Why You Might Want to Reconsider that Carnivore Diet | Dave Asprey on Health Theory
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In this episode of Health Theory, Dave Asprey returns to discuss his latest book, *Superhuman*, and his philosophy on living to 180 years old by optimizing energy rather than just time or money. He begins with a poignant story about his grandfather's death from an autoimmune kidney condition after choosing the "wine diet," illustrating that while one can choose how they leave this life, it is preferable to fight for quality of life and longevity whenever possible. Asprey shares an anecdote about a Fortune 200 CEO who diagnosed himself with pancreatic cancer but refused to accept defeat; by switching immediately to a full keto diet and utilizing insulin-potentiated therapy alongside chemotherapy, he successfully shrank his tumor until it became operable. This narrative underscores the core message of *Superhuman*: aging is not inevitable time-based decay but rather "death by a thousand cuts" caused by specific biological failures that can be addressed through targeted maintenance strategies. The central pillar of Asprey's argument rests on mitochondria, which he describes as the power plants and operating system cells run away from threats like stress or starvation. He explains that mitochondrial performance dictates human health; specifically, sufficient energy production is required to repair nuclear DNA mutations before they become cancerous. A critical statistic highlighted in the discussion is that 48% of people under age 40 already suffer from mitochondrial insufficiency, a condition affecting everyone over 40 unless managed correctly. To combat this decline and promote autophagy—the process where cells clean out old mitochondria to replace them with fresh ones—Asprey advocates for intermittent fasting protocols involving Bulletproof Coffee (zero sugar/protein) during the fasted window, typically skipping breakfast until a late lunch around 2:00 PM. He also emphasizes that while mice in studies only consumed water, humans can maintain ketosis and autophagy by consuming small amounts of MCT oil or Brain Octane C8/C10 fats without breaking the metabolic state. Asprey addresses common dietary pitfalls, particularly regarding protein intake and extreme dieting trends like raw veganism or high-protein carnivore diets. He warns that consuming more than 20% of calories from protein leads to a four times higher increase in all-cause mortality due to systemic inflammation caused by excess essential amino acids like cysteine and methionine. Furthermore, he critiques the "vegan trap," noting that while plants provide soluble fiber for gut bacteria, they lack the saturated fats necessary for human cell membranes; when vegans switch back or fail to adapt their thyroid hormone levels appropriately after an initial period of feeling good on a plant-based diet, they often experience cold intolerance and energy crashes. Consequently, he recommends a balanced approach where individuals eat 80-90% vegan foods but supplement with high-quality saturated fats from grass-fed animals, avoiding industrially raised meats while ensuring adequate intake of collagen for joint health and skin integrity. To further optimize mitochondrial function and longevity, Asprey details the benefits of cold exposure through cryotherapy or ice baths, which trigger a shift in cardiolipin levels within cell membranes to improve heat generation and energy production. He notes that just three days of brief cold exposure can transform one's physiology by increasing brown fat and enhancing overall thermogenic capacity. Additionally, he stresses the importance of sleep hygiene as the highest return on investment for health, recommending specific tools like TrueDark blue-blocking glasses worn an hour before bed to ensure deep REM cycles, raising the head of the bed six inches to aid cerebrospinal fluid drainage, and using red or amber light therapy to regenerate skin collagen. These interventions, combined with a focus on eliminating toxins through activated charcoal during fasts and maintaining low inflammation, form the actionable roadmap for achieving a "superhuman" state where individuals can function well into their 180th year without succumbing to modern degenerative diseases like heart disease or Alzheimer's.
Read the full video transcript
If you eat more than 20% of your
calories from protein, it is going to
cause a four times higher increase in
all cause mortality.
Hey everyone, welcome to Health Theory.
Today's guest is Dave Asprey, he's back
for round two. And if you don't know
Dave, he is the Silicon Valley tech
entrepreneur and New York Times
best-selling author of several books,
including Headstrong, Game Changers, and
most recently Superhuman. He's also one
of the world's most famous biohackers,
the founder and CEO of Bulletproof, and
the host of the top 10 podcast
Bulletproof Radio.
Dave, welcome back.
It's always fun to come to your house
and see the amazing stuff you're working
on. Thank you for having me.
Of course, and speaking of working on,
man, you and I share an obsession with
the new book, You're Living to 180. So,
your book opens with one of my favorite
quotes of all time, which is, "Do not go
gently into that good night. Rage, rage,
rage against the dying of the light."
Why start there? How has this become
your obsession?
It's funny, there's a very old
restaurant in Berkeley, California. In
fact, um
my parents uh used to eat there when my
mom was pregnant with me. Like, way back
in the day. It's called Spenger's. And
they actually have that quote up in when
you enter into the restaurant there. So,
I remember when I was a little kid, my
grandfather uh reading that quote to me.
And I remember my grandfather was uh
passing away, he was in his
his 80s, and he came down with an
autoimmune kidney condition, and he sat
down and he said, "Well, I'm a PhD
scientist, chemist, and I know that if I
work really hard,
I might get to the point where I can sit
at home and be well enough to watch golf
and do dialysis twice a week for the
rest of my life."
Wow.
I don't want that. So, I'm going on the
wine diet.
And and
[laughter]
he said, "Call the family." And I said,
"What does that mean?" He said, "I'm
only having wine. No water, no nothing
else." So, everyone flew in and he
passed away a few days later, literally
doing exactly what he said. He just had
a few sips of wine every once in a
while, but he decided he was going to
go.
Let's talk about that for a second. So,
I'm I'm actually really interested in
this. So,
um like if I knew that that was a
one-way street,
as much as I want to live forever, 180,
like as long as humanly possible, if it
got to the end, man, I'm I'm all about
the wine diet or euthanasia, quite
frankly. Like, where do you come down on
that?
If you think that there's hope, and you
think that there's hope to have the
quality of life that you want, then you
fight for it. And in fact, one of these
guys who never discloses publicly, CEO
of a Fortune 200 company, he was
diagnosed with pancreatic cancer, the
same stuff that took out
uh Steve Jobs.
