Video summary
Experts in longevity science argue that aging can be reversed through specific lifestyle interventions centered on muscle maintenance and cellular repair, rather than accepting a fixed biological limit. A central concept discussed is the role of sirtuins, enzymes responsible for responding to survival threats like hunger or physical adversity. These enzymes require NAD as fuel and are accelerated by molecules such as resveratrol found in red wine. To activate these protective mechanisms without causing lasting damage, experts advocate for "pulsing" stress—engaging in intense exercise until breathless or practicing intermittent fasting a few times a week to trigger repair systems like autophagy. This approach contrasts with chronic calorie restriction, which can make organisms miserable and aggressive; instead, the goal is to simulate ancestral threats, such as running from predators, by occasionally pushing the body's limits while allowing adequate recovery periods. The quality of protein intake emerges as another critical pillar for longevity, with muscle identified as the primary organ responsible for extending life span. High-quality animal proteins are emphasized because they provide essential branched-chain amino acids (BCAAs), particularly leucine, which is necessary to trigger mTOR and stimulate muscle protein synthesis. Grazing on low-protein meals fails to reach the threshold required to activate these repair processes, leading to a "skinny fat" state where tissue degrades over time. While plant proteins are often preferred for ethical reasons, experts note that they require significantly higher caloric intake (25-40% more) and lack sufficient BCAAs unless supplemented with branched-chain amino acids. The consensus is that protecting muscle mass through high-quality protein dosing at specific meals helps prevent diabetes, heart disease, Alzheimer's, and other age-related conditions by keeping inflammation low and metabolic function optimal. Exercise strategies must also be tailored to avoid diminishing returns and potential harm associated with overtraining. Research indicates a law of diminishing return where exceeding 60 minutes of intense exercise or 90 minutes of moderate aerobic activity increases mortality risk and can lead to heart enlargement and arterial stiffness. Instead, experts recommend hacking the environment to maintain low-level physical activity throughout the day using standing desks, kettlebell swings, or walking meetings, ensuring that formal gym sessions are merely an option rather than a necessity. The ideal regimen involves functional movements like lifting heavy objects occasionally and sprinting, which mimic ancestral behaviors without overloading joints. Furthermore, activities involving cold exposure, hypoxia (such as holding one's breath underwater), and sensory deprivation through swimming can provide meditative benefits while enhancing cellular resilience. Sleep quality is presented as a non-negotiable component of longevity that directly impacts cognitive function and immune health. During sleep, the brain undergoes critical processes including memory consolidation, where unnecessary short-term memories are cleared to prevent hippocampal overload, and deep repair cycles involving microglial cells in the brain. Disruptions like sleep apnea or frequent waking can restart these biological clocks repeatedly, preventing sufficient REM cycles needed for restoration. Experts emphasize maintaining a strict circadian rhythm by going to bed at consistent times without alarms, prioritizing 6 to 6.5 hours of high-quality rest over quantity if necessary. This dedication to sleep supports the body's ability to detoxify and repair itself overnight, which is essential given that modern sedentary lifestyles have disconnected humans from their natural movement rhythms. Ultimately, the pursuit of longevity requires balancing scientific optimization with quality-of-life considerations rather than sacrificing immediate enjoyment for a hypothetical extension of life. The speakers discuss "antagonistic pleiotropy," noting that evolution prioritizes health and reproduction until roughly age 40, after which repair systems may become complacent unless artificially stimulated through diet and exercise. While some individuals feel compelled to endure strict diets or grueling workouts based on data promising extra years, others argue for a more hedonistic approach where one enjoys life in the present moment without excessive sacrifice. The ideal outcome is defined not just by living longer but by remaining functional—able to carry groceries, play with grandchildren, and maintain balance well into old age—which requires a bespoke routine combining nutrition, movement, sleep hygiene, and stress management tailored to individual needs.
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There's actually a DNA clock that tells
our bodies how old we are. We I could
take your blood and read it
and I could tell you roughly when you're
going to die.
There's just too many people who aren't
exercising enough or correctly at all.
They're just sort of withering away.
If people could do one thing and leave
this conversation with nothing else
other than muscle is the organ of
longevity and eat high-quality protein.
Anyone who says we've reached our
maximum limit doesn't know what they're
talking about.
Well, so I've been studying these
enzymes, the sirtuins. Uh, we have seven
in our bodies. I've been studying them
for about 25 years.
And what we've learned is that they
respond to the cellular environment. Uh,
there's a chemical that they require for
gas. Think of them as the fuel, called
NAD. And there's another molecule that
is like the accelerator on the enzymes.
Uh, that makes them go even even faster
and that's one of them is called
resveratrol, which we discovered years
ago from red wine. And together they
actually do really great things on these
enzymes and make them keep the body
younger at least.
