These "HEALTHY" Foods Are KILLING Your Energy | Dr. Steven Gundry on Healthy Theory
Watch on YouTubeVideo summary
In his new book, *The Energy Paradox*, Dr. Steven Gundry reveals that chronic fatigue and brain fog are often not merely signs of aging or stress but symptoms of a compromised gut wall integrity known as intestinal permeability, or "leaky gut." The human intestine possesses a surface area roughly the size of a tennis court lined with cells connected by tight junctions; when these barriers break down due to factors like lectins in raw nuts (specifically pecans), saturated fats feeding harmful bacteria, and an imbalanced microbiome, toxins and undigested food particles enter the bloodstream. This breach forces the immune system into constant overdrive to fight perceived invaders, diverting massive amounts of cellular energy away from muscles and the brain—a phenomenon Dr. Gundry illustrates with the example of flu symptoms caused by the body's own inflammatory response rather than the virus itself. Consequently, individuals suffer from a state where their bodies are essentially running on an "inflammation diet," burning fuel to manage internal battles instead of generating vitality for daily life. The root cause of this energy crisis lies in the complex relationship between our gut bacteria and cellular mitochondria, which produce the body's power supply. Dr. Gundry explains that a diverse microbiome requires plant fibers (prebiotics) to ferment into postbiotics, including short-chain fatty acids like butyrate and gases such as hydrogen sulfide. These substances act as "gaso-messengers" or transmitters in what he terms the gut-gas-brain axis, directly communicating with mitochondria via a mechanism involving engulfed bacteria within them. When these signals are disrupted by an unhealthy diet high in processed sugars and fats that feed harmful gram-negative bacteria (gang members), they produce lipopolysaccharides (LPS) that assault the immune system. This disruption prevents the production of beneficial gases like hydrogen sulfide, which is crucial for preventing atherosclerotic plaque even in individuals with high cholesterol, while simultaneously starving mitochondria and causing neuroinflammation where brain microglia prematurely destroy neuronal connections, leading to cognitive decline. To reverse this energy deficit, Dr. Gundry advocates for rebuilding the gut wall through specific dietary changes that eliminate triggers like lectins found in raw beans, wheat, corn (which cross-reacts with gluten), and certain saturated animal fats. He emphasizes that not all fats are equal; while medium-chain triglycerides (MCT oil) can bypass problematic transport mechanisms to directly stimulate ketone production in the liver, other fats must be consumed carefully depending on one's microbiome status. A critical component of his protocol is time-restricted eating, compressing daily food intake into a 6-to-8-hour window rather than grazing over sixteen hours. This practice prevents mitochondria from being overwhelmed by simultaneous influxes of glucose, amino acids, and fats—comparable to rush hour traffic jams on the freeway—which allows these energy-producing organelles time for repair and efficient function. By reducing digestion demands during sleep and limiting exposure to inflammatory triggers, individuals can restore their gut barrier, calm immune responses, and reclaim lost vitality regardless of age or previous health struggles.
Read the full video transcript
It's the gut wall integrity and the
bacteria relationship
that determines your fate.
[music]
Hey everybody, welcome to another
episode of Health Theory. I am here with
the legend Dr. Steven Gundry. He is a
best-selling author multiple times over,
a world-renowned heart surgeon who has
done over 10,000 procedures including
heart transplants, I might add. This man
knows the human body and today we're
going to be talking about his new book,
The Energy Paradox. And Dr. Gundry, as I
was saying before we started rolling, I
really love this book and unfortunately
I have experience uh with this, but if
you would give people just like a quick
encapsulation of what the energy paradox
is and why you wrote it.
So, it's
uh it's dedicated to people when what to
do when your get-up-and-go has got up
and gone.
And actually my my impetus for writing
it uh started pre-COVID.
Uh
I was on my way to Orange County to a
PBS uh fundraiser.
Um and I get a call on the phone on the
way down to Orange County that the
person uh a young millennial who was
going to do the fundraiser with me
uh called in and said she didn't have it
in her
to come in today to uh to do the
fundraiser. And I got oh gosh, you know,
anything wrong? I said, "No, she's just,
you know, she's exhausted and she's
tired and she just doesn't have it in
her. But we don't worry, we we got
another person, we'll be fine."
