They Built a Movement Around Not Dying. Both Now Have Incurable Diseases.

If we are to be don't die, we both have to cure our incurable diseases. So either they get us or we get them. >> Anti-aging entrepreneur Brian Johnson revealed a recent diagnosis of autoimmune gastritis. Kate Tolo is the most measured female in history. >> One of the sharpest content minds Kate pitched Brian what if the science experiment was done in public. >> So we're spending $2.6 million on my protocol. I was like oh yeah I think I have suspected endometriosis. Brian hears about it and I was diagnosed in something like 42 days. Women typically take 6 and 1/2 years to get a diagnosis. >> I think it's possible that we have a cure within like 6 months. This has never been done before. We've done all of this in 4 weeks time. >> There's a perception that this is about you wanting to live forever. >> I can't understand what living forever means. I simply want to say yes to existence. And what I really concluded is that Super nice to be here, you guys. Thank you for inviting me into your beautiful home, into the sanctum. Uh, I'm excited to talk to both of you together. Uh, and my first question really is for Kate. Like, I just want to know like what is it actually like to be in a relationship with this lunatic? >> Yeah. >> To look over and you're just smiling. >> Yeah. Just, you know, have at it. >> Yeah. Um, it's a lot. It's definitely different. Um, Brian is a unique, special human being and I've known that since day one, since the first moment I looked into his eyes and honestly, I feel like it's out of my control. I don't think I am in charge of whether or not I love Brian. My body just does. >> And so, >> what what is your kind of like relationship history prior to this? like in terms of like other guys that you dated and and the kind of delta between that and the experience of like living with Brian. >> Yeah, I mean I think Brian's just one of a kind. So I would categorize myself generally like both in relationships but also lifestyle, how I think about the world as a fairly normal average bell curve person prior to meeting Brian. And so even in just the way I live life now, it's entirely different. Initially you were you came in like as an employee, right? Like you were working here for quite a while, right, before the relationship uh blossomed. What attracted you to want to be in his employee to begin with? Like what was it inside of you that like wanted to be part of this whole thing? >> It was his neuroch company that I fell in love with so deeply. I was 21. I just moved to New York. I had grown up in a small town with immigrant parents. So, I didn't have a ton of exposure to like what is an engineer and you know what's a consultant? Like that those words just didn't mean anything to me. I got to New York. I was working in fashion because I learned how to sew when I was 8 years old and I started to see the world for the big space that it is and learned about AI. This is back in 2016 and I thought that is the next thing happening and I surveyed the world trying to find somebody who's actually working on solving the issue of the crisis that AI might bring. And I really felt like the only path forward would be to merge humanity and and AI in some capacity to be able to speak the same language. And so I was looking into brain computer tech companies brain interfaces. These are you know can you translate the human experience into a computer's experience through some sort of interface. And 2016 December I was sitting in a cafe in Brooklyn and I got an email from Singularity University and I had a quote from a man named Brian Johnson and the quote resonated deeply with me as a person who's working on this whose vision align with mine. So I started reaching out to him and it took a number of years and I was just every year paying him on these various platforms saying I would love to come work your neuroch company. But of course going from fashion to tech is a really hard transition to make and so yeah it took a while and then eventually he responded I think by chance by accident and then we started working together and it took us about a year and a half of when we started this project for science and for health before it actually took off. Mhm. >> And then I transitioned full-time to that with Brian. >> How do you feel about how this AI experiment is going so far in the years between 2016 and what we're seeing currently? Uh and this premise that the future is some merging of humanity with this, you know, superpowered technology. >> Yeah, I definitely was naive and I've been humbled by like what's happened across the last six, seven years. Um, I still have hope that if we can quantify and understand the human experience enough that we may be able to have a world where we truly merge. And what we're building is ultimately a path where we can uh swallow artificial intelligence to use it for humanity's benefit. Like what we're really trying to have survive is our kind. So not like our biological beings necessarily, but our shared intelligence, thoughts, collective consciousness, our libraries, the internet, those spaces where we come together and it's something other than like our biological selves. It's our spiritual selves collectively. That's ultimately we're trying to hitch that onto the backs of AI because AI has the capacity to run away as a train and become its own thing and then we're you know our existence is >> right. have to like how are you reconciling like that vision that aspirational vision with the you know kind of potential for this being an existential threat you know that that will augur the the the extinction of our species >> it's like one or the other like Brian like what's interesting about like everything that you're doing and and and maybe this doesn't get enough uh attention is the fact that like the substrate that's underlying all of this really is AI like I had the privilege of of coming to one of your Jeffersonian dinners and and the provocative prompt to instill the conversation to follow is if there was a superpower AI that had your best interest at heart uh and would basically tell you everything you need to do to be as healthy as possible, would you surrender all of your decision-m over to this AI with the understanding that you could never revoke it? It would never expire. And that's that's the very provocative question obviously. I mean did I get it right? Is that essentially like the prompt? >> And so the premise is that if we can understand this and we can empower a certain technology to help us make these decisions for us because we're terrible at making these decisions, we're emotional beings etc. uh that humanity uh by proxy would be better off as a result. That remains kind of the thesis. I mean the the question itself is is really more to draw out the person's beliefs than it is to practically answer the question. And so I in this Jeffersonian dinner I I set the stages where I give two purposely provocative statements that draws people out. And in doing that they show their cards, their beliefs, their biases, their preferences and then I take that and then I flip it around and give them a mirror. And so it's a process that that I go through. What I'm really trying to do is is with AI, what's happening now is we are trying to say intelligent things about reality. And when you bring up the topic of AI, you can go down a near infinite number of paths in trying to string words together that try to make sense. >> You can talk about jobs, you can talk about meaning, you can talk about, you know, utopia, dystopia, solving cancer. But I think the purest insight is it's possible no human can say anything intelligent about AI. And I don't think we we fully internalize that that relative to AI, we may be cavemen in terms of our ability to understand what's coming. And therefore, our models of reality, our perceptions of ourselves, our goals as a species, maybe they don't translate into the bridge. I don't know. And so what I'm really trying to do is I'm trying to say as at me as Brian Johnson, can I say one intelligent thing in this moment? And what I really concluded is that I simply want to say yes to existence. That's all I can say. Outside of that, I have no idea what to say. I don't know what to think. I don't know how to feel other than like I say yes to existence under all circumstances. >> Mhm. And that's what this project is about. And so, of course, people hear us through the language of the things we do together, the experimentation and the therapies and the performance art, but that's really it is the species at a moment in time of transitioning to something different that we can just openheartedly say we want existence. >> I there's a perception that this is about you wanting to live forever, but there's a ripple in that. Like there's a difference between this notion of living forever and don't die. Like what is the how do you distinguish those two things? The the human brain is very funny if you speak about it through the frames of Buddhism and reincarnation. It doesn't necessarily a person doesn't feel concerned about that reincarnation cycle. If you talk about it through a Christian lens that you go to heaven that's soothing. If you talk about it from an Islamic lens that is soothing. If you talk about it without those safe landing spots, it drives people in crazy. You know, like I can't understand what living forever means. I don't know how to compute that. And so you're just putting them in unknown land. And then the same is true if a person's an atheist. And so the mind has certain tracks that it follows that says this is a safe thought process or this is a dangerous thought process. And then if you try to uh do another frame where you know we're speaking today on a Tuesday, tomorrow's Wednesday, all three of us are probably excited for what's coming tomorrow. And then when tomorrow comes, we're probably all excited about Thursday. So being excited about tomorrow is the same thing as living forever. You're just doing one tomorrow at a time. And so it really is just a it's how the mind processes information. And if you catch somebody off guard of living forever, but you don't give them like a really uh constrained container like it's this, it feels like this, it looks like this, and you feel safe like this. People are like, I don't know, man. That kind of sounds really scary. I don't think I want that. That's kind of that's bad. >> The impetus for this having this conversation now is is because of the the health journey that Kate has been on. Um, and so I want to hear more about um, how that has unfolded and what it is that you're trying to communicate publicly around women's health. We were chatting earlier. I shared that over the course of many years of hosting this podcast. I've I've had the good fortune of conversing with many very accomplished uh women doctors uh who all you know share this this sentiment that you know the science is lacking in terms of our understanding of of the female body like when it comes to hormonal health and the issues that are unique to women uh that kind of get lumped in with just overall health and the cannon of science that is is is basically you know all all of these studies are essentially performed on men and so there's a real gap in understanding and I think there's a lot of women who suffer as a consequence of that oversight and this is something that you've decided to address headon and do it with storytelling by sharing your own kind of personal experience with uh some of the things that you're contending with. >> Yeah. So we're spending $2.6 million on my protocol. I'm measuring 1,900 biomarkers. I'm doing around 100 days of this just to get baseline data on what happens to a female's body as she goes through the menstrual cycle. So like you can think about the female body as a waveform and we know generally there's a waveform like you know X biomarker changes in this way and this biomarker changes this way but we don't actually have enough robust data on exactly what happens through the female body. And so I'm taking on that challenge with Brian's protocol and setting that up. what we were able to do is like take his baseline pretty much one day and then start off the races in terms of optimizing. But for female health, we don't have the luxury of having this huge data set on what we can compare me to and actually understanding the female body. So like for example, something as simple as cholesterol. We know that in the first half of the cycle, it can be up to uh 19% higher the result than in the second half of the cycle. So there's one study that looked at this in women and around 6% of women actually tested high above out of range for cholesterol in the first half and then they get tested again and they're back into the normal range. And so it has these implications because nobody when they go to the doctor to get a blood drawn is being asked what where are you at in your cycle so we can compare reference ranges for cholesterol specifically. And so another study looked at around 400 metabolites in the blood. these like downstream byproducts that are happening in the body and around half of them they discovered did fluctuate through the cycle but that has not been characterized. So we that's we know it moves. We don't know how. We don't know what's normal. And it's a really hard measurement problem because to be able to do that, you need lots of women tracking their hormones daily. And then as soon as you know the LH surge happens and you transition to the second half of your cycle, you go in for blood work testing. That's an extremely logistically complicated problem to solve. And so we thought, why don't we start with my body and see if we can create the most quantified menstrual cycle ever. And so now I'm on day 29 of