Meditz College of Arts & Sciences Dean's Series - The Future of Chemistry, Research, & Careers
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This episode of the Dean's Series explores the evolving landscape of chemistry, research, and career paths through conversations with Mary Duke, a 1991 Fairfield graduate, and Dr. Ed O'Connell, a distinguished faculty member with over five decades of experience. The discussion centers on organic chemistry, often cited as a challenging hurdle for pre-med students, but reframed by the speakers as a discipline that cultivates essential problem-solving skills. Mary recounts her journey from initially fearing blood in medical school to discovering her aptitude for the analytical nature of chemistry under Dr. O'Connell's mentorship. She highlights how his rigorous yet inspiring teaching style and the department's emphasis on undergraduate research at Fairfield provided her with a competitive edge, leading to early publications and eventual success in both academia and the pharmaceutical industry.
The dialogue also addresses significant transformations within the field, particularly regarding technology and interdisciplinary collaboration. Dr. O'Connell notes that while equipment has advanced dramatically from his early days to the present, the core methodology of retrosynthesis remains vital, though AI is emerging as a supportive tool rather than a replacement for human intuition. Mary adds that modern science requires seamless integration between chemistry and biology; one cannot operate in isolation anymore. This shift is evident in how current students are trained to work across departments, utilizing advanced instrumentation to solve real-world problems. The speakers emphasize that while technology like mass spectrometry and AI are becoming indispensable, the human element of critical thinking, experimental design, and resilience in the face of failure remains the defining characteristic of a successful scientist.
Beyond traditional academic and industrial roles, the conversation highlights the importance of service and community impact through Mary's work with Traveling Toys, a nonprofit she co-founded to provide access to play for children in underserved communities. This initiative reflects the Jesuit values instilled at Fairfield, where education is viewed as a means to serve others. The speakers also touch upon the collaborative culture that has grown within the science department over the years, moving from isolated floors to an environment where chemists, biologists, and engineers work together on drug discovery and development. Ultimately, the video concludes with advice for current students: maintain a strong GPA but prioritize gaining hands-on research experience early in their undergraduate careers. This combination of academic excellence and practical lab skills, coupled with the ability to think critically and adapt to new technologies, prepares graduates not just for specific jobs in chemistry, but for any future challenge they may face.
Read the full video transcript
[music]
Hi, I'm Richard Greenwald, dean of the
College of Arts and Sciences at
Fairfield University, and welcome
[music] to the Dean series on the future
of work, where we meet with alum and
faculty to talk about the
transformations of the workplace and how
our students can prepare for uh
launching their careers, whether it be
medical school, graduate, school, law
school or work um into the new 21st
century. Today I'm joined by two
wonderful individuals and we're going to
talk about chemistry, particularly
organic chemistry. We're joined by Mary
Duke, uh Fairfield University graduate
from the class of 1991 with a degree in
chemistry. Uh Mary went on to pursue her
PhD in organic chemistry at Boston
College and graduated in 1996 with her
PhD and then spent a number of years as
a national science foundation post-doal
fellow at Harvard University uh before
joining uh Fizer uh and spent a number
of years at FISA where she co-authored
28 peer-reviewed publications and was
the co-inventor of 10 patents as well as
several additional provisional patent uh
applications. patients. After Harvard,
Mary worked as a researcher and project
team leader at Fizer in Connecticut for
12 years on cardiovascular and metabolic
diseases, therapeutic um areas. Uh
during her time at Fizer, she designed
and synthesized uh novel drugs and led a
team of 40 scientists in drug discovery
and development. She contributed
innovative therapies continuing in
clinical testing. Mary also served as a
board member on the Fiser Women's
Leadership Network and chaired the uh
SURF summer undergraduate research
fellowship program selection committee.
In 2019, Mary co-founded Traveling Toys,
a nonprofit organization dedicated to
expanding access to play through lending
libraries of toys. Traveling Toys has
established lending libraries in 16
towns across Connecticut with funding to
open four more in the fall of 2025. In
2024, Traveling Toys circulated 70,000
toys and games and expanded into Rhode
Island and also in addition has been
working with St. Nicholas Children's
Hospital in Ukraine. Uh Mary, thank you
for joining us. And uh with Mary we have
um Dr. Ed O'Connell who taught and
mentored inspired students for over five
decades 56 years. Ed received his BS
from Providence College in chemistry his
PhD in organic chemistry from Yale. He
spent four years working as a research
scientist at DuPant and then joined the
chemistry faculty at Fairfield
University in 1967.