But that phrase stuck with me for for
days afterwards that, you know, a
millennial would be calling in and
saying, "I don't have it in me."
And I realized that
uh when I first started my restorative
medicine practice over 20 years ago,
at least half the people I saw
uh, would we would use a medical code, a
diagnostic code called fatigue and
malaise.
And uh,
it never really then it always went
away. So, it never really occurred to me
that I was, you know, treating an energy
problem. But, when she said that, I
said, "Oh my gosh, you know, I'm an
energy doctor all along and I need to
tell people what's going on." So, that
was the impetus for the book.
All right. So, one of the things you go
into in the book um, is around cellular
energy and so and and mitochondria
specifically. And I've been asked a lot
about how I maintain my energy levels,
you know, whether it's running a company
or speaking or whatever. I once stood
and answered questions for 11 and 1/2
hours.
Um, and one of the questions was, you
know, how how do you generate the
energy? And my answer was, "Well, the
only real truthful answer to that is
it's at a cellular level." So, it has to
do with diet, it has to do with
exercise. And you do get some benefit
from psychological energy. Um, but I had
always been, you know, since my sort of
mid to early 20s, I've been working out.
I've been very conscious about my diet.
And so, it just sort of felt second
nature until during COVID, probably I
don't know, this is maybe 6 months ago
now, I started to get psychotically
fatigued. Brain fog, just like
so tired. I was like, "Am I losing my
will to fight, to live?" It was really
unnerving. And I thought, "Okay, what
would you tell somebody if they were
asking you this question?" And I said,
"Well, my answer would be I don't know
what's going on with you, but I promise
it's your diet." And so, I was like,
"Okay, well, if that's true, what's
going on in your diet?" And uh,
for me, I started thinking about the
only thing that I was eating a lot of
was this like pecan pudding.
And it was delicious. And I loved it the
most. I can't even begin to tell you how
much I enjoyed this thing. And
because it was like raw pecans and
everything, I thought, you know, it
can't be that, but it's the only thing I
ate a lot so let me cut it out. And it
changed in like 48 hours. It was
surreal. So, I know the punchline
because I've read the book, but walk
people through how it's possible that
something I'm eating simply by removing
it could restore my energy.
Yeah, the I about 80% of the patients I
see now are autoimmune disease patients
who
have kind of been all over the country,
all over the world, and
have not gotten a resolution in their
autoimmune disease, or they're on
immunosuppressant drugs they don't want
to be.
And what we find 100% of the time, and I
can assure you it's 100% of the time,
that all these people suffer from leaky
gut. And or you know, intestinal
permeability, if you want the exact
term.
And
2,500 years ago
just for people that don't know it is
is literally the lining of our
intestines is the same surface area as a
tennis court. And it's only one cell
thick, right?
It's only one cell thick. And the cells
are stuck together with what are called
tight junctions. So, everything we eat,
including all the bacteria that live in
us,
are only one cell away from us, from and
80% of our immune system,
white blood cells, are sitting right
behind this wall, waiting for
troublemakers to come through.
And your example is actually really
good. Hidden in one of my books, the
Plant Paradox Cookbook, the original
one,
there's a little line that says pecans
have a very interesting lectin. And I
can't tell you the number of people who
are sensitive to the lectin in pecans,
particularly if you eat them raw. So,
you
quite frankly, undoubtedly, are one of
those people who are sensitive to
pecans, and these little
pro- proteins, lectins, actually made
your gut porous.
So, so what? Well, the whole book is
literally about that.
Your immune system requires huge amounts
of energy to do battle with whatever is
coming across your border.
And it Really fast on that. That was one
thing from the book that um
I was wondering is is there data coming
out? Cuz in the book you talk a lot
about the Hadza tribe, the studies that
are coming out, how people compared.
You've got the Hadza moving around all
the time, hunting and gathering, and
then you've got somebody sitting at
their desk. And when you measure the
energy output of those two people, you
would think the sedentary person was way
lower in energy output, but they're
actually the same.
Now, is it just your hunch that that
isn't true, or is there actual data
around the um the sort of energy
requirements of the um
inflammation, basically?
I'll use a a great pre-COVID example
that I use in the book.
You catch the flu. The everybody gets
really achy, you feel awful, you don't
want to move, you don't want to read,
you don't want to think, you just want
to, you know, binge-watch Netflix laying
in your bed.
