Video summary
The core concept presented in this discussion redefines the brain not merely as hardware or software, but as a unique entity termed "liveware," which is constantly capable of reconfiguring its own circuitry through learning and experience. This dynamic nature means that every new piece of information physically alters neural patterns; for instance, simply remembering someone's name involves an actual structural change in the brain. A critical finding highlighted by research on nuns who donated their brains to science reveals that high levels of cognitive activity can mask early-stage Alzheimer's symptoms until autopsy, demonstrating how social engagement and mental challenges preserve function even when biological decline is occurring. Consequently, seeking novelty becomes essential for older adults or those retiring, as the brain naturally defaults to "autopilot" modes where it reduces effort on repetitive tasks, failing to form new connections unless forced into unfamiliar situations that demand conscious attention. To optimize performance and decision-making, the speaker outlines a protocol involving self-reflection combined with physiological monitoring, such as using an EEG cap to observe how emotional versus rational brain regions activate during choices. The discussion emphasizes that dopamine is often misunderstood; while it signals reward upon goal achievement, its most vital role occurs *en route* to rewards, driving the pursuit of goals and buffering against fatigue caused by adrenaline. By subjectively attaching these neurochemical rewards to small effort steps rather than just final outcomes—such as celebrating setting running shoes near the door or completing a short run—one can build stronger neural circuits without depleting energy reserves. This approach leverages "reward prediction error," where anticipating success and reinforcing the process of overcoming friction strengthens specific pathways, allowing individuals to push past their natural breaking points in endurance tasks like cycling by delaying the moment they choose to quit. Nutrition plays a pivotal role in maintaining this biological ecosystem, with specific dietary strategies shown to enhance cognitive function beyond simple weight loss goals. The transcript advocates for nutrient-dense foods rich in Omega-3 fatty acids found in salmon and dark leafy greens containing carotenoids like lutein and zeaxanthin, which can boost visual processing speed by up to 20% when consumed with fat-soluble sources like extra virgin olive oil. Furthermore, the concept of intermittent fasting is explained through the lens of ketosis; since the brain evolved as a hybrid vehicle capable of switching between glucose and ketones for fuel, an all-fat diet can force the production of ketones to control seizures in children without medicine or improve focus by shifting metabolic states. Exercise also contributes significantly by releasing neurotrophic factors like BDNF (Brain-Derived Neurotrophic Factor), which act as growth factors that irrigate the brain's "jellyfish-like" neurons and promote plasticity, effectively showering the organ with chemicals necessary for health and repair. The conversation extends into the philosophical implications of neuroscience regarding free will, suggesting that while humans feel they make autonomous choices, experiments using Transcranial Magnetic Stimulation (TMS) can predict or even dictate decisions before a person is consciously aware of them. Despite this "illusion of free will," where individuals defend their agency against evidence of external manipulation, the speaker argues that understanding these internal and external influences allows for better self-management by recognizing multiple competing "puppeteers" within the brain. To harness creativity and metaphorical thinking—linked to excess neural connections seen in synesthetes—one should engage with poetry, humor, and diverse environments rather than relying on unproven genetic engineering or apps. Ultimately, the mission is framed as acquiring useful skills through constant learning and applying them to serve something larger, utilizing a combination of diet, exercise, social connection, and deliberate novelty-seeking to cultivate a flourishing mental "garden."
Read the full video transcript
You can't really think about the brain
as hardware and you can't think about it
as software. It's this weird other thing
that I call liveware, which is that it's
constantly reconfiguring its own
circuitry. So, everything that you
learn, every little thing changes
the the pattern of circuitry in your
brain.
If you ask Usain Bolt, "How do I get
stronger legs to run?" It's intuitive.
But the flesh in our skulls, it's meant
to think and feel.
[music]
That is the most important thing for
people as they get older is to seek new
experiences and that's the thing that
often doesn't happen, especially [music]
when somebody has retired.
So, the conclusion is
anything difficult where you have to
think
is good for your brain.
[music]
You can actually boost visual processing
speed by 20%, even if you're young and
healthy. So, I mean, these are young and
healthy people that are already
considered to be at the peak of their
cognitive prowess.
So, that's proof
that food changes minds. [music]
Lessons about dieting learned through
controlling epilepsy and seizures
[music] in kids in areas where there's
no medicine.
We put electrodes in people's brains and
we look at their brains while things
happen to them and we actually see them
happen in action. We see how the brain
changes when people communicate.
[music]
The excess connections across the brain
creates a greater propensity to link
seemingly unrelated ideas and concepts.
And that's the basis of metaphor and
creativity. [music]
My whole belief about the meaning of
life, it's not the exact right word, but
um is to find out how many skills I can
acquire that have utility, then put that
utility to the test in service of
something bigger than myself. So, that's
like my mission in life, right? So, what
are things that I should understand
about the brain that would allow me to
acquire more skills, acquire them
faster, um put them to use more
effectively? Like, what are either
realizations about the brain or training
techniques that I should know about?
[snorts]
Um yeah, I mean, a big part of this has
to do with the the fact that we live our
lives mostly on autopilot unless we put
a lot of effort into not doing that. And
so
um So, just by [clears throat] getting
off off autopilot, I'm But, wouldn't
that So, that's ultimately just sort of
making new connections. So, examples
that you give often time, drive home a
new way, brush your teeth with your left
hand. Um and I certainly do feel the
impact of that. Like, from a stave off
neurodegenerative decline, that seems to
make a lot of sense. You've talked about
the nuns who donated their brains to
science. Why, I don't know, but that's
incredible. And all of them, right, had
like early stage dementia, but they
showed no signs.