that process. >> And the impetus for this was an endometriosis diagnosis. >> Yeah. >> Can you talk a little bit about that? What is endomtriosis? How is it traditionally treated and how are you kind of like treating this differently or using it as a a means to better understand uh the female body? You know, actually we started this process and then as my team were asking me about my health background, I was like, "Oh, yeah. I think I have suspected endometriosis." And they were like, "Oh, okay. When did that happen?" I was like 7 years ago. Did you do anything about it? No. Like I got heard when I was like 22 from the doctor, you know, you can go get surgery to figure it out. I'm not getting surgery. I have no idea. I'm young in New York and I'm like, I'm not doing that. And so all this time goes by and my symptoms get more and more severe. But because it's a general trend and I know that surgery is the option, I'm like, I don't want to go down that process. Then Brian hears about it and he's like, I think we could solve that. And so he starts calling doctors and scientists from around the world sometimes at 4:00 a.m. when he first wakes up so that he can catch them in various time zones. And through just pure persistence like in a startup like mentality, he able to essentially organize four different ways to confirm my diagnosis and get me diagnosed in something like 42 days. So like an insane change, whereas women typically take 6 and 1/2 years to get a diagnosis. So they live with it for a very very long time. >> Interesting. >> I mean what is it and and how many women suffer from this? It's around 1 in 10 confirmed um women suffering from it, but the suspicion is that it's much much more cuz it's such a general disease that affects so many people and lots of women just never get a get a diagnosis. >> And what it is is in the um uterine lining, you have cells that grow outside of the lining and then that creates problems because they act as if they're still in the uterus. And so they cause all these issues like fusing organs together, scarring, having nerve um firing. So that they're very very painful. Um and so like for example, one of the the symptoms that's very obvious for endo that I experience is pain while defecating on my period. You know, somewhere in my bowel system, there's endo lesions that are firing while I'm on my period and just causing excruciating pain. >> And so this is something that that develops over a long period of time. Hence six and a half years before a proper diagnosis. >> No. The reason it's that long is because surgery is the traditional way of diagnosing it. >> I see. >> And it's expensive to get surgery. It's very invasive. And so women just put up with it. >> Mhm. >> Or they go to the doctor saying, "Hey, I have painful periods." And the doctor will be like, "That's normal." And then they're sent home. But there's a real missing education around what is endo. What can you do about it? What we were able to do, we got a transvaginal ultrasound that came back negative. Then we went and got an endospecific protocol cuz it turns out you really need someone who's trained to do these ultrasounds for endo specifically and that then it came back positive. Same thing with my MRI. Firstly, came back negative. We went and did an endo protocol for MRI. It came back positive. I got a blood test done and I also got a saliva test done. So with four different modalities, we were able to like kind of triangulate this and get a confirmed diagnosis. And at the same time, I also got diagnosed with two other issues at the same time that I had no idea that I had PM PMOS, formerly known as PCOS and then a condition called adonioma. So my uterus is essentially swollen and it shouldn't be. >> So 10% of women are suffering from this. It goes undiagnosed, misdiagnosed or diagnosed late >> and traditionally the treatment is surgery and that's it. Right. And so the exploration that you're on is are there better ways of detecting this and are there alternative treatments that could be effective short of like having to cut you open? >> Exactly. Is that and and where are we at with that? >> Oh man, it's so sad. So much of it is just like pushing things forward like it's like it's laying there. So, we're actually right now working on getting this blood blood test available so that women in the US can go and get this blood test drawn at home and that'll give them sign signal on if they've got it or not without having to go and get an expensive MRI or >> and that's a reliable test so you don't have to do all of the the mult multiplicity of tests that you had to do to really confirm this diagnosis. >> That's right. Yeah. Yep. Yeah. >> And why is that not already widely available? um a combination of sexism, uh people not knowing about this disease, the fact that it is um there's many different ways that this disease can present itself. Um yeah, it's just an infrastructure issue, just not enough attention on this so far. >> And is this initiative something that's being celebrated by the broader medical community? Are you getting push back and criticism? Like what is the feedback been like? >> Very positive. Yeah. >> Yeah. Are there women doctors who are like, "Finally, like I'm glad somebody's doing this because a lot of the criticism that you get, Brian, is like,"Well, if you have all this money, you're spending all this money on yourself, like why don't you put it into trials, you know, like gold standard science? You could be you could be approaching this totally differently that would benefit humanity and also, you know, kind of serve the purpose that you know, this this mission that you're on. These end of one of experiments, like how valid are they really?" Uh so it's easy to like you know for like a traditional scientist medical approach to like have a a battery of criticisms around like what you guys are doing but this seems like it's something that you've is not you're not getting that kind of >> no like a sigh of relief like finally and especially like Brian as a male in power dedicating his brand his platform to this cause like just women around the world and especially like in academic settings are just like finally somebody's going to put the spotlight on this. So, yeah, it's really a testament like Brian truly um I have a hard time accepting love and being seen and being taken care of and um but that entire first process like Brian was just like all in reading books on female health, educating himself. So, yeah, I was really lucky. >> You're feeling seen. >> Yeah. I mean, and it's complicated as a result. It's really complicated. >> Let's talk about that. Yeah. Why do you feel that way, Kate? >> What do you think after having been with me for 5 years? >> Uh, yeah. I So, Kate, we've been trying to get to the bottom of this >> actually. And that the hypothesis we had is that Kate is not legible to herself. >> What does that mean? >> She she can't understand herself. She struggles to understand herself. And I think and we also were trying to explore this hypothesis that women are not broadly legible to society. And so when you read the history of female health, the the same words the Greeks use. So they were trying to understand planetary alignment. And so they were, you know, they they were trying to figure out planets and they would like draw these circles like they spin in circles to make sense of the of um the orbits. They couldn't make sense. because their assumption was they thought Earth was stationary and the planets are circ. >> First of all, like I like I ask a question about like Kate's psychology and you're talking about like planets and >> Yeah. >> And so in the same way they they refer to a the womb as the same kind of chaotic structure. So they're like the planets are chaotic and the female womb is chaotic. And so there's a deep history of seeing females as chaotic, as like systems that that can't be understood. And that's it's not like a a centrial thing. It's recent. And so there's a bunch of carryover where women have never been as legible to the world as men because they're more complicated in the same way as planetary, you know, planets were at some point in time. But the the women thing's never fully resolved. And so that's what we've been working on is is in part what Kate is doing by this quantification is by showing how her microbiome changes throughout her cycle and her eyesight and pain tolerance and metabolism and breast size and and and and and you basically see like there's a system that moves just not in ways that have been intelligible or legible. >> Mhm. But but really it's a system that you know that produces life like that like produces these cycles. And so in many ways we've been trying to like figure out how to explain this to the world. It's not just about biomarkers. Kate is not trying to be the healthiest person in the world. She's not trying to biohack herself. It's a legibility project. And to me like really at the heart of like what does it mean to be female and what does it mean to be a male understanding a female. This episode is brought to you by Element right here in black cherry salt. 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I want all my listeners to enjoy a deep, restful night's sleep with a new mattress from Birch. Go to birchliving.com/richroll for 27% off sitewide. That's birchliving.com/richroll and get 27% off sitewide. Well, legibility is is an interesting word choice. I mean, it's really uh marginality like the you know the long history of women being marginalized and men being confused by women and being dismissive of them and just saying well they're complicated or like she's being hysterical and you know that that's the real context here of like like talk about you know an idea that we've incepted. It's like oh this this less than perspective of women and what they're capable of etc. that has you know been a real violence in terms of like you know existence and you know kind of the shared consciousness etc like in an expansive way like >> it's really you know an awful legacy uh how how we have treated women perceived them uh made assumptions about them and that's reflected in the canon of science in terms of how we understand them and this is sort of an antidote to that um legibility is a digestible word uh that that sort of sidesteps like you know like just this this really awful history in terms of how we've conceptualized women and their >> their role and their their strength and their power and the like in society. And so this is like a a small example of just let's celebrate these women. Let's let's let's improve that. Let's change that understanding. >> Yeah. >> Yeah. Like one simple thing with her endometriosis is that like I've been working on my language to communicate to men what is endometriosis. So, how is it the case that you have this? >> This is a whole black box to us. Like, I don't know. Like, >> exactly. >> My daughter had an issue and I was like, I don't know. This is like a girl problem, you know, like it's a black like it's a mystery, you know, we don't talk we don't talk about it. It's between the women, you know, like this is this is not functional. Right. >> Exactly. So, if if you're hanging out, you're my friend, you're like, "Oh, Brian, I've never heard of endometriosis. What is it?" I'm like, "Okay, Rich, it's like one in 10 women." So, like it's a major disease, right? So, what here's what it is. It's like an alien is inside of you fusing your guts together and then it feels like you get kicked in the balls. That's what that's what endometriosis is. Now, if a man is experiencing that, they're like, "Man, this sucks. We got to solve this." So, it's like this >> women compl it's like, "Oh, you're being you're you know, like you know, you're being emotional or like you know, like just it'll go away or like Yeah. The dismissiveness of that, right?" >> Exactly. Yeah. Yeah. At at the same time, I've been super humbled. I was hoping this was just an issue of historical sexism making its way into the medical world. And of course, it is, but I've been really humbled through this experience of like I'm a systems person. We built a business together. I'm extremely like, you know, if I want to solve a problem, I'll go and solve it. It is so hard to measure myself. It it like just being able to separate the noise in measurement on just one person doing the same thing every day versus the signal of my body's actually changing. That's one thing. And you stack up, okay, you want to do that for hormones so you can correlate it with where you're at in the cycle. Most most people think women ovulate on day 14, halfway through a 28 day cycle. Most women actually don't have a 28 day cycle. Most women actually ovulate on day 17, but it's incredibly variable. like I think I ovulated this year this uh cycle on like day 23 or something like that >> and so there's like tons of myths around this but what it means is that it's very variable so how to kind of lock down in our existing paradigm of how we consider measurement that process is incredibly difficult and if I was to try and measure 100 women at once I'm not sure how I would go about it robustly to the standards by which science has currently set up our system of what we consider justice in terms of good science, you know. So I think we need a paradigm shift entirely and that's actually why weirdly the N of one may be the perfect entry point that actually we may discover population level science on women through many many N of one experiments at home and then with that you're able to kind of detach the signal from the noise >> right and at some point um concoct the best clinical trial that you could run at scale. >> Yes. And it might look entirely different than what it does for men right now. >> Yeah. But in the immediate kind of daytoday of like