And everybody says, "Well, yeah, of
course, that's the flu virus. The flu
virus is causing that to happen." And in
fact, it isn't.
There's nothing in a flu virus to do
that, but our immune system recognizes
the flu virus as a troublemaker,
and mobilizes the troops. And the
troops, if you will, require huge
amounts of fuel.
So, we
ration fuel to energy-hungry muscles,
and we ration fuel to that energy-hungry
brain. How do we ration fuel to the
muscles? We make muscles hurt so that it
doesn't feel good to move. How do we
ration fuel to the brain? We make the
brain not work.
And so, your immune system takes all
this fuel for the fight.
And it's fascinating to see that, you
know, what we thought was the flu virus
causing the problem, in fact, is our own
immune system saying, "You
lay back, sit down for the count. I need
all this energy." And in fact, that's I
think, and other data shows that that's
what happened to these sedentary
workers.
Their energy
expense was just the same as if they
were walking 10 mi a day, but they were
burning
fuel of inflammation, the fire of
inflammation, as I call it.
Yeah, one thing that, um, you know, sort
of bringing these pieces together in my
own life, my wife went through a really
brutal, um, gut problem many years ago,
which frequent listeners of this podcast
will have heard many, many times. Uh,
and I remember she used to say, "It It
just feels like my gut is inflamed. It
feels like my gut is inflamed." And I
had heard people talk about that the
immune system is right there, and I was
like, "Why would the immune system be in
the gut? That seems so bizarre." And
then when you think, okay, well, if that
junction breaks, something gets in, now
the body has to go crazy, you really are
inflaming that whole area. Now, the
question becomes, is that what's causing
the fatigue, or like the just the energy
reallocation or is this something
that has to do with leaky brain and
foreign substances are getting into the
brain that cause like that brain fog?
Like how does this all
um begin to manifest the symptoms? Yeah,
that's you're exactly right. Number one,
it's enough in and of itself to steal
enough energy to have to be tired. But I
think more importantly, we're now
realizing for the most part, if you have
leaky gut,
you will have leaky brain in in one of
two potential ways and I outline them in
the book.
One, which is probably the most
frightening, is that we have a
blood-brain barrier, which is a single
set of cells that keeps really anything
in your bloodstream
away from your brain, which is kind of a
sacred space. It's it's so sacred that
let's suppose you get a brain tumor
uh or you get an infection in your
brain, we can't give you chemotherapy
through your veins and it won't won't
get in your brain. We can't give you
antibiotics through your veins and it
won't get into your brain. It's that
protected.
Yet, what we're now able to do with uh
blood tests is actually find disruption
of the blood-brain barrier. And number
two, we actually see
inflammation in the brain itself,
particularly with these
um secret service protecting agents of
the brain, the microglia. They are
actually the immune system of the brain.
And they're
they're handlers for the neurons, which
are the real important cells of the
brain. And the microglia are you know,
the bodyguards, the handlers.
And if the microglia
sense that there's problems in the gut
that already there's
lack of a better word, an army that's
penetrated our borders and that the army
will soon be up to the brain
the microglia actually cause
neuroinflammation
and it literally begin to kill
Preemptively? preemptively.
Here's
as I talked about in the book
neurons send out these dendrites to talk
to other neurons. Very much like an
airport has a central terminal and then
satellites where you go out to catch the
planes.
Think of the neuron as the central
terminal and the satellites are where
you're going to catch plane or talk to
another neuron.
If the microglia think that an attack is
imminent, they go, "Oh my gosh, we got
to call the guys back from the
satellites." So, since the dendrites are
actually how we talk to another nerve,
how we think, how we create memory
imagine if microglia are actively
popping these guys, you know, away, no
wonder we have brain fog. And you know,
it was something
so you're 80 years old and you don't
think as clear as you did when you were
30 and we go, "Eh, you're 80 years old,
that's okay."
But now we have 30-year-old women,
particularly who have brain fog. And so
many times their physician go, "Oh,
you're a young mother, you have two
kids,
you know, you're not getting enough
sleep, of course you have brain fog."
But when we see these people because
they're not getting any better and we
actually do these tests
they light up, you know, their
blood-brain barrier with all these
inflammatory markers and we see this
neuroinflammation that we can now
measure. This morning I saw a
48-year-old woman
who um has Parkinson's disease. 48 years
old.
