EAT THESE FOODS To Reverse Aging, LIVE LONGER & Feel Better! | Dr. Mark Hyman
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Dr. Mark Hyman, a functional medicine expert and director at the Cleveland Clinic's UltraWellness Center, argues that the human body functions not as isolated systems but as a single, interconnected ecosystem. He critiques traditional Western medicine for treating symptoms in silos—sending patients with rashes to dermatologists or depression to psychiatrists without addressing root causes. Hyman explains his "systems model," which views health through seven interdependent systems: digestion and the microbiome, defense and repair (immune system), energy production, detoxification, transport (circulation/lymphatic), communication (hormones/neurotransmitters), and structure (skeletal/cellular). He emphasizes that when one part of this web breaks down, particularly the gut, it triggers a cascade of issues ranging from autoimmune diseases to dementia. Consequently, his approach involves acting as a "medical detective" to identify predisposing factors like birth history or early antibiotic use alongside triggering events such as mold exposure or infections, aiming to restore balance rather than merely managing disease. A central pillar of Hyman's philosophy is the concept of food as information and medicine that signals genes on an epigenetic level. He introduces his "Pegan" principles—a synthesis of Paleo and vegan diets—as a universal strategy focusing on quality over ideology. This approach prioritizes whole, unprocessed foods while eliminating ultra-processed items like high-fructose corn syrup and industrial seed oils, which he notes are present in 60% of the American diet and significantly increase mortality risk. Hyman strongly advocates for regenerative agriculture to combat soil erosion and climate change, citing that we lose a country's worth of topsoil every year; he argues that regeneratively raised animals can actually sequester carbon into the soil, making them environmentally superior to industrial plant-based alternatives like GMO soy burgers which rely on destructive monocultures. He warns against factory farming but also cautions against restrictive diets or unnecessary elimination of foods unless specific sensitivities exist, urging listeners to listen to their bodies' responses rather than following rigid rules blindly. The discussion delves into the complexities of nutrition and microbiome health, specifically addressing probiotics versus prebiotics. Hyman describes many commercial probiotics as "tourists" that do not colonize effectively; instead, he advocates for a "weed, seed, feed" protocol: eliminating bad bugs with targeted antibiotics or herbs (weeding), introducing beneficial strains like *Akkermansia* through polyphenol-rich foods like cranberries and pomegranates (seeding), and feeding the microbiome with fiber such as acacia. He highlights the critical role of specific bacteria in making immunotherapy drugs work for cancer patients, noting that a healthy gut flora is essential for these treatments to be effective. Furthermore, he addresses controversial topics like lectins and soy, suggesting that while some individuals may need to avoid certain plant defenses or processed soy products due to hormonal effects (like early puberty in children), the vast majority of people benefit from eating colorful vegetables which provide necessary phytochemicals for detoxification pathways like glutathione. Beyond physical nutrition, Hyman integrates Eastern philosophy and mindfulness into his functional medicine framework, drawing heavily on Buddhist concepts of compassion and the phenomenology of the mind to address stress as a primary driver of disease. He explains that chronic stress keeps the body in a state of vigilance, shutting down digestion and impairing immune function, much like running from a tiger constantly would degrade one's health. To counter this, he recommends meditation and yoga not just for relaxation but as essential tools to "unhook" from self-generated suffering caused by our attachment to meanings we assign to events. He posits that functional medicine is essentially the codification of natural laws in biology—similar to physics—and identifies a short list of essentials required for human thriving: right food, nutrients, light, air, water, love, meaning, connection, and purpose. By removing inflammatory triggers like gluten and dairy through protocols such as his 10-day detox and adding these essential elements, he claims it is possible to reverse chronic conditions like type 2 diabetes and heart failure in a matter of months, proving that addressing the root causes within this unified ecosystem can lead to profound healing.
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We lose 200,000 tons of soil every hour.
Every hour?
Every hour. We lose We lose a country
the size of Nicaragua and North Korea of
soil every year.
We have 60 harvests left according to
the UN
before we run out of soil and can't grow
food. No soil, no food, no humans.
Everybody, welcome to Health Theory.
Today's guest is Dr. Mark Hyman, a giant
in the health and wellness space. He's
not only written 11 number one New York
Times best-selling books on a wide range
of health-related topics, but he's also
the director of functional medicine at
the world-renowned Cleveland Clinic.
