Video summary
The episode begins with a discussion on the unprecedented strengthening of El Niño, which researchers have identified as the strongest event in over a thousand years based on coral records from the Galapagos Islands. Data indicates that while ocean warming and cooling cycles existed since around 1100 AD, there was a period of relative stability until the industrial revolution, followed by extreme increases starting in 1984 that have continued to the present day. This finding highlights how current climate conditions are unlike anything seen in recent history, serving as a stark reminder of the need for weather precautions and infrastructure resilience against such powerful natural phenomena.
In space exploration news, NASA successfully launched the Nancy Grace Roman Space Telescope, a mission built upon repurposed spy technology that has arrived ahead of schedule and under budget. Unlike previous missions like Hubble or Webb, this telescope boasts a massive field of view capable of observing 12% of the sky at once, allowing for detailed studies of exoplanets, black holes, and dark energy. However, the host expresses concern that no other major NASA telescope missions are currently scheduled, urging Congress to support continued exploration efforts rather than leaving space science solely to private corporations or foreign nations.
The show then explores several intriguing scientific concepts, including a new theory suggesting that dark matter might exist in macroscopic forms like asteroids or hailstones rather than just subatomic particles, which would leave detectable damage signatures within our own solar system. Additionally, a study on conservation efforts reveals a "beauty bias" where ugly or drab butterfly species are often ignored by the public and databases, despite being highly endangered, whereas charismatic megafauna receive disproportionate attention. Other segments cover the gut-brain connection linking specific microbes to emotional states like anxiety and depression, and a discovery that raindrops carry electrical charges that cause rapid corrosion on metal surfaces, necessitating better protective coatings for infrastructure.
Finally, the episode concludes with promising research into Alzheimer's disease using a platform called "nano eraser," which can convert astrocytes into neurons in mice models, effectively restoring neurogenesis in the hippocampus and reversing cognitive impairments. While this breakthrough currently applies only to mice and requires further metabolic investigation before human application, it offers hope for repairing brain damage caused by the disease. The host wraps up by thanking supporters and encouraging listeners to stay curious about these diverse scientific advancements that shape our understanding of the universe, from the microscopic workings of our brains to the vast scales of space exploration.
Read the full video transcript
This is [singing]
Twist. This week in science, episode
number 1074, recorded September 2nd,
2026.
The butterfly effect. Hey everyone, I'm
Dr. Kiki, and tonight on the show, I
will fill your head with butterflies,
dark matter, and raindrops.
But first, thanks to our amazing Patreon
sponsors for their generous support of
Twist. You can become a part of the
Patreon community at
patreon.com/thiswecience.
Disclaimer, disclaimer, disclaimer.
The future depends on today. Make no
mistake. What you choose has impact.
Ripples from each of us expand and
interact. We are not isolated islands,
but a massive ven diagram. Let's act
like our lives depend on us and enjoy
this week in science. Coming up next.
[music]
>> I want to learn everything. I want to
fill it all up with new [music]
discoveries that happen every day of the
week. There's only one place to go to
find the knowledge I seek. I want to
know what's happening. What's happening?
What's happening [music] this week in
science? What's happening? What's
happening? What's happening this week in
science? [music]
Good science everyone and welcome to
another episode of This Week in Science.
I'm back. Dr. Kiki here to talk about
science with you. I mean really it's all
about what's happened, what we're
curious about, and what other questions
we can come up with. So I'm really glad
that you have decided to spend your time
with me this week. All right. Blair is
out tonight because she's got some new
school stuff for her child and also some
possible job stuff. But, you know,
she'll be hopefully back next week.
We'll see. We'll see what comes of all
of this. We don't know. The future is
still in store. So, let's be good to
each other and let's have questions and
let's explore. All right. What do we
have tonight? I've got a big eye in the
sky. We've got some big dark matter. got
some beauty bias, a little gut brain
connection, also some raindrops on card
tops and anyway, corrosive actions and
uh maybe a cure for Alzheimer's in mice.