Um, so I made a mistake. 54 years of of
of teaching. Uh, retired in 2021.
You served five university presidents
and I gave up counting the number of
deans including me. Um, you know, you
were department chair for 19 years. you
shaped the department, hired all of the
faculty in the department and really
championed student faculty research long
before it was the norm. Ed's research
interests are in organic uh
photochemistry where he studies the
interaction where he studied the
interaction of light uh with organic
molecules. He's known for his intense
interactive Socratic teaching style. uh
generations of Fairfield chemistry
majors and premed students have fond
memories of your kind and rigorous
mentoring and your dedication to
teaching. We were talking about how
premed students are often fearful of
organic chemistry, but so many of our
alum who are successful doctors credit
you with teaching them in that
particular course and inspiring them. Um
Ed is a marathoner, gardener, driftwood,
birdhouse builder, and observer of
climate science. And he has a great love
of the Boston Marathon. In fact, before
we started, he showed me a picture of
some of his students uh from back in the
1990s.
>> 1990. Yeah.
>> Who were cheering you on as you were
running the marathon uh that year. So,
thank you very much, Mary and Ed, for
joining me on this episode. you know,
before we get into it, one of the things
I want to talk about is getting to know
a little bit about your story, right?
Um, I'm a historian, so I, you know, I
have limited knowledge of chemistry or
organic chemistry, but Ed, I'd be
interested in knowing, you know, as this
is one of the the courses that students
worry about because it is one of those
courses that, you know, decides whether
or not a student's going to go to
medical school or graduate school or
not. Um and as someone who was teaching
that course with a really successful
record of having students inspired and
being successful
um what did you see some of the changes
in the field and how it was taught
in the field of organic chemistry? I
think some of the uh the newer
approaches that one of the most
difficult things for students to master
is not only the facts that they have to
learn but be able to know which facts do
I have to draw on. If I want to
synthesize a substance where I know the
structure of what I want to make, how do
you take a look at that structure and
decide what pieces you have to put
together in order to get it to congeal
properly? So there's a a methodology uh
that we call retroynthesis, right? Where
you you basically change the problem
from looking at it from the forward
direction steps to get where you want to
go. Take it from the back and say how
could I get from what I want what I
could go in one step. You know that's
the what you want to call the target.
Now you say what the immediate precursor
could be using a one-step reaction. So
now you move it back and you keep on
moving it back back back back back back
back back back back back back back back
back back until you get what you have
available. That's that's the approach
that no was taught so much. I think in
most times when I learn organic
chemistry there was no systematic way
just because they're just reactions.
They didn't seem to hang together at
all. At least I couldn't hang them
together. And then when I was at Yale I
was really influenced by the person I
had for organic chemistry as a first
year student. His name was William
During. He was a masterful teacher.
Absolutely masterful teacher. great uh
control of his voice control great
drawer on the blackboard. Great thinker,
a person that no one liked. [laughter]
>> But I said, I'm not going to work for
that guy. [laughter]
>> But yet you went into that field.
>> I did because but he had a lot to do
with it because he was he just I just
learned so much from him.
>> Right. and you're you're you know
responsible for involving students in
research at at Fairfield
in in you know higher ed right now
that's a norm for a school like
Fairfield. It wasn't when you started to
do that. Right now we have 300 students
on you know April 23rd who are going to
be presenting their research projects
you know publicly at this university.