Additionally, he's consulted for the
Surgeon General and testified before
Congress on the issues of health care
reform and functional medicine. And
further proving that healthy living
apparently makes you essentially
superhuman, he also founded and serves
as the medical director of the
UltraWellness Center, acts as the
chairman of the board for the Institute
for Functional Medicine, and somehow has
time to be the medical editor of the
Huffington Post. And quite honestly, all
of that is just the tip of a very large
iceberg of incredible accomplishments.
It really is crazy, dude. Doing the
research on you, like seeing how many
things you're involved in, and it all
seems to revolve around a couple of core
things. One of them being shocking,
we'll get to that one in a minute around
Buddhism and connection and love and all
that, which I was really blown away by.
Yeah. But the the core notion of the
body as ecosystem.
Yeah. Talk to me about that. What does
that mean exactly?
know, I I went to medical school and we
learned about the body as a bunch of
separate parts. There was your heart and
your cardiovascular system, your GI
system, your nervous system, and on and
on. And there's all these specialties
that are all siloed. And you go to the
doctor and you have a whole bunch of
different symptoms, and when you
basically ask about, well, you go to the
cardiologist, "Well, I got this rash."
"Oh, don't talk to me about that. I want
Go to the dermatologist. Or you feel
like a little depressed. Oh, go to
psychiatrist. You know, you've got a
doctor for every inch of you. And the
truth is the body is one ecosystem. And
I discovered this by myself becoming
really, really sick and having to
reverse engineer my way to health. And I
discovered this model of thinking that
was basically a systems model. Um
And it it it helped me to understand the
root cause of disease and how the body
works together and everything is
connected like a web. So, when you pull
on the right strings, you don't have to
treat everything separately with
multiple medications. You can get to the
root cause and everything goes away.
Now, one thing, so having lived through
this myself with my wife and seeing how
complicated it becomes when you start
thinking of the body as an ecosystem.
Cuz she's had massive um microbiome
issues, digestive trouble. And where it
all starts, right? So, we started trying
to use traditional Western medicine. So,
it was like, okay, what is this? How do
you And maybe you walking us through
what you did in your own life, cuz I
know that you ran into uh very
catastrophic health problem. How do you
begin to figure out what is the root
cause and then actually take steps to
repair? So, functional medicine is
basically a methodology. It's a an
operating system. It's a way of thinking
differently about disease. And it's
becoming a medical detective to connect
the dots between all these disparate
things. And so, I basically look at a
person's story and try to get a sense of
how they got to where they are. So, for
your wife, I'd want to know, oh, was she
born by C-section or vaginal birth? Was
she
Did you go all the way back to that?
bottle-fed or breastfed? Did she take
early antibiotics? Did she have a
gastroenteritis? Or was she traveling to
foreign country? Or did something happen
where
her gut didn't develop properly?
And then I want to know what other
exposures she's had and whether she's
exposed to toxins, heavy metals. So, I
ask a lot of questions. I want to know
everything she eats, exactly her
lifestyle, what she does, how she
sleeps, exercises. So, like I'm looking
at whether the body's in balance in
these systems. So, functional medicine
has a map, they call it the matrix. And
essentially as we look at, you know, you
know, your genetics and triggering
factors, we look at your lifestyle, you
know. Give me an example of triggering
factors.
you exposed to a moldy house? Like I got
really sick living in a moldy house. I
lived in China, got exposed to mercury.
That's a triggering factor, right? You
could have got Lyme disease, you could
have eaten bad sushi and got something,
you know. So, all that is relevant as a
triggering factor, but then there might
be predisposing factors like she had a
gut that wasn't so great in the first
place. She might have had, you know,
again, more my C-section, not a bottle
bottle fed, not not taking antibiotics.
And then we see where where are the
things are in or out of balance. When
you have too much of the bad stuff and
not enough of the good stuff that your
body needs, you know,
sleep, exercise, nutrition,
relationships, connection, love,
meaning, all that stuff.
When you have too much of the bad stuff,
not enough of the good stuff, your body
breaks down. So, we look at these seven
systems and how they're in balance or
out of balance. And that relates to all
the So, there's your gut and they're all
connected. They're not really separate.
