, right? So,
most people who exercise can't actually
tell you why they're doing what they're
doing. The 99.9% of us who don't get
paid to play a sport and who aren't even
really competing at a serious level
outside the professional ranks,
I don't think we know what our sport is.
And I think the sport should be being
the most kickass 100-year-old that ever
lived.
So, what would that look like? Like,
what does it mean to be the most
kick-ass 100-year-old? And I think you
have to then reverse engineer all of the
things one should be able to do.
So, a kick-ass 100-year-old should be
able to I I don't know. I'm making this
up because I haven't fully codified this
yet, but they should certainly be able
to carry two 25-lb bags from a grocery
store. They should be able to lift a
30-lb bag over their head to put it in
a, you know, compartment of an airport
uh of an airplane. They should be able
to have a, you know, 25-lb little terror
run at them, you know, I either
great-grandchild or dip down into a
squat and grab them and pick them up.
They should be able to jump down on the
floor and play with cars or dolls and
stand up without assistance. And if you
start to map out the 25 or 35 things,
that becomes a new decathlon.
So, instead of saying the decathlon is
running this distance, jumping this far,
swimming this far, it's like, great.
Those are kind of arbitrary. Now, we're
going to come up with like real-world
things that you have to be able to do
when you're 100 if you want to live
what I would describe as potentially uh
a more fulfilling physical life to enjoy
the fruits of having not died by that
point in your life.
All right. So, how do we build towards
that? I love this, by the way. Like, I
always tell people, I want to live
forever. I'm well aware that as of right
now, I'm going to die.
Um so, my thing is, how do we stay alive
long enough to give time for these step
function breakthroughs to happen? So,
what do I do? Like, what are the things
that I train or the hormone replacement
therapies that I need to go What do I
need to watch? What are those things
that I should be doing?
Taking a step back, I would say 3 years
ago, 80 to 90% of my energy went into
how to not die.
Which basically Yeah, which is
tantamount to how do you delay the onset
of chronic disease. So, the mathematical
equivalent of longevity from a lifespan
perspective is creating a phase shift in
disease onset.
If you want to live to 100,
it basically means you have to delay the
onset by about two decades of every
major chronic disease. So, it doesn't
mean you can't get cancer or heart
disease or any of these other things,
but you better figure out a way to get
them 20 years after the average person
gets them.
I would say now that occupies 50% of my
brainwave energy, whatever, and much
more time goes into two other things,
which is how to minimize suffering,
which is kind of an emotional problem,
and then how to be this kickass
100-year-old. So, to the latter, um
the model I have in my mind is that of
sort of Bruce Lee. Bruce Lee sort of
looked at each and every discipline of
martial arts, including boxing and
wrestling and things like that, and
said, "Let me extract from each of these
disciplines that which I believe is
useful, discard those that I think are
useless, and create a perfect fighting
form that is truly geared toward
self-defense. So, it is not a sport,
there is no tournament, there is no
rank, there is no belt, there is no
sensei. It is, can you handle yourself
in a life-or-death situation?"
If I go to a yoga class,
or if I do a Pilates class, invariably
there's something in there that I think
is really valuable. And truthfully,
there's a bunch of stuff that I'm like,
I don't need this. This is just If I had
infinite time, this would be fine to do,
but I don't have infinite time.
So, now you apply a constraint to the
problem, which is not only do you want
to be sort of the best 100-year-old
imaginable, what if you're only willing
to spend 10 to 12 hours a week preparing
for that?
And so, you say, "Okay, well, so there's
a new sport, which we define some of the
parameters of. That's your new Olympics,
and that Olympics is 50 years from now.
How will you train for it if you're only
willing to spend 10 to 12 hours a week
training for it?"
Well, my guess is you will take a lot of
things
from various disciplines, discard a lot
of things, and sort of have to build a
very bespoke routine around it that will
involve the maintenance of muscle mass,
joint integrity, flexibility, uh
functional movement, balance, things
that we don't even really think about
anymore. How many times does someone
who's 90 fall because they've lost their
balance? And it's that fall that
ultimately leads to their demise. How
much of that the balancing do you think
is neurological and how much is
physical? They're just not doing enough
physical [ __ ] to figure out to maintain
that.
My guess is it's probably both. There's
a stability issue that starts to go away
as you age. Also, the consequences of a
fall become much more apparent. So,
um
it's probably not just the case that
someone who's older falls that much
more. It might be that the the severity
of the injury becomes so much more
severe. So, right now, if I were walking
here and I tripped on that stair and
fell,
you know, maybe on a really, really bad
day I break my wrist. But, most likely
nothing happens.
Uh
In 50 years, if I do that same thing,
the probability that something bad
happens is going to be much greater.