When you started there weren't nearly
that many students. I was I uh I think
uh one of the things that you want me to
think about what what's changed the most
since when I started as to now. So one
of the things was when I first came here
there was almost no research going on in
chemistry. There was a professor who was
hired a couple years before me. His name
was Joseph Boio. He was a physical
chemist and he was doing research but it
was really difficult research. difficult
instrumentation, difficult conceptually,
difficult how to do computations to get
to where you wanted to go. So it wasn't
really good for students to get involved
in. So I came and I had all sorts of uh
very doable projects. So, so for a long
time research in the department was
basically myself and Joe Bojo and that
was there for a long time and then I
would say maybe 10 15 years later
roughly Joe Zarneski came and he uh
involved lots of students in research
and he also collaborated with someone at
Yale on photosynthesis and he was he was
really good. Okay. And then uh uh then
after that it was another good gap until
Matt Kubasa came and then a gap and then
the where the uh amount of research with
students really mushroomed was when
Amanda and Johnowski came and then Aaron
van Djk after that. So now you got to
and then Jill also. So now you have uh
four or five people who were doing lots
of research with students and students
who lots of they've got a lot of
practice in presenting to become more
classy as far as the way they present.
So it's been from when I started zero up
to now where it's pretty prolific.
>> Yeah. And then we have to say every year
there's probably between 13 and 17
students presenting at the American
Chemical Society conference. um you know
that's a you know there's always a
wonderful photograph of them but they're
uh doing amazing work and I think that's
part of your legacy hiring the the
faculty getting that situated and seeing
that as a priority within the department
I think it's vibrant now it wasn't so
much me it's just the fact that as time
went on that became a higher and higher
expectation of a of a successful
candidate for a position not only had to
have a good research background yourself
but you had show that you could probably
incorporate students into your work.
It's no good if you could bring someone
in here who I work at. It's too
sophisticated. Right. Right.
>> But you were also a chair mentoring
those faculty. So that's something to
keep in mind.
>> Yeah. Yeah. So yeah.
>> And one of the the students you were
teaching you know um you know in the
late 80s and early 90s was Mary. And so,
you know, Mary, tell us a little bit
about your path and why chemistry, why
organic chemistry, and what was your
experience like when you were a student
here.
>> So, I selected chemistry because I
thought that I would be going to medical
school. That was kind of what I always
had in my head. And then as a senior, I
worked in a hospital and I realized that
I had kind of an aversion to blood. So,
um, I came to Fairfield as a chemistry
major because for me, chemistry is
something that you could kind of problem
solve, whereas in biology, I felt like I
had to memorize everything. So, I
thought maybe I could kind of problem
solve my way through my chemistry
degree. And, you know, I didn't really
think about the different types of
chemistry, but when I met Dr. Okonnell
and he came into the classroom,
comes in, you know, just walks in and
starts writing on the board. no notes,
nothing, and just blew everyone away in
that class. And there was only five
chemistry majors in my class at the
time. So, we were really kind of a close
group and we got to know the faculty
here. And then I was really lucky to
have the experience to go with Dr.
Serneski to Yale in the summer with a
summer undergraduate research fellowship
from Fizer. and having hands-on
experience as an undergraduate is what's
going to distinguish you from other
candidates if you are looking for a job,
you know, right out of school. And that
really helped and and Dr. Okonnell was
there teaching organic chemistry in the
summer at Yale. So, we all, you know,
kind of hung out together and it was the
chemistry faculty here really made my
experience wonderful and that's why I
decided to go on to graduate school.
And uh I didn't even actually really
appreciate at the time but when you go
to graduate school uh it's free and they
give you a stipend which was a bonus
from my parents who were like how are
you going to pay for this? So that was
something that I think you know I
thought well I'll go and in the worst
case I could leave with my masters and I
just was in a program and it just kept
going and I and it's like never turned
back and I think when people say I hated
chemistry in high school that's usually
what I get and and and then they say
organic chemistry and they're like that
that's crazy and then I think well they
didn't have someone like Dr. OConnell
teaching organic chemistry because that
was what really inspired me to to want
to continue.
>> Thank you. Very nice. And and just going
back to that, you're
you thinking about medical school, you
decide to do chemistry, you spend a
summer in a research lab working with a
faculty member, right? Um and then you
start looking at graduate schools. So
when you get to graduate school, you
know, you're it's a competitive
environment. There are students from
everywhere, right? So how did you feel
your education stacked up against some
some of your colleagues?
>> Well, I was in a really good position
because I left um Fairfield with two
publications
even before I got to graduate school,
which I think really helped me set
myself apart from the other students.