But before we get to all those stories,
I do want to remind you that as we jump
into the show here, subscribing to the
Twist podcast is the best way you can
get Twist wherever you are, whenever you
are on your favorite podcast platform.
We're on YouTube, Facebook, and Twitch
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And you should hit those notification
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or when we're going live. If you want
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those fun things, well, I want to make
sure that you get to twist.org, our
website. All that information is there,
in addition to links to our Patreon and
our Zazzle store. So, that's great. And
now it's time for the science. You
ready? I don't have Blair's voice here
going, "Yeah."
Okay. All right. Let's dig into the
science.
Quick call back to last week. We talked
with um with Weather West and had a
wonderful conversation about uh El Nino
last week. What a great great
conversation that was.
Just a day or two later, a new study was
published
by researchers who have been studying
coral records outside the Galapagos or
from the Galapagos Islands. And uh from
these records what and this is published
in science. What they were able to say
is that hey recent strengthening of this
eastern Pacific ENSO El Nino
oscillation right um this is the
strongest
over the last decade or so. It's the
strongest it's been in a thousand years.
So they were able to go back using the
coral record off the Gapagos from the
eastern Pacific Ocean to be able to look
at the history of ocean warming and
cooling based on oxygen events. And what
they were able to show is that hey it's
been going on since uh about 1100
AD, right? Yeah. 80 um until about the
industrial revolution where it kind of
evened off for a while until about from
about 1850 to 1984. And then there was
extreme increases from 1984 to current
day. And so as a result, where we are is
unprecedented. Woohoo. Yay. Thanks,
Coral Record.
Anyway, anyway, I just thought I'd give
you a nice reminder of our conversation
with Daniel Swain last week and
hopefully get you thinking about um
putting any weather stripping or weather
precautions into your homes or other
properties that you might have that
might be appropriate. I think that would
be appropriate.
Our optimistic wonderful news for this
week.
NASA has launched the Nancy Grace Roman
Space Telescope successfully on its
journey to the L2 Lrange point, four
times the distance the moon from the
Earth, but you know out there where it
has a nice gravitational dwell point
that it will be able to sit along with
some other spacecraft. That's not the
only one out there.
But this telescope, the Nancy Grace
Roman Telescope, otherwise known as or
priorly known as the W first telescope,
was launched on a SpaceX Falcon Heavy
rocket this week and it was able to it
it it's going on. It's going to take
three months to get to this Lrangee
point. It's not going to be doing
anything really till it gets there. Once
it gets to the launch lrangee point,
it's going to undergo similar
startup, you know, making sure
everything works similar to what we saw
the web go through. This telescope,
we're very excited about it because it's
spy technology.
Well, I mean, that's not why we're
excited about it, but it is repurposed
spy telescope technology. the National
Reconnaissance Office or Surveillance
Office had [snorts] two of these amazing
telescope mirrors that it wasn't using
because of funding that got cut for some
surveillance program in the past. And so
like be prior to the whole COVID
kurfuffle that we went through, there
was money and a mission put together and
a bunch of people have been able to get
this telescope going. Whereas
the web took decades. It went over
budget. It had all these issues. The
Nancy Grace Roman Telescope named after
the first chief astronomer for NASA who
was a woman. It's wonderful.
It was on budget, under budget. It was
on time, early even. It's like 9 months
ahead of schedule. This is incredible.
It's getting out there. Fingers crossed
everything is hunky dory once it gets
out to its lrangee point. But the
excitement is that because of
the size of the mirror and the view that
it's going to be able to get. It's got
some near infrared. It's also got some
real light, but it has a massive field
of view. And this is the exciting thing.
Everybody is
absolutely excited that what we're going
to be able to do is see much more of the
sky at a time than with the Hubble or
even with the web. So the web is looking
at deep field, but it's also looking in
this infrared, right? Um but it's not
the same view. So the Nancy Roman uh
Nancy Grace Roman telescope is going to
be huge percent of like 12% of the sky
whereas the Hubble can only do like 1%.
And so we'll be able to get really great
views of more of the sky. We're going to
over the course of the fiveyear
mission for this craft, we are going to
have
something like 20 pabytes worth of data.