They're like a web, but we just break
them out for the purposes of thinking
about them. So, there's the gut and
digestion and the microbiome, there's
your immune system, we call it defense
and repair, your energy system, how you
make energy from oxygen and and food,
your detoxification system, how you
process your metabolic toxins,
environmental toxins, your transport
system, which is circulation, lymphatic
circulation, your communication system,
which is hormones, neurotransmitters,
messenger molecules that communicate,
and then your structural system, which
is everything from your biomechanical
skeletal structure down to the structure
of your cell membranes. And all those
are influencing how you feel at any
moment, influencing whether you're
getting more disease or less disease.
So, when your gut breaks down and the
gut is really the central thing because
when your gut breaks down,
everything breaks down because the
microbiome is this extraordinary
ecosystem of bugs within you that
control a lot of what happens in your
body. And when they're out of balance,
you not only have digestive symptoms,
but you can have everything from
dementia to cancer to heart disease to
diabetes
to autoimmune diseases and lots more.
So, I know you've talked a lot about the
need for coaches and getting a health
and wellness coach involved in your
life. If somebody right now is at home
listening, so now they understand the
seven systems that are working together,
um how can they begin to diagnose
what's going on? Are there like simple
questions that they can ask themselves?
So, like in Lisa's case, we sort of
backed into there were probably several
problems including um
bordering on an eating disorder when she
was younger. Yeah. And then
That'll mess up your system. Yeah, for
sure. And then a lot of antibiotics. And
the threshold event um ended up being
she just got some sort of bug of some
kind. Um but it was because she had
taken antibiotics I mean a lot. She was
taking antibiotics like four or five
times a year for years. Uh she had
chronic chest infections. Right. And so
then she hits this bug whatever here in
LA.
Yeah, yeah. And
That was a tipping point. That's the
triggering factor, right?
Yeah. So, they the whole the whole point
of functional medicine is about creating
health. You know, regular medicine is
about diagnosing and treating disease. I
don't really care what disease you have.
I want to know how do we create health?
How do you get the best microbiome on
the planet? How do you create a healthy
inner garden? What do you have to do to
do that? How do you diagnose what's out
of balance there?
You get rid of the bad bugs and then put
in the good bugs. But it's not just as
simple as taking probiotics. You know, I
actually had a Do you think probiotics
work? They they're like tourists. You
know, they come through the economy,
they affect, you know,
things a little bit, but they're not
they don't stick around that long. So,
you have to keep taking them, which is
not bad necessarily, but what what's
really extraordinary is that I recently
developed ulcerative colitis as a result
of taking an antibiotic for a bad tooth
I had, tooth infection.
Wow.
That led to C. diff, which is a deathly
intestinal infection. It then spiraled
into colitis.
And you know, in doing what I do, I was
like, "Okay, well, this is kind of
messed up. I got to rebuild my gut." And
I, you know, took all the things I knew
and I put together this cocktail of
stuff. And there was one particular bug
called Akkermansia,
which is really important in regulating
immune function and cardiovascular
health and lots of things. And it
protects the biofilm. It restabilizes
your gut.
And this is all really relatively new
research. If you have If you have low
levels of this, for example, if you get
those new checkpoint inhibitors that are
anti-cancer drugs that are
immunotherapy, they don't work.
inhibitor?
It's It's an immunotherapy drug which
activates your immune system Okay.
to kill the cancer. And this is like an
100% like, if it works, you're cured.
You have melanoma like Jimmy Carter,
that's stage four melanoma, you're going
to be dead in a few months, you take
this drug, you're cured, and he's still
building houses at 99 years old or
something. So, that's the These are
amazing drugs, but they don't work on
everybody. And turns out if you don't
have a healthy microbiome, they don't
work. So, all this research is going on,
I started looking at it, and I realized,
you know what?
Taking prebiotics is good. Take which is
fiber, feed the good bugs. Taking
probiotics is good, but they also like
polyphenols, which are these
extraordinary compounds in colorful
fruits and vegetables that the
microbiome needs to to grow. And so,
think about creating healthy soil. You
can put all kinds of chemicals on,
right? Fertilizers and this and you have
a damaged soil, it doesn't really grow
good food, but if you have a healthy,
you know, rich soil, you can you can
create health. And so, we put in all
these things like cranberry,
pomegranate, green tea, and they are
really great for Akkermansia. Okay. And
then I used prebiotics, fiber, like
acacia fiber, to help feed the good
bugs. And I also used a form of
colostrum, which is immunoglobulin, so
it's like passive immunity, helps
regulate immune system. And I used a
little collagen peptides. I took some
something called tributyrate, which is a
product that helps with fats in the gut.