Uh
yeah, healthy as a horse, you know, kind
of out of the blue after started after a
funny viral illness a couple years ago.
But, long story short,
we've been working with her for about 6
months, and I saw her back for a visit.
And when we first checked her, she had
not only leaky gut, she had markers for
an autoimmune disease, lupus,
uh antinuclear antibody,
and she had leaky brain, and she
actually had an attack on the movement
center of her brain, uh anticerebellum
antibodies.
And we're going, "Well, no wonder, you
know, you got this. You know, let's get
after this."
And we've now been 6 months. Each time
we check her,
her leaky gut is better and better. It's
about uh halfway to where we want her.
Her autoimmune markers are gone.
Her leaky brain is about half of what it
was when we started, and her
anticerebellar marker is pretty much
gone, still mildly positive.
And so, you can kind of track what's
happened to her by looking at how leaky
your gut is. And
we've gone through what she's sensitive
to, and some really healthy foods she's
sensitive to, like you were sensitive to
a really healthy food.
And once you get a leaky gut,
even what would normally be a healthy
food, if it can get past this leak, your
immune system says, "Hey, wait a minute.
This isn't supposed to be in here in
this form. It's supposed to be digested,
and what are you doing there?" And
literally makes an antibody, just like
if you got a shot for COVID, you made an
antibody to the spike protein in in
COVID.
So, we make
an antibody to
pecans. And it's like, what what the
heck? So, every time you eat pecans,
your immune system goes, "Wow, you know,
we got to we've got to summon the
troops. This is awful. We got to take
all the energy to help poor Tom."
So, now let's walk people through
step-by-step cuz we haven't even gotten
to mitochondria in detail yet, which
we'll get there in a minute. It's such
an important part of this story, but so
first I want to um begin to help people
to understand what it is that breaks the
junction in their gut because that's
such a huge part of this. Uh
what is it that triggers the breakdown?
Let's start with that.
Well, so there's you know, there's three
kind of major components. So, first of
all, and we don't need to talk about
this extensively, but lectins are plant
Paradox. We go all into that.
They're plant proteins that were
designed by plants to protect themselves
and their seeds, their babies, from
being eaten by making their predator ill
to pay attention. Number two,
particularly if we're eating a typical
American diet with lots of saturated
fats, lots of fats in general, and lots
of sugars,
we in our gut have classes of bacteria,
and we have 10,000 different bacteria.
And I divide them into gut buddies, good
bacteria, and gang members.
Gang members love saturated fats and
simple sugars.
And the problem with these gang members
is that they divide and
die
and pieces of these bacteria called
LPS's, lipopolysaccharides,
in In all my books I call them little
pieces of because that's literally
what they are.
These guys actually hop on
fat molecules
and ride through our gut, even without a
leaky gut.
And when they get to the other side, the
immune system cannot tell the difference
between a living bacteria and a
bacterial cell wall.
It's so impressive that, for instance,
we could take you or me
and inject these LPS's into our
bloodstream
and both of us would go into septic
shock as if living bacteria had been put
into us. So, believe it or not, in the
American diet, 24 hours a day,
we're
causing leaky gut, we're assaulting our
immune system with these LPS's.
And it's no wonder that just from fat,
we all, you know, are just a giant ball
of inflammation.
Okay, so, um, for my own sake, it'll be
interesting to tease out some of the
ideas around fat, but first I want to,
um, stand this point just for a second
of how people end up getting in a state
where they're prone to having that
junction break. So, I'm going to make
some assertations, you tell me, or
assertions, you tell me if these are
correct assertions or not. Um, so, one,
that part of the problem is a breakdown
in the actual microbiome, so the
integrity of a well-balanced microbiome.
So, you've probably done something to
assault that microbiome for a long time.
It could be a very non-diverse diet, so
some of the bugs are just dying out, and
so, because they're starved to death,
and And you get, you know, some
dysbiosis there. You've got people just
shoveling sugar in their face that comes
in a gazillion different forms that
causes all kinds of havoc, not only in
the microbiome, but elsewhere and you
know, we'll get into some of the other
ramifications, I'm sure, later.
Um antibiotics, which are causing that.