And I sat down at the Rosewood Hotel,
and uh he said, "Dave, I'm I'm going to
tell you what I did." And the day he was
diagnosed, he he said, "I'm not going to
die. I have I have a a company and I
have kids. This isn't fair." He never
told anyone. So, he went on a full keto
diet that day.
And he shrunk his tumor to the point
that it became operable. They did chemo
on it, and when the doctors weren't
looking, he'd inject insulin to do
insulin-potentiated therapy, which works
way better than chemotherapy, but the
doctors wouldn't do. And so, he was
like, "I'm taking charge." And you know
what? He He did it. Right? So, and I And
in running an anti-aging nonprofit group
for 20 years, I have met people who are
saying, "I have this life-threatening
condition, and I am going to own this."
And they do. And I've also met with some
who say, "I'm going to own this." And at
a certain point, they go, "It's not
working." And they make peace with it.
And the people who die kicking and
screaming are the most unhappy. And if
you believe any of the Buddhist
perspectives on hell or any of those
other things like that, those are the
people who have probably a shitty
afterlife, and aren't going to like
their next life, if you're into
reincarnation.
Do you believe in that?
Absolutely.
Really?
Yeah.
That's so interesting. How did you get
into that? Like when did that become
your dominant belief system?
There's the western side of this. So I
grew up as in a in a atheist household
full of
rigorous engineers and you know, like
all these stupid people would believe
that stuff.
But here's what it comes down to.
If your nervous system believes that you
get to you get a game over at the end of
this game, you relax a lot more.
Okay.
Okay. Keep going.
So check this out. If I can do anything
to remove my unconscious fear of death
which inhibits me from doing the things
that I want to do when I'm here.
If believing reincarnation can do that,
fine. I'll sign up for it cuz here's the
deal. If I'm right, great. If I'm wrong,
I'm dead. I don't care. Like I you can't
lose by believing in reincarnation. So I
can't tell you that it's provable. I've
also done very deep states of
neurofeedback. I've done deep stuff
shamanic wise and I've talked to
different people from different
traditions who look at me and say the
same things about stuff that I have no
knowledge of. So as a curious person
where that scientific method is observe
is the first step, I've observed stuff I
can't explain via any normal hypothesis.
So I know the stuff that we believe has
holes in it just like it does
biologically. So I'm just going to say I
like that choice best because even if
it's complete [ __ ] it still
enhances my quality of life.
That's really interesting. So one, the
reason that the one thing in all that
that doesn't resonate with me is that
believing that you get a game over at
the end of this causes you to relax
which is the exact opposite I would say
certainly for me. Even if I live
forever, like I want to go hard hard
hard every day. And if there's an end,
then I really want to go hard every day.
Whereas I feel like the the opposite
might be true. If I knew I were getting
reincarnated,
one of my lives might be the donut life
where I just chill and I'm like, look,
I'm going to tap out early. I get it,
but I'm just going to eat me some tasty
food until it comes."
If you believe that I went to Tibet to
learn meditation from the masters. Like
I've debated the llamas. And what
they'll tell you is Oh, you've probably
done that.
[laughter]
But had the donut life, you mean?
Yeah. Absolutely. Like if you're asking
that question now, you probably already
had your donut life.
Right.
Right. So, the idea is you're going to
keep making the same mistakes for
lifetime after lifetime after lifetime
until you learn your lesson. So, for me
that's pretty good motivation to learn
my lesson this time so I don't have to
repeat the lesson again because who
wants to repeat first grade over and
over and over? Eventually, that's going
to get boring.
All right. So, while we have this one
and this isn't our donut life, then what
should we be doing? Like I love the
concept that you explore in the book
about, okay, you may be here and maybe
here is even pretty good, but there
actually is something above that and
that you're not kidding when you say
that you really want to live to 180. How
do we actually get there? Like walk us
through the you call it the the four
killers.
Sure.
Start there.
And
everything in Superhuman comes down to
something called return on investment.
And it you just have to look at what
you're investing. And we usually think
of investment as dollars, but what we're
really investing is not even time. We're
investing energy.
Cuz if you have energy, you can use the
energy to make money. If you have time
but no energy, the time is useless. If
you have money but no energy, the money
is mostly useless unless you spend it to
get energy back, which is what I had to
do when I weighed 300 lb and you know, I
was I was screwed up.
So,
if you don't have money, you don't have
time, you don't have energy, you're in
pretty desperate straits. So,
when it comes to living to 180, what if
during this entire life, however long it
is, you did the things that gave you the
highest return on investment for
learning the lessons that you need to
learn, whether because this is the only
life you have and you tricked yourself
into believing in reincarnation so your
heart rate variability could go higher,
or because you actually are going to
come back in your life. I have no idea.
But I'm good either way. So, just in
case I think living to at least 180 is a
good plan. It lets me do more of the fun
stuff. And when we get down to what's in
Superhuman, first step to living to 180
is not dying.
It sounds
It sounds kind of obvious, but a lot of
people read that book and go, "I never
thought about it, but let's just play
the odds." If you're average, by the
way, okay, if you're listening to the
show you're already not average because
you're paying attention to health,
right? And if you're reading Superhuman,
you're not average. But if you are
average, what's going to kill you is
probably heart disease, cancer,
or Alzheimer's disease, or diabetes. And
diabetes is turned out as a risk factor
for the other three. So,
pretty much that's your future. You're
going to be unable to metabolize food
until you puff up and die of a sugar
overload and other diseases. That's no
good. Uh you're going to pop a gasket,
your heart will stop beating. Um or you
could just forget your name and your
kids' names and end up in diapers. And
uh cancer, we all know, you know,
chemical poisoning, radiation poisoning,
surgery. And what no one talks about
though is that your chances of living if
you had cancer are twice as high now as
they used to be. So, we're actually not
preventing cancer very well. The
incidence is higher, but the survival
rate is increasing pretty dramatically.