And this is a general cocktail that I
take. It's a shake, take it every
morning, and within 3 weeks my ulcer
class was gone. Like gone, and now I'm
like best poops in my life.
So, that's uh that's very interesting.
So, first we had to kill the C. diff,
then we have our magical cocktail. What
if somebody has SIBO? Is would you
recommend doing a round of antibiotics
to kill the SIBO first?
Yeah, SIBO for everybody that's
listening that doesn't know what that
is, it's basically where the bugs
migrate up in your small intestine and
you from your large intestine. So, you
normally should have a sterile upper
gut, and your lower gut, your colon, is
where your poop is and your bad bugs are
or good bugs. Uh when they migrate up,
that's when you get bloating,
distension, I call it food baby. You
know, you know, like every time you eat
you just feel bloated and full after.
That's often a sign of bacterial
overgrowth, really common. Uh so, you
can you have to figure out why it's
happening cuz it's if you just treat it
without knowing that, it can come back.
That's interesting. Why would it happen?
Well, it can happen because uh you have
motility issues, you have low magnesium,
you have a parasite, you know, you there
may be some reasons why. You could have
babesia, which is a tick infection. So,
you have to figure all that out. But
then um you can take herbs or you can
take uh especially antibiotics that are
only in the gut. And I also use
antifungals to clear out the bad bugs.
It's kind of I call it the weeding,
seeding, and feeding program. You weed
out the bad bugs, then you seed it with
good bugs, and you feed it with all this
good stuff. Okay, so if we're doing
weeding, seeding, and feeding, um what
do you use to identify what the current
state of your microbiome is? Is there a
particular test that you recommend?
Yes, there's so many tests out there,
but clinically I think the most useful
one, I've been doing this for 30 years,
and it is it's called GI effects from a
lab called Genova, and it looks at not
just the microbiome
from from measuring the bacteria cuz you
can do that. You can measure with new
um you know, DNA testing, which is
really actually RNA testing for bugs.
You can actually measure all the bugs in
there, but then what does it mean? How
clinically relevant is it? So, I I look
at the function of the gut. Are there
are there the products, for example, in
there that are made by healthy bugs
called short-chain fats? If they're low,
you know that there's no good fats, and
that's the fuel for the colon. I want to
look at your are your digestive enzymes
working? Are you absorbing food
properly? Is there inflammation in your
gut? What's your immune system doing in
your gut? What is growing in your gut?
Do you have a parasite or bad bugs? So,
I look at all that, and then I can come
up with a sense of what's going on. And
often people have leaky gut and food
sensitivities and this vicious cycle of
these bad bugs and food sensitivities,
and it it's what makes so many people
sick.
How long would you expect, when done
well, how long would you expect this
repair protocol to take? If you combine
it with diet, cuz you also have to
eliminate the things that are in your
diet that are driving gut problems,
right? Cuz
think about it, you're eating pounds of
food every day,
and that is what's landing in your gut
and feeding your bugs. And if you're
eating processed food, sugar, starch,
bad fats, it's going to be a problem.
You're not going to get better. So, you
need a whole foods diet. I call it the
Paleo diet, which is kind of a joke, but
it's like, you know, less extreme, more
inclusive, but whole foods, focusing on
quality, not so much worrying about
quantity.
And uh and sometimes eliminating things
like gluten and dairy and and other
things that can be trigger food
sensitivities. And combined with a diet
and this protocol, within a few weeks
people start to feel significantly
better.
And
it takes about 3 months to really kind
of reset the whole thing. When somebody
has a stubborn problem, like Lisa's is
insanely disciplined. If you tell her to
do something, she's going to do it for
sure.
Um her diet is clean. In fact, I would
probably consider that one of the things
that um became her problem was it was
too restrictive. Too restrictive. So,
and then once the SIBO kicked in, once
she encountered the parasite and had the
threshold event, it's like the the weed,
seed, and feed thing, I don't know that
we've ever gotten perfect. Like is there
um is there any particular thing that
creates a stubborn problem when when the
person is being disciplined, but it
continues to not go away?