Yeah. Um but that said, I already can
tell my balance is not what it was when
I was 20. Mhm. When I was 15. I mean, I
used to do I used to be able to do this
exercise when I was 15 where I would do
a with blindfolded I could do a single
leg squat with the with the
non-squatting leg straight out in front
of me. So, I could go all the way to the
floor and all the way up, arms crossed,
blindfolded I could do 20 each leg. I
can't do that once today with my eyes
open.
Mhm.
So, admittedly, I'm nowhere near as
strong as I used to be, so there's a
strength component, but I also just
clearly lack the balance.
And so, so the question is
now maybe that activity is a bit over,
you know, it's that's just unnecessary.
Um and again, I don't know what the
answer is. I don't know if this means I
need to get out there and practice on a
tightrope or something like, but there's
there's something that needs to be done.
So,
every time I do some sort of really
well-thought-out workout, I find myself
thinking, "God, like some percentage of
this is so essential." All of those
things need to be put into this new
discipline, this new sport which is
called, for lack of a better word, being
a kick-ass 100-year-old.
I definitely like the sport. Now, one
thing that I found really interesting is
so people complain a lot about lower
back pain, talking about unnecessarily
loading the lumbar.
Um
I found that if I don't deadlift, my
lower back hurts, not if I do deadlift.
Now, some of that is probably that I
have decent form, it's certainly not
exceptional, but I have decent form, I
know how to avoid injury. Um but it is
so weird to me that doing nothing will
end up causing me pain in my lower back,
but if I'm religious and I'm doing it,
you know, once or twice a week every
week, I feel bulletproof.
The advantage of deadlifting and
squatting to me is uh they reveal all of
your errors in movement, right? Like
they are
I don't know how to describe it, but you
can't hide from those movements. Like
you can't take bad form into those
things and not get revealed. Right. So,
I like that. The question is, is it an
unnecessary risk?
Right? Am I one bad deadlift away from
doing something stupid where And And
again, I
you know, I'm as empathetic and in love
with those movements as anybody, but
I also don't know if I need to do that
to be the best version of myself as a
100-year-old. So, the stuff I've been
doing for the last
4 to 6 weeks,
um
I basically haven't had more than 155 lb
on my back in 6 weeks.
And but by changing the form of what I'm
doing and making everything a single leg
movement, uh so a lot of courtesy
squats, lateral lunges, incredibly
strict lunges where you are
so specifically loading the the front
leg glute,
I got to tell you like I'm not And then
doing a lot of single leg body weight
squats,
but with
meticulous form so that I'm fully
loading the glute, not overloading the
quad, which is my absolute common
mistake.
By doing these things, I don't feel like
I've lost a step,
but I absolutely know I'm loading myself
less.
Now, the question is, does that matter?
And I don't think I know the answer yet.
So, unfortunately, I feel like I'm still
too early in this process to know what
the finish line looks like.
And there's other problems that we
haven't even touched on, right? Like,
what VO2 max
and what aerobic base are necessary as a
minimum threshold.
Yeah, talk to me about that, cuz I hate
cardio. But, it's one of those if I have
to to have the kind of longevity, then
so be it.
and and the term cardio is itself so
confusing, right? Because
even if you think of what is VO2 max, I
mean, most people think, well, that's
really a
a heart lung issue. It's actually not.
It's more of a muscle issue.
Interesting. Because that's where the
the bottleneck is not in how much oxygen
can you get in your lungs.
The bottleneck is how much can your
muscles utilize. So, when you look at,
you know, the winner of the Tour de
France or, you know, the gold medalist
in, you know, cross-country skiing or
the person who wins the Boston Marathon,
like when you when you look at the most
extreme endurance athletes who have
these very high VO2 maxes,
what's unique about these people is
their muscles, which is counterintuitive
cuz they're usually very slender
individuals, but their muscles are so
efficient at aerobic metabolism that
they are able to extract so much oxygen
out of blood. When you and I, you know,
are at our maximum capacity, we're still
breathing out, you know,
80% of the oxygen we breathed in.
So, it's really not a gas exchange
problem. It's a muscle problem. That
said, VO2 max is a very specific energy
system that probably gets a little more
credit than it deserves. So,
what are the alternatives? Well, um so
so VO2 max is really, as its name
suggests, it is
So, the definition is what is your
maximal extraction or utilization of
oxygen?
The way to experience what that is is go
out and run for 4 minutes as hard as you
possibly can. Yeah. That is that energy
system. But, there are other energy
systems, right? There are In cycling, we
talk about seven different energy
systems, but again, you can really
simplify this and say there's sort of
the energy system we're in right now,
which is the smoking and joking energy
system. At the far under end of the
spectrum is this neuromuscular area
where you're basically doing the most
explosive movement imaginable for, you
know, 10 to 15 seconds.
And I suspect that for
each of those energy systems, there's an
there's a minimum threshold that you'd
want to be above as you age.