For 25 years we've been studying mostly
um, animals. Um, and even little fungi,
uh, yeast cells. And what we've learned
from those studies is that these are
largely
involved in responding to when organisms
are under threat of survival.
So how do you make the body feel like
it's under threat? Adversity. Uh, so one
is run a lot or at least become out of
breath, you know, a few times a week.
Your body will say, "Oh man,
we had we had to outpace one of those
saber-tooth cats again. Got to got to
build up the body." Um, the other is to
be hungry, either a couple of times a
week or every day, you know, skip a meal
or two. And then your body will turn on
these sirtuins, make more of that fuel,
NAD, for the enzymes. And we think
that's what's
in part responsible for the health
benefits of those uh, lifestyle choices.
All right, one thing though that you
talk about that I found really
interesting is this notion of what may
be good for you when you're young may
come back to bite you in the ass when
you're older. So, it's like um the whole
notion of hormesis that a little bit of
bad is actually extraordinarily good,
which is exactly what you're describing
now. Get out of breath through all the
stuff. And so, when the information
started pouring out that the only thing
across every known um living organism
that extends lifespan is the eat less,
which you talk about in your own book,
it feels like you're saying to do it for
that reason. Just don't put as much
stress on the system. But now I hear you
saying, "No, no, no, what you actually
want to do is stress the system." Won't
that stress of I just ran from a lion,
[ __ ] I'm starving, won't that begin to
stack up and become problematic?
Well, actually if if you step on a
snail, it's going to die. So,
there's certain amounts of stress that
that you don't want to do. But what you
want to do is get the body to fear
adversity in the future, but not enough
to cause lasting damage or the
unspooling of the DNA that'll lead to
disease and eventually death. So, you
you don't want to overdo it. You want to
be a little bit puffed, you want to be a
little bit hungry. But of course,
starvation, malnutrition is not going to
make you live longer. So, it's a fine
line and what we've learned from many
animal studies and increasing numbers of
clinical trials in humans is that you
want to pulse it. Let the body recover.
Not constant. We used to make animals go
hungry all their lives and it worked,
but it actually works better if you let
them recover and I think that's that's
the secret.
Then let's really dive into that. So,
I'm guessing you're talking about where
um animals were denied something like 20
to 30% of their caloric intake for very
long periods of time is extending their
life by what, like 30% or something? Um
so, super interesting. But you're saying
that if their caloric intake over a long
period of time is roughly the same as an
animal that's just allowed to eat until
it's satiated, that if it's done in a
pulse pattern of hunger and and almost
overfeed,
Yeah.
they actually have the same benefits as
the animal that has a chronic deficit of
calories.
All right. Well, well, let's be clear.
Nobody knows what the perfect diet is,
even when it comes to fasting. It's all
largely based on
rodent studies. So, what I can tell you
about the rodent studies, which I'm very
familiar with, is that if you take a
rodent and reduce its calories by 25%
for its whole life,
it will live longer, 30%, but it'll be
really miserable and aggressive. Uh and
that's true for us as well. I've tried
calorie restriction for about a week and
I gave up. I was pretty angry. But, what
we discovered, our my colleagues um
discovered is that if you
it's not just what you eat, it's when
you eat that's important. And what's
been found is that if as long as you
have that period of hunger,
um in a mouse, so you can feed them
every other day, then they can gorge
themselves as much as they want, and
they do. They eat about 90% of what a
mouse having free access to food would
eat.
Uh
but they
they have the same longevity benefit as
a mouse that's always been hungry. And
if that's true, what that means is for
us is that we can enjoy life as long as
we have that period of hunger once a day
or maybe twice a week. And I believe the
only reason we age,
um
you know, we could live for a thousand
years otherwise. The only reason we age
is that our repair systems become
complacent. You mentioned that what what
is beneficial for you when you're young
comes back to bite you when you're old.
What we think is that these repair
systems are very good when we're young.
So, the idea is it's called antagonistic
pleiotropy, and I think it's right. And
that is that we evolved to stay healthy
and alive and fit till we're 40,
and then the the forces of natural
selection decline after that cuz we've
essentially bred.
Right.
We've often had children,
but we don't need to stick around beyond
that. And building a a body that will
last a thousand years
Right. is pointless at that, you know.
So, most species only live as long as
they need to to reproduce, and then a
little bit more.
If you're a mouse that could die within
two years, they only build a body that
last two years. If you're a whale that
has no predators, you can live for a
couple of hundred years. That makes more
sense.
Hope you enjoyed the episode, brought to
you by our sponsor Ombre Labs. Get 70%
off your at-home gut health test when
you go to tryombre.com/impact.
Enjoy the episode.
If people could do one thing
and leave this conversation with nothing
else other than muscle is the organ of
longevity and eat high-quality protein,
animal protein and plant protein are
totally different, and if you have a
diet of plant protein and it's very hard
to sustain and calorically devastating
cuz you need between 25 and 40% more.