But when I first started graduate
school, the first year is just classes.
And I did so well in organic chemistry
that you had to take an entrance exam
that I had received a women's fellowship
for two years that paid my stipend,
which really helped me because I started
my research earlier because I didn't
have to be a teaching assistant. So it
it it just really worked out really well
for me. And you know like I said
Fairfield really set me up for success
in graduate school.
>> So after you received your PhD you you
went the normal posttock route and right
at Harvard which is you know impressive
but then decided to pivot to industry
because the typical path might be
academia.
>> Yeah. So I was at the time I wanted to
try something different in my postoc.
So, I started to try to go into biology,
more more biology research. And then I
realized I'm so much better as a chemist
that I am as a biologist. And thinking
about weighing the pros and cons between
academics and and going into the
pharmaceutical industry, for me anyway,
it was like a life choice because at the
time in organic chemistry, there was
only about 17% women in in organic
chemistry anyway. And if you looked at
academics, I think at the level of being
a professor was about 11% or something.
And when I started to realize why is
that is just because of
your life balance. And what I thought
Fiser really offered was the opportunity
to do really great research and kind of
have a normal life. So that's why I
chose Fizer and Fizer supported me as an
undergraduate and when I went back to
give my talk there for for a job
interview. I was in the same room that I
g that I gave a talk when I was an
undergraduate which kind of was that
deja vu feeling. Um but the people there
I loved how they ran a project. They put
a chemist with a biologist and drug
metabolism person and you worked on a
really great team. So,
>> and you then you were part of the
committee that selected students for
those kinds of opportunities, right? And
so, what was that like sitting on the
other side of the table? And you know,
and Ed, you had prepared many students
for sitting
>> Yeah.
>> you know, for that interview.
>> Yeah.
>> So, what was that that like? I mean, Ed,
how did you help prepare students? And
then what did you see on the other side?
Well, we had to write a research
proposal with our professor or I would
say our professor really wrote it at the
time and submit it to say this is the
research we're going to do in the
summer. And then I think I felt like
Fiser was really good at if you have a
good plan they want students to have
that experience because that's the kind
of student they want to hire. you know,
if you're coming out with your
bachelor's degree or your masters,
someone that has lab experience.
>> And so, how would you go about working
with a student to prepare that proposal?
And
>> oh, I would assume that I would know of
a student in in the department and maybe
even worked a little bit with them so
they they know how to approach a
research problem. And then I would just
say, well, you got to make sure in the
first few sentences of your proposal,
you make it clear what you want to do,
how you're going to do it, and you have
the wherewithal to do it. That's
important to get those things out early.
So then the reader has more confidence
in you. Yeah. Then the the the the
minutiae part, you know, isn't as
important as that, I don't think.
Anyway, and and Fairfield has always had
a very strong core curriculum. I mean in
the liberal arts and in you know um
ability to communicate write clearly and
all of that. Did you think that that
helped prepare you as well for some of
these things and in in in your career? I
I I think so because what I didn't
realize is you would be presenting so
much of your science to your peers and
your professor and that gives the
opportunity to work on your public
speaking and um kind of think on the
spot because people ask you some really
hard questions about your research.
So I I felt like when I went to graduate
school I had gotten all of that here.
And you know I'm also thinking that
Ed in your time teaching and researching
there there were enormous um
transformations with technology and
equipment. Right.
>> In my time absolutely
>> and we're living through one now where
where we're we're looking at what is the
meaning for AI and science research and
all of those things. Is that a
continuation or in some way you know an
evolution of tech and science and
research methods or is that something
completely disruptive? I not it's not I
don't think I was disruptor but I think
the the biggest change is looking at
myself as an undergraduate and and and
then early on here the the the the types
of equipment available was minimal and
there's been a boom of equipment right
you know magnetic resonance right so
many mass spectrometry so many things
right so that was a big no AI is is not
really instrumental but I mean I think I
don't know I read that I'm not up on it.
But in terms of retroynthesis, it would
seem like AI would be a good tool to to
mimic that. But as far as I can tell,
you still need a human person there at
the same time. It can't always drive you
back the way you would want to approach
the problem yourself. But
>> I just think of the AI for science is is
a a wonderful tool and you'll always
need the scientist to actually go into
the lab and perform it. Even if you have
robots, you still need to have someone
that's critically looking at what's
going on and saying, you know, this is
how we want to run it.