Not all of them, but a much bigger
percentage than they once thought. About
a third of them. Wow. Had had
Alzheimer's, but it wasn't clear when
they were alive because they were so
cognitively active, because they were
doing stuff. They were First of all,
they were embedded in a social network
cuz they were living in the convent. And
so, they had responsibilities and
conversations and so on. And that made
it so that even though their brain was
falling apart with Alzheimer's, nobody
knew it. They they didn't have the
cognitive effects there.
And is this at the center of your
upcoming book, Livewired? Yeah, it's you
know, the theme of that book is that you
can't really think about the brain as
hardware, and you can't think about it
as software. It's this weird other thing
that I call liveware, which is that it's
constantly reconfiguring its own
circuitry. So, everything that you
learn, every little thing changes uh the
the pattern of circuitry in your brain.
So, when you first learned that my name
was David,
you know, that that's underpinned by a
physical change in the structure of your
brain, which is wild. I mean, every
single thing that you learn
watching this right now and they're
thinking, "Okay, wait. Do I make better
decisions when I'm hungry or full?
Night? Day?"
What what are you looking for and what
can they look for at home?
So, I would say what we do with a lot of
people who are kind of in senior
positions in companies that want to
actually make decisions better. We have
a protocol that's a little bit tedious.
So, it's not easy to do it, but I'll
tell you what it is and then you can
think of ways to maybe try it yourself.
So, we have them basically walk for a
week with a diary and make choices and
just write them down. So, tell us,
"Okay, you know, I had this fish or the
steak for lunch and I chose this and
this is how I chose it." And they also
write whether they were happy or not
with the choice.
Now, this is done
the way they would do it normally, but
we also add one more thing.
We put an EEG cap on their head all day
for more than 24 hours. So, they walk
with something that measures their brain
activity. And there's a moment where we
have to replace there's a lot of like
gaps there, but all together we have
them walk through life with both living
life the way they do and reflect on
their the choices, but also have us look
at their brain. And what we do at the
end of the 3 days, 1 week, as long as
they would do that, it's kind of
uncomfortable and embarrassing
sometimes.
Uh we ask them to kind of look at all
the choices and tell us which ones were
good, which ones were bad. And then we
look at their brains and we see what was
their brain looking like. What what did
it look like when they made choices that
they were happy with.
And we sometimes see that there are
things in their brain that are kind of
repeated. So, maybe they make choices
more using this part of the brain that
I'm I'm trying to simplify it by looking
at part of the brain that are more
emotional rather than
like rational. We see that they activate
more parts of the brain that are buried
deep inside that have to do with
reflection rather than like thinking.
So, we kind of and we tell them, "You
know, here's what we learned about you.
You are better in this and that state."
So, that's one thing. So, it's kind of
not easy to apply because you still have
to have this thing on your head. Right.
So, not everyone can do it, but at least
people in senior positions who feel
that, you know, their social life is
critical, come to us and they say,
"Okay, help me. I want to know who I am
better." And are there any things that
somebody with normal cognitive function
can do to elevate? Like, how do we start
pushing the mind a bit? Yeah. I want to
do some cool stuff.
Yeah, the general story Yeah, the
general story about that is that
um it's about seeking novelty because
with the brain
uh
it very quickly gets into uh when you're
repeating something, the brain puts less
and less effort into it. And you're not
forming new connections and so on. But
when people push themselves to do novel
things all the time, that forces new
connectivity. And so, Um the best thing
that people can do, I mean, we don't
really have to worry about it at our
age, but, you know, once we get to a
certain point and when you when you get
to 200, um
[laughter]
the
the thing you have to worry about at
some point is the issue of Um
your world shrinking and doing the same
little things and not sort of expanding
and seeking new things. So, Um Isn't
there a name for this? Like, the default
when you go into autopilot? Oh, I mean,
I I talk about this as the unconscious
brain, which is um
you know, which is essentially almost
everything that you do. So, everything
about, you know, the way we the way we
shift on the seat as our, you know, as
our blood needs it and we
and and talking and so on. This is all
generated unconsciously. Um But when you
enter into a completely novel situation
where you really don't know what you're
doing, that's when the conscious mind
has to sort of be a part of what's going
on.
And and and that's when you form new
connections and make new pathways. So,
that, it turns out, is I mean, this is a
very general statement, but that is the
most important thing for people as they
get older is to seek new experiences.
And that's the thing that often doesn't
happen, especially when somebody has
retired.
Now, dopamine is a very misunderstood
molecule. It's often talked about only
in the context of reward, like I'm going
to work to this goal, I'm going to build
my company, I'm going to, you know, get
tenure as a professor, whatever it is,
and you reach it and you get this
dopamine reward. And indeed, that's
true. But what's often not discussed is
that dopamine is secreted en route to
rewards, while you pursue rewards. Now,
the ability to tap into that system
to subjectively amplify that pathway of
reward in pursuit of goals is an
absolute game-changer when it comes to
things like
anything challenging that of long
duration or uncertainty or getting
through this COVID, you know, pandemic
situation.
The
but the amazing thing is, remember, the
brain only does five things, and we get
to decide which of those sensations and
perceptions have relevance and which
ones don't or which ones are attached to
a goal and which ones aren't. So, growth
mindset in its purest form is the
attachment of these reward systems to
the effort process, to the friction
process, and not just to obtaining a
reward.
And just as a kind of final point to
that, there's a very, um,
well-known body of literature in
neuroscience, at least among
neuroscientists, that talks about
something called reward prediction
error. And it says, if you can dose the
dopamine
subjectively as you go through the
pursuit of something and then have a lot
of dopamine when you reach that thing,
it's very likely that you're going to
reinforce that circuit. There will be
neural plasticity, and that circuit will
become stronger. So, the next time you
will revisit those sets of behaviors.