So, it's like six cups of quinoa for one
small chicken breast. If you really
wanted to think about the amino acids
necessary to stimulate that tissue. And
listen, that's not the only way to do
it. Could we add in branched-chain amino
acids to lower-quality protein?
Absolutely. But why would you do that
when we have you know, cattle or a
ruminant that have that we've been
consuming for two and a half million
years and have the capacity to take
low-quality plant nutrition and produce
high-quality
nutrition with that is nutrient-dense
and highly bioavailable for humans.
So, I understand I've heard you say the
same thing. Like, I understand people
have they may have a um
a moral desire to eat plant-based food,
and I get that, dude. As somebody who's
absolutely just love animals, and I long
for the day where we can lab grow meat
and that there was never an animal um
involved in that process, but I'm also
just selfish enough to say I'm going to
protect my health.
Um, you know, when you look at obviously
sustainable farming and things like
that, I'm all for it. I couldn't be more
behind that. Um, but wanting to
understand sort of at a mechanistic
cellular level what's happening, and I
don't care what the answer is, vegan,
vegetarian, animal, a mix thereof, um, I
just want to understand like at a
cellular level what's happening, um, and
to get that, I think understanding the
what branched-chain amino acids are, why
they matter, and how the profiles differ
from plants to meat, I think it'd be
really helpful.
Yeah, I I couldn't agree with you more.
So, really the quality of our diet, and
this is globally, the quality of our
diet is largely dependent on protein.
So, there's 20 amino acids,
and nine of those are essential.
Of those essential amino acids, you have
to have
meaning I I cannot produce it in my
body.
Exactly. So, the key branched-chain
amino acids, and when you think about
branched-chain, it's just a structure,
right? It's just a nomenclature. You've
got leucine, isoleucine, and valine.
And out of those three, which by the way
should all be consumed together, cuz
everything in life has its own balance.
Of those three amino acids, leucine is
the most relevant for protecting the
organ of longevity. And on a cellular
level, having the right amount at one
time, dosed appropriately, which is
where that 2 and 1/2 g, that's from the
that's just from research. You know,
it's really truthfully it's between 1.8
to 2.5 g of leucine, which the majority
of people are not going to go,
"Hmm, how much leucine is in my food?"
right? It's not on the back of a label,
which just goes to show you how protein
has been the black sheep of the
macronutrient family for decades. When
you look at a label, all it simply says
is protein.
But understanding on a cellular level
that really eating protein at a
meal-centric
dosing, meaning you at one time, you're
not drinking protein shakes over a
course of 2 hours, but at one meal at a
bolus amount, you are getting
between 30 and 50 g of protein, which
would translate to between 4 and 6 oz of
high-quality protein would reach that
leucine threshold. So, once you reach
that leucine threshold, you trigger this
um
this complex called mTOR.
mTOR is a mechanistic target of
rapamycin, which then is actually a
nutrient sensor.
Anything below that, the body's like,
"Mhm, I don't care. I'm not going to put
on muscle." Or, "Mhm, I don't care. I'm
not going to really stimulate this very
expensive, elaborate process for the
body."
It doesn't care.
So, that's where you get skinny fat
because you're grazing all day at this
low-threshold meal, especially important
in aging because you don't have that
flexibility.
And when I say aging, I'm talking about
40s.
You know, you've got to stay on top of
it, but once you reach that threshold of
arguably 2 and 1/2 g of leucine, which
you could have a 2 oz of fish and then a
scoop of branched chain and get up that
leucine level. But, mechanistically, you
need that branched chain, that essential
amino acid to then
trigger the rest of what needs to happen
for muscle protein synthesis. And
listen, the way that they measure muscle
protein synthesis,
it's not like you eat it and then you're
laying down protein. It true I mean,
that's not an accurate assessment,
right? I would be
um not being truthful if I said that,
but it really is a period of time over a
period of time as you continue to do
with anything correct, optimized habits,
you then can protect tissue.
And protecting tissue is everything.
You know, and it's very dangerous
because when people do weight loss,
you know, you lose some fat, but you
also lose tissue.
And now we're in a situation where we're
not outside and we're not doing
resistance training,
and we're not actually moving that
endocrine organ.
So, you know, it becomes much more
difficult to maintain and recoup that
tissue. And the tissue is just one
aspect. It's truly the metabolic
aspects,
you know, of the of muscle. And if you
want to prevent diabetes,
heart disease, Alzheimer's,
cardiovascular, you know, cardiovascular
disease, that whole spectrum,
tissue, you know, muscle tissue will do
that for you. And then you put on
high-quality protein,
you're going to keep inflammation low,
you're going to keep calories in check,
you're going to upregulate your thermal
effective feeding. These are all really
important. You're going to do You're
going to have a lower blood pressure
because some of the amino acids, one in
particular, helps lower blood pressure.