Right? So,
I
I end up looking at all these and
saying, "Okay, what do we do the basic
things to avoid your risk of all of
those?" Because if you just turn that
down, your quality of life is
unquestionably going to be higher even
if you die at 87 or whatever the average
would be given your demographics.
And then, once you've lowered those
risks, you say, "All right, what are the
things that are going to make me die of
some other cause?" And maybe one of
these.
And for those, there's these seven
pillars of aging that now scientists
understand. We used to think, "Oh, we
don't know why we age. We age because of
time, you know, we age because of
whatever." But it's not one thing.
And it's sort of like, why does your car
break?
Well, is it cuz you didn't change the
oil? You didn't put gas in the tank? You
didn't change the tires? You didn't
rotate the timing belt and all the other
stuff you do to maintain a car? And did
you do it the right time throughout the
life of the car? If you do it right,
there's cars with 700,000 mi on them
driving today, and there's cars in the
junkyard with 70,000 mi.
Right.
I'd like this to be a 700,000 mi car. It
might have a few wrinkles in the seats,
but it's perfectly serviceable and it
gets around under its own power. And
this is doable, but only if you know the
maintenance schedule. So, the seven
pillars in Superhuman are about those.
For each of the pillars,
um there's things you can do that are
free, they're lifestyle based. There's
things you can do that are pretty cheap,
like, you know, maybe change your diet a
little bit or take a supplement, uh or a
small gadget, let's say. And then there
are things that are based on the very
cutting-edge science. Some of them are
frighteningly expensive, but this is
what the millionaires are doing.
And I went to the trouble of going out
and doing as many of those as I could
afford or find, and
those things are are in here. So, I'm
Here's the experience of doing it.
Here's, you know, an expert. Here's, you
know, my own assessment of this. And
here's the results I had. And what I
want people to walk away from this
interview, from reading the book, just
from thinking about this,
aging is death by a thousand cuts, and
these seven pillars are what are holding
you up. But what if you took less cuts,
they were less deep, and then you healed
those cuts like Wolverine,
instead of just putting Band-Aids on
them? You'll find that when you're old,
you have a lot less scars,
and you function a lot better, and
actually you're not old. You just have
lots of years. And that is the path that
I'm on, and and it's an accessible,
achievable path for everyone.
So, one of the things you talk about in
the book, I was actually, um excited to
see that you put it into a nice simple
sentence. And basically, aging boils
down to the mitochondria.
Yeah.
And I've never heard anybody put such a
fine point on it before. One, for people
that don't know, what are mitochondria?
And then two, why is aging so related to
that?
Mitochondria are we like to say the
power plants of the cells. This is
seventh grade biology. It's what you
hear on every news show. But I went
really deep on the biology of these
ancient bacteria that we like to say we
harnessed for ourselves. They're
actually running a lot of the decisions
in our bodies. They're the ones who run
the operating system of life for us. And
the operating system of life is run away
from, kill, or hide from scary things.
They decide how much energy goes into
fight or flight and how much goes into
cellular protein folding. They're making
the electrons and deciding what to do
with them. And they're keenly interested
in food because without food their job
is to take food and air and a little bit
of light and make energy out of that.
And if they don't get enough of those
things, they freak out and they change
their behaviors. That changes your
behaviors.
And mitochondria, because we are talking
about them, make them sound like they're
a separate entity. And they actually do
have their own DNA, right?
They are separate bacteria that are now
inside our cells. They have their own
DNA and they share some functions with
our DNA. But after this book came out,
when I said very straightforward,
mitochondria are at the root of aging.
And one of the seven pillars is
mitochondrial
uh mutation. However, their performance
determines how well you live. Then the
study came out and what they found was
profound. They found that when
mitochondria make enough energy that the
energy gets used by your nuclear DNA
repair facilities. So, if you have
enough energy in your cells because you
ate the right stuff, because you did the
right stuff like sleep and exercise the
right way and all the other things that
that I talk about in here, you will have
enough energy to repair your human DNA,
not your mitochondrial DNA. So, if you
don't want to get cancer, you don't want
to get these mutations over time, you've
got to have enough energy to repair. And
this is what's happening to a lot of us.
When I say a lot of us, 48% of people
under age 40 have mitochondrial
insufficiency.
Everyone over age 40 has mitochondrial
insufficiency unless they're managing
it.
How do you test for that?
It just so happens that Upgrade Labs, we
have the gold standard test. In fact,
we're the only ones who have it. We have
exclusive rights to it. And you use a
VO2 mask and it actually measures your
oxygen consumption and how efficient you
are at using it. There are other blood
tests and all that are just not that
reliable. I've been searching for a
mitochondrial sufficiency test for
years. The only one that I know is you
get on an exercise bike breathing
through a mask with a special algorithm
that analyzes what you're doing to see
how much energy you make and how much
oxygen was left over. There's no lying
to that system.
Right.
So, the studies show those numbers are
accurate. So, what that means is as we
age, we get worse at using air and food
to make electrons, whether it's to ride
a bike or to think a thought or to feel
an emotion. All of those are driven by
the same exact electrons that are
powering your phone. And we,
unfortunately, can't plug into a USB
cable to recharge yet. That would be a
lot easier.
That's the next book.
That would be a lot easier.
Um so,
if mitochondria are the source of aging,
you threw out a couple things really
fast there that we can do to protect
against that or to optimize our
mitochondria, what does that look like?
There's about a quadrillion mitochondria
in your body, way more than there are
bacteria in your gut, and way, way more
than there are cells in your body. So,
your neurons in your brain have 15,000
mitochondria in one cell.
And these things have their own little
unique consciousness, the cell level
consciousness like a bacteria would
have, you know, very basic things that
they do, but it's become this elegant
dance where inside a neuron, these
mitochondria will move back and forth
and they'll break in half and and they
do stuff that is at the very very core
of life. Stuff if didn't understand 20
30 years ago cuz we couldn't see it, we
couldn't measure it.