Glyphosate, which is causing that. So
it's like there are so many things that
are assaulting our guts. And the reason
I'm I'm prefacing all of this is because
one thing that I've had tremendous
success with in my life is high fat, low
carb. So I'm curious to see like it
in my N of 1 experience
fat of certain kinds, anyway, do not
seem to be problematic. N of 1, I'm well
aware of that. So you know, everybody
freaking out that that is not empirical
data, I understand.
Um
but you know, there's also obviously a
pretty interesting carnivore movement.
Um so is it certain types of fat? Is it
only fat when you have compromised your
microbiome or is it No, no, no. Fat is
in and of itself an assault upon even a
healthy microbiome. So I'm I'm the guy
who's famous for saying the only purpose
of food is to get olive oil in your
mouth. So I'm absolutely not anti-fat.
And in all my books, I have a ketogenic
plant paradox chapter of exactly that.
But having said that, interestingly
enough
um most fats, even including olive oil,
are transported across the wall of our
gut using these carriers called
chylomicrons.
And it's the chylomicrons that these
LPSs hop onto.
So interesting
a metabolite of some kind?
No, chylomicrons are the
uh moving van that literally carries fat
across your gut wall. Fat transverses
your gut wall in a totally different way
than sugars or proteins.
The exception to that is medium-chain
triglycerides.
Now, medium-chain triglycerides, MCT
oil,
are a saturated fat, but they are a
unique saturated fat in that they're
water soluble. So, they transverse the
gut wall without chylomicrons, number
one.
And they don't enter our lymphatic
system where chylomicrons go. They go
directly from our gut through our portal
vein into our liver.
And in the liver, MCTs actually
tell the liver to make ketone bodies.
So, whenever you eat MCT oil or eat MCTs
in other forms, you will automatically
do not stop, do not pass go, do not
collect $200. You will automatically
make ketones in your liver.
And they'll be released. I understand
the difference then. So, if if not all
fats are bad,
what are the fats that are bad that are
causing this problem? I didn't I didn't
get that. So, sadly, a lot of the
saturated animal fats
are some of the biggest mischief-makers.
But,
the other fats
Specifically because they're feeding the
wrong bacteria. They're feeding the
wrong bacteria. And if you don't have
these gram-negative bacteria in your gut
in huge amounts, you will not produce
LPSs, lipopolysaccharides.
So, you could have
a very high-fat diet as long as you
don't have these gang members in your in
your life. And those gang members got
there, quite frankly, by eating a lot of
sugar. So, help me then understand. So,
um there you said there is a time for a
carnivore diet. I'm guessing there's a
pretty narrow band where you would
recommend that, but what would that
narrow band be?
So, we we will use it
for an elimination diet where we've got
someone who is
really intolerant to plant lectins in
general, and we do see these people. Uh
they're totally intolerant to raw
plants.
Most of the time
um
the lectins in plants can be cooked
away. There are exceptions. Beans, you
cannot cook the lectins away.
Uh wheat, you cannot cook lectins away.
You can't pressure cook wheat to get rid
of the lectins. Oats have a molecule
that mimics gluten. Corn has virtually
identical molecules to a gluten. In
fact, 70% of people who are sensitive to
gluten react to corn as if it was wheat.
And so many patient Yeah, so many
patients that I see on a gluten-free
diet for celiac disease, for extremely
leaky gut, they're eating corn because
it's gluten-free. And when we take corn
away from them, so many of them resolve
the problem. And you know, it's like "Oh
my gosh, you know, I've been eating corn
chips and corn muffins and cornbread,
and I thought that was, you know,
gluten-free." Well, it is, but it
cross-reacts. So,
if you if you combine a carnivore diet
with what I recommend in the book, which
is time-restricted eating, or
compressing your eating window,
you can I want to say get away with a
carnivore diet
a period of time.
Um there's a very famous young lady who
follows a carnivore diet who really
wants to get off the carnivore diet, uh
but she can't.
Um and I think we've seen this
And if we were going to really simplify
why she can't, I'm guessing [snorts]
it's it is simply a question of the
microbiome, right? Like if we could uh
repopulate her microbiome whether
through fecal microbial transplant or
magic, whatever, but if we could
repopulate her gut, then theoretically
she would be able to get off it. The
only reason that people get trapped in
something like that is because of the
changes in their microbiome.