Um, it's an incredible amount of data,
one terabyte of data per 20 per day,
something like that. um they're going to
have to be using a different download
for this space data than the deep the
deep space network. We're going to have
to have a very special uh a special
a special pipe from the sky, I guess,
for all the data coming from this from
this telescope and it's going to be able
to give us
much more information. And so one of one
of the things they're very excited about
is not just the big view of the sky and
being able to see much more and much
more with clarity
and high resolution. It's also going to
be uh enabling
um us to look at transits of stars. And
so there is a one of the tools it has is
a way of kind of ob obsticating uh star
light. So you can see stuff around the
stars more easily. And so this might
give us better views of exoplanets
around stars which is really cool. This
coronosphere kind of view is going to be
very exciting for the search and the
identification of other planets. We are
going to be able to look at our entire
Milky Way galaxy in a time that we have
never we've never look we will never
have looked at it. This is brand new.
Our view of it is going to be totally
fast and brand new and it's very
exciting. So really, I hope that it
works really well. But the bad news, I'm
gonna, you know, come back down to Earth
here. We don't have any more telescope
missions scheduled. We really don't have
any
big missions scheduled in NASA anymore.
And this is a really
big concern. Um
it's not good to have not have another
mission in the pipeline. And so um
because we know how long missions take
to build and come to fruition. It's just
it's hugely rare for the speed at which
they were able to get this telescope
together and to make it work and get it
out there. That
missions don't do this normally. So,
um I really hope that we are able to get
Congress and NASA back on the
exploration plan and really trying to do
science around our solar system
locally. Like we have to send things
places and we have to put that in the
timeline, the time it takes to get
places and to do things. And so if you
want more amazing science
for your kids generation or I even
moving forward, we have to push for it.
We have to ask for that science to
happen. So you know ask your
representatives to support NASA and the
science that NASA does.
I mean we also need to look here at
home. We do need to be keeping an eye
here at home, but I really don't think
that it it should be other countries and
I mean other countries are going to keep
still keep doing stuff, but I also don't
think that it should be corporations
taking the lead. Is it going to be a
corporate space? I really don't think
that's a great idea. But that's just me.
Um I'm I'm not like the rest of people.
Um so
you all know me, of course. you say yes,
no, Kiki, you're not like the rest of
people. Um, but it's a wonderful
new space telescope and we will find out
in a couple of months whether or not
it's able to get first light and whether
things are working. Um, and whether the
coronagraph is working and it's going to
be amazing. We're going to get great
data from I I am going to be optimistic
here. We're going to get great data from
the Nancy Roman Space Telescope.
There are uh three core surveys to the
Space Telescope. It's going to be
looking at the galactic bulge. So,
there's go we're going to be looking for
exoplanets, transients, and black holes.
And it's going to have a massive spread
of the sky. The area of as they say 8.5
full moons. The full SE survey area is
going to be imaged every 12 minutes
over 438 days in six sets of 72 days
each. There's also the high latitude
wide area survey. This is going to be
looking at 12% of the entire sky. That's
the equivalent of 25,500
full moons.
This is the full 5-year mission for the
Roman telescope. The exposure time is
going to be from 11 to 150 minutes. That
depends on distance, resolution, all the
things they want to be getting there.
And then the third mission, the third
survey for the mission is the high
latitude time domain survey. And this is
over 180 days, which is about how many
days my child goes to school every year.
And [snorts] he was mentioning this
morning on the way to school how strange
it is that it's really that little.
Anyway, this is going to be over 2 years
for the Roman Space Telescope. uh 30
hours every five days and it will be
doing a timed survey looking for
supernova transients, galaxies and also
dark energy.
Some really cool stuff there
on the uh the the topic of dark energy.
Let's get away from this space telescope
that I am exceedingly excited about, but
we just have to wait and see what's
going to happen and what's what'll come
what'll come from it.