So, ways that you could test that would
be I mean, any even someone our age
probably knows if you carry two bags of
groceries up four flights of stairs,
most people are feeling that. Very few
people get to the top of that fourth I I
know that cuz that's my apartment's on
the fourth floor. So, like [laughter] in
New York, I'm always that, you know, I'm
always paying attention to like
what will happen when the when the day
comes that this is not pleasant. Like
when I'm deciding I have to take the
elevator up these four flights of
stairs.
Um
and so if that becomes the minimum
threshold, then you and and then that
you want to be there at 100,
then you need to be there at 60, and you
need to be there at 50, and you need to
be there at 40. And so, I think part of
it is just defining those things, and
that determines then what's the level of
training you need to do. But, I do think
in this current environment of everybody
loving high-intensity interval training,
which I love just as much as the next
person,
that's really only training one energy
system.
And I think
you if you ignore these other energy
systems, you're you're sort of not fully
optimizing around your performance.
Translating that to this new sport, this
100-year-old kick-ass sport,
I think it's just going to require a
little more thought. I'm talking to
orthopedic surgeons and saying, "Okay,
talk to me about the injuries that are
killing people."
Cuz there's two types of orthopedic
injuries that kill people. There's fast
death and slow death. So, fast death is
patient falls and, you know, within a
day or so is dead from whatever the
injury was. So, they, you know, break
their femur, they have a fat embolism,
they're dead. Or they fall and they hit
their head and they, you know, have a
cerebrovascular accident, they're dead.
Um but then there's also the slow
deaths, right? And these ones are, to
me,
far less talked about, but in many ways
more tragic. Um so, so one of my closest
friends, his father died recently.
Um 89 years old, complications of
Alzheimer's disease.
He'd been diagnosed mm 8 months before
he died. So, in some senses, you could
say, "Well, the good news is he was
spared he and his family were spared a
lot of suffering because, you know, he's
diagnosed in January, he died in
August."
But, when I went home for the funeral,
I was sort of struck by how difficult it
had been for him since he was 81. The
two things he loved most in life, which
were golf and tending to his yard, he
couldn't do because of more chronic
orthopedic injuries. So, he spent the
last decade of his life kind of watching
TV.
And to me, that's the thing we have to
be able to avoid. And uh you know, for
me, I don't know what it's going to be
when I'm 100, but I know that today, if
I had to start
say, you know, if someone said, "Well,
you can't drive a race car and you can't
shoot a bow and arrow and you can't lift
weights."
It doesn't doesn't matter how heavy it
is, right? But you can't do these
movements. Or you can't lay on the floor
to play.
Uh if I start if I had to give those
things up, I'm not sure how much I'd
want to kick around. And so, talking to
these orthopedic surgeons is giving me a
real insight into where those failures
are coming from. And the single most
important insight I've gained from them
is something you alluded to at the
outset, which is just joint overload.
You know, so much of what we do is even
while trying to be good, meaning trying
to exercise and do these things is just
disproportionately taking on risk. So,
for I'll give you one silly example,
right? A military press. Is there a time
and a place for a military press?
Absolutely. Does it have any role in my
life? Absolutely not. Right? Why not?
First of all, I don't need to load my
spine in that way. And if I could get
80% of the benefit that I get out of a
military press by doing loaded
activities below my shoulder line, below
my neck, and using more static loaded
mo- movements above,
and that gives me 80% of the benefit at
20% of the risk,
that's exactly the kind of compromise
I'm willing to make. And yet, I don't
think we're applying that level of risk
reward to how we exercise.
That's really interesting, and I Do you
have a fundamental insight into the way
that humans are that you think leads us
to do that? Because it
You You once said, and I forget what you
were talking about, but you said people
just don't run the math. And this is a
very good example of people just don't
run the math.
Well, we are um innately really, really
bad at estimating risk. And, oddly
enough, makes me wonder about you and
race cars. So, what is it that draws you
to race cars? Do you think you're
accurately assessing the risk on that?
I I I will say, you know, that's not an
unusual question I get asked a lot. I I
think that I feel safer in a race car
than I do in my street car. Really?
Absolutely. I feel far, far more
frightened in the drive I have to take
tonight from here to San Diego.
Because I'm going to be on the 405 and
the 5, and I know that 80% of people at
some point on that drive are going to be
checking their phone, or losing focus,
or not paying attention. I don't know
what percentage of them, maybe 10% of
them are also going to be under the
influence of alcohol, and
uh they pose a infinitely greater threat
to me than I I feel like I could ever
face in a race car. So, other than
driving, what are some just grotesque
misjudgments of the risk in terms of
behaviors that people do just on a daily
basis?
I think I think automotive is is a very
big one. So, yeah, good that we got that
one first. I think another one that
people sort of misunderstand
is
alcohol.
You know, I mean
I I enjoy alcohol as much as anybody,
but I don't think people understand how
once you get beyond one to two drinks,
like how harmful it is on your liver.
And
it's sort of like Tylenol, right? Like
at any dose, Tylenol is really hard on
your liver.