I mean, this is amazing stuff. It's a
muscle-centric approach to wellness, and
the paradigm is totally wrong.
Human beings are wired, in a certain
sense, to go out and slay dragons, to
climb our own personal Mount Everest, to
to get out and and and just to move,
right? Living in a modern,
post-industrial, largely sedentary era,
we no longer are scratching that itch
with our jobs. Unless you're lucky
enough to be a construction worker,
or a painter, or, you know, like my wife
out there, you know, bringing alfalfa to
the goats in the wheelbarrow, and taking
care of the chickens, and pulling weeds
out in the garden, and just being out in
the sunshine, lifting heavy rocks every
once in a while, uh or maybe, you know,
you're you're a you're a
hunter-gatherer,
if you don't fall into any of those
categories,
you get to the end of the work day or or
start the beginning of the work day and
you do have this ancestral itch to move.
And hence, we now live in an era of
CrossFit boxes and pop-up gyms and quick
done-for-you 45-minute super brutal
exercise sessions to replace what would
have normally just been our day-to-day
job 100 years ago. And you know
up until very recently, gyms and
exercise and beating up and buffeting
the body, that was the realm of athletes
and gymnasts and and warriors and
knights and gladiators and it wasn't
something the average person really even
felt the pressure to do. You know, you
want to survive, you want to get through
the day, you
you want to move and this idea of of
intentionally starving yourself or
fasting and also intentionally beating
up the body with exercise, like this is
a relatively new phenomenon, you know,
in an era where we're where we're
sitting all day and surrounded by food.
You know, we've had to figure out a way
to to kind of kind of fight that battle,
right? So, we fast and we exercise. But
the idea with exercise is of course we
don't see to in return and kick this
horse to death. Not many of the blue
zones or longevity hotspots engaging in
formal exercise sessions, right? They
are moving, lifting heavy things every
once in a while, you know, occasionally
sprinting or playing game of soccer or
tennis or you know, if you look at it in
in terms of like an ancestral context,
maybe running from a lion. But you know,
we're we're not doing a lot of those
things now and so we need to to go to
the gym. Now, what research has shown is
that you know, to respond more directly
to your question about how much
more than 60 minutes of intense
exercise, let's you know, let's say like
a CrossFit intensity. Once you exceed
about 60 minutes of that, which sounds
ridiculous, but I know a lot of people
who are who are literally pushing
themselves with two-a-days or or
exercising hard more than 60 minutes a
day, you see a law of diminishing
returns and an increased risk of
mortality. And in the same way with
aerobic exercise, let's say moderate
aerobic exercise, right? Where you're
pretty aware that you're exercising.
It's not like you're out picking weeds
in your garden. Once you exceed about 90
minutes of that, you also see an
increased risk of mortality, a decreased
rate of return on your exercise, and we
see things like a cardiomegaly, like an
enlarged left ventricle of the heart. We
see increased risk for arterial
stiffness. So, it appears to be about 60
minutes of intense exercise and 90
minutes of aerobic exercise where you
definitely see a law of diminishing
returns.
And so,
what I recommend that people do
is A,
you hack your environment so that you
are somehow trying to simulate
that
all day long low-level physical activity
type of scenario. You get a standing
workstation. You get a treadmill
workstation. You litter your office or
your cubicle with things that allow you
to do short movement spurts throughout
the day, such as a kettlebell to stop
and do some kettlebell swings or jumping
jacks or, you know, I even have a hex
bar in my office with some plates on it
where I can lift heavy things every once
in a while when I take a break. So, I
work hard for 25 minutes, take 5
minutes, move, change positions, walk,
swing kettlebell, do a few pull-ups,
lift the hex bar a few time, keep going.
Uh you know, I I wait to take all my
phone calls until the afternoon when I
can go outside in the sunshine and walk
and take my phone calls. So, you figure
out a way to get your body to be to to
engage in low-level physical activity
during the entire day. The way I like to
think of it is that exercise should be
an option when you finished your day,
not a necessity. Then when you do
exercise, exercise with the minimum
effective dose of exercise. Walking is
one of my favorite modes of exercise
period cuz I can, you know, I can talk
on the phone while I'm doing it. I can
be in the sunshine, very low barrier to
entry. I can do it when I'm sleep
deprived. I can go see a city when I'm
in a city. You know, I can it can be
functional if I'm commuting. Uh but
walking speed, particularly walking at a
slightly faster rate than what is
comfortable for you, slightly faster
than your stroll rate, and being kind of
cognizant of your walking speed as
you're walking, like pushing yourself to
walk just a little bit faster than you
want to walk. Walking speed is
correlated with longevity as well. Uh
and I'll I'll throw one other at you. Uh
this particular mode of exercise
involves cold exposure. It involves
hypoxia. It involves some amount of
sensory deprivation, you know, swimming.