Absolutely. Absolutely. You know, 30
almost 30 years ago I had another
problem, which was mercury poisoning.
And that messed up my gut big time. And
I I got a triggering event, which was
some bug I picked up somewhere in a lake
in Maine. And then my entire gut broke
down. And I literally had diarrhea,
bloating, pain for years. And a whole
and I developed chronic fatigue
syndrome, my whole system broke down.
And it wasn't until I got rid of the
mercury that my gut sorted out.
So, she has mercury poisoning, if she's
mold toxic, if
she has a tick it can impede people
getting fully better. Yeah.
So, now let's say that we've identified
the problem, we've done the weeding.
Um,
what should somebody be eating? So,
obviously in your new book,
uh What the Heck,
um
you go into it's all whole food based,
but there's obviously a lot of whole
foods in the world. So, what should
people be aiming at?
the thing. You know, there's so many
diet wars. We you know, nutrition is
often based on ideology,
uh not on good science. And there's so
much conflicting information, and people
are buffeted about by the media. One day
that meat's bad, then it's good. One day
eggs are bad, then they're good, then
they're bad. I mean, it's just it kind
of makes people crazy and give up, and
what are scientists doing, and what's
just a mess, right? But, you know, I've
I've been studying nutrition for 40
years, and I've been not only studying
it in a book, I've been using food as
medicine for 30 years as a doctor.
And I I'm humbled by it, because I
realize everybody is different.
Everybody needs different approaches
based on their genetics, their
preferences, and so forth. But,
there are some common principles, I call
them the Pegan principles, that are
universal, that no one will argue with.
And I, you know, I was sort of joking,
cuz I was I was on a panel with a friend
of mine who was vegan, who was a
cardiologist, and another guy was a
paleo doc, and they were fighting, and I
was in the middle,
and I'm like, well, if you're peg paleo,
and you're vegan, then I must be pegan.
And it was like just kind of a goofy
joke, and and I realized, wait a minute,
they they agree on about everything,
except where you get your protein from.
So, they all agree that we should be
eating whole foods. They all agree we
shouldn't be eating any industrial
processed foods. They all agree we
should uh be eating a ton of vegetables,
uh lots of good fruit, lots of nuts and
seeds, lots of good fats.
Everybody agrees that. Um the things
that are different are, should we have
our protein from animals, or from beans
and grains? That's the only difference.
And I thought, you know, well, not
everybody has a problem with beans and
grains, and not everybody has a problem
with animal protein. In fact, it can be
a very important source of food for most
people.
The question is, what, right? What
grains? What beans? What meat? What
fish? And so, that's really what those
principles are about, is focusing on
quality. So, for example, do you want to
eat a feedlot burger? Heck, no. Because
they're raised on grain? For many
reasons. One, um they're they're raised
in a way that is inhumane for them.
They're raised on foods that uh create,
you know, bad metabolic profiles in the
animal, so you're eating a lot of
inflammatory stuff. They feed them, you
know, chicken [ __ ] They feed them
candy. They feed them corn. And then,
there's how they grow the food for the
animals, which it creates massive
environmental destruction, you know,
loss of biodiversity in the soils and
animals, uh loss of of water resources,
cuz of all the irrigation to grow the
crops for the animals, the deforestation
that results, the destruction of our
soil, the use of fertilizers,
pesticides. The fertilizers run off and
destroy all the rivers and lakes and
oceans and create dead zones the size of
New Jersey in the Gulf of Mexico that
killed 212,000 metric tons of fish a
year.
And there's 400 dead zones like that the
size of Europe around the world that are
in coastal areas that are killing the
food supply for half a billion people.
You know, that's because of the
consequences of how we're growing our
food. And
not only that, it's a giant source of
climate change for all those reasons.
So, no one should be eating factory
farmed animals.
On the other hand, you look at
regenerative animals, which means
regenerative means you you farm or grow
animals in a way that is bringing the
ecosystem back to health, which is
restoring soils, reducing water use,
reducing or eliminating fertilizer,
pesticides, herbicides.
And there was a an interesting analysis.
Everyone's eating these plant-based
burgers now. And you know, I think yeah,
it's better that we eat plants and
that's great. But what plants? Should it
be a highly industrial product like
Impossible Burger for example?