But for most of us, because Tylenol has
no
good feeling associated with it, we
don't really tend to use it more than we
should. We, you know, if we have a
headache, we take it and it makes the
headache go away, and but but we don't
find ourselves like taking four Tylenol
every day just because of whatever
reason. And yet, I'm I'm constantly
amazed at how much people drink
even when there's no apparent reason for
it, right? So, so there's always a
reason to have a drink, right? There's
there you can always come up with a
great reason to have a drink, but
there's too many sort of blah reasons
that people are drinking. So, I think
that
that that to me is an asymmetric and
unnecessary risk. Meaning the pleasure
that they're giving from that, you know,
those four shitty Budweisers that they
have isn't anything worth that potential
downside it's causing in the long run.
Which says nothing, by the way, of how
often I think people do get behind the
wheel of their car when they've had a
drink in them. And if there's one thing
I've learned in the simulator, it's how
even one drink compromises your ability
when it matters. So, I remember
Simulator or driving simulator? Yeah, so
I have a driving simulator at home,
which is where I do much of my learning.
Um but I remember one day I was like,
yeah, I was going to go drive the sim
after dinner and I had a glass of wine
with dinner.
I remember getting in the simulator and
I was like,
what in the hell is wrong with me here?
Like I am missing every apex, my I'm
just a little bit off, I'm a little bit
off and I realized, oh, I had a glass of
wine. Even one glass of wine is
compromising me.
Um so how many times have I gotten a car
having two glasses of wine at a
restaurant? The answer is tons. Was I
legally drunk? No, I was well below
0.08.
But if even if I'm 0.06, I'm legally
fine, is that still a reasonable
strategy? Right. And you know, I think
the answer is it's probably not.
You think there are dietary things that
people are doing that have just an
asymmetric risk reward?
Yeah. You know, I'm probably kind of a
a huge advocate for caloric restriction.
Um
at least intermittent bouts of caloric
restriction. So I believe that the
short-term discomfort of not eating for
5 days,
once, twice, four, five times a year,
going through a cycle like that, I think
that the short-term
inconvenience of that is
trivial compared to the potential
benefit of of a true fast, you know,
water only fast for some period of time.
And I still don't know what that minimum
is. I think it's probably a minimum of 3
days are necessary to start to get some
of the real benefits of autophagy,
mitophagy, and things like that, but
What's the difference between autophagy
and mitophagy? Um autophagy is the cell
eating itself and mitophagy specifically
is the recycling of the mitochondria.
Okay. Um
So I think when someone says, and I have
many patients or friends or family
members who have said like,
yeah, that's just there's no way I'm
ever going to I could never give up
food.
Even transiently, I think.
That's that's an asymmetric
from?
Like
not not even being willing to give it a
shot.
Like what's the emotional
hang-up?
Cuz you were you used to be literally
the epitome of the robotic eater
just insanely strict. You said about 3
years ago you were like, "Nope, not
doing that anymore." And I think to
quote you exactly, "I no longer have the
intestinal fortitude to eat like a
robot." So there was something in you
that it no longer was worth it.
Yeah, that became much harder than what
I do today, which is So so back then
I wasn't doing any time restricted
feeding. I wasn't doing any fasting. It
was a pure form of dietary restriction.
So my my sort of mental model for
nutrition is everybody is starting out
on one side eating the standard American
diet.
Abbreviated as SAD, which is an
appropriate abbreviation.
[laughter]
And the the thing I always tell patients
on day one is like, "Look, the good news
is you can't get any worse than this.
The only thing if you're starting at the
SAD, the only thing you can do to make
it worse is eat more of the SAD."
Right. But it's like the standard
American diet, and I don't believe this
was deliberate, right? I don't think
there's a conspiracy theory here.
But just through a lot of bad luck
uh has arrived at the absolute worst
combination of macronutrients you could
possibly imagine. Like you couldn't come
up with a way to confuse someone's
metabolism than to combine fats and
carbohydrates in the ratios that they
are combined in most of the foods that
we would eat by default if we were left
to our druthers.
So from there I say, "Look, there's kind
of two introductory moves, which are not
mutually exclusive, but you can pick one
or the other." The first is time
restricted feeding. Where now you don't
limit what you eat, you you limit when
you eat it. And then the second is
dietary restriction. You don't restrict
when you eat, you don't restrict how
much you eat, which you also don't
restrict in time restricted feeding, but
you restrict certain elements of what
you eat. So, for those 3 years that I
was on a ketogenic diet, which is
I mean, probably one of the most
demanding subsets of dietary
restriction,
um
you know, I pulled that lever as hard as
it could be pulled. Then you move into
diets that sort of mimic fasting, um
which is basically just another way of
saying hypocaloric diets for transient
uh periods of time.
And then ultimately, even beyond that is
fasting. Just you know, water only also
for limited periods of time.