Just swimming.
Just swimming. Interesting that you call
that sensory deprivation.
Oh, if you've uh you know, this is one
of the favorite things I like to do in
the mornings when I travel is I'll get
into a pool at the hotel and I go under
the water. I hold my breath. I go under
the water back and forth. And when I
need to come up for a breath, I come up
for a breath, and I train myself how to
control the heart rate. And it's even
better if the pool's a little bit cold,
right? So, you're getting some of your
cold therapy. And then as soon as I
recovered my breath, I go back under,
and it's peaceful, and you can't hear
much other than the little swish of your
hands or the swish of your feet. Your
heart rate's up. You're training your
breath. You're a little bit cold, and
you're sensory deprived. So, you almost
get a very kind of meditative feeling
from it.
So, swimming.
Swimming would be the one.
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So far my my exploration to this topic
has has suggested a couple of things.
So, one is we do tend to
disproportionately load joints over
muscles.
So, in an ideal world, you would want to
figure out a way to exercise where you
can maximally load the muscle while
minimally loading the joint. So, there
is a lot of joint failure that becomes
problematic. I mean, and I'm separating
the obvious, which is there's just too
many people who aren't exercising enough
or correctly at all, and so they're just
sort of withering away. But, if you
come at this through the lens of, okay,
well, what if we're dealing with a
subset of people who are committed to
figuring out how can they exercise best?
In many ways, it's just a lack of
specificity, right? So,
most people who exercise can't actually
tell you why they're doing what they're
doing. The 99.9% of us who don't get
paid to play a sport and who aren't even
really competing at a serious level
outside of the professional ranks,
I don't think we know what our sport is.
And I think the sport should be being
the most kick-ass 100-year-old that ever
lived.
So, what would that look like? Like,
what does it mean to be the most
kick-ass 100-year-old? And I think you
have to then reverse engineer all of the
things one should be able to do.
So, a kick-ass 100-year-old should be
able to I I don't know. I'm making this
up because I haven't fully codified this
yet, but they should certainly be able
to carry two 25-lb bags from a grocery
store. They should be able to lift a
30-lb or 40-lb bag over their head to
put it in a you know, compartment of an
airport uh of an airplane. They should
be able to have a you know, 25-lb little
terror run at them, you know, I either
great-grandchild or dip down into a
squat and grab them and pick them up.
They should be able to jump down on the
floor and play with cars or dolls and
stand up without assistance. And if you
start to map out the 25 or 35 things,
that becomes a new decathlon.
So, instead of saying the decathlon is
running this distance, jumping this far,
swimming this far, it's like, great.
Those are kind of arbitrary. Now, we're
going to come up with like real-world
things that you have to be able to do
when you're 100 if you want to live
what I would describe as potentially a
more fulfilling physical life to enjoy
the fruits of having not died by that
point in your life.
All right. So, how do we build towards
that? I love this, by the way. Like, I
always tell people, I want to live
forever. I'm well aware that as of right
now, I'm going to die. Um so, my thing
is, how do we stay alive long enough to
give time for these step function
breakthroughs to happen? So, what do I
do? Like, what are the things that I
train or the hormone replacement
therapies that I need to go What do I
need to watch? What are those things
that I should be doing?
Taking a step back, I would say 3 years
ago, 80 to 90% of my energy went into
how to not die.
Which basically Yeah, which is
tantamount to how do you delay the onset
of chronic disease? So, the mathematical
equivalent of longevity from a lifespan
perspective is creating a phase shift in
disease onset.
If you want to live to a hundred,
it basically means you have to delay the
onset by about two decades of every
major chronic disease. So, it doesn't
mean you can't get cancer or heart
disease or any of these other things,
but you better figure out a way to get
them 20 years after the average person
gets them.
I would say now that occupies 50% of my
brainwave energy, whatever, and much
more time goes into two other things,
which is how to minimize suffering,
which is kind of an emotional problem,
and then how to be this kick-ass
100-year-old. So, to the latter, um
the model I have in my mind is that of
sort of Bruce Lee. Bruce Lee sort of
looked at each and every discipline of
martial arts, including boxing and
wrestling and things like that, and
said, "Let me extract from each of these
disciplines that which I believe is
useful, discard those that I think are
useless, and create a perfect fighting
form that is truly geared towards
self-defense. So, it is not a sport,
there is no tournament, there is no
rank, there is no belt, there is no
sensei. It is Can you handle yourself in
a life-or-death situation?"
If I go to a yoga class
or if I do a Pilates class, invariably
there's something in there that I think
is really valuable. And truthfully,
there's a bunch of stuff that I'm like,
I don't need this. This is just If I had
infinite time, this would be fine to do,
but I don't have infinite time.