And
one of the things that they do is they
hang around even if they don't work very
well. That means that if you don't
provide enough stress for them, they
will not go to the biological expensive
trouble of killing the weak ones and
replacing them with fresh young ones.
Interesting, I didn't know that.
So, it's kind of like a cell in your
battery, right? You're in your Tesla or
even in your phone, there's multiple
cells in your battery and if one of the
cells goes bad, the battery the phone
keeps working doesn't charge quite as
well. Two of the cells go bad,
eventually enough of the cells go bad,
it only holds a charge for 5 minutes,
you're in the hospital your phone's
getting replaced.
Well, what if there was a way to say,
"Oh, this cell's going wrong, let me
kick that cell out and grow a fresh new
cell." That's what our bodies do.
And when you do things like fasting
and you just don't eat breakfast, it's
not that hard or don't eat for a couple
days. When you do that, all the cells
that cannot survive because they're
freaking out, I don't mean your cells, I
mean the cells within the cells, the
mitochondria, they'll actually die
through a process called autophagy.
And when that happens, your body cleans
out the dead ones and you grow fresh new
young ones.
But if you never experience hunger cuz
you're living that donut life,
then
you won't do that. And if you get really
cold for a brief period of time,
any cell that can't make enough heat
to keep you warm, your body says, "Oh, a
nice age might be coming. I better have
enough young cells that can make heat."
And it gets rid of the cells
All right, let's get real specific on
both of those and then we'll we'll keep
going. But so, intermittent fasting,
what's your protocol?
So, Bulletproof Diet 2014, I talked
about doing a 16-hour window. It turns
out you can and this has since been
backed up by several experts in
autophagy, you can have Bulletproof
Coffee
in the morning. Zero sugar, zero protein
is important, zero carbs. So, you're
only doing fat and coffee or just coffee
or tea. A lot of people can't go for 16
hours. I mean, if you're like I was when
when I weighed 300 lbs,
the idea of going without eating six or
eight meals a day is abhorrent cuz you
know you're going to die. And so,
or you're saying, "Okay, I've got this
willpower. I'm going to do it." And at
11:00 in in the morning, you're looking
around going, "Everyone around me is a
jerk. Like I want to punch all these
people. I'm going to make it to lunch,
but why is everyone such a you know"
That's not functional. So, a lot of
people they're starting it off with
Bulletproof Coffee cuz they're getting
their energy up, right? So, I'm going to
put that in the realm of intermittent
fasting. I call that one Bulletproof
Fasting, shocking, right? Uh but I'm
also very clear. The amount of caffeine
in two cups of coffee
doubles ketone production. Right? So,
you can have And that's just caffeine,
but uh coffee itself has other benefits.
So, you can have two cups, even a decaf
if you want to, but calf works better in
the morning without any of the
Bulletproof stuff in it, and you're
still going to see a metabolic advantage
from doing that. And if you go for 16 or
18 hours of fasting, for me I skip
breakfast and have a late lunch. Works
really well. The recommendations in here
exercise
before the late lunch because exercising
in a fasted state increases autophagy,
increases stress on the cells. The ones
who can't hack it get out of dodge, and
you grow new ones.
And
I'll tell you the data actually shows if
you want to be a circadian, you know,
great golden god, you probably should
have breakfast and an early lunch and
then fast. But you'll have no friends if
you do that, so it's not worth it.
That's literally how I live my life. So,
I eat my last meal at 2:00 p.m.
Yep.
Um
And you have no friends. It's perfect.
I
Literally, Dave, how did you know?
[laughter]
Uh it is It does make it hard, though.
Um how often do you go days without
eating?
I would say twice a month I'll go a
couple days without eating. And I've
experimented I I feel really good if I
go more than 48 hours. So, we'll
You feel better?
Oh, yeah. I feel great when I'm fasting
and I feel really good when I'm done.
And here's the kicker though. If I'm
going to go that amount of time and I
want to feel really good and be able to
write, you know, work on my books and do
projects, I'm not going to do working
out during a two or three-day fast, but
I'll not have dinner on Friday.
And then on Saturday morning, I'm going
to have coffee, but I'm going to put a
teaspoon of Brain Octane in there, which
is a very small amount. Different people
have all sorts of different debates
about, you know, how much of what makes
it a fast cuz the mice only had water.
I'm just going to say like Brain Octane
specifically doesn't get stored as fat
and doesn't get metabolized by the
liver. It goes around those things
directly into energy and you're doing a
teaspoon of it. I get the same results
from that as I do with I just drink
black coffee, but my hunger levels are
like way, way lower. So, I I just feel
nothing. I do that
Does Brain Octane have uh calories?
It does have calories. Yeah, but
different calories do different things,
right?
So, this is a calorie that doesn't uh
require anything from the liver and it
doesn't require uh any insulin. In fact,
it'll have no effect on your insulin
whatsoever and uh it doesn't require any
protease or any of the protein digestion
things. So, it pretty much goes in and
gets used as energy. In Superhuman, I
call it one of the energy fats, where
most fats get stored as fat or have to
get broken down by the liver to become
energy. They become energy building
blocks. This stuff doesn't do that.
Yeah, with fast, it's interesting. So,
the very first time I fasted, I did a
three-day fast and I had a brutal
headache the second night and
I woke up in the middle of the night, my
head is pounding and I'm like, I don't
know if Advil has calories or not, so I
refused to take it. Um
You know what would have worked?
Activated charcoal. Like I
I've never tried that.
Oh, it's one of the In fact, it's the
first supplement that that I made for
Bulletproof. And it it's an ultra-fine
one.
It helps with headaches?