>> And how familiar should students be with
the new technology today, you think, if
they're going to prepare for themselves,
whether it's going into graduate school
or working in industry, right?
>> Well, by new technology, you mean the
the types of instrumentation they would
use in a laboratory, they have to be
familiar with it. They have to be. There
isn't there's no question about it.
they'd be lost without it. They they So
that's that's up to the departments that
teach the students to make sure they're
exposed to it. Okay? And and learn how
to use these tools to solve real
problems. You just don't want to learn
the tool unless you can apply it to a
real problem. So then it becomes almost
second nature. You have a problem. Oh, I
can use this method, this method, this
meth this will work. Yeah.
>> Yeah. And I do I'm I'm assuming, you
know,
when I go visit the science faculty, one
of the things I notice is that they're
always around. They're always in their
labs and there are always students. And
I'm wondering if that was also the case,
Mary, when you were a student here.
>> I That's exactly what it was like. and
you could go, you didn't really have to
worry about office hours because you
could just find whoever was here and
they would help you go through whatever
you know if you didn't understand
something because like for me physical
chemistry was not easy. I mean all the
faculty we just felt like you you knew
them all um very very well and they knew
you.
>> Yeah. So like say uh like I would I
would routinely come to the class to
school maybe a half hour before class. I
always had a first period and I was
there till late in the afternoon, you
know, no one worried about office hours.
You're wandering around here, there,
everywhere, but people find you and that
was just that was just the norm.
>> Yeah. Yeah.
>> And and how collaborative
uh between science departments was it um
you know it's it was a smaller school um
but with all the scientists in the same
building. Um what were the relationships
between faculty and different
departments and what were the
relationships between students? Well,
there there wasn't a whole lot in my
time almost no collaboration with
physics, almost no collaboration with
psychology.
biology small and then we had a lot of
conflict with biology for I would say uh
a 5 to 10 year period deciding who would
be in charge of developing and running a
biochemistry program because when I
first came here and for a long time
after that there wasn't even a
biochemistry course taught and then
there was a Jesuit did you know father
Elder
>> yes he taught me biochemistry
>> yeah so well so father Elder uh showed
up from uh Colorado. Uh I'm trying to
think of the school he went to. I I
forget now. He showed up and when he
first showed up, he wore his Jesuit
clothes for about a day or two and then
No, never again. [snorts and laughter]
>> But and I uh I'm only a kid at this time
and uh the dean of the time was
Coughlin. Dean Coughlin comes up to me.
He says, "Look at we're trying to hire
this guy, John Elder. You know, could
you come interview him?" So I'm I'm
probably 26 or seven years old. probably
looked 20. So Elder comes in. He's
what's this guy talking to? [laughter]
He joined the department and he
developed a biochemistry course and then
as he got older he slowed down some, but
it looked like it would be a good idea
to make that mushroom some. So we
changed our name. Well, didn't have to
change it from it was already in the
book. We made now chemistry and
biochemistry and that kind of aggravated
biology. So, uh, there was some there
was some really nasty times for at least
a couple of years and that got settled.
>> Yeah.
>> Now it's harmonious.
>> Now it's harmonious. Yeah.
>> Yeah.
>> And and what about when you were a
student? Were there, you know, you were
all in the same building, you know, on
different floors and different labs? Um,
what was that like? We we pretty much
never left the same chemistry floor and
we didn't really mix with biology or
physics and we spent all of our time if
you were doing depending on what lab you
were taking you were in in the building
working on whatever you were working on.
That's I can I can say from from my
perspective again not a scientist just
looking at faculty talking with faculty
talking with students and being in the
building there's a lot more
collaboration a lot more interchange and
interplay between uh disciplines right
and maybe that has to do with the
science institute which might not have
been you know in existence then but
that's a you know a way of organizing
and supporting student and faculty
research through a collaboration and
through interdicciplinary activity.