Yes. Um one of the things that I um I
think is critically important for our
health in so many ways that I talk about
in the energy paradox
is we now know that the the microbiome,
number one, has to be diverse. We know
that the Western diet produces the worst
kind of
non-diverse microbiome that you could
possibly, you know, wish for and you
don't wish for that. That's number one.
Number two,
if you don't give the microbiome
plant fibers, which are
prebiotic fibers. These are soluble
fibers that we can't digest, but the
microbiome needs.
The microbiome can't produce what are
called postbiotics, and I spend a lot of
time in the book talking about this
exciting discovery of postbiotics.
Yeah, it helped me understand what the
difference between a postbiotic and a
metabolite is.
Okay, so literally when bacteria ferment
fibers,
then they the fermentation process
produces
both short-chain fatty acids like
butyrate, like acetate, like propionate.
And they produce a series of gases,
hydrogen gas, hydrogen sulfide gas, the
rotten egg smell, methane, carbon
dioxide, nitric oxide.
We used to think that these were just
farts that everybody made and they
didn't do anything.
But about 10 years ago, I usually
present a talk at the uh
uh World Congress of Microbiota, which
is which happens in Paris
before COVID.
And the organizer is professor from
Paris, Dr. Marvin Edis.
He pulled pulled me aside about 8 years
ago and he says, "You know,
the microbiome talks to mitochondria."
And I'm going,
"Well, that's interesting. How do you
know that?" He says, "Well, it has to
because
mitochondria, the little
energy-producing organelles in all of
our cells, are actually engulfed
bacteria.
And the bacteria of the microbiome talk
to their sisters. And they control what
happens to the mitochondria. They either
tell them to produce energy or things
are bad in the engine room, cut back on
energy production. I'm going, "Well,
this is fascinating, but why hasn't
anybody discovered this?" He says, "You
watch. Uh we will."
And sure enough, he was right. So, we
now know that these, they're now called
postbiotics.
The gases are called gaso-messengers
or gaso-transmitters.
And the short-chain fatty acids, we now
know nourish the gut wall, number one,
and also nourish brain cells, number
two.
So, the discovery of this language, and
it's literally called a trans kingdom
language, where
Sutter bacteria
talk to us, in particular our
mitochondria.
And it won the Nobel Prize for medicine
a few years ago with the discovery of
specifically the gas, or is it the gas
and the postbiotic?
So, the gas is a postbiotic. Okay, are
the short the short-chain fatty acids
considered postbiotic? Correct.
Okay. Yeah, they're they're all
classified as
do they do? Is it is uh hey, nitric
oxide has arrived, therefore do this,
and the flip side, nitric oxide has not
arrived, and therefore do that? Correct.
So, for instance, we know that hydrogen
sulfide, the rotten egg smell,
if you produce the right amount of
hydrogen sulfide,
you will not produce
atherosclerotic disease plaque in
coronary arteries, despite a monstrously
high level of cholesterol in the diet.
But if you don't produce the right
amount of hydrogen sulfide,
it's as if, you know,
let the hell loose from L LDL.
Hold on. Hold on. Hold on. Hold on. Hold
on. That sounds like a life-changing uh
revelation. I've never heard that
before. So, I can have freakishly high
uh
cholesterol, but if I get the right
signal from the my microbiome in the
form of gas,
then my body's like, we're good. We're
not going to form the the the
atherosclerotic plaque. That's like the
hardest word in the English language.
I know it, yeah.
That's crazy. Why are people not talking
about that?
Because there's no money in it, you
know? As statin drugs are
make a lot of money.
Um
You know, and this is you know, when I
look back at the man who changed my life
25 years ago, Big Ed, and watched him
clean out the, you know, inoperable
plaque in his coronary arteries,
Did you see him under the knife or was
he
uh not surgical? So, it Yeah,
interesting enough, he had so much
plaque in all his blood vessels you
couldn't put stents in them. You
couldn't
do bypasses cuz there weren't many place
to land. And like so many people, he
would go around the country looking for
idiots like me to operate on him, to
take him on. That's kind of what I did.
And he spent 6 months going to major
centers, and I've named them before. Um
And everybody turned him down. Said,
"Nope, go away. Nothing we can do for
you." Well, during the 6 months, he went
on a diet,
and he started taking a bunch of
supplements from a health food store.
And he lost 45 lbs in 6 months. Now, he
was still big guy. I called him Big Ed
cuz he was 265 when I met him.