The opposite can happen, too, where
you're in real anticipation of
something, this is going to be great,
this is going to be great, this is going
to be great, and then you reach that
goal and it's kind of underwhelming. And
that generally triggers this this
circuit that I referred to earlier, this
kind of disappointment or depr-
pro-depressive circuit. So, dopamine
is involved in reward, but it's also
involved in the pursuit of rewards. And
so, as you reach a milestone or as you
tell yourself, "I'm on the right track.
This friction I'm feeling, this late
night, this early morning, this hard
conversation with somebody that doesn't
feel good, I'm going to tell myself this
is for a larger purpose." That's that
subjective insertion, that abstraction
that we're talking about earlier. And
when you start releasing dopamine to
those kinds of things, there's
essentially no limit on the number of
things you can do or the energy to do
them. So, just as a last last point
about dopamine, when we're in effort,
we're always secreting adrenaline. We're
always in pursuit and it's draining,
it's tiring.
Dopamine has this beautiful capacity to
buffer adrenaline. And you know this,
you've experienced this before because
if you've ever been working really
really hard, maybe your team is
depleted, everything's just a mess and
somebody cracks a joke, and all of a
sudden, in an instant, it's like
everything's reframed. That couldn't
have been hormonal. Hormones work on
that on the schedule of like hours to
days to weeks. It had to be
neurochemical. It absolutely had to be
neurochemical and that neurochemical is
dopamine. Now, what about the the study
you did where you've got the cyclist on
the bike, they're going hard hard hard
hard hard, and you watch for certain
brain states where you know, "Okay,
they're going to quit." And then you use
that information over time to get them
to delay quitting farther and farther.
So, so behind that lies
the idea that the brain is kind of like
a muscle. Mhm. And specifically, there's
a part of the brain that we really care
about that's the part that's doing
self-control. So, if you think about it
in simple way to look at is that you
start running. You go running.
The first mile, your legs say, "Let's
run." And the brain that controls them
says, "Let's run." And another part of
the brain says, "No problem at all."
After 1 mile, your legs say, "It's a
little bit painful." But the part of the
other brain that controls them say,
"Keep going." After 10 miles, the legs
say, "I want to quit." And the other
part say, "No, keep going." And there's
like a battle there and at some point
you're going to break. Now, when you're
going to break depends on a lot of
things. Your muscles, but it also
depends on this kind of control coming
from the front of your brain that
overrides your experience, your pain.
And if we can see this moment where you
break, the moment where you stop despite
the fact that you can do a little more,
we can come back to you tomorrow and
say, "Let's do the same thing you did
yesterday. Have you run?" Only this time
when you get to the moment when we see
that you're about to break, we're going
to play a sound. We're going to tell you
that we can see that you're about to
break. And we ask you to just continue
for 1 more minute at this moment that is
beyond where you did yesterday. What In
that moment, how do you appeal to them?
Is it like, "Come on,
Like, you got this." Or
It's like there's there's a question in
in sports for a while, "Why is it that
people do better when they play home
game versus outside game?" Like, what
what is it about your mom being in the
audience that makes [laughter] you win
the game? Like, we we In theory, it
shouldn't matter. Like, you throwing the
basketball should be the same. But
somehow, we know that if your friends
are there, if you're feeling better, we
know that people do better when they're
already kind of winning There's a lot of
things that that affect our brain. And
what we try to understand now is where
is it in the brain? What is this part of
the brain that gets better when you're
like when your emotions are are
highlighted or heightened.
Um incidentally, or not so incidentally,
I should say, when you look at
communities of very high performers, and
I'm fortunate enough to do some
consulting with some people from special
forces communities and so forth, they're
very good, as are you, at attaching a
reward to specific behaviors in
subjective ways. So, growth mindset and
these dopamine rewards that we
subjectively apply are not about saying,
"Oh, you know, I had a terrible day. I
performed poorly. But you know what?
It's great. I just feel great anyway."
It's not about that. It's not about
attaching your sense of reward to the
ultimate goal.
It's about attaching your sense of
reward to the fact that you're making
action steps that are generally in the
right direction. The more you can reward
the effort process,
the better off you are at building these
kinds of neural circuits and these kind
of tendencies to be able to lean into
anything challenging over essentially
any duration. So, how does this work?
Like how would somebody do this, right?
Well, keeping in mind that adrenaline
and epinephrine are all great for
getting us into action. This is mother
nature's way of chemically making us
feel kind of agitated. Remember, stress
was designed to agitate us to move us
away from things and toward things. But,
realizing that that's a a limited
resource, that eventually that same
chemical is what makes you
have a negative mindset. It feels
painful. It's the burn in your body.
It's uncomfortable.
And realizing that dopamine can push
back on that neurochemically. It can
suppress those sensations of wanting to
quit. You say, "Well, then how do I get
this dopamine to work for me before I
hit a goal?" Because not every day is
going to be a real win. There's some
days, I mean, I know from my science
career, there were days that were really
hard. Experiments didn't work. Papers
got rejected. And yet, you know, I've
spent two decades or more just drilling
on and drilling on. And it's been a
sheer pleasure at times. But, there's
been, you know, some pain points along
the way. So, what is this process really
about? And how would somebody implement
these dopamine and epinephrine type
neurochemical events in their own life?
Well, we all know the example of like,
"Okay, you're going to run a marathon."
And I've never run a marathon, but um
that'd be a nice goal to have. Let's say
tomorrow morning I set my shoes near the
door. Now, a lot of people have talked
about this. Day one, you set your shoes
near the door. Day two, you go out the
door. Day three, you run around the
block. Day four, but the key thing is
not just to go through the actions. But,
when you hit each one of those
self-designated milestones, the
milestones that you're setting out for
yourself, you have to pause for a moment
and
tell yourself, "I'm heading in the right
direction. I haven't run the marathon
yet, but this is the foundation upon
which I'm going to lay another
foundation upon which I'm going to lay
another foundation. And those little
pulses of dopamine allow you to get that
action step without the depletion that
it would normally bring. Otherwise,
you're just like you're spending money.