It's GMO soy. So, it's grown in a way
that you're getting lots of glyphosate,
which is not good for you. Destroys your
gut. Your the food is grown in big
monocrops intensively with fertilizers,
pesticides, herbicides, destroying the
soil, using up water and so forth. It's
way better than a feedlot beef. But when
you compare it, this was done by an
independent life cycle analysis company
Quantis that looked at both Impossible
Burger and a an regeneratively raised
beef burger from
White Oak Farms in I think Missouri.
And they found that you literally had to
eat one regeneratively raised burger to
offset the carbon emissions of a
plant-based Impossible Burger. To offset
it.
In other words, the the soy burger
added 3 1/2 kilos of carbon to the
environment. The grass-fed burger took
out 3 and 1/2 kilos of carbon from the
environment because soil
is the biggest carbon sink on the
planet. It can hold three times the
amount of carbon in the entire
atmosphere if we took care of it and
built organic matter in the soil, which
only happens through the use of animals.
Right. That dig and pee and poo and move
around and chew down the grass and that
builds soil and this and that doesn't
use fertilizer, doesn't use pesticides,
doesn't use herbicides, uses rain water,
so you're not using 1,800 gallons for
every pound. It's a great called green
water and producing higher quality meat
with high levels of antioxidants, high
levels of omega-3 fats, better for the
animals, and you're not destroying
ecosystems. When you when you grow soy,
you're destroying ecosystems. You know,
you're destroying the habitat of animals
and rabbits and mice and birds when
you're making these giant mega farms.
So, I mean, probably eating a
regenerative grass-fed burger is
probably the most vegan thing you can
do.
So, you know, it's like and and and I
think it's just we get in this false
dichotomy. I mean, like all meat is bad
or only vegan or, you know, oh, you
should only, you know, eat be paleo.
That it just doesn't make sense, you
right? That's really interesting. The
green argument is um is fascinating
seeing sort of the the balancing out
that's going to happen between
whether there is some amount of farm
raised that's actually necessary. I've
heard you talk about the topsoil before
and that that's actually something that
without animals you're going to erode
the soil and that in and of itself
causes some dramatic issues.
We lose 200,000 tons of soil every hour.
Every hour?
We lose We lose country the size of
Nicaragua and North Korea of soil every
year.
We have 60 harvests left according to
the UN
before we run out of soil and can't grow
food. No soil, no food, no humans.
Forget climate change. This is
sounds relatively problematic. And by
actually using the strategy of
regenerative
agriculture, we can draw down carbon,
not add to the carbon in the
environment. Even if we stopped all
fossil fuels
tomorrow,
we still would be screwed. We need
strategies that draw down carbon out of
the environment, and the food system is
the number one set of solutions.
Let me ask you. So, even just forgetting
anything ecological, why plants? So,
that when you were saying everybody
agrees we should eat more vegetables,
obviously I would say Steven Gundry
probably doesn't agree that we should
eat more vegetables. Maybe if there's
certain Yeah, the right vegetables.
Do you have a take on that? Like what's
your vibe about lectins?
Yeah, yeah. Okay. So, I think it's it's
really personalized. And so, for some
people who have serious illnesses,
getting off of inflammatory foods,
including lectins, can be helpful.
Um but, you know, look, 60% of our diet
is ultra-processed food.
That's the first priority I have is get
people off that stuff. Don't restrict
vegetables, you know, cuz like unless
you're really sick and you want to try
it as a therapy, fine. But I I'm really
not uh you know, a big fan of telling
people to not eat vegetables, cuz I
think there's so much value in them, and
I think if we actually have the problem
of of restricting
unnecessarily for people, it's it's not
great. Well, let's talk about So, um
what do you think about the carnivore
diet? Is there any logic there? Well,
you know, it's interesting. I mean, that
you know, like Jordan Peterson's doing
that, and his daughter did it to cure
autoimmune disease. And yes, if you are
really sick, sometimes it can be
profoundly helpful. I mean, if you have
autoimmune disease, if you have um
severe obesity, I mean, it there can be
real benefits.
But I again, you know, we used to eat
800 species of plants as
hunter-gatherers. We ate animal products
when we could find them,
you know, or hunt them.
And it was a part of our diet, it wasn't
a staple. Some cultures, like the Plains
Indians, like the Dakota,
they lived mostly on buffalo, and they
were the longest-lived
people in history. They were had more
centenarians per capita than any other
population at the turn of the century,
yeah.