So, now you apply a constraint to the
problem, which is not only do you want
to be sort of the best 100-year-old
imaginable, what if you're only willing
to spend 10 to 12 hours a week preparing
for that?
And so, you say, "Okay, well, so there's
a new sport, which we defined some of
the parameters of. That's your new
Olympics, and that Olympics is 50 years
from now. How will you train for it if
you're only willing to spend 10 to 12
hours a week training for it?"
Well, my guess is you will take a lot of
things
from various disciplines, discard a lot
of things, and sort of have to build a
very bespoke routine around it that will
involve the maintenance of muscle mass,
joint integrity, flexibility, uh
functional movement, balance, things
that we don't even really think about
anymore. How many times does someone
who's 90 fall because they've lost their
balance? And it's that fall that
ultimately leads to their demise.
How much of that the balancing do you
think is neurological and how much is
physical? They're just not doing enough
physical [ __ ] to figure out to maintain
that.
My guess is it's probably both. There's
a stability issue that starts to go away
as you age. Also, the consequences of a
fall become much more apparent. So,
um
it's probably not just the case that
someone who's older falls that much
more. It might be that the the severity
of the injury becomes so much more
severe. So, right now, if I were walking
here and I tripped on that stair and
fell,
you know, maybe on a really, really bad
day I break my wrist. Right. But most
likely nothing happens. Uh
in 50 years, if I do that same thing,
the probability that something bad
happens is going to be much greater.
Yeah.
Um but that said, I already can tell my
balance is not what it was when I was
20.
Mhm.
When I was 15. I mean, I used to do I
used to be able to do this exercise when
I was 15 where I would do a with
blindfolded I could do a single leg
squat with the with the non-squatting
leg straight out in front of me. So, I
could go all the way to the floor and
all the way up, arms crossed,
blindfolded, I could do 20 each leg. I
can't do that once today with my eyes
open.
Mhm.
So, admittedly, I'm nowhere near as
strong as I used to be, so there's a
strength component, but I also just
clearly lack the balance.
And so so the question is
now maybe that activity is a bit over
you know, it's that's just unnecessary.
Um and again, I don't know what the
answer is. I don't know if this means I
need to get out there and practice on a
tightrope or something like but there's
there's something that needs to be done.
So,
every time I do some sort of really
well-thought-out workout, I find myself
thinking, "God, like some percentage of
this is so essential.
Mhm. All of those things need to be put
into this new discipline, this new
sport, which is called, for lack of a
better word, being a kickass
100-year-old."
So, for me it came out of necessity,
right? I was in my late 30s and I was on
QVC all the time and I remember one day
I was getting my makeup done and I was
like,
"This is crazy. I feel like I just
accelerated my aging overnight.
Something happened and it's really weird
because it's taking so much more time to
sort of bring my glow out and my skin
feels dull and I feel like dull
energy-wise and this is not going to
work for the amount of things that I
want to do in my life. And I think for
every single one of us, right? Sometimes
you can have this feeling of "Oh my god,
I'm like held back by just sort of this
toxic feeling inside." Um and I became
really passionate about this idea of
what is it at the cellular level that
will give me that energy back? And I
knew that my cells were either building,
like building up, you know, through the
protein and the different nutrients, or
they were detoxing. And this is very
much the layman thought process. I was
just thinking they're eliminating
crap, right? Like my cells are either
building on themselves and they're
replicating or they're eliminating junk
and maybe they're dying off, but I
didn't know that there was an actual
biological process that occurred. So,
fast forward to Italy, I'm in the
orchard with this brilliant PhD, Dr.
Elizabeth Janda, and she opens up a
citrus bergamot fruit, shows the white,
gives it to me, I'm eating it. We go
back to our lab, we're drinking this tea
all day long, this citrus tea. I'm like,
"I love this tea, but what's the deal?
Like I've never drank so much tea other
than when I was in Japan where they were
just drinking green tea three, four,
five cups a day. And she was doing the
same with the citrus tea and she's like,
oh, it's my anti-aging secret. And um it
activates my autophagy.
Like a
That What's that word?
And I started to learn from her. She
explained to me that this process is
something that we all have in every
single one of our cells. It's almost
like a little doctor inside of each of
your cells that says, okay, time to
recycle this part. These organelles need
to be removed. This needs to be killed.
This needs to be strengthened. And so
autophagy is like this brilliance within
our cells. And there's so many ways to
activate it and there are so many ways
to deactivate it. You don't always want
to keep it on, right? Like it's it's
kind of like the ocean back and forth.
So she told me about it and I came back
to US and I was obsessed and I was on a
mission. And that was like five years
ago.
And I knew
when my when I looked at my skin and I
saw that I had experienced these
accelerated agers
and I looked older than I was and I
actually looked at a picture of my
mother at 37 years old. I grabbed this
photo of her and I looked at a picture
of me and I looked so much older than
she did.
Woah.