Nowhere in there do I include
constant caloric restriction. So, you
know, reducing by 20 30% your energy
intake indefinitely. I I think the data
are pretty clear that that is not a
winning strategy. There's something
about the cycling into and out of
catabolic versus anabolic state. You're
basically clearing house, right? You're
sort of getting the cells that are
themselves defective, and hopefully the
ones with the most effective
mitochondria, we'd love to target those
the most for other reasons. Um
what you want to see is the regrowth.
You want to when you refeed, you want to
see the selective repopulation of the
better cells.
The most robust experiments done on this
in primates
did not really suggest that as the diet
got better, the benefits of caloric
restriction got better. In other words,
the worse the diet, the better the
benefit of caloric restriction, which
points us to this idea that dietary
restriction should still always be some
component of a healthy nutrition
strategy.
Meaning like if you're eating like [ __ ]
stop eating like [ __ ] stop eating.
Because then you're eating like [ __ ]
if you're if you're committed to never
eating anywhere but McDonald's, caloric
restriction will have a much bigger
effect on you positively
Right. than, you know, if your baseline
intake is, you know, the way you would
eat, for example. That kind of stuff at
like the deep cellular level about where
we're going and what this is going to
look like is is really fascinating to
me. Definitely not something that I have
the kind of grip on even remotely close
to what you do, but nonetheless seems
like if you're
really going to get to 100 at a high
level, it seems like you're going to
have to take that pretty seriously. Now,
you've talked a lot about one of the
tests that you want to make real is the
ability to check for autophagy and to
see in the blood.
Um you've thrown out a couple times that
this is like A, you probably know the
people that would be creating this test,
um and B, that it wouldn't be, you know,
it's not measured in the billions. So,
what what would that really take?
Um
is it something that could be
commercialized and would give people the
impetus to put the capital up for it or
what does that future look like? From a
funding perspective, again, this is not
like
the world's hardest problem to crack. Um
but I if I'm going to be completely
truthful, I don't know how commercially
interesting it is. As a general rule,
diagnostic tests are not very
commercially interesting.
Um
my interests are not remotely
commercial. My interest is in just
knowing what to do. Mhm. It's like I
want this test to tell me exactly what
the right fasting protocol needs to be.
Right.
fasting 3 [clears throat] days a month,
7 days every 3 months, 14 days once a
year? Like I want to know that.
And there's no amount of money that
would make it worth, you know, not
knowing the answer to that question. Um
Wow, that's a bold statement. Well,
think about it. I'm not to suggest that
like money doesn't matter and money you
can't do great things with money. Like I
want money just as much as the next
person, but never at the expense. Like I
don't want anything to get in the way of
the knowledge that can drive living
longer. That to me is such a priority
that I I rather be poor, but know how to
you know, live longer than have all the
money in the world and lose my health.
I totally get that. But, I will say one
thing I want to talk about is you said
that um one, you've said that you think
that you eat dysfunctionally even if you
don't have an eating disorder, which I
actually thought was really interesting.
And then you said that part of why you
gave up the robotic eating was you were
worried about how it's affecting your
daughter's view of food. [snorts]
Talk about that cuz I think certainly in
this the movement that we're all going
through right now, there's a real risk
of that. That if I had had kids 5 years
ago when I was like tear I was shredded.
I was so myopically focused on
everything that went in my mouth and I
loved it about myself and I would rave
about how much discipline I had.
So, for sure if I had kids, they would
have been wildly influenced by how much
pride I took in not eating.
And so, yeah, I do worry what that would
have done. I thought it was super
sensitive of you to recognize that and
change.
Yeah, I mean my brother actually was the
he brought this point to my attention
first, but he said, you know, be
thoughtful about how you describe your
own interactions with food. And when
you're
giving, you know, your kids input on
what to eat or what not to eat, try to
tether it less to, you know, body
dysmorphic ideas and trigger it, you
know,
peg it more to performance issues, for
example. Right? Because those things are
still true, right? If you If you eat
well or eat poorly, it affects your
performance. It affects your cognition.
It affects a lot of things.
Um and if the focus is more on those
things than on, you know, sort of
"Daddy, why aren't you eating this?" Cuz
I don't want to be fat. Well, [laughter]
you know, that's
And and look, there's a truth to it.
Like I I mean, I'm a vain person. I I
I'm not you know, I've come to a place
where I've accepted the fact that I can
I won't look like I used to look. Like
cuz I'm not willing to put in that
amount of sacrifice ever again.
You and I have the luxury of being old
enough to be able to think through that
in a slightly uh less emotional way and
at least
make that make that choice when I think
people who are younger
um
I don't know. I just don't know if
they're equipped fully with the tools to
make all of those decisions. I want to
ask you about change. You have changed a
lot
in your life like multiple times from
starting out and getting your degree in
um engineering and mathematics and then
ultimately pulling the first switcheroo
over into medicine, then leaving
medicine and becoming a consultant, then
going into hardcore research and
um
doing uh nonprofit work, and then now
back to medicine. What What has allowed
you to constantly make those jumps or
what propels you to make those jumps? I
have been able to internalize something
that I think is not innate to most
people,
which is the fallacy of a sunk cost.