dealing with this condition and trying to understand it, what else have you discovered that you think would be helpful to a woman who's watching or listening to this who is struggling with that right now? >> Yeah, we so we have a master plan to cure endometriosis. >> Okay. >> So, right off right up our alley. So like f first >> the the the the hubris sitting right alongside the uh humility. >> Yeah. Exactly. So like f first I'm going to give to the haters. >> So you know Kate and I do this documentary on Netflix. We are brighteyed bushy tails. We're like we're going to you know take on death >> and then within a year we both have a diagnosis of an incurable disease. >> It's so delicious. >> It's so delicious. So there you go haters. Like >> autoimmune disease for you, endometriosis. Yeah. uh you know karma is alive and real. >> Exactly. So like there you go. It's a gift. Now also the dual diagnosis has been the best thing that could have ever happened to us because like if you think about this from uh the universe's perspective, irony is always going to show up and play a role. So it's a journey now, right? Like if we are to be don't die, we both have to cure our incurable diseases. There's just no path forward. >> So either they get us or we get them. But there's just no middle ground. >> It's clarifying. >> So like, you know what? We've got we have our tasks laid out for us very clearly. So we have been hustling um both and we immediately got to work. So we have a we have probably on each of our teams like three or four international groups helping us try to solve this. We've had all these people rally around the the uh intent. So what we find is that these in any given area of course there's a rich world exploring these things but often times they don't have the publicity or reach or focal point and we happen to be that on these two diseases >> and so we've just rallied so many incredible people to work on these things and so we think we could potentially make significant headway on both within 12 months. >> What is your autoimmune disease specifically? Uh, how is it impacting you and where are you at in terms of like addressing it? >> It's I have no symptoms. It's uh basically I don't really I didn't realize I had it. So, it is my immune cells mistakenly attack my stomach. So, they basically eat my endothelial lining of my stomach. It is a autoimmune condition I had starting about 30 years ago with my thyroid. So, it's been cooking in my body for a very long time. That has nothing to do with what I've been doing for the past 5 years. And in fact, had I not been taking such good care of myself for the past 5 years, my diagnosis could be really bad. So, just to be clear, because a lot of people, they think this autoimmune condition is from that. It's not. It's from a thyroid and >> hypothyroidism. >> Yeah, hypothyroidism and the stomach are very closely linked in the immunology. So, that's that's the pairing, but it's not what I've been doing the past couple years. So, what we're doing now is we did two things. as soon went as I got um my immune system sequenced. So, we did a blood draw, we got a million of my immune cells and we looked at each one of these guys individually like who are you? What's your job and what's your you know special key and then I went under again two weeks ago. Kate was there for it. Uh so I went under general anesthesia. Uh we had a a scope down my throat and we took 24 biopsies on my stomach. And so we biopsied the actual autoimmune condition. We took those samples and then we did like an oceans 11 style operation to cool them uh at the proper speed, deeper cool them at the proper speed, then cryopreserve them, transfer them over overseas to a special lab. So we now have uh a mini Brian growing in a dish from these immune cells. >> And so we'll take these, we'll actually get results in a couple days. We'll take my biopsy and my immune system and say now we have a full picture. Who are you guys and what are you doing? And with that we can then say okay we're going to do this therapy or that therapy and we'll carve out the path >> but this has never been done before we've done all of this in four weeks time. >> And how receptive is the traditional medical community to this initiative or this ambition? >> It's purely it's a scientific endeavor. It is as purely scientific as you can get. >> Uhhuh. >> Yeah. So, it's it's like a it doesn't um it doesn't get caught up in things like, you know, should you eat meat or vegetables, you know, where people are like going to war with each other. This is just a pure biology plan. >> Got it. Uh you mentioned uh many many Brians growing in a petri dish. Uh you know, perhaps the the your greatest accomplishment in ter in terms of like attention farming is this idea that you're cloning yourself, right? like this is just headline bait and internet gold again. Uh the reality of that is of course very different. Uh so walk me through uh where you're at with that. What's going on? Basically what you're doing is you're you're establishing a culture of pur potent stem cells, right? Which are cells that can express them in any number of ways that can be replacement for cells that are diseased etc. But uh you know eventually and hopefully like rebuild organs and all kinds of you know interesting things that are happening at the very you know sharp edge of these technological advances in medicine. Is that is that accurate? >> That's right. Yep. So the way this works is I did a blood draw uh 150 milliliters. Uh you separate the out the cells and you take the cells and then you apply Yamina factors and that will reverse the age of my cells from 48 to zero epigenetically. So now they're in an embryionic state. Now what it doesn't do is my cells at age 48 has gone through a number of cell divisions and I have these somatic mutations like it has the errors in my DNA and my mitochondria. So it doesn't fix that. It takes the epigenetic age back to zero. So embryionic. So now I have these raw materials. So if I get a disease like an autoimmune condition and I need to rebuild my stomach lining, I have my own cells. I can say, can we build rebuild my stomach with my own embryionic-like cells? So now I have the raw material to do that because if you take somebody else's cells, your body might reject it. You have a high risk. And so currently in the world there's trials going on where people with Parkinson's disease are using their IPS-CS induced plural stem cells to replace the neurons that die in the Parkinson's process and also for heart failure. So it's the raw material. So the the the technology is phenomenal because everybody should have their their cells banked, >> right? you have this bank and this is available to you if and when you're going to need it at some point in your life. >> Exactly. >> And on a surface level it's like okay this is insane. This is some sort of gatka you know kind of situation. >> Uh an indulgence of a you know wealthy privileged person but it's just like anything else. I mean when Elon Musk started Tesla like his first offering was that like Lotus supercar which was very expensive but that's what you have to do to get to the model 3 that's affordable etc. So by dent of of of you kind of investing in this and trying to share understanding of it, the idea is that at some point um this will catch on. It will incept as an idea and then with scale these things become affordable and just second nature. On some level we've already been doing this. You take like when you have a baby you can get you can get the stem cells then and you can bank them etc for future. So it's not necessarily a new idea. It's just a more kind of like advanced refined version of that. >> Yeah. Yeah. We've done the same with my immune cells. So, we we did uh during this immune profile, we take my immune cells, we also bank them because you want to store your immune system as young as you possibly can, right? Because every day you age and the cells have more somatic mutations. So, I'm trying to basically take all of my body's raw material. In the IPS-C's, you take it back to zero. Uh epigenetically with the immune systems. you're taking 48-year-old Brian, but still like your immune system is your ultimate weapon to detect disease and cure disease. And so we're trying to take all these precautions of like this is the way for everybody eventually like you're saying to have a shot at if we say that we are going to be able to extend our lifespans and imagine a future where we're not decrepit, we're healthy and we're vibrant, we can res, we can rejuvenate our organs, these will be the raw materials that will help along that path. So, we're just like it's it's the next stage in our evolution. We are an example of what we're doing. Uh we're an example of that. We're rolling this out to our customers today so they they also have access and we'll just it'll get cheaper over time and more accessible. >> How accurate are these uh biological age measurements? You know, like now we're all wearing wearables, etc. Depending upon the device, you you get different analytics. These things vary wildly. Like I have one device that says I'm 44 years old. I've got another one that says I'm like one year younger than I am. Like the delta is gigantic, right? And I assume that you have a different measurement system that on some level you're going to contend is superior. But it does seem like do we really how like reliable is any of this or is this just all nonsense in the interest of like this longevity Olympics and the leaderboard of who's the youngest etc. I'll take one example. Um, eight sleep. Um, they're just about to announce this. They did a age predictor where they had a model like an AI model and they showed it data of nights of sleep and it said the question to the AI was here are two separate nights of sleep. Is it from the same person or not? That was the only task that the AI had in determining this data set. So, it just went through a bunch of iterations to find out, okay, yes, these two data sets are from the same people. These ones aren't, these ones are, these ones aren't, etc., etc. And it got checked on that ability. Through that process, essentially mapping what is the same about these data sets establishes the same person versus what's different, what changes. Maybe you have alcohol the night before one and so your breathing rate is a little bit higher. In that process, it actually ironically found all of the markers that are associated with age. So your bu how good is your heart pumping blood for example is a really good age marker. So it was able to detect within I think three and a half years of precision how accurately how old that person is just based on their sleeping patterns. And so that's an example of like scientifically backed um or a scientific process of within 3 years delta accuracy of that. And so then you apply okay take this person have them sleep in this bed. what does their body act like? And it's like, okay, it acts like a 21-year-old with, you know, a threeyear degree of margin. So, some uh of these algorithms are just like pretty much like >> wash outs, you know, they're like they just grabbed like three markers, put it together, and they say, "Yeah, yeah, this is like typical of like a 21-year-old." Others are actually like genuinely um predictive and accurate, and you can actually prove it with science. >> Mhm. Yeah. You could probably just do a ranking. So one thing I'm proud of, we gave birth to biological age. Like everyone doing biological age markers has come from our initiative of like making it as a centerpiece of conversation and bringing people in. And so you can just take a ranking. If you look at volume of the brain via MRI, that's a very good marker predicting age. Like the brain shrinks with age. There's of course some variation according to certain things, but that's going to be a more powerful predictor than your off-the-shelf wearable. And so you just look at we basically in our effort we are willing to accept hundreds of inputs into biological age. We know some are better than others. And so the one like the wearables we kind of discount a little bit because it's like it's a the measurement uh robustness is not as good. You have a lot of variability etc. So yeah I mean biological age is a real thing. We visually know that's true in our lives and then depends on the measurement modality and the data behind it. >> Sure. It depends on how uh how good these sensors are. It's like your wearable is never going to be a comp for like being in a sleep lab where you've got like things all over you or whatever and it's measuring you at a at a at a much more accurate level >> and then the algorithm making decisions about uh >> you know where all of these metrics fall in the hierarchy of what's important like and >> this percolates into you know social media discourse around this. one month it's V2 max and the next month it's you know mitochondrial health and mitochondrial density like you know it's it's all it's all about like it's it's the human mind like wanting to just just give me like this one thing and then I I have certainty around that it's more complicated it's vastly more complicated than that but for the average person who's thinking about their longevity who's living on a budget who has a busy life you talk about these principles for you know how to like live an average life and do what you can within the constraints of your busy life on a budget to you know extend your long your health span and those are >> they're simple things >> they're very simple things yeah I mean I we tell people to to not be intimidated by the complexity of the world the chaos the disagreement but just think about and understand their health through one marker their resting heart rate before bed it's an oversimplification but also