This is like replenishing this bank
account that you have, and it's a neural
bank account. And so, dopamine is the is
the thing that you can control the
dosing of. And so, if you say
today it's my shoes at the door, but
tomorrow it's around the block, and
that's it. But that's in the direction I
want to go. What you do is you now get
those two events, plus the next day the
mile-long runners and so forth, without
it depleting you. It actually builds
this capacity to build more reward. And
this is what you've done. This is what
people from elite special forces can do.
They know how to make small, simple
physical steps in the real world that
allow them to build on these reward
circuitries, but they don't get
delusional about how they're doing. They
they They know they keep the end in
mind, but they get very micro. They move
the horizon in very close. And so, if
you can move the horizon to something
you know you can complete, and you
reward that,
you essentially are where you were
before. You're just as strong, if not
stronger, but you're heading in the
direction you need to go. You're not
depleting, you're not spending out
anything. And it feels a little weird,
because none of us like to reward things
that aren't external. But the ability to
control these internal reward schedules
is everything. Uh so, the the question
is repetition. And I agree, it's not
thinking about the mountaintop. You can
[gasps]
by the way you breathe, you can change
the electricity in your mind. We've seen
that with the people we put grids on.
Like, we have actual measurements now.
But that's the
you know, what's the structure where you
get the most out of repetition? What is
the
perfect spot where uh meditative
breathing hits that sweet spot for
people. And they'll increase it if it
continues to benefit them. But the food,
the breathing, sleep is a hard one, but
to me
um
food, what we eat,
and meditative breathing, I think, are
the most uh graspable
and measurable. Uh the creativity stuff,
the sleep stuff, uh the exercise stuff
is harder for people. Uh but the
exercise stuff is in its own way the
most important if we could get back to
that.
Ooh, why? Keep your brain arteries open,
releases all these neurotrophic factors
inside your brain. So, not just the
plumbing that irrigates the flesh of the
brain.
Tell me about the BDNF. Yeah. They're
nerve growth factors. They're all
neurotrophic factors and the
whatever the the for the in this case
it'd be abbreviation, GDNF, BDNF, NGF,
it doesn't matter they end with GF.
And growth factors. So, it really is I
I've heard your word Miracle-Gro, but
getting back to the garden analogy,
uh to keep the flesh
we're going to get, you know,
electricity's one thing.
To keep the flesh healthy,
uh you have to irrigate it.
And that has to do with your brain
arteries. And since we already said it's
not a it's not a ball, you know, it's
these uh you know, these uh jellyfish
and they're moving and they're throbbing
and they're pulsating and their
tentacles are reaching out. There's a
lot of space in between.
And that extracellular space outside of
the actual cells, outside of the
neurons, outside of the jellyfish, if
you will.
It's not just water.
There's chemicals floating around in
there. Now, dopamine might be just from
tentacle to tentacle,
you know, serotonin might be this way.
But what's it what's in all the stuff
around all those billions and billions
of neurons?
They're growth factors
and minerals and chemicals that the
brain naturally has. But there's also a
soup that these billions and billions of
neurons are floating in. BDNF is a key
component of that soup that helps
regulate the health of each of those
jellyfish or nerve And we can trigger
more of that through exercise.
you exercise and it releases it all it
showers itself. It's not like the thighs
thigh muscles sends it up to the brain.
The brain says, "Hey, I'm feeling good.
This is good. I like this.
I'm going to create a new rut. I'm going
to remind you you feel good when you
run." The brain will shower itself with
growth factors. They are growth factors.
Brain says, "Hey, you know, the
electrochemical balance is better with
those." So, I think that's where you get
the runner's high. You know, it's not
just adrenaline. It's not
dopamine is a happy chemical. I'm jacked
up. I'm on adrenaline. It's just such a
complex ecosystem.
And rather than feeling
um
intimidated by that, to me I just see
opportunities
on how people can, you know, improve
their lives.
So, motivation is a word, right? It's
it's a it's a label that we put a set of
events in our brain.
Uh what you actually want is the outcome
of that. You want to do things that when
you when it's hard.
So, I think that there are a few kind of
things that that we know work.
One is uh evidence of past successes. If
I typically when I go back to your
memories and I reframe them as
successes, suddenly they suddenly the
current event that's the same is a
success. So, I think that one one thing
is like having success stories and
identification stories. As in you find
There's a lot of people out there. There
was a person that is like you that had a
similar experience and chose the thing
that you want to choose. Find this
person or these people and it's going to
rub into you. So, I I get asked by my
students often, "How do I become
funnier? How do I become uh smarter?"
And and like my one tip that I give them
all the time is surround yourself by
people that you want to be like. You
want to be funny? Just sit next to
comedians. Just go to the same room they
are and just sit next to them. It's
going to rub into you by osmosis because
it's just it's the environment that is
around us that really changes everything
and and other people said that before,
but I'll tell you the neuroscience
behind it.
We know now that
brains interact with each other through
language in way that synchronizes the
brains. So, when I talk to you right
now,
if you're engaged with what I say, it
means that if we scanned our brain right
now, our brains are going to look alike
more than yours and someone on the
street that isn't here. So, two people
in the same room,
as soon as they can interact, their
brains literally start kind of if you
want pulsing in the same way. Parts of
the brain light up in the same way,
parts shut down. So, we actually are
affecting This is how we affect each
other. This is how communication made
humans who they are. This is the one
thing that makes us better than all the
other animals because we are able to
communicate using language, affect each
other's brain, and create narratives
that don't exist together. We both
believe in things that we've never seen
before like God or or or ideas that like
democracy or or money. Like those things
we invented and we can communicate them
and create this image in people's brains
and they all share this thing. So, in
the same way, if you surround yourself
by people that you want to be like, you
hear them communicate, they change your
brain, and it's going to rub onto you.