So, uh
the sunk cost fallacy is something that
gets talked about in, you know, any econ
101 class, right? So, you've uh
you know, you're you're building a
bridge and the you know, the cost of the
bridge is $10 million and you're $9
million into it and the contractor says,
"Ah, it's going to be another $11
million."
Um for many people, they are evaluating
that based on how much money they have
already put into the project.
And that becomes a very dangerous game
because you can't get those dollars
back. So, instead you have to evaluate
it from the standpoint of exactly where
you're standing at that moment in time.
And for whatever reason,
I've
I've been able to stand at any point in
my life and sort of say,
"I want to do X.
I'm going to evaluate that only through
the lens of how many years do I have
left on Earth and not at all through the
lens of what have I already put into
this.
Um
and I think that's just made it easier
to do things that on the outside look
odd, look orthogonal. And then to leave
medicine
um
whatever it was 12 years ago
that was something that
a lot of people came to me and said,
"You got to reconsider this. Like you've
put far too much into this."
And I just said like
look, I'm going to do something for the
next 40 years.
I want it to be exactly what I want to
do. And that's way better to me than
saying, "Well, I'm going to do something
that I don't really really want to do
because I've spent the last 10 years
doing it." Which is where I was. I'd put
10 years into medical school and
training
um post-graduate training.
And it was like, "Look, that's
that's 10 years I can't get back."
Um
and it's
that's a fraction of the time that's
still in front of me. So it just it just
seemed very logical to me to always
pursue my bliss.
Um
and also, I mean going back to something
you said, I I think we're in a different
world now. I mean I think the days are
long gone of you do one thing for your
whole life. I mean I think
for some people that will be the way to
do it and that's that's great, but it's
no longer so ridiculous to have a career
change every 5 years.
I don't
I don't know what I'll be doing in 10
years, but I'd be shocked if it looked
exactly like what it looks like today.
Like I think y- y- you know, if you're
not growing, if you're not constantly
being reminded of
how much more how much higher you have
to climb
um I suspect it's I suspect life becomes
a lot less fun.
What drives you?
I mean truthfully, I wish I could come
up with a whole bunch of pleasant, you
know,
sort of nice things to say. I think in
reality, unfortunately, a lot of my
drive is insecurity.
Um That is shocking.
And I've heard you say that before.
Um and the first time I heard you say
it, I thought that's really fascinating
because you're somebody who gives me
insecurity. So, the fact that you feel
insecurity is pretty fascinating.
And so, as a driver, in what way does
that drive you? David Foster Wallace
said in in what what is unquestionably
my absolute favorite 22 minutes that one
could ever listen to, which is his
commencement speech from 2005 called
This Is Water. So, and and the first
time I ever heard this, I it didn't
resonate with me. I needed to hear it a
few times before it really resonated,
where he said,
"If
if if you if you worship power, you will
forever feel powerless."
Right? And and that doesn't really
resonate with me cuz I'm not a power
seeker, but I absolutely
worship intellect.
And and when he said the next words out
of his mouth are, "You will forever feel
like a fraud." I'm like, "That is so
true."
I find myself, at least on a daily
basis, thinking,
"Dude, I hope people don't find out how
much I don't know." Wow. And and and and
I wish I wasn't saying that. I mean, I
wish I could I really wish I I wish I
could say
all of my motivations are pure. It's all
I I'm you know, I'm Mother Teresa. I
just want to fix every problem and make
the world a better place, but the
reality of it is, like, I think a
significant amount of my motivation is
just this
complete desire to not be found out as a
fraud who doesn't know stuff. I love
that for two reasons. One, I think that
and I'll speak very much for myself.
From the moment I met you, I was like,
this guy [ __ ] with my head. Like,
there's just certain people where I'm
like, I it's hard to feel smart around
you. So, the the fascinating
thing is, you know, to hear that uh
that there's some of that driving you.
Um
and then two, hopefully people listening
to this that that um
aren't comparing themselves to you, but
yet are looking at you going, "This
guy's [ __ ] fascinating. I'm really
interested." And they have like a warm
feeling for you.
Uh that's probably equal parts like,
"Oh, he's compassionate towards humanity
and that's rad." And then equal parts
like
"Wow, he's [ __ ] smart. That's, you
know, he's got cool [ __ ] to say."
And so, for them to hear that you can be
so
um open and honest about, "Oh, yeah, I
have insecurity and
um
it's low self-esteem that's pushing me
forward." Because they they will look at
you and think it impossible that you
could possibly have low self-esteem.
Um which I think is really really good
for people to see that that never goes
away. And one of the things that I've
always thought was I'm not going to call
it a superpower, but something that I've
been glad that I have for myself is my
motives are always apparent to me even
when they're ugly and petty. And yeah, I
mean, there are times where like what's
driving me for whatever reason is ugly,
it's petty, it's um
makes me feel worse about myself,
whatever. But at least I have clarity on
what it is.