that's what makes it beautiful and so when you go to before you go go to bed. Your heart rate is basically an accounting system that tells you how much food did you consume, did you drink alcohol, are you stressed, uh did you stay up late, did you have light in your eyes, you know, like it's a basically you can't cheat it. >> And so the resting heart rate is a representation of you in your entirety. And that will then determine how well you sleep. And sleep is, you know, the best longevity drug in the entire world because it determines how you feel in life. When you're poorly rested, you have poor willpower. You're generally more discouraged. When you sleep well, you feel great. You want to exercise and eat well. So, it creates that bifurcation of I do bad stuff or I do good stuff or I have the ability to do so. So, yeah, we simplify and we just say your task is to build your life to lower your heart rate before bed. Most people's current habits drive their heart rate up. So they eat late, they eat close to bed, they have a lot of light exposure, they are stressed, they'll work up until bedtime, they'll scroll on their phones. So the five rules are no food 4 hours before bed. So if your bedtime's 10, final food by 6:00. Two is screens off 30 minutes before bed. Three is a windown routine. So, in that last 30 to 60 minutes, read a book, go for a walk, talk to a friend. Literally anything other than scrolling your phone and working. Uh, light, uh, be be mindful. So, like red and amber are great. White, bright, white, and blue is bad. Uh, then, um, last caffeine by noon. And those five simple things, uh, dramatically change people's lives because they finally get into a state where they can sleep well. A book in hand before bed and that wind up routine is the best thing you can do. It's it's on par with a sleep uh, medication. So, but really just trying to you're trying to curb late night bad habits which come out when you're stressed, you're done, you just want to like do nothing. So, those are the things after 10 p.m. Brian, >> uh, you know, Brian, you you've surrendered your will over to these rules and, you know, it's removed all of the analysis paralysis and and you're relatively robot robotic in your your consistency with this. Like, Kate, where's the sticking point? Like what what is where's the struggle >> for him? >> For you? >> For me? >> Yeah. >> In what sense? >> Like which is the hardest thing for you? Yeah. >> This is like the antithesis of Kate. I was telling we I was meeting Brian somewhere the other day and I arrived at the garage with one kilometer left on my gas tank. Like I'm the most measurable female in the world doing 100 tasks a day. Like this insane morning routine. And I arrive and I'm like, "Brian, can you take me to the gas station so I can fill up like a canister, take it back to my car, fill up my car." so I can get home. So yeah. No, this whole thing is just like the antis. I'm a creative chaotic human being and structure is not my default mode. >> What's the hardest? >> It's everything. Every morning I wake up at 6:30 a.m. on the dot. I immediately spit into a tube. I turn on my my therapy light so I get light in my eyes immediately. I put on a hi HRV device and measure my HIV every morning. I log my subjective sleep score, my subjective feeling. I breathe into a mask for 10 minutes and measure my resting metabolic rate at rest. I take my blood pressure. I measure my face to check for like is the bacteria growing in my skin as I get later into my cycle. I measure my reaction time, my grip strength. I measure my brain using essentially like a portable MRI device, the neuroch company that Brian built, Colonel. I measure my vaginal microbiome, my female hormones through urine, my cortisol through urine, I measure my breast size, I do my smart scales, just goes on. >> I mean, you have to understand that hearing that it comes across like some kind of uh uh obsessivecompulsive like neurotic condition. >> 100%. That's what I'm saying. >> So, how sustainable to me? Yeah, that sound like a stained person to me. >> He's like, I love that routine. No, totally. I'm doing this because women need it. Somebody has to do it. There needs to be a Rosetta Stone for women to make to translate it into the masculine world we live in of numbers and everything's digestible through data. And so I will I will zip my mouth shut and do my task. Doesn't the constriction of it like impinge upon your happiness and your ability to enjoy your life and the ways in which >> those are very important emotions to be able to channel and experience in terms of like your overall well-being. >> Yes, I am not doing this for my happiness. >> I appreciate on that. >> I am not doing on my second week I had a panic attack. My cortisol was through the roof. Like now fortunately I'm in a routine where it's I've stabilized so I feel like I can go a little bit on autopilot in my 5hour morning routine but absolutely this is not happening. So that's why as much as I can hit home that like we would rather be in a cabin not living this life. >> What about your girlfriends? Like what do those texts look like? What do they think about all this? I mean, you know, my sister's an Olympic athlete. And so, we've grew up in a family where we like hard things. And so, everyone knows that I I wake up, I'm alive, and I'm like, what do I do? That's the most valuable thing for humanity. And that's my the way I look at things through. So, my friends and family are like, you know what? That's just Kate. Like, she's going to do her thing. One of the things I love about Rivian is the way they fill their vehicles with so much amazing high performance technology, but always make sure it feels like second nature, that it keeps that human touch. And a great example would be the haptic halo wheels on the new R2. On either side of the steering wheel, there's a dial that you could roll, push, and pull to adjust things like the AC or skipped in the next song. and they have this incredibly satisfying tactile feel because you're really clicking a button and rolling a mechanical wheel. I was recently able to drive an R2 with R.J. Scrange, the founder and CEO, and he shared the thinking behind this cool and unique feature. They have these really nice haptic wheels that are on the steering that give you this mechanical feel and it's all software. So, it's haptic feedback and what you're feeling is actually there's no detents there. It's all with software. So walk me through the thinking on that because as technology is sort of informing this screen only experience there is something in the human animal that craves that kind of tactile control. >> Yeah. And that was part of what the logic was here is we and that was from the feedback we had in R1 is the desire from some more mechanical touch points and and also the ability to not have to use the multi-touch screen for everything. Mhm. >> And so being able to do HVAC through this side, your entertainment through that side, you also have drive modes in here as well. >> There are just so many features packed into this vehicle. You can learn all about them, watch the rest of our conversation, and even book a demo drive at stories. Roll. 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I mean, I guess my favorite >> I mean, this is this was internet gold, you know, like you're live streaming this, you've got like Grimes coming on, there's special guests, you're putting on a show. It's all part part of like this bizarre romcom that you guys are living. Like this this whole thing is like it's total theater on one level while also trying to get at something meaningful at the same time. >> Yeah. I mean one I'm very proud that this was the most quantified uh psychedelic experiment ever done. We bridged psilocybin into the world of longevity. Whereas before it's been an ancient medicine, it's been more recently in clinical trials for various uh you know indications and we bridged it to longevity and I'm very proud of that. So it's now people are seeking funding for that. So that would be cool if psilocybin were understood as a longevity therapy. But then I think our our adventure spirit as a species is to look outward which makes sense. Our eyes point forward. Our brain is right behind us. So in many ways our brain is kind of hidden from our own perspective. So we see the world and we say I want to climb that mountain or I want to go to that star or I want to go to that moon or I want to go to this place. We very much think about ourselves moving forward with visual contact moving forward. And psychedelics you reverse that, right? you're actually going to things you can't see and you're exploring the inner world. And if we map the space of exploration going forward and you say what is how big is space and how how fast can you get there? What is the space internally? I think it's possible internal exploration is the new world of exploration. Even though right now Mars and the moon kind of has the zeitgeist of like how do we be adventurous as a species? What is what is cool to do? M >> and I think this is certainly you know you find these kind of thought processes in the world of psychedelics but as we get really good at drug design with with AI we don't I mean if you look at the number of possible psychedelic molecules that have the capacity to be like psilocybin or 5DMT it's very large and if you can now start designing these and and constructing experiments you may find that like that itself is the deliciousness of the future our ability to start changing the ways we process reality in ways that you like in new ways that like almost like a a GLP1 but for consciousness, right? Like these these modifications of how we process the world that just fundamentally change how we understand ourselves and how we go about. So I think that to me is very promising. >> What was your experience Kate? I mean, I think it was reflective of our roles where I can't imagine having so much faith in your own mind to be able to do that on a live stream and then not only do that but then do 5 MO DMT on a live stream, too. >> So, my experience was just like, how can I be the container for Brian in this moment such that there's a safety net here that if he wobbles that there's like some buffering around him. Um, so yeah, I was just really proud and and in awe of his ability to like navigate that so such a complex space publicly and in lifetime. >> I mean, for me, it just gave me a humility and a capaciousness like it just rewrote my understanding of reality like how we process time like you're saying tomorrow and the next day and it's like this is all an illusion, you know? Like I went in thinking I'm going to heal this childhood wound and it sort of said, "Well, that's really cute. let me just show you the way things actually are. And you know, it just >> not a day goes by that I don't think about it. Um, and it has fundamentally altered >> my convictions around like what's real. And I'm becoming increasingly convinced that that, you know, the real outer space is the nature of consciousness. I really don't think that this materialist definition of consciousness is correct. >> You know, it's called the hard problem for a reason. And the materialist definition just always falls apart. And I think that like we're all I think that there is one vast consciousness and the material world is a projection of that as much as anything else. Like it seems it seems like that that makes more sense in the wake of having that experience. Whether or not that's true is almost irrelevant to my daily experience because it's enriched me in that way and gave me a different lens on how to make decisions and and navigate, you know, the difficulties of being in a human body. >> Yeah. I feel like that's part of what you see for yourself having gone through these experiences is like that's the prize on the other side of this ginormous transformation we're going through as a species that potentially it's the tools and ability to be able to go and explore that freely like do you know what I'm saying like the 10th dimension type thinking >> what is it >> what I really enjoy about these thought experiments is um and the the one the contrast I always use which makes sense to me is contrasting myself with Homoctus a million years a million years ago. So let's just say we are going to experience a million years equivalent of evolutionary advance in the next what 10 years 15 years 20 years >> and that we have access to our root biology like we now can we can design these molecules we can discover these molecules at speeds that would defy any previous model and so if you if that's the stage then I don't think it's a reasonable basis at all to imagine that what is will be that will have the same motivations, same aspirations, same characteristics. I mean we see even now like GLP1s turn off a hunger response like a primal need of the body just gets turned off with an injection, right? That is crazy. What other primal things just get turned off and so or on or or or created? And so I guess I what I like about this is I like that you can basically ask a question with no assumptions about what would be limited is the full suite of possibilities. And so that to me is the most exciting moment of this. >> Yeah. I mean that's a fundamentally optimistic view of what's going on. And it's not that I don't share it, but I think I couch it with recognition that humans are they're overconfident in their predictive abilities. Like we kind of think we know how things are going to go. And the history of our species is that we rush forward impulsively and break things and then deal with the unforeseen ramifications in the aftermath. And I don't see any precedent for this being any different. And so in your example of like homo erectus, it's like dropping and giving them an