So, he arrives in my office carrying his
angiogram, the cardiac catheterization,
from 6 months previous. And I look at
it, and I go, "You know, Yeah,
everybody's right. Nothing we can do for
you.
You know, sorry." And he says, "Wait a
minute, you know, look, I've been on a
diet. I'm taking all these supplements.
Maybe I did something." And I said,
"Well, you know, good for you for losing
weight, but that's not going to do
anything in here." He says, "Look, but
what do we got to lose? Let's do another
angiogram." And
I said, "Okay." So, in 6 months'
putting a camera in his veins. Yeah,
it's do- putting dye in his veins and
taking a 3D picture of where the
blockages are. And in 6 months' time,
50% of the blockages are now gone. Now,
he's still got blockages, but now
there's open spaces
where I could land a bypass. So,
if I knew what I knew now, I'd say,
"Great job. See you in 6 months. They'll
probably be all cleaned out." But, I
didn't know that. So, I said, "Great.
You know, we're going to do an operation
on you." And we did a five-vessel
bypass, and I'm pretty smart. And then I
said, "Um tell me about this diet, and
let me look at those supplements."
And son of a gun, this guy had actually
put himself on a diet with that was my
thesis as an undergraduate at Yale on
what turned a great ape into a human
being.
And I was so shocked that, you know,
this guy did this, that I put myself on
my thesis, and I lost 70 lb. I was a big
fat art surgeon. Even though I was
running 30 mi a week and going to the
gym 1 hour a day.
So, that's a long way of saying
that he actually was the guy who opened
my eyes
that
we've got this all wrong.
Yeah, it's it's bananas, man. Every time
I talk to you, I mean, you forget your
book, which is already just chock-full
of enlightening things, but that that's
really crazy. You So, you say in the
book, you make a prediction that in the
future we're going to realize
a couple things. One, you say that you
refer to the gut as the first brain and
not the second brain. But, the other
thing is this gut-gas brain axis.
And I've never heard anybody talk about
it before, and just to to re-anchor
everybody, we're we're talking about
energy and your body's ability to
generate energy. And you've got your
gut, which is far more complicated than
anybody could possibly realize.
It's [snorts] communicating to the
organs inside your cell or the
organelles inside your cells that
generate the actual energy that are are
bacteria, that have their own DNA, which
is fascinating unto itself. And all of
this then is also
having an effect, I won't just say
communicating cuz I think it's more than
that, having an effect on the brain,
which is then having massive effects,
whether it's fatigue, whether it's the
the fogginess, which was the worst part
of what I went through. So, you just
blew my mind with the whole gas
communication thing and how it can even
play out with plaque. Now, mitochondria,
we have to talk about the the idea of um
the the traffic jam that ends up
happening.
And it's really important for people.
You've already mentioned time
restricted, but now talk to me in in the
context of that traffic jam. Because
this to me was a big player in why you
feel lethargic if you feel like you're
lacking energy.
Yeah, so mitochondria produce energy
from either glucose, which comes from
the carbohydrates we eat,
or amino acids, proteins that we eat, or
from free fatty acids, fats that we eat
or that we have stored that we produce.
And normally, mitochondria use one of
those substances at a time. And quite
frankly, if we actually ate whole foods
like I talk in the book, like our
great-grandparents did,
normally carbohydrates, sugar molecules,
would arrive first for processing. And
mitochondria are really good using one
thing at a time.
Then, after the carbohydrates are gone,
protein takes a long time to digest into
amino acids, and they arrive second.
Fat literally takes a circuitous route.
It's not even absorbed into our
bloodstream. It's absorbed into our
lymph system, and then comes around
later. But what's happened with our
processed foods and our ultra-processed
foods
is that we have had made
perfect pre-digested
sugar, amino acids, and small fat
molecules
that literally instantaneously
enter our bloodstream and wham into our
mitochondria simultaneously.
And it's literally, uh, since both of us
live in the LA area, it is like rush
hour traffic in LA. With all of these
streets leading into our freeways
and nothing moves.
And what we're doing now, the average
American work by Satchin Panda at the
Salk Institute in San Diego, has shown
that the average American is eating for
16 hours a day.
And 60% of the food we eat is processed.
So, we're just constant in rush hour.
It's like the 405
24 hours a day as you and I know.