The there is a question uh a paper that
was recently published in physical
review letters. It is a closed access
paper, but there is a link to the
preprint in archive.org. And so I've
taken a look at the archive.org or paper
and also there's a good summary that we
we will link to on the twist website on
the site astroytes. All right. Zachary
SC Picker from UCLA has published a
paper questioning
the size of dark matter. The paper is
called dark matter hail detecting
macroscopic dark matter with asteroids,
planetary rings and craters.
And so we've always talked about dark
matter as you know this
idea of uh
I don't know subatomic particles that
the dark matter is little stuff that
doesn't interact with light. Dark matter
is just matter that does not interact
with light. But what if it's bigger and
what kind of limitations are there on
the size and how could it how big could
these things be? And so the idea that
Zachary has put forward is that maybe
there are primordial black holes. Maybe
there are clumps of quarks or what
they're calling quark nuggets.
Also maybe there are stable clumps of
fields and particles called Q balls and
fairmy balls. And how big could they be?
Like instead of
subatomic particle size, what if they
are hailized? What if they are asteroid
size? What if they are the size of a
planet? How big could they be?
So the question is, how do we look for
them? And really the author says, well,
you got to look for the damage that they
do. And so the uh Zachary is has put
together this idea that we need to be
looking around our own solar system for
the signature of damage from dark matter
particles. So damage that we know did
not occur from particles that interact
with light, but rather damage that we
can't really that we've been like, "Oh,
I don't know what would do that."
Anyway, it's a really interesting idea
that's kind of breaking my brain a
little bit. And I love the concept
that why does it have to be subatomic?
Why does it like distributed subatomic
if it's clumpy?
Not exactly like berionic matter but
just matter that doesn't interact with
light. What property if it's like normal
matter otherwise
what properties would keep it from
growing in size accumulating?
So he lists a whole bunch of different
possibilities for things we should be
looking at. So asteroid destruction,
Kyper belt evaporation, ring particle
destruction, ring evaporation,
whole bunch of different ideas. And so
what damage could there be? What should
we be looking for? And so he comes up
with a bunch of possibilities and says
the first place we really should be
looking for this evidence of dark matter
hail is our own solar system.
It's close. Why don't we just look at
our solar system
as a model system for all sorts of ideas
related to astronomical phenomena? So
that's I mean the Roman telescope is
going to be amazing for looking way out
there. But still like let's keep looking
at our own solar system. There's so much
here for us to take a lot take a look
at. [snorts]
But it's a wonderful question. I am
it dark matter has [snorts] mass like
berionic ma it's basically berionic
matter that does not interact with light
why would it not interact with light I
don't understand these things myself but
being like any other matter with mass
it would attract it would clump it would
interact with other matter potentially
unless of course there's Um and and we
know that dark matter does interact with
other matter because of the signature of
dark matter clouds and uh where how we
have seen the large evidence of dark
matter um over
in the galactic scale.
Anyway, so it's it's a very interesting
thing. Paul Disney saying uh if it
clumps it would have to use a force
other than gravity or electromagnetic to
match the effects that dark matter seems
to have or not on structures in the
universe. Right?
I could say I I think maybe not
electromagnetic, right? But uh gravity,
why not? So, uh I think gravity would
still potentially work with dark matter,
but electromagnetic
interactions would not necessarily work
in the same way.
Ah, Paul, dark matter affects gravity
but does not seem to be affected by it.
How much do we really I mean I gota like
keep looking at that. But um Kevin Ruden
says it does not interact with light but
does interact with matter by showing
some damage. So it wouldn't be the
damage to dark matter. would be the
damage to the matter it inter interacts
with and which is where we've seen on
the galactic scale where there are
clouds that have um been separated
from certain areas because where the
mass is separated from the matter and it
doesn't make any sense. So you've got a
visual of matter yet you have a
measurement of mass in another place.
And so that is that separation that has
led us to
hypothesize that there is this massive
amount of dark matter in the universe.
So who knows there are still so many
questions but I think it's very
interesting. So,
the weather for forecast, right? We're
going to be looking at hail, dark
matter, hail in our solar system. So,
cratering.
Should we find craters on Earth from
dark matter? Can that even be possible?