Like this is really messed up.
Like I know I put a lot more stress on
myself. You know, I travel around the
globe like on average eight times a
year.
Woah.
Yeah, I'm I'm on the go.
Um so I'm dealing with a lot of that. I
have four kids, you you
built I was running, you know, Twinlab,
CEO of Twinlab. I had sold my company to
them. Um public company.
So, all of these factors
put stress,
but still, I shouldn't have been looking
that much older than my mother. And so,
that's when I got into activating
autophagy.
Okay, that's really interesting. And
let's um sort of bring it down from the
scientific for a second because so, I
heard you on um Bulletproof Radio, and
Dave was talking about how wow, your
skin really looks good in person. And
so, the second I saw you, I was like,
"What's going on with this guy?" It
really is fascinating seeing you up
close. Like, truly, your skin is
phenomenal. Um so, now becomes a
question of what are you doing on a
daily basis? You've talked about things
you put on your skin, which I thought
was super weird, but maybe you want to
go out and do it. Um and you were
talking about like coffee grounds and
all kinds of crazy [ __ ] So,
walk us through the things that you eat,
and then walk us through the things that
you apply externally.
Okay. I I consume tons of super herbs,
tons of power phenols.
Okay.
Um which is like cacao and and a lot of
those things. I eat a ton of
microgreens. So, that's like broccoli
sprouts.
Mhm. Microgreens?
Yes. So, like little sprouts.
Uh-huh.
So, when you go to Japan, you should be
taking sulforaphane, which comes from
the broccoli sprout, because it's an
incredible autophagy activator and
detoxifier. So, you're going to be in a
very polluted city.
Yeah, you can take it in a supplement
form. You can find it anywhere.
Sulforaphane um is it's really awesome.
Okay.
So, I take those foods, those
supplements. I personally um really
benefit from a ketogenic diet. It
reduces the inflammation in my body.
There's maybe what, 15 or 20% of the
population that does well on a low-fat
carb-rich diet, but the rest of us just
are better off, you know,
I'll very much put myself in that camp.
Um do you live in ketosis, like year
round?
Yeah. I only got um, really into it
about a year and a half ago myself
personally. I had um, maybe eight years
ago, one of um, my translator had
cancer, and so we put him on a ketogenic
diet um, with his cancer, and that was
many years ago. And um, that was based
on Tom Seyfried's work, and
um, one of my children, my
seven-year-old has suffered from
seizures, so he's ketogenic, so he was
ketogenic before I was.
And uh, a year and a half ago, I was
just like,
I have to figure out how
I myself, my family, my mother, I mean,
you spoke about metabolic um, disorders,
and you know, metabolic syndrome, and
and and obesity, and morbidly obese. Um,
when we moved to this country, my mother
developed metabolic syndrome.
Interesting.
And uh, that has been the most one of
the most painful things for me
personally, cuz I couldn't solve it for
her.
So, a year and a half ago, I interviewed
over 80 experts, and I created a
documentary called The Real Skinny on
Fat. It's a free documentary, it's
online.
And um, I got so inspired by these
genius minds
that I went ketogenic, and I haven't
gone back.
When you're sleeping,
what will happen is
it you have this thing called a
circadian rhythm.
And
animals are really good about not
screwing up their circadian rhythm.
All right? Like, the birds don't wake up
late. There's not a bird that's like,
you know, oh, I don't get up until noon.
Right?
They just get up. Right? And they go to
bed at the same time, and so what that
does is it really sets this biological
clock, so that everything happens on a
on a 24-hour cycle.
And certain hormones need to be released
at certain times.
And then certain repair mechanisms need
to happen at the immune system level or
in your brain.
Um and you can be quote unquote
sleeping, but if you're not really
sleeping well, like you're have sleep
apnea or you keep waking up or you have
a lot of anxiety,
then you're not going to be able to go
into deep sleep. You're not going to get
enough REM cycles,
you know, and every time you wake up,
you restart the whole sleep system
because you have this thing called sleep
inertia. So, your first REM cycle takes
a long time.
Takes over 2 hours usually for you to do
that. And then every successive REM
cycle, it can be
um compressed.
So, in 7 hours, you could easily get
four REM cycles.
But if you keep waking up, you could be
in the bed for 9 hours and never get it.
So, I hate sleep. Uh if I didn't need
it, I wouldn't get it. I fully
understand I actually prioritize it in
my life. It's one of the most important
things that I do. Um if I had to guess
though, I average without an alarm
clock. I never set an alarm clock. I
always go to bed at the same time. I'm
very aware of my circadian rhythms, but
just in terms of where I'm at in my
life, levels of excitement, levels of
stress, whatever, I probably average
about 6 to 6 and 1/2 hours of sleep a
night. Um and one thing that I heard is
that while you're sleeping, your brain
actually shrinks and or de-inflames
maybe is the right way to think about it
and allows like a a brainwashing, if you
will.