atom bomb and saying like figure out how to use this like you know like like we're literally playing with fire and the fire is more potent in ways that we can't possibly imagine. And I think we're arrogant to think that we can control it and put these guard rails on and make it work for us. What are we like intentionally bringing in like in a way that we're we're not we're not developed enough to really truly understand like how is that experiment going to go, right? And I think anybody who says they know how it's going to go is going to be proven incorrect. >> Yeah. Well, I agree with that. This is the struggle for literally anybody on planet Earth to say anything intelligent, >> right? It's back to that premise then. And and so >> and and we're just going to do it. We're gonna do it. We're gonna barrel forward and we're gonna see what happens. Yes. And what will be will be. >> Yeah. And so the gu the only guardrail I want to have in place, which again this I'm not saying this guardrail is not going to have also negative consequences because everything always is a double double-edged sword. >> But I'm saying the guardrail I want to have in place is that we as a species prioritize existence. That we say what what we can say would might be bad is we don't want to go to war with each other. We don't want to put ourselves in that kind of situation. We don't want to kill each other. We we don't want to be making products and services that kill other humans or make them degraded in their in their ability that gives them disease. Like some basic rules of the road of like can we agree? We don't have to be kumbaya. >> Don't we already agree on that? It's just that our actions bely that sentiment. >> Yeah. I mean there there is a starting point like you know if you look over the past couple uh decades we've made good progress right marching those basic principles forward but still we are a society that says your highest status is given with abstract you know accumulation of money >> power and status that's that's the ultimate trophy we give out to people in society so I'd say that that but that trophy has side effects and consequences now it's a good engine of innovation, but it says we will give you that trophy even if you kill yourself, even if you kill others and even if you kill the planet, you still get the trophy. And so we just have some misalignment among us humans on what is worth doing and what is worth uh granting someone a trophy. >> Mhm. I'm in total agreement with the power, property, and prestige incentive structure of our society being misaligned with human flourishing. Uh while also acknowledging, yes, it's it's given us, you know, all of this bounty and it incentivizes people to work hard and innovate and and all the like. It's also given rise to, you know, tremendous economic disparity and suffering and addiction and, you know, all the like that you talk about all the time. And so another kind of like substrate underneath all of this is a questioning of these of these systems right from government to healthcare etc. Uh and back to like the Jeffersonian dinner that I attended uh you know that was populated with some interesting characters who are questioning our governmental systems. Um, in a way maybe I don't agree with uh I appreciate the curiosity to uh engage with a difference of opinion about like where we should go. Um, but I can't help but think that there is this strain of wealthy uh tech personality, these people like yourself who are very wealthy and have figured out a way to like bend the universe to their will. Uh, and then in the wake of that like enjoy, you know, the the benefits of that like surround themselves with the trappings of wealth etc. only to discover like, oh well, this isn't actually like fulfilling in a way that I thought it was. Uh, and in the in that kind of like history of being able to like make [ __ ] happen and um, and the kind of uh, hubris that can set in with that like I know better than everybody because I was successful in this regard. Uh, the the real frustration is that you can't you can't bend time like you know like time and your mortality are hanging out there. it doesn't matter how powerful or prestigious you are etc. Uh and so what are we going to do about that you know and so hence we see this movement around very wealthy people trying to expend their extend their health span etc. And with that kind of galaxy brain mentality, there's a sense of like, well, we need to change the government and it needs to be this way and we know better and like people shouldn't really have to vote. You know, they shouldn't they shouldn't have the right to vote. Like we should just what they really need is a strong leader and like maybe a technocratic society would be better. Like where are you on that? I think it would be good to like have a little bit of clarity around like where you fall and that because it's it's sympatico with this idea of like giving your like surrendering your decision-m and your will over to like a superpower AI. Similarly, in a government context, like let's just have somebody who is in charge, we're going to trust them with our well-being and society would be better. >> Does that make sense? >> It does. Yeah. >> Yeah. I've steered clear of any political engagement and any expression of opinion. I think our existence is about a singular thing. We're trying to change the objective function of the human race from power, prestige, and wealth to existence. Now, you can still achieve power, wealth, and status in the pursuit of existence. the same things work, but our only objective is that swap and and primarily because I do think that like on some grand scale in the universe, there's this question where is life? Are we the only life? Is it true that other species get to a point of advance like we are and they destroy themselves? like we're we're playing the biggest of all possible games and politics plays a game in the species. We do you know it's like a part of our of our society. I don't think my opinions matter in that regard. We are as far as I know we are a singular voice of this new philosophy. If you look at planet earth, who is fighting for existence? Like who is actually saying like you guys this is very precious? This is it's unbelievable. We're actually conscious all of us on this planet. Our planet is precious and delicate and we should probably suspend everything that compromises um or or makes us weak in our ability to persist as a species. And so I'd rather us be a singular voice, a singular focus than I would dabble in all these little side quests which create acrimony, disagreement. It was splinter. We're trying to be more of a unifying focus. And like this is true among all religions, political class, all people. So we're really trying to be extremely narrow in what we say and what we're trying to achieve. >> Yeah, fair enough. It was also one of the things that like was really important to me when we first started dating cuz we were private for 3 years before we announced our relationship. And a big part of that 3 years was a like what happens when we reach conflict? How do we resolve that? It's also like I remember having conversations with you really early on being like I don't know like what happens if we become really successful in this path like who are you going to be on the other side of that? Are you going to be that person that you're describing that doesn't realize that they're pursuing something and then ultimately changes their mind? >> And Brian was really clear. He was like, Kate, like I've already been successful in all these ways and like it and who am I? I've set my life up in a way where he's devoting his body to the bigger picture of humankind. And that really for me was like okay yeah I actually I believe that and I see that and it's held true that the more power we gain we try to have real integrity that we are devoted to the cause rather than to our own individual self-interests. Now, of course, like I'm we're, you know, faultable human beings and so I'm sure there's plenty of ways that I'm like not able to see that that still holds. But I think out of the people, you know, like we're we're really trying to our essence is in devotion of a cause. >> Mhm. >> You have the property box checked and this kind of social media celebrity is sort of checking the prestige box on some level. like it's human to like enjoy the attention and all of that. So, how do you keep that in check so it doesn't become this hypnotic addictive thing where you're >> serving a digital audience? >> We don't we don't care about it for for real. I think we would we would be happier >> in a cabin in the woods doing our thing. >> I don't buy that. I don't buy that. You're loving this, dude. Come on. >> You you mean we have this conversation all the time. It's a sacrifice. I know that sounds like insane to say, but you you become not a human. You're a symbol. And that's a giant that's the biggest trade-off you can make in life. Like you walk somewhere and people relate to you as something that you're not ultimately. They relate to you as a symbol. They think you are versus who you are. And so we like knowingly have walked into that being like we accept those terms. Sure, like it's fun at times, but you know, are we going out to parties in the weekends, like having these really insane, lavish lives? Like, no. We're like hanging out, playing pickle ball, >> watching a movie. Um it seems that you've you've backed away from there was a moment maybe a year ago where it was like oh you're entering guru terrain like you know these don't die gettogethers which are cool like these community events but it was there was sort of a there's some drapery around like you know cult status stuff and it seems like you've retreated from that. Is that a is that true? Is that a conscious thing? >> I say retreat. I think a a truly intelligent being on planet Earth right now would say, "Okay, let me survey the situation. I am on a habitable planet with resources. I'm going to measure the energy capacity of my distant stars. I have this much capacity to exist and these are the threats that could undermine my existence." That would be like the most coherent thought process of an intelligent being. And instead we branch off into these groups like I hate you because of blank or I want to pursue this because of my own sensory needs of filling status or power. But like we are are we are an intelligent species but we are also an idiotic species, right? Like you if you're really truly intelligent, you just you just want to exist and you want to not die. And so we just have never had that opportunity and as a species we've death has always been inevitable. Therefore, we make up these other games like religions and afterlifees and these status games are capitalism and accumulation. But I guess like to get to your point, this is not about fame. It's not about attention. It's not about what we personally want. Like we would so much rather be playing another game. We're trying to we're trying to pierce this moment with our best intellect and say in the like the most sober way possible, how can you say something intelligent? >> Mhm. >> Without getting distracted in all the the primal things that occupy our minds. So, but that genuinely is is our thing. So, the the don't die back to your question on the gatherings. We were formulating a hypothesis on how you build don't die globally. So like build these these events, build up local chapters and we came back because we said we we're not convinced this is the right strategy. What you really want to do and so we wrote two essays. Kate wrote one called the anti-tropic systems. I wrote one called immortalism. And uh Kate's frame was like you want to basically build anti-tropic systems. Like think of it like a nation state is an anti-inropic system. Like it propels itself over time. uh religion propels us this over time and individuals if you look at it through an age perspective religions are the most enduring institution society has ever created they're remarkably resilient actually DNA even exceeds religions and so we're trying to say like how do you build this incredibly resilient structure that rides through the next couple centuries with AI and however it emerges and so I approached it via math Kate approached it through this framework we said basically We don't think the move right now is to build a humanbased system of organization. It's you have to build like a computational model that works on entropy like they like basically you have to give AI the philosophy and the math to to go after this objective. So we wrote this out in the essays but um that's probably a very confusing answer. >> Mhm. >> I'll I'll take a stab about it. um we stop the don't die summits because they reach like 1,700 people per time whereas our social media efforts reach millions of people every time and so it's just a strategy on like communication and anti-inropic system is like why has Christianity been around for 2,000 years and there's no CEO in charge and I'm not saying that there's not some spiritual element to it that propels it. And I'm saying why has it survived that long? Out of all of our institutions, why has that and other religions survived for so long? So something about the structure of that allows it to defy entropy for that long. And you compare that to, you know, the world's most powerful company as of when I wrote this was like Nvidia and that's been around for I think like 33 years or something like that. And so like the contrast there on how anti-inropic is Nvidia versus Christianity. Christianity has proven itself so far to be much more anti-anropic. So what structure would allow itself for us to build to be as anti-ropic as possible? People currently point themselves at companies. They say that is the best