You are going to actually become funnier
if you sit and listen to funny people
next to you. You are actually become
more motivated if you next to people
that are motivated.
The next version of that, if you cannot
find them, if you're sitting right now
in a rural part of Alaska and you can't
just find yourself in Los Angeles with
the people you want to be with, is to
actually just look at them on videos, on
books, and that's the way our brain
basically gets content and change. So,
changing brains happens in many many
ways, but the easiest one that everyone
can try is to say what kind of world I
want to be in,
and bring this world to you in the form
of movies, stories,
TV shows, or people. That's the the ways
to kind of get
things that you want next to you.
So, this is not to lose weight. It's
what nutrients to put inside you where
if you have a thousand people here and
you have a thousand people here and for
20 years they eat differently,
what are the numbers of people with
dementia, all of the things being equal?
It essentially says
uh it doesn't have to be Mediterranean.
It just has to be plant like as I tell
my kids, plants, which is
you know, fruit or salad. It doesn't
have to be just salad. You know, yogurt,
nuts,
lean meats like po you know, chicken and
salmon. What is it that salmon has?
Omega-3s. It's the only thing in our
literature that we know is an is
a nutritional component in food that is
good for brain health. And the omega-3s
are a unique type of fat that are, you
know, the brain is an extremely fatty
organ. And so it needs to it needs to
have those fats. So omega-3s
are the only things nutritionally that I
would say is you could supplement or
actually add salmon in a couple times a
week. So that's the MIND diet twist on
the heart diet by adding a little bit
more emphasis on salmon. What you can't
have is a lot of fried processed food.
And if you have
a cheat day or whatever, you have a
burger, it doesn't negate what you've
done. I think that's the hardest thing
about dieting for people. They feel like
the shift has to be complete and
religious. And to me it's more glacial
because the benefits will also take
decades to accrue. You know, that's my
that's my you know,
those are the nutrients that are best
for the brain. So, you know, opt for
foods that are nutrient dense.
One of the easiest things that I
recommend that people
can do every single day is to consume
what I call a large fatty salad.
Um
I think it's one of the best ways to
really check off so many of your
nutritional boxes to get an abundance of
uh dietary fiber that the microbes that
live in your large intestine love to
consume. Um and when I say fatty, I
don't mean, you know,
throwing on tortilla strips and cheese
and ranch dressing. I mean,
you know, taking a bowl of dark leafy
greens,
kale, spinach, which are, you know, top
sources of magnesium, which 50% of
people do not consume adequate amounts
of, folate,
um arugula. Arugula is a top source of
nitrates. Dietary nitrate really
important in terms of increasing blood
flow to the brain. One single high
nitrate meal might actually improve
cognitive function. So that powerful.
Um dousing those dark leafy greens with
extra virgin olive oil, which research
has shown out of Barcelona, Spain, the
PREDIMED study, you can consume about a
liter a week
to better cognitive function, cognitive
health, cardiovascular health, and it
might even help you lose weight because
it's so anti-inflammatory. Actually,
there's a compound in extra virgin olive
oil that is as anti-inflammatory as
low-dose Advil, but without any of the
potential for negative side effects.
And importantly,
you need to have fat in that salad
because fat allows many of the most
important nutrients in the salad to
become bioavailable. So, I talk a lot
about in this book, which I think is
bringing, you know, especially
um you know, there's a lot I I think
actually that there's a lot uh of new
information that I bring to the
conversation, but I talk particularly
about um carotenoids and how research
has shown
out of University of Georgia that by
eating uh lutein and zeaxanthin, by by
supplementing with these carotenoids,
you can actually boost visual processing
speed by 20%, even if you're young and
healthy. So, I mean, these are young and
healthy people that are already
considered to be at the peak of their
cognitive prowess. Visual processing
speed is so important. I mean, think
about it in terms of responding to
visual stimuli, you know, driving,
athletic performance, sports
performance, things like
Video games.
Video games. Yeah. Absolutely. So,
dark leafy greens are abundant in these
two carotenoids and they're only
absorbed through the digestive tract
when in the presence of fat. You don't
absorb any of them unless you're
consuming them with fat. So, like that
fat-free dressing, throw that in the
trash. Extra virgin olive oil, you know,
is super key. Eating a large fatty
salad,
I think it's just really key. People
tend to think about salads in terms of
like weight loss. I want to lose weight,
I'm going to eat more salad. But really,
in terms of the brain,
it's powerful. You also get the benefit
of I mentioned dietary fiber. We now
know that you have microbes that live in
your large intestine that when you
consume uh fermentable soluble prebiotic
fiber, which is found in abundance in
that in that bowl of greens,
the microbes churn out a compound called
butyrate, which is profoundly
anti-inflammatory. It is really, you
know, beneficial in terms of the gut
ecosystem. It's been shown to boost
levels of uh
growth factors in the brain,
which promote neuroplasticity, which is
your brain's ability to change over
time. Very important stuff. You talk
about intermittent fasting in the book.
What do you think about that? What is
its impact on the mind, longevity?
Um what's its place?
you want to kick the mind diet into next
year,
and you're thinking, "I don't want to
just stave off
brain degeneration, right? Like, what if
you wanted to work on focus and
cognition? These things are harder to
test, but when you go into the big
neuroscience journals, they speak about
intermittent fasting. And the best way I
can explain it is your brain's a hybrid
vehicle.