This is so weird. Such It's an
interesting question. There is the
possibility that it will bear no fruit
whatsoever. But I think it is um this is
what science is about. It's about asking
questions and
getting rid of hypothesis, you know. Oh,
that one didn't that idea didn't work.
That's okay.
There I'm going to move away from
[laughter] right law coned. We see
everything end on. We don't know what
anything really looks like. And then
Paul says, "Everything looks like
chicken." No, everything tastes like
chicken. Paul, not looks like it
necessarily.
Moving on from chickens to butterflies.
And this is the butterfly effect, but
it's not the quantum butterfly effect.
This is actually a conservational
butterfly effect. And I would love to
talk about this story with Blair, but
she's not here. researchers published in
current biology their
investigation of how conservation
databases in Europe and conservation
efforts have impacted different
butterfly species. And so the
researchers
were looking at different conservation
um databases and looking and they were
like okay let's see how the human
like idea of beauty how does that or
what we think is beautiful how does that
influence conservation and what they
determined in this study is that ugly
butterflies or the plain butterflies
guys. They've gotten ignored by some of
the major uh European databases that are
being used
for conservation efforts. The IUCN,
which is the International Union
Conservation Network, that database, it
has all of the endangered butterflies in
it. All of the, you know, almost
extinct, endangered, soon to be
endangered, those are the ones that are.
So, all of them are listed in there.
However,
when it comes to the butterflies that
are actually getting attention and are
getting the the public's
benefit,
it's not the pretty ones. The I mean, or
it is the pretty ones, the plain ones,
the ones that are more mothlike, the
ones that are drab, the ones that don't
capture your attention,
they are getting ignored. But you know
my question is is it be it's not beauty
necessarily
is it just what people pay attention to?
We we are drawn to the bright colors
because of our visual system. So
movement
might first get us to something but more
often it's movement with color. And so
in a shadowed place, we're very likely
to misidentify, not identify, not even
see butterflies
that are potentially highly endangered
because they just don't strike our
fancy. So this study was pretty much
pretty much nail on the head which is
hey people your ideas of beauty are
negatively impacting conservation
efforts. We need to pay attention to
more drabby ugly things. We really need
to pay attention to things that don't
strike our fancy. Not everything needs
to be a panda with wings, right? I mean,
Blair would really like this story, I'm
sure. Yeah. Charismatic mega insects.
Abs. [laughter] Exactly. Those are the
only ones we're paying attention to,
Lon. Absolutely.
So,
if we were really just paying attention
to mods at night, then you pay attention
to moths. like the the butterflies that
are really rare, the ones that are
potentially really being influenced and
affected by human activity, by
pesticides, by so many things, they're
being ignored and then they're being
lost. And this is to our detriment.
Butterflies are pollinators.
So, it is to our benefit to pay
attention to all the butterflies, not
just the pretty ones.
If it's got wings, go look at it. Okay.
[laughter]
Eric Knap is saying Steve Irwin talked
about this issue. Said, "Beautiful
animals got all the attention and that's
why he liked working with crocs and
reptiles." And I I understand that. But
I mean I still think that crocs and
reptiles are megapauna that are
charismatic megapa because we think of
them as dangerous. Who thinks of a gray
butterfly as dangerous or even
interesting, right? Yet it may play an
integral role in an ecosystem.
And um yeah, we're just we are not wired
for beige.
I mean, maybe we will be after like
several decades of AI influence, but
right now we are not wired for beige. We
really like color and activeness and
charismatism.
Charisma. Charisma. Yeah.
All right. Uh moving on from
butterflies. Let's talk about the gut
brain connection.
So, a study out of the University of
Suri is the one of the first to really
put a link between our microbial action
in our gut and the human brain's
neurochemistry.
And I really think this this paper is
interesting because this is one of the
first papers where the uh the sample
population
is only women and it is not because
women have menstrual cycles or might
complicate it. It it is just they only
they only recruited women for their
study. So they had around 60 women in
their study
between the ages of 17 and 25. So this
is the college student population. And
um the researchers used what's known as
proton magnetic resonance spectroscopy.