Yeah, I wish I could say I always could
see it. I don't think I can. I think it
requires a lot of
I I don't think 2 years ago I could have
acknowledged
um
what I can be much more brutally honest
with myself about today. What happened
that made that? I mean, you know, I've
always seen therapists. My, you know,
there's been very rare has there been a
season in my life where I wasn't sort of
searching for some sense of
you know, why do I feel so tormented?
And
you know, one of them said the most
insightful thing to me I've ever heard.
You know, your entire life your entire
life has been basically driven by um
three
skills, three things that you do
um
that you're really good at. And they're
not good things, by the way, right?
Emotional detachment rage and obsession.
Wow. You Those are like the only three
tools You're a guy that has a toolbox
that has three tools and those are the
three tools. And she said, "Look, you've
got a lot of good stuff out of those
tools. There are a lot of people who get
those three tools and they just end up
in jail. Mhm. So, you've managed to
through a lot of luck um
you know wind up not in jail, wind up as
a quasi successful human being, a
contributor to society, a father. Like,
you've done some good stuff, but she
just said, "You're sort of at the end of
your rope with those three tools. Like,
you can't get any more juice out of
squeezing those things. There is no
combination
of emotional detachment, obsession, and
rage that is going to produce anything
of value and you're actually now at the
diminishing part of the curve. So, now
you're actually you're regressing. So,
you're going to need new tools. And, you
know, so in many ways I think that's
what has allowed me to go back and say,
"Okay, well, what what is the impetus of
that? Why is the Why are these things
happening? What
you know who do I want to be in 5 years,
right? Cuz I can't fathom what I Like, I
can't fathom being any different in 5
days. So, I have to think bigger. I have
to think of like, "Okay, in 5 years you
want to be It's sort of like what we
talked about at the outset. If if when
you're 100, you want to be able to do
these things, you can back out of that
and say this is what you have to be able
to do when you're, you know, 70 or 60.
And similarly, if in 5 years, when my
kids are aged this, this, and this
I want to be this kind of a person.
And right now I'm not on a path to be
anywhere near that. In fact, I'm on a
path to be completely different in a in
a completely different place.
Okay, so start backing out. What the
person who can do those things in 5
years has to be able to do what
in a month? How would they react in this
situation versus how do you always react
in a situation? People like me who are
very good at doing things where harder
work produces better results,
like when that's your playbook and you
are now confronted with trying to do
something where that playbook doesn't
work,
it is
ego-demoralizing.
Right. Like if the answer is just swim
further,
like all you have to do is just keep
swimming. Don't stop swimming. I got it.
Like I That is my book, man. But if the
answer is no, you now have to be able to
control your emotions in a certain way.
You now have to be able to, as you said,
recognize in a moment
when you have an emotional reaction, why
it's what it's really about. Cuz it's
never about what you think it's about.
It's about something else.
Can you stop yourself in the moment and
recognize that?
That is a new skill. And I'm a baby
trying to learn that skill. And my old
trick of just work harder, just work
harder, it fails.
So, in many senses, it's like the most
intimidating thing I've ever tried to
do, right?
What's your process in all this? Like
how are you actively getting better?
One is just showing up every day, right?
So, it's
like
you know, the last time I
last week when it was the last time I
spoke with one of these therapists, I
just had a really miserable day. I mean,
I just didn't want to talk to them at
all.
You know, I was in a really, really bad
mood. And so, part of it, I guess, is
you set yourself up around people who
are never going to take your [ __ ]
Right? So, you have therapists who for
me, having these these collection of
people around me,
it's like
they absolutely, positively don't let me
get away with anything.
You know?
I I part of it, too, is just having
really patient people around you because
you're going to make a lot of mistakes
in this process, right? So, you have to,
you know, in my case I feel very
fortunate. I have a spouse who is uh
you know, I I would say more forgiving
than probably she should be.
She believes in the in the sort of like
this is what you could be in 5 years.
This is this is the guy you can be. So,
when someone believes in that, they're
much more willing to help you
when you fall, they'll pick you up as
opposed to point out that you fell.
And do you have like a specific vision
of yourself that you're building towards
or chasing?
I mean, I do. Um
and it's not it's not a professional
version of me. It's a personal version
of me. If I get wave a magic wand, what
kind of a husband, what kind of a father
am I? And the reason I use those two as
an example is it's unfortunate the
people who are closest to me who always
see the worst of me. And so, most of
what I think about is how do you uh
how do you show up for those people? Cuz
if you can show up as the best version
of you for those people, the trickle
effect is everyone's going to be fine.
Like you will be a great version of you
with everybody. So, it's it's less about
how do you show up at the TSA check gate
when the person's obnoxious. I'm not I
don't worry about that that much. That
that's a relatively easy thing to
control.