Um is that what's happening or is there
something else going on um during the
different phases of sleep that make it
so critical?
Yeah, so there's a lot more going on.
And really probably one of the most
important things that's going on are the
immune cells that get stimulated in your
brain.
So, these microglial cells and these
astrocytes that are in your brain, they
they're doing all the repair.
And they're more active during the
night.
Um the other thing is that your brain is
taking all the memories from the day
and you're forgetting.
Forgetting is really the most important
process because your hippocampus will
just get full of all these proteins that
just get accumulated during the during
the day. You don't want to remember like
every single little detail of the day.
You just don't have that capacity. And
if you don't make sure that you process
all that short-term memory and free it
up, the next day you're going to be
compromising your ability to remember.
This is This is the the generational
difference between the two of us, Tom.
So So like, you know, you're looking for
the hacks. Like, what's the ideal? How
do I live the longest and how do I live
you know, and how do I optimize that?
And and I have to take everything
together and I say, well, first of all,
I don't care if I live forever. I don't
want to live forever. I don't need to
live forever because what I'm of that
mindset that what defines my enjoyment
of life right now is partly offset by
the knowledge that it ain't going to be
there one day. So I'm trying to, you
know, meet out the the pleasure over a
finite period of time.
Again, I talk about like if there's if
somebody said, "Look, you got to eat
this, Mark. It tastes like [ __ ] but
you're going to live 5 years longer and
you're going to have to eat it twice a
day." I'm like, "I'm out. I don't need I
don't need to um sacrifice the sort of
short-term hedonistic experience
uh that I crave, you know, whether it's
a
serotonin or dopamine. It's just I want
I'm looking for that. And if you tell me
that it's been proven by science that's
going to have me live 5 years longer,
I'm probably going to reconsider
whether, you know, it's worth the
sacrifice of the of the of the immediate
experience because
you know, as you get as we get down to
this, we can talk about what happens in
20 or 50 years from now, but right now
all that matters is is this moment. I'm
hanging out with with Tom Bilyeu. We're
having a great conversation. That's all
that matters to me right now. Uh and I
want to I want to be in that moment as
often as I can.
Um and it takes it takes work uh for it
for as long as I can and not have to
make a sacrifice of whatever today's
experience or now's experience is
because somebody did some research that
said you know if you do it differently
and and you sacrifice significantly um
you'll live longer. I'm like, well,
okay. Quality of life has to factor into
the equation. Uh you know, you can't
just tell me I'm I'm going to live
forever and then say, but your life's
going to suck and you're and you're
going to some you know, whatever. Right?
So
No, no, I totally get it.
I'm I'm rambling on here. Sorry about
that.
Not at all. That that's super
interesting to me. I love that people
come at this stuff from different
angles. Um so to that point, so you have
a very specific way of looking at the
world and and you just laid it out for
us. If you could only have five
ingredients, not uh five meals, but five
ingredients. So, it could be uh filet
mignon, it could be asparagus. What are
the five things that that you would want
if that was all you could eat for the
rest of time and you wanted the the kind
of life you have now. So, it's
delicious, but it's also, you know,
cognitively it's great.
On and on.
What No, what's interesting is because
um the
typically people ask me what are like
what are some of the things that you
wish you could eat every day but you
can't. And to me, it's peanuts and beer.
Like, I could live the rest of my life
on peanuts and beer.
That's amazing.
I can't eat I can't I can't eat peanuts
cuz they're horrible for me. And and you
know, I I I I still like beer, but I I'm
limited to like a half a glass once in a
while.
Um No, I mean, my my my favorite food of
all is lamb. So, you know, a lamb lamb
chop would be one.
Um probably pick if I had to pick a
vegetable, you know, broccoli's probably
my favorite vegetable.
If I had to pick
some sort of a starchy tuber,
don't don't think I'm weird but um
like either turnips or rutabagas with
butter.
I did not see that coming.
No, nobody does. I like the I like the
real bitter aspect of that.
But I'm I'm sort of picking one from
from each of these categories. Right? If
I sort like a fruit. If I had to pick a
fruit, it would be
like Bing cherries. I think are
probably, you know, one of my favorite
fruits.
And
um
you know, and probably
red wine. And and I could live the rest
of my life on those on those five
things.
Word. Those Those are some fantastic
choices. Respect. So, we talked about
this the last time we met. I was I did a
rabbit starvation diet which is
basically 85 or more percent of my
calories came from protein. Took my fat
as low as I could. My carbohydrates were
essentially zero. My doctor loved me. He
was telling me I was going to live
forever but I felt like [ __ ] And when
you talk about steer by how you feel and
not, you know, worry so much about all
the things you can measure,
that seems wild.
There's a great example. You're born to
measurement than you.
Feeling certainly trumps everything.