So, you've talked about, you know, one
thing that medicine really has got to
start doing is looking at the laws of
biology. So, you know, physicists are
looking at the laws of the universe.
What are the laws of biology? I'd love
to hear what are some of the laws of
biology? How does that play out in terms
of um plants? Because I can walk you
through it's admittedly like a
layperson's understanding, but when I
walk through the notion of the plant
paradox and you start thinking of a
plant as having a basically a chemical
um evolutionary advantage or the way
that they stop predators is by creating
these chemicals that either upset their
stomach or they're bad for them or they
are bitter tasting or whatever. It's
like, oh, that makes sense. When you
have something, it has to have a
mechanism against predation.
Yeah. And humans are one of the
predators. And so, okay, it didn't
develop claws or whatever. It developed
like these chemical signals. You've
talked about food being signals more
than just calories. So, it's like, okay,
well, there's actually some logic.
Whether it's true or not is a totally
different question. But there's a a
followable chain of logic to why plants
potentially
have issues. And so, it's like, is there
anything that they all share that for
somebody with the sensitivity they're,
you know, they're an issue? Or no, no,
no, like there's so many other nutrients
in vegetables. If you're not eating
them, you're kidding committing a
cardinal sin of the laws of biology.
Well, if you're eating nose to tail,
like you're eating the liver, which has
more vitamin C, more vitamin A than any
vegetable on the planet, right? Um
you know, you can get by, but You can
get by or it's ideal? I don't think it's
ideal. I mean, I think your gut m- the
microbiome feeds on
carbohydrates. Feeds on phytochemicals.
So, it feeds on fiber, right? Which is
What does happen to your microbiome if
you're only eating
a carnivore diet? Nose to tail?
changes.
a bad way? Potentially. Uh potentially.
I think you know there's there's some
interesting experiments. I think we're
still in the exploration of like what
happens when you eat different diets.
But I have a little different view about
vegetables. Um and I call it symbiotic
phyto-adaptation.
Which is a fascinating concept. But
essentially,
yes, there are defense mechanisms in
plants that help the plants,
but also can help us, right? So for
example, we don't make vitamin C. We get
it from plants. We need things to help
us detoxify. So when we eat broccoli,
you upregulate the glutathione the
pathways of detox in your liver through
phytochemicals called glucosinolates.
Your microbiome loves the polyphenols in
pomegranate and cranberry, right? So I
think we have evolved co-evolved with
plants. So we use these compounds these
phytochemicals to regulate all sorts of
biological functions from inflammation
to our microbiome to detoxification
to brain function or transmitters and so
on so on. So I think
we there are plants you wouldn't want to
eat. You don't You don't want to eat
poison mushrooms, right? You don't want
to eat foxglove which kill you. But
there are a lot of plants that we've
evolved with that we use in our bodies
to regulate our biological functions and
I think they're really necessary. Mhm.
Talk to me about soy. I heard you say
something which I'd heard before, but I
don't know there's something about the
way you said it that really hit me that
um you see women drinking or young girls
drinking like soy milk like it's going
out of style and then it it will put
them into premature
Yeah, happened to my stepdaughter. She
you know, soy milk was the big rage and
she liked to drink I mean she was
allergic to dairy. So she just like
drank, you know, quart of soy milk a day
and and she ended up like at 9 years old
getting little boobs. Whoa. And we're
like, "Oh." Because it's upping her
estrogen? Yeah. So so soy soy is a a
very controversial topic for many
reasons. There's all the environmental
issues, obviously
big monocrop fields, of tearing down
rainforests in Brazil, of all the
consequences of climate change, and all
that. But, uh from a dietary
perspective, it's been a staple in diets
for millennia in Asia, and it's always
been processed in a way that makes it
more digestible. Tofu, tempeh, right?
Miso, soy sauce.
Mhm. Those are traditional foods. When
you start, you know, making soy hot
dogs, and soy burgers, and eating all
these, you know, processed things. Even
soy milk is not something we used to
consume.
It It It You get one, trouble with
digestion. Two, increased risk of
allergy. And three, you get extra
hormonal effects when you have these
massive quantities of these things.