place for me to spend our time. Our hypothesis is that there are so many other anti-ropic systems that people don't look at right now that are higher chance success that have been pooed by society because they're not in the zeitgeist. So religion is one of those things incredibly important. Our brains operate through storytelling and it's untapped that we have no zeic guy storytelling to connect us as a species. On the individual level, yeah, we care about each other and we won't, you know, do something horrible for 50 bucks, but on the global level, we create systems for that exact exchange because on the global level, there's something missing in terms of our zeitgeist storytelling. So the guru element is it's framed in that way, right? Because that's the way we relate to it today. But what we're trying to say is science has bulldozed through storytelling. It's made it very hard to believe in bigger picture stuff because science is extremely sound and it's really like entered the zy. How can you pair storytelling of our species to soothe our conscious minds and science at the same time? That's what immortals don't die is. >> Humans are storytelling animals. We use story to understand the world. It's how we relate to each other. It's how we form emotional bonds. Uh and I think you're you're correct in saying that we've like lost our appreciation for the stories that we rely upon to like understand what's important etc. we've supplanted it with the rationalist model with uh you know kind of the enlightenment of of science and we've we've kind of put that on you know the pedestal as the ultimate in human understanding at the cost of storytelling and when you were sharing Brian I was thinking about the movie uh inception have you seen this movie so the most entropic thing is is an idea right like how do you incept it's not about an indiv individual and once that idea is firmly planted it has anthropic properties right it will it will outlast and have a certain legacy that isn't contingent upon a certain individual and as much as >> you know Jesus Christ is fundamental to Christianity it it it exists beyond that individual as an idea as a story >> you know you look at alcoholics anonymous there's nobody in charge there's no boss like this is an idea right that is about >> a shared agreement and a story amongst people, right? And so the idea that you are trying to incept is this challenge to a presupposition around our mortality. Essentially what you're trying to say, >> you said it so well. We are playing inception >> with life with consciousness. >> That's entirely what we're doing. We're implanting an idea in humans minds about what it means to exist as an intelligent being. You start at that basic. I wake up and I'm intelligent. What do I care about? What are my priorities? How do I relate to to you? What stories do I tell? We're trying to get at the core of like that thing and and around it, of course, is like we've got thousands and thousands of years of stories and and architecture and culture and ethics and norms. And this has a friction with what we're doing, which you've pointed out, but that's what we hit at every day. We're basically we're provoking that and reminding people there's a contrast with the way they understand reality and there's a different way to understand reality and that may be scary initially but if you just can slow walk bit by bit you can kind of warm people up thaw them out. If you look at the actually we did this deep um analysis on sentiment towards us for the past 5 years and you look at the chart it was deeply negative when this went viral initially. report is like I'm repulsed by this situation. It has steadily climbed where now we just crossed over majority positive and so we now have defenders actively out there. So it has been unbelievable that the zeitgeist has changed so fast in a 5-year time period to almost be thought of like we might be open to new ideas about ourselves in the world. >> And that's why we're willing to make the tradeoff of losing our day-to-day existence for it. if you had to distill uh you know this definition of reality or this like different understanding of it down to you know like like a log line like what is that yes to existence so I I personally experienced this with 5DMT so it's an anthogen right and I did 27 milligrams which is a gigantic dose so for those listening you know It's like 5 MOS, psilocybin, like they're kind of like in the same like similar worlds. That uh took me to the most challenging experience I've ever had in my entire life. It was also the pinnacle. It was like peak experience I've had as a conscious being. And where I went is to the absolute epicenter of existence. And at every layer, it's almost like Dante's Inferno where like every layer, it was like, I'm going to put this enormity of pain upon you and you have to say yes to existence when the body is screaming panic. Like, I can't control anything. I don't know what's happening. I just want to be out. And you have to just breathe through it and say yes. And then you get to the next gate and it gets even more punishing. And you have to say yes. And then you get to the center after you finally kind of breathe through it and you are just absolutely dumbfounded, speechless at the the exquisite and magna like magnificent nature of existence. Like just our minds cannot understand it. And so I'm sure people who are listening to me speak, they're struggling to connect like what is he talking about and how do I relate to that? You can't you can't convey through words. But you just leave that and you're so humbled and so appreciative that we are alive. It's like you just weep like you just I was speechless for I don't know how long but it's like that it's like as a species we just say yes more fully than anything we've ever done before. And that to me is it is like um that's the beauty of this moment. >> The moment is all there is. We live our lives captured, you know, rehashing the past or or or lost in imagining a future that hasn't happened yet. And we're very rarely actually present for the only thing that is real, which is like what's happening right now. You know, that's a a form of insanity that is has an evolutionary advantage. allows us to, you know, kind of live and thrive and procreate and all the like, but um it's fundamentally blind to the true nature of what actually is, you know, which is interesting. And you know, my experiences with a version of of what you just shared, you know, uh like mimic that in that way. It just gives you this profound humility and appreciation and you're flirting with a sort of understanding of that reality while also appreciating that you can't you can't actually grasp it. >> Mhm. >> We never got to the bottom of uh Kate's discomfort with being seen >> and a theory of mind. >> Well, isn't that a nice reflective of reality? Maybe we'll never get to the bottom of it. >> Yeah, that's you're deflecting right now. I know, but like see, >> you know. >> Yeah. I don't know. I I'm really good at being the space between objects rather than the object itself. And I think we live in a world that views things as objects. >> But I'm someone who says, how can I influence the room such that people might not even notice my involvement or my presence? Obviously now I'm stepping more into this object related role but traditionally I've been much more of the space and so I'm I'm much more like in your head in his head trying to facilitate a certain vibe within the world. Um but that does make it hard for me to be seen by others but also for me to see myself. >> So you have a sibling who's an Olympic athlete. Do you grow up in Australia? >> Where in Australia >> in Do you know where Brisbane is? >> Like a 10 to 12 hour drive north. So kind of right in between the middle of Australia and the very top. So far north Queensland >> but like Olympic athlete sibling. So I imagine I'm projecting but like some discipline in the household some expectations that parents who raised you to be achievementoriented. >> Yes and no. They um immigrated from Bosnia. So more of a immigrant child mindset where we felt we needed to >> do them justice for everything they gave up to move to this to Australia and give us such a fortunate life. >> Um my sister's also 6'5 and so from a very young age both her and my brother were really into basketball and so our whole lives centered around basketball and getting them to practice and driving. My parents were extremely dedicated and never like letting them miss a game. But I mean, Brian just went home to Australia to my to meet my parents. What what's your sense on discipline >> or just the impact of her upbringing? Like what you noticed and saw Yeah. >> that contributes to her character and um sense of self >> or or failure of legibility. Yeah. As you put it. >> That's what it is. Uh Kate was not legible to her family. invisible because your sibling was 6'5 and getting all the attention. >> She's neurode divergent and her thought patterns are different and she's difficult to understand. She expresses her ways herself in ways that are not obvious. They don't fit into certain boxes or certain patterns. And so unless you really investigate and can kind of get your head around it, I went through her old bedroom and we went through her art books and school books. She is just a different person. Like wildly different. Like even when we go out now, I always joke that, you know, she's like socially, you know, challenged because you'll see a bunch of women you swapping like gossip and and case like stunned like she just can't she doesn't know how to what to do. She's like speechless. And so you get her engaged on like a meaningful topic and she'll chime in on a certain thing, but she just doesn't flow within society. And so I think you know she'll I think she'll say this that I was probably the first person to see her when she showed up in my life. I was like, "Ah, I got you." Like, "I understand this." And um, you know, we would be in my office at Colonel and I would just say, "Talk." You know, and she'd be like, "About what? I don't care. Just like go." And she was able to explore like her expression of what she is, but no one had ever done that. And so, I think that she's had a legibility problem her entire life that she basically gave up on it at the age we met at you were 23, 24. >> Mhm. 25. >> She had 25. she had given up in terms of you know like >> expecting that a person would understand her. So, she was in this supportive capacity where she could show up and >> understand you and service you and be present for you and and give you all the social signals of like, I understand the rules of the game and I'm going to be, you know, a good social partner. But if you flipped it, there was it's very hard to get something out of her cuz she >> Is this a point of commonality like a a source of your bonding? Because I would imagine there might have been a legibility problem with you, Brian, growing up. I mean, you're a very unique individual. Uh I don't know if you're neurode divergent or not, but you're certainly unique in your uh in in in your wiring and perhaps, you know, just a different kind of kid. >> Uh I do have a a you know, a better understanding of of how you were raised and the impact of that on the person that you've become. >> Um but now I'm starting to see like maybe that's something that you share. >> Yeah. >> Yeah. I mean, um, the funny thing about Brian, well, so one is when we met, it was just that like he he just wanted to know more. Like I didn't even feel particularly like understood initially because it's very hard to understand, but he just like was like, "Go like start giving me breadcrumbs and and every time I usually do that with someone, I'd get blank stairs." And I like I remember my very first memory in life. I was like 6 years old. I was pacing around the top floor of my family home growing up. It was like a Queenslander where like similar to Florida where you have a lot of cyclones and so yeah um on stilts and um I was pacing around and I remember just being like I've I can I can see that I'm being taught all these rules subconsciously by everyone and no none of the adults realize that they know that they're being run by all these rules that they learned a long time ago that no one's present to now. And I >> we're all just playing out a program that was imprinted upon us. >> Exactly. And I was like, I want to write all these things down because I know I will forget them too and I will become cemented in these rules that oblivious to me. And I was noticing that the street signs were the popular kids last names at school. And I was like, I'm walking into this system that's like pre-established that is greater than me and this frustration of um how much we don't see what's right in front of us, the space between the objects rather than the objects themselves. M >> and so I just remember wanting to write that down but never quite being able to um communicate to the people around me like do you guys see this and feel like they could understand. Then Brian rolls around 25 years later or you know 20 years later and we're interfacing and I'm kind of just like I'll I'll take a gamble cuz you gave me the space to say something. Can you see what I see? And we slowly, you know, walked into this world of where we're at now, where we're saying, "Hey, we'll give up our our our anonymity, our individual identity as human beings become symbols because we see the same picture and like the world being run by this certain algorithm." >> Yeah. >> So, so the legibility issue being a young person who's seeing things differently is trying to connect with other individuals who aren't really understanding you. And so then there's a withdrawal. Like I guess I'm I'm I'm on a solo mission here and better to just you know