So really, you know, magnetic MRI
spectros spectroscopy
to see which areas of the brain are
being activated at certain periods of
time. And they were looking at
specifically GABA
and glutamate which are these are
neurotransmitters involved in activation
and deactivation within the brain and
also the rest of the body. They also
took poop samples to analyze the uh the
metabol. So the metabolum was able to
tell them what microbes were in their
guts of the 60 ladies
and what genetic capacity those microbes
had to be able to carry out certain
metabolic processes.
And the of course these processes
involve GABA, glutamate and then other
things like short-chain fatty acids and
other neuro neuroactive compounds that
are known to be neuroactive.
Okay. Generally GABA and glutamate like
it's not uniform across the brain. They
had uh one particular area that was kind
of a control region. That's the inferior
occipital gyrus. This is a visual
processing area and it is really not
known to be influenced one way or
another
by gabaglutamate or these neuroactive
compounds. It's just generally active
and so it had like micro it was
associated with microbial actions in the
gut just generally if the microbes were
doing it that area was active.
However,
the anterior singulate cortex, this is
involved in attention, cognitive control
and emotional regulation.
This was linked to microbial action in
the gut related to glutamate and another
compound called proprianate.
Another area the dorsolateral
preffrontal cortex. This is involved in
cognition and emotion and that was
associated with gut micro GABA
production.
So they were able to
specifically
connect these areas of the brain with
what the bugs in
the gut were doing and how they made
people feel. So they had the had the
participants also uh self-report their
psych their psychological outcomes. So
whether or not they were feeling
particular way, how they were doing and
they found that like all these micro
processing pathways were connected to
specific emotional states. Uh they're
associated with depression, mental
health, anxiety, etc. And so they're um
they're very excited that we might be at
there needs to be much more study of
course, but they're very excited that
this might be one of the first real
connections of the gut brain axis where
there's stuff happening in the gut that
is specifically influencing particular
areas of the brain. And of course they
do say, you know, well, we didn't look
at menstrual activity or illness or
other things. And so there might be
some,
you know, there might be some other uh
confounding factors out there. But at
the same time, they're really excited
because this gives some real direction
for
looking at microbial pathways and how
they influence cognition and emotion
within the human brain. And because of
this, there may be
pathways that can be uh used can be can
be impacted
for micro microbiome based
interventions. So instead of affecting
the brain directly with neuro with um
anti-depressants, neurotransmitter
focused drugs, maybe there's probiotics,
maybe there are foodbased or
nutritionally based supplements that can
be given to help cognition and emotion
within the brain. understanding how
these things work together. There's a
lot more work to be done, but I think it
is very interesting.
Yeah, a gut response. That's right,
Kevin Ruden.
Okay, two more studies for the night.
This is not going to be my longest show
ever because it's just me and you and I
don't have Blair for all the
conversations, but we're going to keep
moving forward. I have two more stories.
The next story is related to raindrops.
And I really think somebody needs to
make this song instead of the uh
raindrops on roses and you know that
that old song. But this is raindrops on
cart tops and I don't know something
corrosion.
Turns out based on this new study
published in Nature that raindrops are
super corrosive and not because they're
acid rain
because they are
electric electrically charged. So
there is electrification of raindrops
and we know that in the atmosphere the
atmosphere is charged. We have clouds
and rain and charges are going on. We
have lightning to discharge
current out of the uh between the
atmosphere and the ground.
This study just published this is uh
from the Maxplank Institute for Polymer
Research in Mines Germany.
They're basically this study basically
suggests that we need to put much better
coatings on our vehicles to keep the the
metal from corroding bridges.
Um anything related to infrastructure
that is metal and can be corroded we
need to look at it complete from a
completely different direction. So this
is an open access study and I think it's
just fa fascinating because really what
we have done is
looked at uh the coding of
of so many uh of so many surfaces from a
chemical perspective and not from an
electrochemical perspective where there
could be a a current or charge basis
that could lead to a discharge and
cratering of a metallic surface
and basically corrosion in like a faster
rate of corrosion. We know that okay,
we've got outdoor your the furniture out
on your patio. If you live on the coast,
you've got special patio furniture that
doesn't get corroded as quickly,
hopefully.