It grew and evolved through through
thousands and thousands and thousands of
years of lots of food scarcity.
You didn't eat all the time.
And so, it's got a backup mechanism
called ketones. So, after 16 hours,
if you don't put glucose in,
and the liver's done releasing the
glucose it's held onto
through glycogen reserves,
then it'll start burning fat. Mhm.
They'll clip off those oxygens and
hydrogens, and they'll make ketones out
of it.
Intermittent fasting can also help you
lose weight. I think that's why most
people are interested in it. But it's
the way the brain prefers to get its
fuel source. And it's based on a diet um
lessons about dieting learned through
uh controlling epilepsy and seizures in
kids in areas where there's no medicine.
So, I was in Ukraine and
when they don't have medicine or a type
of seizure seizure is abnormal
electrical activity of the brain just
like an arrhythmia would be an abnormal
electrical activity of the heart.
Uh they would just feed them all fat
diet. You could smell it in the
hospitals. So, something about an all
fat diet forcing you into just using
ketones.
Now, intermittent fasting is back and
forth glucose and then ketones glucose
and then ketones. But, for kids if you
just get them almost nearly all ketone
as the source that goes up to the brain
through an all fat diet, their
seizure rates
go down. You know, so that's proof
that food changes mind. Because the mind
is the electricity sparking through that
flesh. Food will change the electricity
detectable measurable electricity in
your brain.
Food affects mind. Food affects brain.
With that premise
we can talk about okay, mind diet will
hold off
dementia and intermittent fasting might
make you feel like you've had a cup of
coffee once you get in the rhythm of it.
It's not going to make you smarter, but
it'll bring you to your most focused to
bring you to your most attentive. It's
not going to oh, I'm intermittent
fasting and now I can do physics. It's
it's [laughter] it's not like that. It's
your personal best. And then the habits
you demonstrate to your family by trying
to be at your personal best. And then
your kids see that and your friends see
that and I think that's how you impact
generation change is to have
uh capable people demonstrate hey, it's
not hard and this is the best we can do
for ourselves.
So, I think that
in a way there's an application to free
will, right? We live life thinking we
make decisions all the time and are
responsible for our decisions and also
kind of determined and defined by those.
So, if I ask you what you want to have
for lunch and I offer you five different
things and you make a choice, then your
choice is somehow your identity. This is
like what you what you
care about.
And if I told you right now that I could
predict what you're going to choose an
hour before you made the choice, a day,
20 years before, it kind of takes away
some of our identity in a way. Mhm. But
also
kind of gives us meaning because it
says, "Okay, there's actually a
narrative that we carry with us
throughout life." And now now the choice
has become really something that defines
who we are, not just the moment of but
as a person in the world. So, I always
cared about like free will,
understanding it, predicting it and also
using it to change things. So, if you if
you think that, "Okay, all my choices
are kind of determined, do I have any
meaning to my life?" The answer is
they're not determined. We do have
control over them and that's what makes
us kind of human. So, you believe that
we do have free will or you believe that
it's totally different than how we're
thinking of it and we have to totally
reimagine it. So, there's like two kind
of moments that need to be addressed.
One is
whether we do actually have this moment
of spark that happens when the choice is
totally arbitrary and we have like a
choice. I do believe that we have that
free will. Kind of toss of a coin where
something gets determined. But what's
interesting is the moment where we
become aware of the free will choice as
in
I ask you, you're sitting in a
restaurant and I ask you, "Do you want
the fish or the steak?" There's this
moment. Like you have two options and
now you're about to make a choice. What
do you want?
Steak. Steak for sure. You had a second
now where you had kind of to look at all
the options I gave you only two and make
a decision. So, now
at some point if I asked you, "When did
you make the choice?" you would say,
"Well, maybe as soon as I finished the
sentence, maybe I would maybe you would
say a a fraction of a second
afterwards." The question is A, how far
before did we know the answer to that?
Also, did the Was there anything I could
have said differently that would have
make you say the fish? And most
importantly, what's the gap between the
moment you would tell me that's the
moment that you chose and the moment
that you actually chose? And apparently
there is a gap. And this gap is what we
call the illusion of free will. The
moment where you say
that's the moment. T0 is T0. This is
when it happened. And I can look at your
brain and say, "You know what? Actually,
here you already knew that you're going
to choose." Or even like even if you
want to take it one step further, we can
actually stimulate your brain and make
you choose this thing. And I will tell
you and say, "Who made the choice?" And
you say, "I definitely made the choice
myself. This was my decision." And I
say, "Well, you know what? Here's me
zapping your brain before making you say
fish." In one of the episodes of The
Brain on PBS, such a cool one. I know
this one really got my wife's attention,
where you show the puppets playing. And
one puppet's like trying to open the box
and the other puppet's like trying to
help it. And then there's a third puppet
and he comes and like crushes the box
down and keep and like is mean to the
other puppet. Then you give kids,
babies, young babies, the opportunity to
play with either the nice puppet or the
mean puppet. And they choose They choose
the nice puppet. This was an experiment
done by Paul Bloom at Yale and then I
recreated this experiment for the show.
And
yeah, what this demonstrates is that we
come to the table with a lot of
intuitions and instincts about things,
including because we're extremely social
animals, we
are very good at judging right away
whether, for example, this person is
helpful or that person is mean. And and
we associate ourselves with the helpful
people
instead of the bullies. You know,
there's there was this debate for many
decades about nature versus nurture, but
the answer that question is dead because
it's not either of those. It's it's both
of those together.
Yeah. The only demo of that that I saw
was one person basically having a little
box and they have buttons and have to
choose whether you want to press the
left or the right button. And people sit
there and they press left, right, right,
left, left, left for like 10 minutes.