>> I mean, right now it's like if you're an
organic chemist, you can make a molecule
and your biologist can test it to see
where how it works in the body, how it
works in the cell. And that's the kind
of collaboration I think, you know,
that's how we discover drugs, right? You
make a a compound and then you have it
tested in your system. So there's you
would think that there's a lot of
opportunity to work together.
>> Yeah. And I see that with grant
applications, you know, between chemists
and biologists, but also between
bioengineers
and students working in each of the
labs, so they get multiple kinds of
experiences.
>> Right. Right.
>> Yeah. So now I just think it's just the
way the game is played. It isn't there's
no it just happens now. The the
collaboration of chemistry and biology,
it has to be because you can't operate
as alone an island by yourself anymore.
Can't.
>> Yeah. I I want to pivot Mary to talk
about your new work with the not for
profofit. Um it is different than your
industry experience, but it seems very
much fitting with like um a Jesuit
sensitivity and sensibility. And I'm
wondering where that drive came from and
you know how you built that up.
>> Yeah. So, I had been trying to figure
out what's a good way to give back to
the community and one of my very good
friends and I were trying to come up
with some kind of concept. And so, we
incorporated Traveling Toys in 2019,
which is a nonprofit that provides
highquality age appropriate toys to
promote play because play is so
important for children. And we felt that
if we could establish toy lendium
libraries that that would help us
enhance creativity, learning and the
development of children and teens. And
so since 2019 we have right now in
Connecticut opened up we partner with
public libraries and we've opened up now
I think there's 20 toy libraries that
are open and we have funding for four
more to open soon. And it's been really
wonderful to see the impact it's had on
communities
>> and and 70,000 toys in that catalog is a
lot.
>> Well, in 2023 we thought we were really
astounded that we had circulated 22,000
toys and then in 2024 it was 70,000. And
and when you hear back from the
librarians like that the grandparents
are coming in to borrow toys and that
you know families that can't afford to
buy toys are coming in every week. the
stories that we're here really that's
what makes this nonprofit
really mean so much to us and I think
that's falls in with what we've learned
at Fairfield right for service and to
give back and it feels really good to be
able to do that through this
>> seems very Jesuitical uh for sure and
and and also expanding that not just in
Connecticut to Rhode Island and Ukraine.
>> Yes. So, we were hoping I mean our goal
is to be all over the United States.
That's like what our big dream would be.
And so, we've expanded into Rhode
Island. We're working in Rhode Island
right now. And then Kids Operating Room,
which is a global nonprofit, approached
us and asked us if we would set up play
spaces in in in a hospital. And in this
particular case, they were putting
operating rooms in St. Nicholas's
Children's Hospital in Leviv, Ukraine.
and I am 100% Ukrainian and it just it
felt like the universe was telling me
that this made a lot of sense for us to
do and my partner and I just felt like
let's expand traveling toys. So it
construction is ongoing now and we did
fundraising to build six play spaces. So
it's the like the waiting rooms for post
and pre-op operative
surgical rooms. So,
>> and how big is your staff?
>> Um,
four.
>> Yeah,
>> four. But we're we're getting volunteers
all the time, but yes, it's it's pretty
small because how we operate is we write
grants to get the money and we work with
the library and the librarians are are
rock stars pretty much in this because
they run the program. So, we give them
the money and they run the program.
>> Yeah. And that I mean I think partnering
with an anchor institution like a
library is so important right it it it
provides those resources but organizing
a team of volunteers
doing that kind of work um you know the
drive is there but I'm I'm wondering you
know
working in in in science working in
business you know what were the
challenges you faced when you moved into
that not forprofit space.
>> Well, it's so much easier than organic
chemistry. [laughter]
So, the the problem solving is just
different and I feel like it's just a a
different time in my life and you know,
I have boys that are teenagers now. So,
I kind of went through every single toy
that was on the market and thinking
about, you know, giving children access
to different things.
>> That's terrific. Yeah. Wow.
Do you miss the lab?
>> You know, the funny thing about the lab
is a lot of people say, "Well, I
wouldn't want to, you know, spend all my
time in this lonely lab." Well, when I
was at Fizer, I was only in my first
about third year, I stopped working in
the lab. So, I was then running the lab.