kind of keep quiet. >> Y >> yeah, >> precisely. >> That makes sense. >> Like that's the entirety like you maybe now see our pattern, right? Like we that experience she had at six is what I've been experiencing the past couple years and we we're both just like wait a second the world is structured a certain way that makes no sense in the context of AI. Like no sense. Isn't this obvious? like all the rules and we're like we got to change the situation because these rules don't make any sense. And people here say this are like you guys are [ __ ] up. What are you talking about? Right? Like I'm going to give you all the reasons why that is an unacceptable way to view the world. But for Kate and I, we're just like, oh, like this is so clear. >> And and specifically like we need to help people create the systems that they're going to be able to survive this next thing. like we'll be fine, right? Everyone will be fine. But we're not set up in a way where we have um support systems, value systems, ideologies, beliefs that will allow us to usher in and not panic as AI upheavalss our societal rules. And we're left with what ties us together. And so we're like, can we build some infrastructure and some ideological thinking to help >> keep us our brains intact as we go through this transition, which we think can anchor on. >> Prioritize the fact that you're alive and hold on to that for dear life. Let go of the politics. Let go of the wanting status and fame and capitalism and money in your bank account to go up and just hold on to those close to you and your existence and say that's our most priority asset and we won't give it up for anything else. So there's there's an example this I'm I'm going to give an attempt at this explanation. There's a professor from University of Chicago who has this theory called unicontext where she says that social media has basically flattened context where before this you if you went to church you behaved in a church setting. If you were home you were home setting right? So you you wore different masks you had different uh mannerisms uh and behaviors in those settings. And now it's because social media knocks down all those walls and it's just one unit of context. It has this side effect where we now live in a perpetually comparative world where you're you're never isolated in these small groups but you're compared across the spectrum that creates this intense pressure this in psychological pressure. And then two is that everything turns negative. Mhm. >> So, in a private setting, the example she uses, I believe, is I can say, "I really enjoy chicken enchiladas." And the person's like, "That's cool." But if you post that on social media, people are like, "I don't care. You got to tell me who's racist, right? Because they like enchiladas." And so, it turns into like these really sharp takes, which then creates this perception the world is very bad. And so, he like the point of that I think for me is that if a person in the modern world says, "I kind of feel bad about life. I kind of feel bad about myself. I don't know why. I just like I don't feel good, you know. Um and h so the the tectonic plates are shifting underneath the feet of humans and we don't know what's happening. We can't quite put our fingers on it. We just know we feel stuff that makes us feel different. And so that's what we're trying to get at is as technology continues to move fast, we kind of slip into the psychosis where we can't quite orient ourselves to say like who are we? What are we doing? Where's safe? Where's connection? And that's why we think that spirituality is the path is like there's this open question. What does it mean to be connected >> and to have a spiritual experience? What does it mean to be spiritual? And it's kind of the first opening in kind of 2,000 years since Jesus was here of like because you had Buddha uh like some big figures like Buddha, Muhammad, Jesus where they kind of set these big structures but right now is this opening for society of like what is spirituality? And like we're trying to poke at this question of like what does it mean to be human? What does it mean to exist? What do you value? Why? How do you behave? How do you relate to others? And so we're really trying to get our minds around this and that's why we're experimenting with all these approaches is like we think it's really open like very open for the first time in a very long time. >> I actually really love that and I think that that gets to the very heart of what initiated this journey and this obsession, you know, in the first place. I mean, I have a theory of mind for you, Brian. I have no idea if it's accurate. Um, but I want to share it with you because I think it's relevant to what you just what you just said. My theory is that you were somebody who suffered a tremendous amount of trauma as a young person. Uh, you grew up in a chaotic environment uh of lack in poverty. You didn't have a dad. you were indoctrinated into the Mormon faith and you dutifully uh you know kind of showed up as as a you know good citizen in that community. Uh at some point uh you questioned the faith and broke ranks with your community. You were like otherred right and this alienated you and exiled you uh not only from the church but from the broader community and ultimately your nuclear family. And so there's a tremendous amount of pain uh that I think you carry and that you're trying to heal and make sense of uh that is a consequence of a set of circumstances that were extremely difficult to heal that. your first impulse was well let me transcend my environment and in a sort of I don't know if it was like I'll show them but like I'm gonna make a make you know I'm gonna make my own way in the world you go out you become this very successful entrepreneur you make a lot of money you get a lot of attention for that and you you know enjoy enjoy the spoils of all of that only to realize like oh this actually didn't heal me and maybe the way I initially thought it might because I'm just following blueprint 1.0, which is power, property, and prestige, only to discover that it it has betrayed its promise, right? You still have this hole in your soul in the Mormon faith according to that blueprint. You live your life in a certain way and you are promised this beautiful afterlife. All those questions are answered for yourself. All you have to do is like act accordingly. that being stripped away, you fill it first with material things, realizing that's not working. What am I going to do now? There's sort of a bereftness, a depression, perhaps a bit of an existential crisis. And what I've seen you do is attempt to fill it um maybe not initially with some version of spirituality, a sense of a higher power, uh a surrender to, you know, a humble sense of powerlessness and the vastness of the universe and trying to find comfort in some kind of spiritual tenants to hang on to, but instead to deny the prospect of death altogether because it's so ultimately terrifying. If there is no afterlife, as I was told in the Mormon church, and we don't know what it is, I I can't that I I short circuit on that. So, what I'm going to do is create a life in which I don't have to think about it because I'm going to do all these things that's going to allow me to sidestep it and prevent it. What I think you have now matured into is a recognition on some level, maybe not, you're not going to admit it, of of like perhaps mortality is inescapable, but in the midst of that and maybe as a consequence of some of these, you know, alternative experiences you've had with psychedelics, in appreciation for some version of bespoke faith in something larger than yourself. So, how does that land? Am I like way off the reservation with that? Kate, what do you think? Like >> I want to >> Is this a Is this a reductive explanation to help me make sense of uh you know, Brian's mind? >> Do you have anything to say? >> I would love to hear your take. >> I figured that you would. Um I think he's like 20 times more complicated than that. Like I spend every single second of my day decoding people from 5 seconds of information. There are still things that just don't add up. Like Brian was also captain of the football team, high school captain, what do you call it when you're like see? >> Yeah. Like I don't know, some mayor position. Like didn't have any qualms with Mormonism until he went on his mission. So, what I I agree that a large portion of what propels Brian into the position that he's in right now is these this historical context. I don't even want to call it traum tra trauma because it's very hard to actually look back and truly pick up the tangible fingerprints of trauma and you know that's obviously a really complicated word but >> well you know he the video that you made where you visited your father it was a very beautiful video but I think it was it's it's it's pretty revealing you know it provided some context for that relationship anyway sorry I interrupted you >> it's almost like you know how you can arrive at something from the top down or bottom up like for example Brian does therapy through his body like he's very somatic and he arrives at the same conclusions as me through physical experience and the moving of his atoms in the world whereas I do that through being alone thinking processing analyzing getting data points contrasting them until I find the overlap um and so you could say it's entirely you know context trauma driven or you can say it's entirely analysis until he came at the conclusion that he's at right now. Like I don't think it's one or the other. I've gone so deep on with it on him that even now I'm I still put my hands up on like there's only so much I can understand or or structure together into a coherent pretty story that has a very clear throughine. >> It's like most people are like that. Um I think weirdly Brian escapes that >> pigeon holing bucketing you know paradigm. >> Okay. What do you think? >> I mean that's first I appreciate the attempt. That's cool. Um, my lived experience of myself is I wake up every day and I try to shed my skin and I say, "What do I think is true?" And in that contemplation, I'm willing to basically eliminate everything in my life that is not true. And that's my lived experience as I've tried to crawl through because I feel like, you know, I was born into a system. >> I had to experience that system. I had to at some point question the system. And if you look at the stages of my life, I've changed pretty radically, pretty quickly over short periods of time. And I still have that same kind of velocity. And so that's uh and maybe I've said that multiple times in our discussion today. I'm just ultimately trying to string together. I give myself some kind of constraint. Seven words is the budget and you can say what is true to you. And anything more than that is verbose and garbage. And so you have to distill reality into those seven words. Otherwise, I'm in an intelligible track. But it's very hard. It's very hard for me to see myself outside of that. Of course, my own experience. >> I understand. I understand. >> Can I can I ask you something, Brian? How does it feel to hear that synopsis? >> Your facial expression changed and so I sensed like there there's some kind of emotional response there. >> Yeah. I I don't want to I don't I don't mean to offend you like >> Yeah. It's not offensive >> or to presuppose anything either. >> Yeah. >> Yeah. I mean, it definitely feels um like Kate said, my lived experience feels much more complex that so I from your vantage point, I think the pattern matching is good, right? You're trying to piece together these these elements. >> Yes. This this is what I see. This is what shows up on the internet. I'm trying to like make sense of it. Like how how does this fit into something that I can understand? And I can understand how he went from there to here. >> Yeah. Yeah. So I guess like intuitively it um it doesn't isn't it doesn't uh match my internal liv experience of what I have. I understand from your perspective why you would think that and I think that uh a lot of people make similar conclusions in looking at me and I also don't want to say they're wrong because I I'm not quite sure how to express confidence of myself right of my subjective experience and other others oftentimes have the superpower of seeing you much more clearly than you can yourself so I try to be very careful to never step on other people's insights which may be the thing I I need to hear or would be helpful to hear. So I try to tread very carefully, but yeah, my lived experience is is it's much more complicated than what others perceive. >> Of course. Well, it always is going to be, you know, because everything is more complicated than our ability to like reduce it to something that we can articulate in a few sentences. >> I think if I had to like summarize it, you know how when you do your LLM creation, you're predicting the next token, you know, how like it's like you could have >> theoretically I understand that, but I'm not like an AI scientist person. >> Me either. At least that that much. >> Yeah, like the cat, you know, the dog jumped over the fence. The fence would being the predictive word when I try I've gotten much better at predicting what Brian's next word will be, but I still am unable to be extremely good at predicting the next word. And so that's the part that I'm with you. I do this analysis on him all the time. He hears it all the time. We talk about I always say like the comment section is actually the always the most right section ultimately. like it's the consolidation of the humankind into one space and it says something about the way that we all it's it's it's collective collective intelligence and consciousness the comment section in in places but still I'm unable to predict