And then someone asked them, "Was it
your choice which button to press at any
point?" And they say, course. And then
you zoom out and you see a person
sitting with a TMS like this machine
that looks at the brain and basically
playing like a puppeteer. Left, right,
right, left.
out of here. That's real? It's real and
what's interesting isn't that you can do
that. This is not surprising. We know
that we can actually zap your brain and
make you move your head. What's
surprising is that you would tell me it
was my choice. Like you would you would
believe that it was your decision. You
wouldn't question the fact that what you
did was your decision. And this to me is
interesting part that we we kind of have
this
way with our brain to always defend it.
Always say whatever I did I wanted to
do. If I made this thing this was not my
choice. And now we know that it wasn't
necessarily your choice. That things
affected you. That things made you do
what you did and you will always claim
that it was your decision. So we can
actually show you that you're not really
fully How do people respond when you
show them? Funny.
They mostly try to defend free will. So
they try to argue with me. And you know
I show them the video of me changing
[laughter] things and they say no, no,
no. We have this experiment where we
bring them to the lab and we just tell
them things. We say okay, what do you
want to eat after the experiment? What
do you want to sit here or there? We ask
them to make decisions and we don't
really tell them anything. We just say
take decisions. Like sit here or there.
Do you want this pen or that pen? Do you
want the light on or off? And then we
ask them after the experiment how many
choices you made. The people who
experienced us toying with our free will
think that they made hundreds of
choices. They made about 14. But they
really feel that okay, I had so many
choices. I controlled everything. This
was my decision. They kind of try to
grasp into the idea of free will and say
I had a lot of choices in my life and I
made them. They become a little more
religious. They become a little bit more
ethical. A lot of things happen to you
when you feel that what's in question is
your identity. One of the stories that
was my favorite was there's heaven and
there's hell and they in heaven they use
the same information to reward and
excite that hell uses to punish and
condemn which is the knowledge that free
will is non-existent. Walk people
through like how how was that great for
some people and so heartbreaking for
others?
Um well, it's just a matter of whether
you believe in whether you feel like
it's it's too strange
to to imagine that we are these giant
vast creatures. I mean, think of the
fact that you're made up of 30 trillion
trillion cells.
And you're this huge giant creature
that's driven around by this 3-lb
mission control center that's sort of
controlling all this and through these
cables that come out, you know, moves it
all around and so on. It's very
weird to think about. Maybe that's it
about what's going on. Just like just
like you said you were freaked out when
I mentioned the thing about vision
before. Um,
it's really freaky to think about not
having any free will and that
fundamentally we're these very complex
robots.
free will,
um,
because I feel like I'm in control, it
doesn't seem to matter. Right? So,
where it might get weird is if you
actually could break down like exactly
what algorithm is firing that. But then
even that So, let's pretend you can
identify the algorithm. Here's the other
algorithm that makes you feel that way
or do this thing. And then here's the
algorithm that makes you, Tom, not care.
That would get a little weird, but then
it's so like recursive back to well,
there's, you know, something that's
feeding into how I feel about that exact
moment. So, since I feel like I'm in
control,
it doesn't really change that.
Yeah, and this, by the way, is related
to to that same story from Sam where
it's this issue of
if I were to get out of whiteboard, we
can't do this yet in neuroscience, but
imagine that I were to say like, "Here's
exactly why strawberry ice cream tastes
the way it does to you and why it's so
delicious to you and blah blah blah." I
could explain that and show the pathways
and the genes or whatever, and it
wouldn't affect your enjoyment of it at
all. It wouldn't change anything about
your experience of it. And so, there's
this funny disconnect between what we're
able to do in science
and what it is like to be a human. And
and there's this gap there in in the
explanatory framework.
So,
help me understand how you know that you
can manipulate the brain and yet you
still believe in free will, but it
sounds like you believe in free will in
the way that it's tied to your own self
narrative.
So,
here's the idea. I feel that
there's a lot of things that affect our
decisions.
The temperature in the room, the height
of the chair, the
weight of the book we're holding, a lot
of things. And this is studied by a lot
of people in many many ways that show
time and again that you can actually
change a person's behavior. And we can
list those things, so someone can take
them and now have a kind of, you know,
list of things that they can apply if
they want to have better interactions
with people, what temperature should the
room be, what they should do. So, there
we know that. We know that thing. And at
the same time, we still live life as if
it's our decisions entirely. So, we know
that I can trick you by,
you know,
making the price of the food 6.99 rather
than seven and you would think it's six,
not seven. This is like the simplest one
in the book. And all of us know it and
it still works.
Taking that to a larger scale, we know
that there's hundreds of thousands of
biases that affect our brain.
And even if I tell you what they are,
you will still work the same way. So,
free will is becoming interesting to me
when we learn all of those things and we
say, "Okay, then who am I?" Kind of
what's then what's who's who's in
charge? Who's the puppeteer in this
example? And the reality is that
there what we learn is that there are
more than one puppeteer in our brain.
There's many many. And every day one of
the guy wakes up. And so, one day we're
this guy, one day we're this guy, and
they're kind of vying for dominance.
They fight and they compete. They
kind of make a decision together. They
they vote. And ultimately, we protect
the person who spoke last and we say,
"This is who I am." And to me, what's
interesting is that we can now actually
show all the characters. We can show
them fighting. We can tell you that
there are more people in your brain. And
in doing so, we can actually allow you
to really manifest different sides of
yours. So, you know, maybe that you're
making better choices in the morning and
I make better choices in the evening.
You might know that you're making better
decisions when you're hungry and I'm
when I'm full. When you're talking to
your friends, when you're alone. So, we
can now profile your brain.
Uh the other element is brain training.