But these researchers were like, "Wow,
what's going on about how these drops
move and whatever." And so, basically,
they had uh a measurement of uh of
raindrops
that they simulated from the lab. They
had them roll down surfaces to see when
they impacted a surface.
Did they take the charge from the
surface they rolled down with them? And
how did that impact the surface that
they landed on? Well,
the impact
was not great. So what they were able to
show is that there was a massive
increase in this pock marking this
corrosion and it comes from not a
chemical
impact
but from the charge that h that is
involved.
And so, um, I just find this, uh, a
fascinating new finding because what
they suggest, the bottom line is is that
we need to either have thicker
coatings over our cars, our planes, our
patio furniture to keep them from
corroding as quickly. or we need to
figure out how to create anti-charge
coatings that do not that aren't that
aren't impacted as much by the amount of
electrification that raindrops bring.
Yep. Uh they had a they tried on a bunch
of surfaces about 3,000 drops which is
about the equivalent of an afternoon of
moderate rain. Maybe like what we had in
Portland today. They had copper plates
beneath different surfaces that had
Teflon coatings. Atomic Force microscopy
of the impact zones found pits several
nanometers deep in places deeper than
the entire thickness of the Teflon film,
meaning the damage ran clean through the
coating into the metal. Drops that fell
directly on the target without sliding
first and did not carry a charge left
the surface pristine after the same
30,000 impacts. This is from an article
in RS Technica that will be linked to on
our website by Jessek Kerwink.
It's a it's a fascinating um
investigation from of the physics of
raindrops and how they impact our
everyday life. And it could impact
so much about I mean when we think about
the the nuts and bolts on our bridges
that corrode out too quickly. Maybe this
has to do with it, not just the paint.
Um, but we're we haven't been thinking
about this enough. And so, are we taking
electric fields into account
when it comes to our materials for our
infrastructure?
It's cool stuff. Very cool stuff.
And then finally, my last story. Oh,
look. I'm sharing everything, all the
behind the scenes with you.
you get to see all of my pictures. Um,
we have Oh, this was a great picture of
their charge measurement. Maybe I'll
share that one. It's nice. This was It's
fun stuff where they uh were able to
show the charge that was able to um that
the raindrops picked up from moving down
surfaces. And it doesn't even the thing
is the raindrops don't even need to move
down surfaces. They get charged in the
atmosphere. So that happens in clouds in
the atmosphere. This was just in a
laboratory. They were trying to do
something. But can you imagine the
charge that like you've got it coming
from the atmosphere. Maybe it lands on a
leaf. Maybe it lands on a roof. It rolls
off the roof. Lands on your car.
Whatever. Rolls down a bridge. It's a
very um
I am now thinking of raindrops from a
very different perspective.
Uh final story. Let's talk about
Alzheimer's being cured
in mice because of course it's always in
mice and never in people. But maybe,
just maybe, we will actually be able to
see this happen in people in the future.
I mean, that is really where we hope we
can get with all this stuff, right?
researchers publishing in cell bio this
uh this last week. Cell biio materials
they are using um a platform that they
call nano eraser. Now, nano eraser
delivers antibodies across the bloodb
brain barrier and according to their
abstract achieves potent astroight
specific intracellular degradation of
PTBP1.
I don't know what that is but it's very
exciting actually. PTBP1
is a molecular barrier to neuronal
identity.
And so according to their abstract, the
targeted protein depletion triggers
robust aststerite to neuron conversion.
So what does that mean? When they get
rid of PTBP1
with their nano eraser,
aststerittes
can turn into neurons. So cells that are
evolved in neuronal support or immune
function can actually be converted into
neurons.
And so this is kind of an interesting
side step of uh the regular stem cell
neurogenesis pathway. But what this does
is it restores neurogenesis in the
hippocampus which is an area of the
brain responsible for memory and a lot
of cognition and our daily functioning.
It reverses nano eraser reverses
cognitive impairments
in mice with um that are a model for as
Alzheimer's disease.