the next word so all that to say that for some reason his his essence is far more complicated than I think most people and I think it's what he said the shedding constantly constantly ly rebirththing himself every couple of months. It feels like a new Brian arrives and we're all just like, "Who's it going to be? We don't know." >> You're in this constant process of like change, evolution, growth, and and transformation, right? Like you're engaged with change as a as a relationship, not as a thing you did or plan to do or in the middle of doing, but just as a as a as a way of being in the world, right? So many people struggle with trying to make a change. All of us want to be better in a certain way. I wish I could do that or I plan to do that. Uh most people fall short. Not usually because of a lack of information. It's because of systems or because of uh emotional reasons etc. So from an emotional psychological perspective, what is it that you think you could share for somebody who has struggled to make a change but feel strongly about like wanting to make a change that would be helpful to the average person? >> For me, the singular thing I care about is being correct from the vantage point of the year 2500. that when they look back, >> I'm not going to get a simple answer out of this guy. He's going to tell us 50 years into the future. >> So like, but but the reason why that's helpful to me is because, you know, with that distance of time, we have sobriety to look back at historical figures and assess their wisdom in the context where they they could see something that was extremely unique and hard, like invisible, like zero. And so why I use this as an example is so much of what keeps people locked in to their aversions is they're scared of what other people say. They're scared of the reactions of their immediate family, their co-workers, of the comment section. Like so many of my smart friends, you know, we're in similar chat groups and really powerful, smart, capable people are legitimately fearful of the comment section. and it keeps them in a certain state. And so the reason why the 21st century frame is useful for me and I think for others is it tells you to not give a [ __ ] what anyone thinks. >> Right? That basically the starting premise is everybody in the 21st century is wrong. And there's probably like, you know, a few hundred of us that maybe get through with a kernel of truth, like some kind of insight that carries over the ages. Otherwise, most things that exist today will be viewed as extremely primitive. They're just like you we're puppeting behaviors that we were given. So to me, that's it is like you want to unshackle yourself so you can explore concepts and uh be a persona. Like you know, so much of like the the lunacy of us online is we're willing to do things that re hell upon us, right? that are that it's so outrageous and anyone else who did it would just be clobbered by hate and dismissal and they would worry about being ostracized by the tribe and we're like, you know, we love it. It feeds us. Um, and so yeah, I'd say that would be my advice to people is is try to get yourself in a position where you don't get trapped by the influence of other people because ultimately it's a it's an illusion. >> Mhm. uh that they don't represent the the things you necessarily want. And if you can overcome that, then it gives you more space to say, I'm okay to ride through this and and experiment with what I want to become. >> Yeah, sure. I mean, that's sort of an ephemeral idea, though, like I'm imagining the person who's like, just help me get over myself so I can lose those 10 pounds, you know, or like like drilling it down into something practical. they wake up in the morning like what am I going to do differently today to set myself up for success in the wake of you know relapses and and you know shortcomings etc. >> Okay, so here's something very practical. Uh so like I had a I had a behavioral problem uh I ate a lot of food at night time 7 p.m. the day that would come I would be dealing from all the stress of building a startup. I had little three little kids a challenging personal relationship and chronic depression. You stack those on top of each other and at 7:00 p.m. I'm powerless to stop myself. So, like if I have a box of graham crackers, I'm going to eat the whole goddamn thing, right? Or like if there's a pan of brownies, not just one, it's a whole pan, right? It's the way I soothe myself to deal with my pain. So, I try to >> share that. Go ahead, keep going. >> So, I I c I couldn't stop this self-destructive behavior. And of course, when I did that, it made me miserable, right? I couldn't sleep. Then I woke up the next day, I felt awful. Made my depression worse. I got fat. Like everything was awful. And so what I realized was that when I woke up in the morning, even if I was, you know, uh, beat down, my willpower and my spirit was as high as it's going to get. Like, I am going to change myself. I am going to exercise. I'm going to make good decisions. I'm not going to do that thing tonight again. But then as the day tapers on, different versions of Brian come out, right? So by the time 700 p.m. comes, it's a literally a different Brian. It's a different biochemical Brian. That biochemical Brian does not have the capacity to say no. He's just like he's too worn down. And so the system I created as I said morning Brian is my best Brian and he gets to have the authority to make decisions in my life. So that means evening Brian who comes on duty around 5:00 p.m. and then hits his peak at 7:00 p.m. he does not have authorization to eat food ever. It's just it's out. He cannot eat food period. And that kind of firm rule for me was like really helpful cuz then I could break myself out to my different Brian. But to to give myself space to say I don't need to need to feel shameful about Indian Brian. I don't need to punish him. He doesn't need to feel guilt. Like he's just doing his best with the situation he has. But then setting that firm rule and that has led to my ability now where I have absolute perfect control with what I put in my body. Like absolute perfect. I do not eat anything that does not nourish my body and I'm at the proper weight. I'm the proper biomarkers. I feel great about food. I don't have an eating disorder. But to have this kind of perfection is like one of my life goals. It's like it's unbelievably empowering to just say I'm not going to do it. I'm not going to eat bad stuff. It's it's real. So, separate yourself into your different versions. Um, make decisions and then follow through on those actions because uh it is the easiest way to set rules for yourself. You you never want to put yourself in a situation where you're making a call in the moment. >> This is another version of basically acknowledging your negative inner monologue that doesn't have your best interest at heart. First of all, realizing that there's you and there's your inner monologue. Like these are two different things. uh not pretending it doesn't exist, acknowledging it, but just saying but disempowering it I guess on some level uh and then recognizing that like discipline is freedom, you know, in this I mean is this is would you do you share that? Do you have a different means for this? Like you're you're now you're the chaotic creative person who seems maybe a little more resistant to the notion that your life should be driven by all of these restrictive, you know, kind of tenants. Mhm. >> How are you wired to like navigate through all of this? >> Yeah. I definitely wouldn't be this disciplined if it wasn't for the thousands of women watching. Like it's not like I'm >> also the communal pressure the as an accountability partner. >> Exactly. Yeah. I haven't reached some like next level of self-control here, right? >> You have to do it because like there's an expectation. There's an external uh layer on top of this that's >> informing it. Interesting. You've said that eradicating death is the most urgent and important issue of our time. Um, but setting aside notions of of lifespan extension, immortality, etc., I think that we can all agree, and this goes back to like systems, that our culture has a very unhealthy relationship with death. I have aging parents right now. I have a mother with dementia who's in a memory care unit. And the whole kind of industrial complex around aging and death is one of the most inhumane things I've ever seen. And the degree of suffering is off the charts. Um, not to mention the kind of economic incentives that are driving all of this. And it was interesting. I recently visited my mother and it was in the midst of having to put down one of our dogs who was very, very old and was suffering. that our culture accepts as compassionate, right? >> And it led me to thinking about like why we contextualize it different with human beings when these people really have no quality of life whatsoever. Yeah. >> Our priority is to nonetheless extend it. Um and I think that stems from an unhealthy relationship or understanding of death and what this signifies. >> Uh that is that is kind of a disease in our society. So I'm curious like setting aside like okay death is not happening to acknowledging that death is a reality you know how do you think about that like how we interface with the notion of of death and how we could perhaps have a healthier perspective on it for the people we care about. >> Yeah. Both my parents are in their mid70s. They're experiencing aging and I watch it happen in real time and it's excruciating to watch. It's so unpleasant. It's so uncomfortable to watch it. And I've had this conversation with my dad as well of raising the topic with him in ways I haven't before of dad, how do you feel about death? And dad, have you reconciled with death? And dad, have we talked about everything you and I want to talk about before death? Do you have things you want to say? And do I have things I want to say? And Kate has been instrumental. Like I had the sweetest moment with my dad. We were having a conversation. We retraced my childhood and and were frank in ways that we had never been before. and we were in a studio and Kate was bridging the conversation and she said something to my dad of something like Brian you doesn't express himself to you because he's played this role in your life where he's tried to be protective and supportive and always there and he hasn't take on the role of being a son And my dad got into a position where he said, "I'm open to I I'm open like I I want to hear from you." And for whatever reason, these sounds started happening inside the studio and we weren't quite sure what was happening. And the only thing I could do is just be quiet. I had nothing to say to my dad. And after I said I when I kind of like understood what was happening, I said, "Dad, I want you to understand what silence feels like, you know, and like it's like being in middle school like I I'm going to break down and cry when like I'm waiting for my dad and he's not there." And um like so many times where he's just not there. And um he just said, "I want you to feel it." Silence. And um to his credit, he did. He sat in it. And I think we were able to um you know broach that because death that's kind of been the backdrop now of our conversation. >> Mhm. >> And so there's this beauty of reconciliation that happens between humans when you're faced with that. You get this sobriety. So I I certainly haven't reconciled with it. Um, my default disposition is defiance that, you know, I'm going to personally save my father from death through all these things we're doing and my mother and I'm much less accepting of it >> than maybe one would expect. But I also in being open to it, it's allowed me to have experiences and conversations that are healing for both of us. I appreciate the openness that answer. I think that's worthy of deeper interrogation on your part. You know, I think there's a lot there. >> Yeah. >> The intolerability, the unacceptability of it, you know, as an animating influence on your daily life now in the present moment, you know, >> it's beautiful. I think that's a great place to end it for today. I'll end it by saying that I appreciate again like you opening your home and and and being so vulnerable and open with me. Um I have a great fondness for you. Like I don't know you that well. We've spent some hours together and I think there's a lot of misunderstanding about you know who you are as a human being and who you guys are as a couple. Part of that is your fault because of the way you present you know on the internet. you're inviting, you know, that kind of misunderstanding on some level. Uh, but I appreciate the service that you're performing and I certainly enjoy watching you perform all these experiments and you know, I think from a spirit of trying to better understand things so that we can understand things better. There's so much confusion on the internet right now like you know it's just it just everything's flip-flopping every single way and we need ballast and we need stewards you know of of information in this age of skepticism and the denigration of institutions and the distrust of experts etc. like where do we find our footing and behind the the kind of PT Barnum entertainment value of what you guys provide. I think that that is is is the true sensibility of who you guys are and my hope is that I've helped to underscore that for you. So, thank you for sharing this afternoon with me. You guys, >> thanks for being here. I I really enjoyed it. >> Cheers. >> Yeah. And thanks for putting a spotlight on female health. >> Awesome. and keep us posted on the women's health front, please. I think what you're doing is is is vital and important, and I'm here to celebrate it. >> Yay. Thank you. >> Thanks, you guys. >> Thanks. >> Peace.