It can help with headaches if they're
induced by toxins. And what happened is
your gut bacteria were getting really
pissed off. They were making extra
lipopolysaccharides,
and you might have been dehydrated. You
might have needed magnesium and sodium
and potassium. But, what's most likely
is you were pumping out tons of
lipopolysaccharides that are making you
feel bad. So, anyone who's fasting, I
highly recommend take activated charcoal
cuz your body's going to be dumping
toxins. You might as well absorb them in
the gut and poop them out instead of
putting them into your liver and letting
your body recirculate them when the
liver doesn't have glucose available for
oxidative destruction of toxins. One of
the reasons you get a sugar craving, if
you eat a food that has toxins in it or
even moldy coffee, you get that sugar
craving cuz your liver's like, "God,
this is a stressor. I need energy right
now." It's going to call on you to get
that energy. So, when you're fasting,
absorbing toxins transformative, there
are zero calories, at least digestible
calories in charcoal.
Right.
Interesting. Yeah, I've never tried
charcoal. Okay, so now the cold thing.
So, what's your protocol for cold? How
long and how cold?
I have a cryotherapy machine at home. We
put them in Bulletproof Labs. So, 3
minutes of air that's chilled to 270°
below zero.
That's cold.
Now,
What artificial?
air. Okay, this is different than a cold
shower. Cold shower's like,
Right.
Walking outside in shorts during a
snowstorm when you're warm is not that
big of a deal, and cryotherapy is more
like that. So, I'm getting the signal
into my body. It's a very strong signal
in a very short period of time. You come
out, you have like goose pimples, but
I'm I'm not shivering. Most people don't
shiver. If they're healthy, they
shouldn't shiver.
And I I also went through a period of
ice baths. I have a digitally controlled
ice bath that'll hold the temperature
constant and circulate the water and
freeze your butt off if you want to do
that. And there's peripheral cold
sensors that are in the skin, which
cryotherapy with air does. And then
there's stuff from cold showers or ice
baths, which are the core temperature
receptors and the ones on the skin. And
it's arguable which one's better. I know
which one takes less time, and I know
you get similar results from both. So,
um a mouse research a study came out and
they show how much cold exposure and how
much time is necessary and it matches
exactly what I've seen in humans. So,
I'm going to say this one works for
humans as well just because it's the
same numbers.
Right.
What I noticed from myself and others,
you take a cold shower the first day,
after 8 seconds and by the way, the
water hits you in the forehead and the
chest. After 8 seconds,
you're like, "Dave's a jerk." And you
jump out of the shower and you're
hitting yourself in the head cuz your
head hurts, right? And then you go back
in the next day and you're going to be
20, 30 seconds before you do the same
thing. And the third day you can do a
minute and you come out going, "I still
think Dave's a jerk, but it wasn't that
bad." And the fourth day you get in
like, "This feels really good." Well,
what changed in 3 days?
Well, the mouse study showed that 3 days
of brief cold exposure changes the
levels of cardiolipin in the
mitochondrial cell membrane.
And cardiolipin?
Cardiolipin. And it's one of the things
that makes mitochondrial membranes and
all cells their membrane is what is what
essentially allows some things in,
allows some things out. In mitochondria,
the mitochondrial membrane potential is
what makes the electrons.
So, what [snorts] it's doing is it's
making the mitochondria work better and
they shift the amount of this compound
that's in the membrane to allow them to
be better at making electricity. And
that's why after 3 days, oh, I can make
enough electricity to handle the cold.
Whereas before, I couldn't do it. And
that's why that 3-day period of swearing
at at you for listening to this show is
worth it because on the fourth day, I
feel good. But then you burn way more
calories throughout the day, you feel
better. So, 2 minutes
making the mitochondria more
thermogenic?
Like what's why
question.
Why would the response to cold be that?
The only thing I can think is, all
right, my understanding of the
difference between traditional adipose
tissue and brown fat is that you have
more dense mitochondria, which are able
to generate more energy, which thusly
creates more heat and therefore you're
able to keep yourself more warm. So,
that was sort of always I thought more
mitochondria being formed. I didn't
realize there was actually something
happening to that mitochondria itself.
You will see a shift over time to have
more brown fat and less white fat. As
the demands on the body to instantly
turn on lots of heat goes up, the body
says, "Okay, let me shape myself to an
environment where I'm required to turn
on lots of heat quickly." So, this is
just a a shift to match the environment
that that your body thinks it's in,
which is one where cold could happen at
any time.
Right.
So, the brown fat that mostly is along
your upper spine, that will that will
get stronger and bigger and it has more
mitochondria. But, the rest of the
mitochondria throughout your body will
also shift their levels of cardiolipin.
So, what you're getting is more
mitochondria in the form of more brown
fat and you're getting better
mitochondria everywhere else. And the
mitochondria that cannot make enough
heat will get replaced. And that's I
think the big win and the amount of time
that it takes to do that, I don't know
the amount of time that it takes to grow
a single new mitochondria. It's probably
different for different cells based on
nutritional availability.
Right.
But, it's an interesting question.
Yeah, I used to get just Dave
ferociously cold. Like, I was cold all
the time. I was like bundled up. I had I
lost a ton of weight. So, I lost 60 lb.
But, I did it really stupidly and I did
it through essentially rabbit
starvation. I wasn't eating any fat, no
carbs. 85, maybe a little more,
percentage of my calories came from
protein. I was basically eating boiled
chicken breast and steamed broccoli all
day, every day.
It's a crappy life, isn't it?
Oh my god, it was horrible, horrible.
And finally, my wife and my business
partners pulled me aside and said,
"Dude, you no longer have a
personality."
Yeah.
Like, it
it just sucked. But, I got super lean.
But, I
almost certainly did some sort of
cellular or metabolic damage and for
years after that, I was so [ __ ] cold
all the time. Yeah. Now, that didn't
change until I started taking cold
showers. And now I find that like
I'm just not that cold very often
anymore.
Interesting.
So, I have definitely developed a
resilience to cold.
Did you ever have your thyroid levels
checked?
