Video summary
Bryan Johnson shares his enthusiastic endorsement of Hyperbaric Oxygen Therapy (HBOT), describing it as a transformative experience he underwent while inside his large hyperbaric chamber, which he jokingly refers to as a "metal dildo." He recounts the initial anxiety surrounding the procedure following an explosion in Arizona and explains the mechanics of HBOT, where patients breathe 100% oxygen within a pressurized environment that doubles atmospheric pressure. Johnson highlights the specific protocol used during his sessions: twenty minutes with the mask on followed by five minutes off to prevent oxygen toxicity, noting that while the process is relaxing once pressurized, it prevents sleep due to the need for frequent adjustments and breathing exercises like HRV resonance breathing. Despite acknowledging the therapy's high efficacy across multiple biological markers—including a significant drop in cognitive decline indicators (marker 217), zero signs of microbiome dysbiosis, and undetectable systemic inflammation—Johnson admits that HBOT is currently inaccessible to most due to its cost, time commitment, and logistical hurdles. He emphasizes that unlike other therapies targeting single metrics, HBOT offers a broad-spectrum improvement but requires dedication; he completed 60 sessions over the first ninety days and has since performed roughly two hundred total sessions annually. The therapy involves significant inconvenience, such as traveling in a chamber weighing two tons or taking week-long breaks between intensive sprints to avoid harm from overexposure. Beyond general health benefits like accelerating wound healing for diabetics and aiding post-surgical recovery for athletes, Johnson identifies HBOT as the superior method for skin rejuvenation compared to red light therapy, microneedling, vampire facials, or lasers. He explains that the treatment remodels every layer of the skin by rebuilding collagen and elastin while reducing senescent cells, creating a distinct signature visible in biopsies. To maximize these results, he recommends pairing HBOT with surface-level treatments like 1550 nm ter lasers for texture and spots, followed by deeper ultrasound devices like SoftWave to rebuild the dermal scaffolding, effectively accelerating healing after acute skin interventions. The conversation also touches on the biological reality of aging as an irreversible decline from which one cannot simply recover without continuous intervention. Johnson argues that because both he and his audience are past their peak physical years—having crossed over into a state of entropy—they must consistently engage in modalities like HBOT to maintain youthfulness, contrasting this with younger individuals who naturally improve daily. He illustrates the intensity required for certain treatments by describing a painful laser procedure where settings were adjusted from 3.5 joules to around 4.2 due to discomfort resembling being singed by a hot iron, underscoring that effective therapies often require enduring significant physical stressors to achieve lasting physiological changes.
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Hbot, talk to me about that. I was
messaging you the day that I started my
Hbot. Yeah. Was the day that you put
your video out and I went in there and
you were like,
>> I can't remember what the [ __ ]
[laughter] you you replied with a a 20
20 and five.
>> Yeah.
>> Uh 83% with natural blah blah blah. And
I just cuz I'm in this big [ __ ] metal
dildo and the guy that's there, Vance
from Beam Hyperbarics in Austin, if
anyone wants to go to a great
hyperbarics place, it's [ __ ] sick.
You can book it by the hour. advance is
great. And I'm like knocking on the
little [laughter] this tiny little
portal out of my submarine and he comes
in and I just showed my phone. I'm like
that. [laughter] And I couldn't be
bothered to use the radio to get outside
like is Brian Brian messaged you. Are we
doing this? And he sort of went
[laughter] so funny.
>> Yeah. Put his thumb up like that. So,
uh,
>> yeah,
>> hyperbaric.
>> I was when you messaged me, I was
worried about you because, uh, like a
week before somebody had blown up in
Arizona.
>> So, yeah. So,
>> what does that look like?
>> Well, so in in hyperbaric, the idea is
you pressurize. So, u, you're actually,
so at atmosphere at sea level, we're
about 15 pounds per square inch of of
concentration of oxygen.
>> At two atmospheres, you're at 30. So you
you pressurize and some hyperbaric
chambers they pressurize and then they
just push 100% oxygen into the chamber.
So you're just hanging out and breathing
the oxygen. But if you're doing that
you're sitting in a pressurized chamber
and you're basically a flammable
>> ball handle.
>> If you're you're bomb like so if
something if if there's a spark of any
type
>> Yeah.
>> you just blow up
>> your phone or some device that you've
got with you or whatever the [ __ ] Okay.