So, I haven't really been in the lab for
a really long time. I'd be kind of
scared to go back in there. But, I feel
like there's a lot of overlap between
cooking and chemistry, which I love to
cook. I'm I'm a great cook.
>> Okay. I I feel like I am, too.
[laughter]
>> That's the thing I do best as a cook.
>> But I I do I do miss the project and the
excitement when you get some compound
that you know lights up in an assay and
then that's your lead. And the thing
about organic chemistry when Ed was
saying you know you take the molecule
apart like if you gave Ed and I a
compound and went into different rooms
we would come back and we make it a
different way.
>> That could be. And you know the thing
about it is is like as a medicinal
chemist we just needed to make the
compound to see if it was going to work
and then like process chemistry they
have to make that compound in the most
highly efficient way to scale it up. So
there's all these really exciting things
in organic chemistry to think about. Um
>> so when you were a student and you were
teaching did you break down those
different research opportunities and and
sort of subcategories of the field
itself? Uh well I I as I say I worked in
the area of of photochemistry but it
also involved a lot of uh correlation of
spectroscopic measurements with the
structures of the compounds. So you're
interested in fluoresence possibilities,
phosphoresence possibilities, lifetimes
of excited states, all sorts of
different things. So, it was a a
wonderful area to work in and and it was
easy easy enough to teach kids because
you could have them start out by doing a
part of it and then they would integrate
themselves into it. So, it was a great
area to work in. Yeah.
>> Well, I'm just thinking like you were
talking about you you build a compound
and then someone else has to figure out
the process for producing it more
efficiently. Right. So, it's it's that's
the business aspect of it, right?
>> Yes. cuz you can make something and be
like so proud of it and then it doesn't
do anything. So then no one cares how
you made it.
>> Well, that's true.
>> That happens a lot actually because I
think as one thing you learn as a
scientist is not to take failure as a
negative but to take it as this is the
next step is going to teach me this
didn't work so what am I going to do
next? So you have to kind of be always
moving because 95% of what you do fails.
And I would imagine that's, you know,
something students have to learn.
They're um and and you know, this is
different. I'm a historian, so it's it's
a little different. You're working with
students in your lab, Ed. You're you
know, publishing papers with students.
You had published, you said two papers,
Mary, with a faculty member working with
students, not grad students, not PhD
students. There's going to be mistakes,
right? So how how do you you know how do
you coach a student through that so they
have resilience to continue forward?
>> I I don't think I had to coach anybody.
I mean so I I wasn't in synthesis for
synthesis sake. I was trying to figure
out what kinds of structures
uh could withstand
input of energy using uh UV invisible
light and not change because when I was
at Dupant I was trying to make things
photostable. So you learn what kind of
structural features lend themselves to
photo stability rather than photo
reactivity. So when you come up with the
kind of based on what you see in a
laboratory say oh this structure I'll
tweak it a little bit and see if it
makes it better. So the tweak then
becomes a synthesis. I'm a hacker in the
laboratories but I'm not a synthetic
chemist at all but I I got better. So I
would only be doing synthesis to come up
with something that I could test for
another reason. But the students did a
lot of good synthesis for me. You know,
I would I would lay out what I wanted
and I say this is just should work. And
as you check these references in in the
literature, you can get ways of
approaching the problem and see what
happens. Yeah.
>> Yeah. And you you probably had those
experiences in the lab as a student and
also as a scientist where certain things
didn't work, right?
>> Yeah. A lot a lot of things don't work
but you know you can make your molecule
again and then you know you prove that
you made it but then what are you making
it for is the next bigger question right
so in in at Fizer that's what you're
doing is you're looking for the next
drug candidate and so does it have all
the qualities that you want and then you
get something that's you something that
looks good that might be active that you
continue on and then you find out that
it has some terrible property that it's
not going to be a drug because it's not
stable. So then you you know scrap that
and keep going. So there's a lot a lot
of a lot of things you need to think
about but you have to look at it as what
what did we learn so we can go forward.
>> So one piece of advice I'd wonder if you
can give uh current students who are
looking for
uh you know entry into pharmaceutical
firms or into the business world from a
chemistry major. What kinds of skills do
you think that they might need and what
advice would you have for those current
students that how they should prepare
for that?