I did not that I paid attention to. How
about that?
happened is that something happened that
lowered your thyroid function, which is
part of the reason you got fat. Cuz your
thyroid is the thermostat for all your
cells. The mitochondria listen to
thyroid hormone to figure out what to
do. And this is why in Superhuman I talk
about the vegan trap.
Tell me more. This was one of the more
interesting parts of the book.
And so I was a raw vegan for a while. I
was cold when I was raw vegan, too, come
to think of it.
That's interesting.
But and I got a lot of other health
issues I hadn't had before even though I
did lose some weight on that. But what
happens is you say, all right, based on
an assumption, and the assumption is
it's going to make me healthy or it's
going to be better for the planet, both
of which are wrong, by the way.
So,
I I did this and
what happens for the first 6 weeks is
the type of fat in your cell membranes
changes. And it changes to match
vegetables. Newsflash, we're not
vegetables. So, as that happens, your
body says, oh, my ability to make energy
just went down. I will compensate by
turning up my thyroid hormone. But then
at a certain point, your thyroid is
turned all the way up and then nothing
nothing's happening. You're still not
making enough energy and then you can
get thyroid problems including
Hashimoto's, which is a common problem
of doing that.
And not to mention you're eating
excessive carbs just by definition cuz
that's what plants make mostly.
And
the vegan trap there is this idea that
you feel great for 6 weeks. The period
of time that it takes to make a new
habit is 40 days or maybe it's 6 weeks,
which is 42 days. And after that period
of time, like, look, I felt better on
the vegan diet. And you did. You cranked
up your thyroid hormone. So, now you
feel good and
that can't be why I'm not feeling good.
That can't be why I'm getting cold. But,
that's the vegan trap is that you you
were convinced it made you feel good
because it did. So, it can't be that and
you start looking at all these other
things. Well, it's maybe it's cuz I'm
not vegan enough. Like, I'm going to cut
out salt. Right? And like you just keep
doing these things trying to figure out
why didn't I recapture that initial
glow? And it's because various
biological systems are turning off. So,
for cleansing or whatever, yeah, be
vegan for a little while. It's great.
The rest of the time you should be
pretty much 80 90% vegan with some of
the types of fat that you're made out
of, which are saturated fats. You don't
get the right ones from plants alone.
And the amount of building block protein
that your body needs.
Things like collagen protein are
essential. You do not need the amount of
animal protein that most people eat. And
you should never eat industrially raised
animal proteins. It's bad for them and
it's bad for the soil, it's bad for the
earth and it's bad for your soul,
depending on whatever soul uh belief
systems you have. Like, nobody wins uh
when you crowd animals.
So, I will eat the vegan meal every time
or I'll fast before I'll eat the the
industrially raised feedlot animals.
This is not okay.
However, um I have a small farm. I raise
sheep and pigs and I eat them and
they're delicious. And I don't eat a lot
of them cuz you don't need a lot of
them. And the total deaths per
calorie on the Bulletproof Diet, which
is primarily vegetables, which don't
kill anything. Grains actually do kill a
lot of things through habitat
destruction and just mechanized uh
cutting down of crops.
Uh so, we have big problems there where
a tractor comes through and kills the
turtles, the bunnies, the ladybugs, the
butterflies and destroys lots of crops
for you to get low yield calories from
these things.
So, what you probably need is
uh 4 oz and maybe 6 oz um of meat a day
and not more than that. And the
guidelines in Super Human, that's for
normal people. If you're a weightlifter
um or you're over age 60, it's probably
0.6
g per pound of body weight, which is way
less than bodybuilders so it's 1 or 2 g.
So, you can really want to pound your
protein. And what the studies are
showing is whether it's animal or plant
protein, you don't want to overdo
protein like you did with the rabbit
thing there. If you eat more than 20% of
your calories from protein, it is going
to cause a four times higher increase in
all cause mortality.
Is that protein no matter the source? Uh
I know like sure if it's fried and stuff
like that
Oh no, there's there's the the cooking
of the protein really matters. But it it
actually matters based on amino acid
ratios.
Okay, so are you saying 20% whether it's
plant or animal?
Animal protein is worse with the 20%,
but if you eat 20% plant protein, you're
still not going to get the benefits and
you're going to start having problems
from it.
So, there are essential amino acids.
Amino acids they're the building blocks
of proteins. So, you can kind of look at
those they're letters in the alphabet.
And then you string them together and
you get peptides which are protein
fragments and you so each each peptide
is a word. And when you put the words
together into a sentence, that's a
protein.
Right? And so, if you look at the
composition of letters that are in what
you eat, there's ones that are required
for us to live called cysteine and
methionine and tryptophan.
Mhm.
So, you must have them or over time
you'll starve.
Slight problem. If you have too much of
them, they lead to systemic
inflammation. Systemic inflammation is a
sign of mitochondrial dysfunction, which
means they're making you older. So, your
risks for cancer and cardiovascular
disease do go up if you over consume
animal protein. So then the logical say,
"Well, don't eat any of it then." Except
for the fact that you need those.
They're essential and they're building
blocks. The good news is that almost no
one is going to be protein deficient if
they were to go vegan. It's not about
protein. You might miss a few of your
conditionally essential ones, but you
would miss out on things like collagen
proteins including di and tripeptides
that really help you to and
the cartilage in your joints and keep
your skin working. And the types of fats
that come in animals are very important.
So, what you end up finding is all of us
should be eating way less animals, but
that doesn't mean we should eat zero
animals. All of us should be eating way
more dairy fat, but not more dairy
protein cuz that protein is is not the
ideal protein for us. You can have some
of it, but you don't need too much of
it. And you end up in this thing where
we've made these artificial divides of
that's a
plant-based protein, therefore it's good
for you.