So this work, if they can get it to work
in humans,
the exciting aspect of it is that
if we can get nano eraser to work in
humans,
it could reverse the damage of
Alzheimer's disease. It wouldn't fix the
underlying problem necessarily, but it
would instead of having a brain that no
longer has neurogenesis or creates new
neurons, now at least you have a
function to create new neurons and have
neurogenesis within the adult human
brain to form a connected network and
regenerate functional connections with
new neuron. It it could be really
amazing.
Um I mean there are other steps to it
that are essential in that
we do have to figure out the metabolic
trigger for Alzheimer's disease. Is it
you know is it the immune system? Is it
the lymph? Is it um you know what could
is it mitochondria? Is it is it the
aststerytes? What could it be? So
there's there are the causal aspects
that need to be need to be fixed. and
need to be determined. But this
this new tool,
if they can move it past the mouse
model, this could be
a tool for repairing the damage caused
by Alzheimer's disease,
which in itself would be huge.
There are so many of us who with family
members who are impacted by Alzheimer's
disease and it is it is something that
we should be getting rid of. You want to
do that? I would like to do that.
Anyway, those are my stories for the
night. Did anybody else have exciting
news? Any stories that you think are the
best stories in the entire world for
science? Did I miss anything big? It's
9:00 here on the West Coast. Let's see.
H Kevin Rearen, the primary cause of
Alzheimer's disease is the human brain.
Get rid of that. You get rid of
Alzheimer's. Wacka wacka waka.
[laughter]
Uh let's see. One by land asking how the
lunar eclipse was.
It was fantastic. We ran out and were
able to catch it at the very last
minute. Um absolutely beautiful. really
really enjoyed getting to see the lunar
eclipse and um how lucky that Portland
had a clear night for us to be able to
view it. Uh went up to Council Crest
Park with my son and my husband and
there were so many people out sitting on
the sitting on the grass enjoying a
beautiful night, one of the probably
last nights of summer here in the
Pacific Northwest. So it was really a
really amazing
>> [laughter]
>> Paul Disney is saying, "Oh, what's going
on in the world?" Eyeballs deep in video
editing. Something about the heat death
of the universe being called into
question. It does seem neat.
I think those kinds of stories, they're
always coming up. It just is a back and
forth, a constant lob and a return in
the in the theoretical astrophysics
community.
So, um, yeah, we'll see. So, the the the
lunar eclipse, going back to that for a
minute, it wasn't a complete eclipse,
but it was like 96%. So, it was dark. It
did get very reddish.
It was very It was wonderful to see.
[clears throat]
Got to see that, if not the solar
eclipse this year, which was a gift.
What a wonderful thing to be able to see
something like that.
>> [laughter]
>> And yeah, Paul, the uh the back and
forth of science is where things are
most interesting for sure. It's where
that's the conversation. It's what
information what idea do we have? What
information do we have support it? What
what information is against it? What
other ideas? What what works? What
doesn't work? Right? It's so great.
Kevin, I'm sorry that your lunar eclipse
was fogged over in San Diego.
That's unusual.
The sky is full of satellites.
All right. Well, it is the end of my
show for this evening. So, I'm going to
finish it up with the normal show end.
Bring us to the end of things with
a thank you. Thank you for joining me.
Yes. Well, from Britney, Kevin Reen,
Paul Disney, One by Land. Who else is
there? We've got FOD, we've got Gourd,
we've got Eric Knap, got some great
lawn, if you're still there, Derek
Schmidt, whoever's around in the chat
room still, thank you for being here
tonight. I really, really appreciate
you're joining me. Thank you. I
appreciate your time and your thoughtful
comments and questions. I hope these
news stories gave you a little bit of
curiosity and I don't know little
optimism for the world that we are in. B
thank you for your help with social
media and show notes. Gourd R and lure
others thank you for keeping the chat
room I mean all of you really thank you
for keeping the chat rooms great places
to be. Identity 4, thank you for
recording the show. And Rachel, thank
you for editing. And to our Patreon
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of people who have also supported us
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It's the end of the show. And if you've
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remember
it's all in your head.
[laughter]
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