No, no, no, no. I this was I was not I
was I had the [sighs] I was breathing
the mask. I was
>> great. Okay, cool. Yeah. Um yes,
hyperbaric oxygen therapy uh I think to
date it's fair to say has been the
single best performing therapy we've
ever done and the this is both good news
and bad news because bad news is that
it's expensive it's inaccessible it's
timeconuming
>> super inconvenient
>> so it sucks because I hate sharing this
because people it's very exciting but
then it sucks because people can't do it
like
>> I mean if you're already to say I've got
to find a sauna to use and most people
don't have a sauna in their
Oh god, now you're telling me I need to
produce my own oxygen. This thing weighs
[ __ ] two tons. It's I don't where
does it fit?
>> Totally. Yeah. And like who has 90
minutes in a day to go do this thing? So
I would just say for for people who have
a serious condition and there's a
variety of conditions that that uh this
could address like even cognitive
decline or you know um wounds for
diabetes.
>> What would be on the list? uh like so
there's a lot of emerging evidence for
uh cognitive decline that if you're
entering the latter parts of your life
and you're really struggling, this could
have a meaningful impact on that. Um it
is used for diabetics who can't heal
very well, it's used for healing. So
people who have had surgeries uh to
accelerate the healing process. If you
have some kind of injury you're really
trying to overcome, that's that can be
great. So like there are
>> telling me that some athletes post
surgery are in 90 minutes three times a
day.
>> Exactly. they're trying to get they're
trying to hit that 90 session number
within weeks.
>> Yes. So like there are some specialized
applications where and people where it
makes sense for the person to do but I
just want to be very sensitive. I
understand like it sucks to hear
something's really efficacious and you
can't get out of
>> exclusionary. Yeah, it makes sense. So
like uh but yeah, we we we basically
like we do with all things, we measured
we had this we cast this really wide
net. We measured everything we could. my
brain, my microbiome, um a full blood
panel, um saliva stool, metabolomics,
proteomics, like you name it, we
measured it and we just found
improvements across the board. It was
really because most therapies will
improve like this particular marker or
that marker, but rarely do they have
this broadspectctrum improvement. So, we
saw like the the cognitive decline
marker pile 217 drop. We saw my
microbiome. I had zero dispiosis in my
microbiome. Like no signatures at all of
disbiosis. Um we saw I had no detectable
inflammation in my body. So like when my
HSCP came back zero
>> the 99.99 we like he's beaten the test.
>> Exactly. It just like it was really
remarkable uh across the board. And so
it was really efficacious. I did 60
sessions over 90 days and I've continued
to do it. I've now done something like
200 sessions over the past year or
something like that. So I just have it
as part of my routine. I do it um you
you want to be careful not to do it too
much because you're you'll have oxygen
toxicity. Yes. So you want to have some
>> But that's why the five minute break is
so important, right?
>> Yeah. And I also take a like a week long
break. I'll do a sprint then a week long
break. So you just need to be careful
because you can overdo it and cause
harm.
>> What was the protocol of mask on, mask
off?
>> 20 minutes on, five minutes off.
>> Cool. Yeah, I was doing that. that what
the one super [ __ ] annoying thing
there is. It's very relaxing to be in It
can be very relaxing to once you've
pressurized. Uh but you can't sleep.
>> Yeah.
>> Because
>> Exactly. Yeah. You're busy.
>> Got to put this to take this thing on
and off.
>> Um one of the things that I really
enjoyed doing was HIV resonance
breathing. Yeah. While I was in there,
have you got into resonance breathing
yet? Have you been doing it in the HBO?
Yes.
>> So much fun.
>> Yeah, it is so much fun. Um, there's a a
a
product that I got sent. I think I'm the
first person outside of the company to
have got it. It's this little lamp. I
wouldn't be able to take it in. It would
all [ __ ] hell would break loose. But
it's basically a resonance breathing
>> uh stone and you pick it up and it's got
an FDA approved thing in it and the lamp
goes up and down. You put it back and
it's done. So, you don't need your
phone, you don't need. That's brilliant.
But, um, Elite HRV is what I was using
with the strap. I'm going to guess
you'll have seen. Um, one thing that I
noticed about that niche niche issue,
the strap that came with the Elite HRV
thing, which you put on so that it can
detect like real high fidelity, high
hertz heart rate thing.
>> Yeah.
>> Um, the button that you use to press to
turn it on, has a tiny little air pocket
around it. So, I got into the [ __ ]
Hbot and by the time I'd pressurized to
get down there, the [laughter] button
had been smashed and I couldn't pre
there was no air to press the button and
then I ke I was like trying to press it
and it's just
>> Yeah. Yeah.
>> like Spongebob when he gets outside of
the water.
>> Um, so anyway, HBO,
>> uh, so I mean, couple of questions on
this
>> 60 sessions as quickly as possible
basically with uh to start to
accumulate. It's not like a a one and
done type thing.