Or we could just say, "Guys, different
proteins do different things, and you
should choose the right proteins whether
they come from a a test tube, whether
they come from an animal. Look at what
the protein is. The source is less
important." And then you look at the
source and you say, "Okay, which of
these sources builds our soil and makes
for a healthy world where there is
diversity
and
I I just ha- having run uh an organic
farm that looks at permaculture,
I can tell you I can't eat grass, but I
can eat the thing that ate the grass,
and its poop sure is good for the
garden. Right? So, we have this this
ecosystem where we all get along. And
this is how it worked before there were
humans. We had
100 million buffalo running around in
the US keeping our soil healthy as part
of that's their job was to go out and
fertilize things. And it's it's very
interesting to watch how we we've taken
on these belief systems
um that you know, nothing can ever die,
not paying attention to the fact that
when the tractor came through and cut
the bread for your sandwich, that you
killed many many creatures. And back
when we had a healthy ecosystem, you
could walk around behind the tractor
with a bag and pick up hundreds of frogs
and snakes. You could have frog legs for
dinner every time they cut the grain.
Well, now all the frogs are dead and
there's no more snakes because we have
monoculture everywhere. But hey, at
least we're not killing anything.
How do you really feel, Dave?
[laughter]
Let me ask you, what do you think about
the carnivore diet?
I did something similar to that when I
was testing out like the edges of the
Bulletproof recommendations, I did
one serving of vegetables a day for 3
months, right? So, it wasn't pure
carnivore because, you know, I did eat a
little bit of broccoli every day.
Shame on you.
It jacked me up.
Really?
Oh, my god.
though, or did you just like hammer
over?
Well, I was already,
you know, doing keto and cyclical and
Bulletproof stuff.
uh meat, or keto plant-based?
Oh, keto with meat.
Okay. Yeah, you're one of the few people
I've heard like really throw out some
heavy warnings about protein. So, keep
going.
Got it.
When you say that it jacked you up,
yeah.
Uh I was tracking my sleep. I've tracked
my sleep for almost 15 years.
Yeah, 6 hours and 17 minutes or
something. I'm so [ __ ] close to the
truth. What is it?
6 hours and 10 minutes, but you're
close.
See? Come on. 7 minutes off?
All right, I'm going to give you full
credit on that one. That That's pretty
amazing.
Um
Yeah, and this is like for many years
now that much sleep, and I'm I my
percentage of deep and REM keeps going
up. But during that time, I felt really
good for the first week or two, and
after that, my sleep I was waking up 10
to 12 times a night without knowing it.
I'd wake up in the morning, I'd look at
my results, and I'm like, this is the
worst sleep ever. What's going on? And I
had like like a kind of a constant
headache, and I I got angry, and I was
my joints hurt, and it it was not
working. And I was
really convinced, okay, we we don't need
any carbs. By the way, that's wrong. You
do need carbs. And I think what it did
is it Tell me more.
Why do you say that? Because as of this
moment, I don't believe that to be true.
So, tell me how I'm wrong.
Um because the gut bacteria that eat
carbs benefit from soluble fiber. So, if
you're not getting soluble fiber,
there's a little chapter in here on
that. You can still be keto and have
soluble fiber, but you got to have
something to feed certain species of gut
bacteria so they can do stuff. Now,
if you go back, a Bulletproof Diet was
the first book in the entire genre that
talked about how collagen can be
um used in the gut to make butyric acid.
So, maybe my problem was I was eating
too many ribeyes and I wasn't eating
enough collagen when I was doing my my
diet there. I've interviewed Steve
O'Mahony Andrew.
This is a guy who is a leader in
artificial intelligence creating a
global brain who came down with um
cancer in his blood.
And he'd been fighting it for a long
time with and it was he was slowly going
down. Went carnivore cured him.
Woah.
Completely fixed. And so he came on and
talked about that. There's pictures of
his freezer and things. It's all just
meat. So, I'm a huge fan. Just like I
would say, go vegan for a month, go
carnivore for a month. Reset your gut
bacteria.
I actually have questions about the
sustainability
of eating only grass-fed meat. And I
know if we took most of our golf courses
and turned them into grass-fed meat
production facilities, i.e. farms, we
could handle a lot more than we do, but
we're just eating too much meat as a
species. So, as a a brief intervention
to cure yourself,
I I'm in huge support of it, but you
better do nose-to-tail. And
being the guy who has learned how to
take our lambs down, you know, how to
how to take them down as in I've been
like I've learned how to at a butcher
shop how to do it, there's a lot of
stuff in there that you're supposed to
be eating that you don't. And the idea
here is you need to get the skin, you
need to get the organs and things like
that if you're going to go carnivore.
So, there's there's a case for it. There
are people who've done it for many years
successfully.
I think it's very expensive, very
limiting, and probably bad for the
planet, and maybe good for you, but
I'd want some more evidence.
All right, give me some rapid-fire
things that are going to help me be
superhuman.
Green tea,
black coffee,
dark chocolate, blueberries, sleeping
like a professional even if you get less
sleep.
Give me some of your sleep tips. Like is
it timing? Obviously light. You're like
[ __ ] synonymous with blue blocking.
Yeah, I I did make those kind of cool. I
I have a company called TrueDark. Just
to give you full disclosure, I founded
the thing. But, if I don't wear my
glasses before bed for at least an hour,
I do not get the 1 and 1/2 to 2 hours of
deep sleep that I expect in 6 hours. If
And this is even if the lights are dim
and it it doesn't matter. It really
matters. If I travel, it matters even
more. So, I landed last night. I got to
my hotel around midnight.
Mhm.
And I got my hour and 40 minutes of deep
sleep last night in a hotel after
landing and coming in. That I could
never do that ever. That's amazing.
That's the glasses. But, for dreaming,
it's been a real problem. Getting enough
REM sleep for me for years has been an
issue. And there's a company called Life
Cycle that makes an Australian lion's
mane mushroom extract. I had the guys on
the show. They went really deep on the
science. And I've lion's mane is
well-known for its cognitive enhancing
properties. Um this stuff for sleep
though
uh is something that that that has
worked for me. And I can tell you if I
don't I do a lot. I do five droppers of
it. If I do that, I get my hour and a
half of REM. And if I don't, I'm going
to get 30 minutes.