But
when you're taking out your problems on
your kids or on your spouse,
you know, to me that's
that's the stuff that's just got to
stop. And um
and if you can get to that, to me that's
like the that's the hill of the
mountain. That's like that's the hill
when you climb that. Well, at that point
you're going to be treating everybody
the way that they deserve to be treated,
including yourself, by the way. I mean,
as you probably know,
um those of us who are the biggest
you know,
sort of jerks to others are usually
jerks to ourselves.
You're quite aware of how hard you are
on other people when they make mistakes.
Do you realize how hard you are on
yourself? Look at Do you know what your
self-talk is when you're making errors?
And I And I started paying attention to
it and I was like, "Wow.
That's really That's harsh."
Mhm. That's very harsh that you would
that you that you think these things of
yourself. Which again, it all comes back
comes back to this insecurity. And at
the outset I I I said um
you know, whatever 5 years ago or 4
years ago, 90% of my bandwidth was on
like how to not die and today that's
only 50% of my bandwidth. The other 50%
is the whole physical stuff we talked
about. And then it's this, right? It's
this
um
What does an examined life mean? And
is it a life worth living?
Um because
you know,
I I do think we suffer so much in our
own heads
uh more than we suffer any any other
way.
Um
And I don't know the answer to that. I
Here's what I know. I know that that's
way harder than reducing the risk of
heart disease.
Um I know that's way harder than, you
know, addressing that is way harder than
fasting or doing all of these other
things that are even non-pharmacologic
interventions that I think can fix all
those other things. And certainly for
someone like me, it's harder than
you know, exercising or being
disciplined about all these other
things. Um
And I suspect in part because it's less
amenable to doing. Right. Right? The
things that we do um tend to be a little
bit easier. But this is this is tough
stuff. So,
I don't know. I mean May Maybe part of
the reason to want to live longer is to
just give more runway to figure this
out.
100%.
No question. All right, man. With that,
before I ask my last question, tell
these guys where they can find you
online.
Oh, um
so website is Peter Attia md.com
and uh you can find everything there.
So, the podcast although it's of course
on all the usual places, you know,
iTunes and such. Um,
and then it's Peter Attia MD on social
as well. Awesome. My final question,
what is one thing that people could
change that would have the biggest
impact on their health?
You're going to hate my answer, man.
It's going to depend on where they are
on each of these four metrics to begin
with, meaning where they are on
exercise, sleep, nutrition, and
management of distress. So, in other
words, the biggest impact will be the
one in which you are most lacking for
each of those. So, for example, somebody
whose sleep is completely you know,
abysmal, if they could address their
sleep, that will probably have the
biggest impact. For somebody whose
nutrition is atrocious,
addressing that will have the biggest
impact.
Um,
if you ask that question in reverse,
it's a little easier.
A catastrophic interruption to which of
those four things will have the greatest
detriment on you? It's probably sleep.
Oh. Right? So, again, not really
appreciated, but if you take an extreme
posture,
how long can you go without eating?
2 months.
How long can you go with not sleeping
without becoming completely psychotic? I
don't know. Days. Yeah. Right? Maybe 6,
7 days. I don't know the answer, but but
you're going to more quickly
uh completely lose it if you don't sleep
than if you're blowing any of those
other things. So,
um,
if someone's sleep is a is a real mess,
um,
it's it's remarkable what you can fix
and how much of bad sleep permeates into
other things. Mhm.
Awesome. Great answer, Peter. Thank you
so much for coming on the show, man.
That was amazing.
Guys, this is somebody who is one of the
most extraordinary humans I've ever met.
The way that they think about the world,
the way that they're not afraid to
change, the way that he has constantly
evolved, that he's constantly pushing
himself. I literally could have talked
to him all day. The number of topics
that we didn't get to cover is even
longer than the ones that we did. Uh
from everything, you know, why he does
racing the way that he does and why that
pushes and drives him to some of the
extraordinary things that he's learning
in the field of medicine and nutritional
science is just absolutely astonishing.
I highly encourage you to follow his
podcast called The Drive with Peter
Attia. It is amazing. The The breadth of
things that he can talk about with just
absolute clarity is really, really
astonishing. But the coolest thing about
him is that he is never afraid to say
that he doesn't know. And that, when you
find somebody that is hell-bent to get
great at something, and at the same time
they're just never afraid to say that
they don't know. And you just saw the
he's raw and real and not afraid to talk
about the things um about himself that
he's working on and pushing and trying
to improve. He doesn't posture. He's not
trying to look cool.
But [ __ ] that makes him cool. So, I
hope that you guys will dive into his
world. He is somebody that's had a
tremendous impact on me and I think he
will have a similar impact on you. All
right, if you haven't already, be sure
to subscribe. And until next time, my
friends, be legendary. Take care.
[applause]
Thank you again, man.
That was wicked. Thank you guys so much
for watching and being part of this
community. If you haven't already, be
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