>> Yeah.
>> Uh I think I asked you this at the time.
I'm interested if there's any more
information going from uh state change
to trait change. Like is this the sort
of thing that locks in? I'm aware you
haven't then tested coming off and
seeing what the tail of this is. But the
same thing goes for sauna. Are you just
fighting entropy with this? Is it
something that you just need to do or is
there anything because I think there's a
I I certainly know in me if I look at a
therapy or a modality or whatever and I
find that uh there's no carryover.
>> Yeah.
>> I feel despondent. I'm like [ __ ]
hell. Like I've just found this new
thing. Here's another another thing I
have to do. Does that make sense?
>> Yeah. Yeah.
>> Yeah. I mean it's because both you and I
are on the other side of the entropy
curve, you know, like the the deal you
want is youth, right? Like when you're
12,
>> you you just keep on getting better.
[laughter]
But once you cross over into your
Exactly. Like they just every day they
get up and like [ __ ] just better, you
know? So like, but yeah, you and I are
both on the other side where it we're on
this irreversible decline. And so yes,
you've got to keep it up. But like one
thing people are not aware of with Hbot
is it's the best skin rejuvenation
therapy in the world. So a lot of people
>> better than red light, better than micro
needling,
>> everything like better than the vampire
facials, better than any laser. Uh it is
because if you look at the data on the
biopsies of rebuilding collagen, elastin
and reducing scesscent cell uh it
basically remodels your entire skin.
It's not just face like every layer of
skin you're remodeling. It's really
remarkable. Like if you look at people
like if I see people now um I can tell a
signature of Hbot skin
>> like it's ve it's very very clear to me
what it looks like. And so it just it
happens. So yeah, that's the other thing
is like a lot of a lot of women uh you
know who are really care a lot about
skin HBOT
>> getting the [ __ ] HB.
>> Yeah. I mean then you if you pair like
the the best banger protocol is to for
skin is to pair the best devices with
HBO. So you basically you do like a
surface level like a 1550 nmter to
resurface the skin for for like spots,
wrinkles, stuff like that. Then you do
HBO and you can accelerate the healing.
>> Is that micro needling? Is that what
you're referring? No, just a laser like
a 1550 nmter laser where it's like uh
it's a very uh very benign laser uh if
you do it right has lower risk of like
pigmentation issues
>> um
>> for wrinkles, spots uh just like reach
for texture
>> and then you can do a deeper device like
a soft wave SOF wav where it's
ultrasound where it's 1.5 milliliters
below millimeters below the dermis. So
you have top layer and underneath the
dermis. So you're rebuilding collagen y
and like the entire scaffolding the skin
and then you do agebot and then you
accelerate the healing. So you basically
do more sessions in this. Yeah. So
that's like
>> you do an acute like skin rejuvenation
thing and then [ __ ] up. Are you still
here?
>> She's outside. I think I did soft wave
cuz I went to your dermatologist in LA.
>> Which one?
>> Uh [ __ ] I can't remember the lady's
name. It was in That was why I had a
mustache. I grew a mustache cuz I needed
to get rid of my facial hair. because
they needed to do that in order to be
able I'm pretty I'm almost certain it
was software that that
>> Yeah. Did Was it like um It felt like a
>> cigarette burn that never actually got
to the
>> burn. Exactly. Yeah. Like like you're
being singed by like a a hot metal iron.
>> Yeah. But it never actually peaks to the
It was a really interesting lesson in uh
and there
>> Yeah.
>> blowing the [ __ ] Yeah. Yeah. Yeah.
>> Um
>> it was a really interesting lesson in
pain. uh that because what you realize
is you ride this crescendo. For the
people that haven't seen it, it's
literally as if someone was to put
something really hot out on you. And
when that happens, there is a swelling.
There is a crescendo,
>> but it usually peaks at you can almost
hear it, right? If you ever put alcohol
on an open wound, that's
>> it like goes like that, but it doesn't
ever get above a six or so. So if if she
did uh if she set the settings to 3.5
jewels, which is the lowest setting,
>> then it gets pretty tolerable. If she
goes to 4.2 top end, cuz basically it's
it's a total energy per area.
>> I think I had it at around about 3 I
think she had it at 3.6 3.7. So I was I
was being a weenie.
>> Okay. Yeah. So like if you have the 4.2
where basically like it cuts down the
number of pulses by 30%. If you want to
like zip through it. God damn. That
>> that is so painful. Thank you. Oh man,
it it does. It just feels like uh a a
red hot iron.
>> I'm all right. Send to the face.
>> No more. No more. Thank you.
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