The other things that work aside from
dark, you know, that lowering the
temperature of the room
for people wake up late like 3:00 or
4:00 in the morning and can't go back to
sleep racing thoughts, that's a cortisol
and a fueling issue. Before bed, you
need either raw honey or collagen or MCT
oil/brain octane or maybe all three. And
there's different pathways. Raw honey,
not in hot water cuz it's not raw
anymore, raises liver glycogen but not
uh muscle glycogen. And we're talking a
small amount. It stabilizes it so you
don't get a blood sugar crash. Brain
octane provides ketones which are the
backup energy supply for the brain to
pump itself out at night. And for some
people the amino acid glycine that's
present in collagen can be calming and
help them sleep through the night. I do
those. I take the sleep mode supplement
I formulated.
[snorts]
Blackout curtains are a necessity at
this point. Raising the head of your bed
by 6 in.
There's really good evidence that that's
going to change blood flow dynamics and
cerebral spinal fluid dynamics in the
brain and make it easier for your brain
to drain stuff out.
That's interesting.
So, literally put a couple bricks under
the head of your bed. It's pretty easy
to do that and it's a one-time hack that
can have ongoing benefits.
Hm.
What about red and amber light?
Amber light is good. Amber light, in
fact, true light, one of the parts of
TrueDark, we make a light that uses
amber for like blood vessel formation in
the skin along with collagen
regeneration. And so, there's usefulness
for that. During the day, you usually
see me wearing uh yellow glasses that
block some blue light, but not all cuz
you need blue light during the day. So,
amber light as a therapeutic wavelength
on the skin works on blood vessels
mostly and on fine wrinkles.
Red light and infrared light also work
on fine wrinkles, on collagen
regeneration, on tissue regeneration.
And if you're looking to use an amber
light at night, it turns out blue
blocking isn't enough to make you go to
sleep. There's four kinds of light that
mess with your sleep and blue blockers
only get one of the four. So, your
melatonin will go up, but the other
three are still there. So, you need to
block all four, that's why the sleep
glasses are different than blue
blocking.
So, you see a lot of people walking
around blue blockers during the day.
They got no daytime signal at all, so
that's a bad thing.
[snorts]
But, if you're walking around under
bright LEDs and staring at your screen
on full power all day, you're getting an
overwhelm of daylight signal. So, it's
about getting it getting it right, but
for me it's that hour before bed where
you just have to nail it.
Hm.
Uh
and for looking younger, red light
therapy is profound for the skin.
And what can What do you use for red
light therapy? Is there a device?
Yeah, there's a variety of devices. So,
you go to Upgrade Labs, we have, you
know, the the many tens of thousands of
dollar whole body thing you kind of
roast on it with systemic effects
including you can actually see your
nitric oxide levels go up on a on a
spit strip after you're exposed to red
light. It has biological effects. And
then it's kind of the mid-range of cost
and performance. There's a company
called Joovv. And they have a very very
powerful LEDs in an array. And then at
the most affordable end of things is the
TrueLight stuff from the company I have
that makes the glasses. They're more
affordable. They have yellow
they have the red and they have the
infrared, but they're not as powerful of
LEDs. So I would say you got to look at
your
your price point, where you want to go,
what you want to do. But it's an LED
therapy kind of thing. And you know,
Joovv makes a little box you can take
with you and there's panels you can
string together.
The bottom line is if you're feeling
weird in your stomach and you you have
nausea or you have a headache and you
put red light on your stomach or on your
head, it's shocking what happens.
There's studies of putting red light in
conjunction with ketosis. And they
looked at somewhere in Minnesota they
looked at
say a dozen people. They put them on a
strict keto diet. They put them on red
light therapy with a strict keto diet
and a standard diet and red light
therapy with a standard diet. And the
men who were on keto plus red light
therapy had a doubling of testosterone
production.
But keto alone and red light alone both
bumped it up, but nowhere near as much.
So there's synergistic effects between
keto and red light, which is really
cool.
a timing of that? Like when do you want
your red light in the morning and the
night?
Um generally you just think of sunset
and sun
Okay.
So you would do it when you wake up, do
before bed. And during the day if you if
you have time, you know, and you're
looking at skin repair or something, you
can do it anytime during the day, but
the two peak periods are before bed and
uh upon waking.
Nice.
All right, man. There is a lot more in
this book. You are a very easy man to
find online, but where's your ideal for
people to connect with you? Where's your
ideal for people to snatch up the book?
Go to daveasprey.com
and this is my author URL. You can
clearly go to bulletproof.com, pick up
all the cool Bulletproof stuff. Um, I've
put most of my blog posts and all the
podcast transcripts and all that kind of
stuff on daveasprey.com. So, go there
and if you send me your receipt from
picking up Superhuman, um, there's eight
interviews with like the leading gods of
anti-aging that are just for people who
picked up the books. So, I'm really
serious about this, building a community
around people that do the stuff that has
been a nonprofit activity for me for 20
years that's now becoming my my primary
focus.
Nice, man.
What's one change that you would have
people make that would take them the
farthest towards becoming superhuman?
This is going to sound really, really
lame. It's probably sleep today.
Doesn't sound lame to me at all.
I I like to tell you you should meditate
or you should, you know, make sure that
you're not eating toxins. That It all is
synergistic, but seriously, if you just
learn to get better sleep in whatever
time you have to sleep, it is the most
leverage return on investment and it's
probably also the cheapest thing you can
do.
So, that and maybe learning some
breathing exercises is pretty good deal.
Nice. I like it. It's good advice. Guys,
this is somebody who literally puts out
good advice for a living. If you're not
already following him on one of the many
platforms that he's active on, you
definitely want to. Check out the book.
It really is interesting and offers a
whole host of things you can be doing to
better your life. And speaking of
bettering your life, if you haven't
already, be sure to subscribe and until
next time, my friends, be legendary.
Take care.
[applause]
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