And nothing moves. So, if we look at
energy production as literally cars
moving down through a freeway
it's no wonder that even though we're
eating huge amounts of calories
we have no energy because we literally
log jam the mitochondria.
And just as a fun fun side note, the
first pre-digested food
that was actually advertised as a
benefit was Kellogg's Corn Flakes. It
was actually advertised as the first
pre-digested
food.
And why anybody would want to have their
food pre-digested like most of our food
is now
you can thank Kellogg's for doing that
over 100 years ago.
Yeah. Okay. Now, in the last, um,
few minutes that we have, walk people
through what do they do? Like, how do
you you right now you have it. You're me
pre-realizing that I'm eating something
I shouldn't be eating. How do they
rebuild back better and stronger than
ever? You talk about, you know, these
80-year-olds that, you know, are
charging up hills and
um you know, aren't aren't thinking of
fatigue. They're just they're ready to
rock. How do we get anybody there at any
age?
So,
uh I had the pleasure of knowing Jack
LaLanne
uh in his later years and
um Jack LaLanne was the godfather of
fitness in in my humble opinion. You
might think that, too. But, Jack LaLanne
said he used to say, "If it tastes good,
spit it out." Now, he wasn't saying that
because don't eat, you know, tasty food.
What he was saying is, "Look, you've got
to eat for your gut microbiome first.
And you have to choose foods that they
want to eat. And if you do that, they
will take care of you." And I spent the
Longevity Paradox book explaining why if
you want to be a 90-year-old charging up
a hill in Sardinia,
you got to take care of your gut
microbiome because you're actually their
home.
And again, in a very weird way, we have
to get over the fact that this complex
organism
may in the end be totally dependent on
single one-cell creatures that live in
our gut. And, you know, it it really
knocks you down a notch to think that
maybe I'm here for them.
But, all the available evidence is that
we
die, we get diseases by breaks in the
wall of our gut that start this process
just like Hippocrates said 2500 years
ago and he doesn't have the
sophisticated test that we have to prove
it. But the guy was right and you can do
this in animal models, you can do this
in worms
and it's the gut wall integrity and the
bacteria relationship
that determines your fate. So, eat for
them, that's number one. Number two,
you got to eat for your mitochondria.
You cannot overload them 24 hours a day.
They actually have to have down time.
And the more down time they have, the
more repair work they do and they will
actually make more energy and it's a
paradox.
If you
begin to gradually restrict the time you
eat down to about 6 to 8 hours a day,
you will develop much better functioning
mitochondria, you actually have a better
gut wall because you're not working on
digestion 24 hours a day
and you're going to protect your brain.
Dr. Dale Bredesen and I who he wrote The
End of Alzheimer's have become friends
through the years.
And Dr. Bredesen says, "Look, if you
want to protect your brain,
restrict your eating hours down to about
6 to 8 hours a day and it's the number
one thing you can do to protect your
brain
by restricting your eating." It's like,
"Really?"
Wow, okay. So, this is extraordinary.
When you take your um the three paradox
books that you've written together, you
really get a a pretty holistic picture
of what is going on. I'm super excited.
So, obviously people can find your book
on Amazon wherever books are sold. Uh
how else can they stay in contact with
you?
So, come to the Dr. Gundry podcast.
Um you can get it wherever you find your
podcast. We're a part of Podcast One
now, so we're readily available. Uh
please visit me at drgundry.com
or gundrymd.com,
my uh supplement and food company.
I'm on Twitter. I'm on Instagram. I have
two YouTube channels. I would do
recipes. I cook. Uh just did another
recipe this week, so
um
and hopefully I appear on your email
visiting you every day, so.
[laughter]
Nice. Awesome. Well, thank you so much
for joining me. This was really
wonderful. And guys, I'm telling you
this stuff is so important. There are
few things that have had a bigger impact
on my life than diet. For the most part,
it's been uh the amplitude of effect was
bad because of what Lisa went through.
Um but it is such a key component once
you get it down how good you feel, and
um Dr. Gundry talks about that in the
book that there's nothing that tastes as
good as feeling alert and energetic
feels. Um so keep that in mind. It
really is a game changer. And speaking
of game changers, if you haven't
already, be sure to subscribe. And until
next time, my friends, be legendary.
Take care.
Thank you guys so much for watching and
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