>> Yes. So, I think if you're going to take
an entry level position like a chemistry
bachelor's degree right out of school,
you really want to you want to have a
good GPA because that's the first thing
that they're going to use to kind of
>> screen your resume. But I think what's
going to differentiate you from another
candidate is if you had any
undergraduate research experience. And
that will put your resume up to the top.
And and it can be, you know, I would I
would encourage students to start
looking sophomore year for some
opportunities whether it's in a lab here
at Fairfield with their faculty or
there's many outside opportunities, but
just at least get themselves familiar
with a laboratory before they're
considering a job. it. Well, I'm I'm
basically say your G your GPA is going
to get someone's attention, right? And
then once you get they get your get
someone's attention, they're going to
look down deeper into your application.
And if you have a research experience,
it means you you know how to take this
and that and put it together. This
doesn't work. What can I adjust it? So
you you you have a person who can think
through problems. So those are the kind
of things I think as a a person looking
as a to try and pick a potential
candidate. First of all, he wants
someone who's capable. Then he wants
someone who has a way who can think
their way through a problem and and a
research experience would would almost
guarantee that. That's the way I think,
>> right? And now, you know, just you we're
getting towards the end of our time and
one of the things I always ask folks,
you know, what are the some of the
enduring questions in the field of
chemistry that have remained constant
that you think all students
still have to ponder.
>> So you you say all students certainly
have to always keep up with
spectroscopic measurements, the new and
better ways of determining structure,
etc. You always have to do that, right?
And uh
you're always going to be dealing with
all sorts of aspects of energetics
because that's what makes things happen.
Yes or no? And how fast. So you have to
be able to connect all of that phenomena
that you observe hopefully to from an
organic chemist perspective to
structure. If you can correlate
structure to energy, you have you you
have a real good handle on what's going
to happen and what's not going to
happen. So I so I did a lot of that, an
awful lot of that because I a lot of
that comes from my experience when I was
at DuPont. I was hired into Dupont to as
becoming I was part of a problem-solving
group. We didn't manufacture anything.
We didn't make anything. the the
president of DuPont decided it would be
a good idea to come up with a establish
a problem-solving group that will be at
the beck and call of the what they call
the operating department. They made
products and money but sometimes they
had problems they couldn't they didn't
have the wherewithal to solve them so
they would come to us. So I the organic
chemists in in the group got promoted to
be supervisor so they need organic
chemists. So lo and behold
>> that was you. Yeah.
And I just fit right into that. I loved
it.
>> I think if you come out of Fairfield
University with a chemistry degree, you
know, you're not an organic chemist. You
know a little bit about all chemistry,
right? Oh, that's right.
>> And and what you do really learn here is
to be a a problem solver and someone
that looks at things and thinks about
them critically and makes a decision and
then you use that data to go forward.
And I think that what they Fairfield did
for me was exactly that. And you can use
that in every aspect of your life.
>> Problem solving. That's that's basically
that's what I do
>> except for my wife says I create
problems. [laughter]
>> I mean it was it was interesting earlier
today. Um, I had the pleasure of having
a, you know, an ex- email exchange, a
brief conversation with one of your
students and one of your classmates, uh,
Thomas Poon of of, uh, class of 1990,
Fairfield, graduate chemistry major. It
was just announced he's now the
president of Lyola Marry Mount
University. And, and one could imagine
that the problem solving he learned as
an undergraduate will come in handy as
president of a university. So, um, you
know, thank you so much for being here
and teaching all of our students and
Mary for coming back and sharing your
journey with us. Um, I always like to
ask a question from a student. What
class outside of your major do you
remember most?
>> There was so much I mean there's so much
science there's so much science here.
Um, but I think my [clears throat] Latin
class probably was what I remember most.
I it was a very small class that again
there was only six people in it and we
only took it for a year and you stayed
with those six people and it was very
interesting. That was the other class
that really stood out as far as it's
very different again from organic
action.
>> Yes. Yes. Well, thank you very much for
being here. I really do appreciate the
time. Um and thank you for joining us
for the uh college of arts and sciences
dean series on the future of work.
>> [music]
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