I I doesn't have to be some weird game
that's not intuitive. I think brain
training just means learning
as a habit. Mhm. One step past where
you're comfortable. If you're reading
it, you know it, your brain's in it's in
idle. If it's too hard, it's not even
engaged. It's it's I'm not I'm not even
going to win this race. I'm not going to
kick in a second gear. So, just just
like video games, just good enough to
get to the next level, right? They don't
hit you with the fifth level, the tilt
level up front. It's level one to level
two, level two to level three. And
that's what learning is. So, despite
your knowledge and intellect, it's just
that level right beyond you that is
brain training. So, you don't have to
buy an app. You just have to challenge
yourself and think. And do you think
when you're doing that that it's um
you're getting into a repetitive brain
firing pattern that ultimately wires
You actually change your brain. So, so
we didn't mention that the science
behind it much like in terms of what we
do, but we put electrodes in people's
brains and we look at their brains while
things happen to them. And we actually
see it in action. In in action, we see
how the brain changes when people
communicate. We see how the brain looks
when two when you watch a movie,
we see how your brain aligns with the
movie and when you tell someone else the
story of the movie, their brain aligns
with your brain but aligns also with the
brain of the director of the movie. So,
communication is this mechanism by which
information flows between brains and
changes the brains. And actually, if you
want to take it one step above, this is
also how we change ourselves because we
talk to ourselves all the time. You walk
You drive your car or you walk to to
work and you're just alone with yourself
and you communicate. You also change
your brain. You kind of solidify the
things that you want to be more like and
you suppress the ones you don't want.
So, we always talk and those voices
those are basically the other characters
in our brain that talk to each other.
You kind of choose which ones to give
more weight to. So, this is how you
become the better person you want to be.
So, we actually now play with things
that change behavior during the night
when you're sleeping in the following
way. As somebody who's not a synesthete,
are there ways to train my brain to draw
more of these connections? It's a
fascinating question and we haven't
quite got that yet, but
we're getting there, I think. With
synesthesia, so there's this gene that
causes excess connections.
We got there what are called
transcription factors which allow the
gene to be expressed selectively in one
region.
If it's expressed selectively in the
fusiform gyrus where the number area and
color area that they get cross-wired and
you get number color synesthesia and
that's no big deal.
And they it helps them remember phone
numbers.
Unlike us, they see a spectrum of colors
in front of them.
Not very useful these days with cell
phones later.
But it turns out if the gene is
expressed diffusely, which can happen,
then you get more cross-wiring
throughout the brain.
Now, that I claim is the basis of
creativity and metaphor. But when the
bard Shakespeare said, "It is the East
and Juliet is the sun."
You don't go Juliet is the sun. Does
that mean she was a
radiant fireball?
Actually, you could
It's not a bad metaphor, yeah.
He meant she was radiant, she was
nurturing, she was warm.
She rises in bed like the sun rises in
the East. I mean, you can make any
number of connections you want. She's
the center of my solar system like the
sun is the center of the solar system.
Right. And Shakespeare was a master of
of doing this.
I bet Shakespeare might have been a
synesthete. I'm not sure, but could have
been a synesthete. But synesthetes have
more connections throughout the brain
and therefore if concepts and ideas like
sun and Juliet and
are enshrined in different neural
architecture in different parts of the
brain, even far-flung regions of the
brain,
ideas and concepts,
the excess connections across the brain
creates a greater propensity to link
seemingly unrelated ideas and concepts.
And that's the basis of metaphor and
creativity. So, now you can get to the
molecular basis. You can clone the gene,
look at the brain connections, molecular
basis, neural basis of esoteric
abilities like creativity for the first
time in in in in in history of
neuroscience and brain research. This is
Now, how you can tap into it? Now,
that's the big question. I'll get to
that. Yeah.
No, no, no, please jump in.
going to say
there we're still
we just scratched the surface. We don't
know quite how to harness it in this
ability sort of genetic engineering or
something. Hey. But I would say in
schools and in in fact in your own life,
poetry has a tremendous role. I think we
should all
try to become poets. Wow, that's
interesting. Yeah, because poetry and
laughter and humor because humor
involves unusual juxtapositions of
ideas.
So, it has a lot in common with
creativity and not surprisingly many
very creative people Mhm. have a great
sense of humor.
I mean, the only exception would be
Germans who
[laughter]
Any Germans in the house? were
exceptionally creative as you know.
So, um
telling This sounds frivolous, but you
know, having courses on humor and
laughter So, the conclusion is
anything difficult where you have to
think
is good for your brain.
If you ask Usain Bolt, "How do I get
stronger legs?" Run. It It's intuitive.
But the flesh in our skulls, it's meant
to think and feel.
Mhm. And that is the power of
self-growth. And it's a thinking
machine. It's a thinking flesh that you
actually have to use or to protect
itself cuz it's an energy hog, right?
It's 3 lb but use it 20%. If you're not
using parts of it, it'll program itself
to let those parts of the garden wither.
So, the diversity of thinking and the
depth of thinking just one level past
what you're used to is the way to keep
the whole garden flourishing. And it is
a garden in there. There's chemicals,
there's things moving, there're
different types of brain cells, it's not
just neurons. So, I would try to give
that metaphor analogy, if you will, that
it's a garden and you have to irrigate
it and stimulate and tend to all the
corners, particularly the ones you're
starting to neglect. Maybe it's your
left hand. Getting out of the box and
engaging the recesses of your mind is
the most important thing. And then you
have the then the then the creative
things happen.
You don't just sit down and have them
happen. You got to work and dream and go
hard. And on top of that, something
creative can happen. Everybody, thank
you so much for watching. If you haven't
already, be sure to smash that subscribe
button and hit the bell notification so
you never miss a thing. Till next time,
my friends. Be legendary. Take care.