Yeah, thinking of food as a signaling
molecule, and then the all the talk
around soy,
what is the mechanism that's happening
that makes soy trigger an estrogen
response? I've never understood that.
Well,
you know,
all all food is information, not just
calories, it's all information. It's
instructions. It's literally like code
that programs your biology with every
bite.
So, at like an epigenetic level, it's
it's
level. So, every bite of food you take
can change your gene expression across a
whole range of genes. So, you eat green
You drink green tea or eat broccoli, you
upregulate the gene called glutathione
S-transferase that helps you detoxify
heavy metals, environmental chemicals,
metabolic toxins.
Um so, so it it it regulates your genes.
It regulates your hormones. So, if you
lie start eating sugar, it increases
insulin, lowers testosterone, increases
estrogen, for example. Uh it affects
your brain chemistry, and what your
hunger hormones are, your craving levels
are,
uh and what foods you you know, you're
attracted to. It affects your immune
system, and it regulates inflammation,
or it's anti-inflammatory. It regulates
your microbiome with every bite. So,
every single system of your body is
regulated by the quality of the food you
eat.
And when you realize
you shouldn't just focus on calories,
you should focus on quality and the
information you're eating changes
everything. So, that's really what I
have people focus on and I think when
people do that, then you have a
different relationship to your food. You
go, well, I'm eating Am I going to eat
toxic information or am I going to eat
healing information?
So, if you were to put together a few
groups of
the sort of healing signals, what would
they be? Like, what would be if if you
were so
In investing, there's a saying called
the all-weather strategy. And they say,
okay, look, I'm sort of blindly talking
to my grandchildren. I'm, you know,
going to pass away and all I can leave
behind is a strategy that will work in
in any environment. But, if you had to
just put together an all-weather eating
strategy, what would the
ideal, in air quotes, diet
I wrote about it. I wrote a whole book
about it. It's called Food, What the
Heck Should I Eat? And it's about these
principles I call the Pegan principles.
Well, it's really focused on quality
first, right?
Nobody thinks we should be adding
additives and hormones and antibiotics
and pesticides and glyphosate to our
food. Like, it's in it, but nobody's
like, yeah, let's do this.
it at the grocery store. Uh, you know,
you if you look at the label of
something, if it has something you can't
recognize pronounce,
uh, then you shouldn't have it. Or if
you don't have it in your cupboard at
home, like
butylated hydroxytoluene, which is in
almost every processed food, is BHT, so
illegal in Europe. You wouldn't sprinkle
that on your salad, would you?
No. No. So, that's a good rule. Uh, the
second principle is, you know, we should
be eating a plant-rich diet. Uh,
and and across the spectrum from
fruits and vegetables to Do you treat
fruits and vegetables as sort of one in
the same or
should be vegetables and fruit, right?
So, it's like we should You don't want
to be consuming only fruit cuz that's
full of sugar and and if you're diabetic
or you're overweight or have issues, you
might want to cut back on the sugary
fruits or eat berries, which are less
glycemic.
Um, lots of nuts and seeds. Everybody
agrees we should be eating lots of nuts
and seeds. You want to soak them or
reduce lectins, that's fine. If you're
going to eat beans and grains, pick low
starch ones, right? And and also
examples of low starch.
rice, which is like the blueberries of
rice, quinoa. What does that mean? Well,
the black rice was called the emperor's
rice or forbidden rice and it's full of
these dark It's black. So, anytime you
see color in nature, there are
polyphenols and phytochemicals in there.
So, it's got more antioxidants per
serving than blueberries. And then And
then you want to make sure
if you're eating, you know, grains like
gluten grains are are interesting. So,
most of the gluten we eat is is wheat.
Um, it's 133 lb per person per year.
That's a pharmacological dose and is
worse for your blood sugar than table
sugar.
Really?
Yes. What? Yes. When you look at the
glycemic index, which is how much the
fixed amount of the food will raise your
blood sugar, table sugar is
80, bread is 100.
Whoa, I had no idea. Why?
Because it's so processed and so quickly
absorbed. And if you want to eat like If
you're not gluten sensitive, you want to
have farro or einkorn wheat or, you
know, spelt, you might tolerate those
cuz those aren't highly altered
genetically. But, the new The wheat we
eat is super starchy, has a lot more
gliadin proteins, create more gluten
sensitivity, is sprayed with glyphosate
at harvest to to de- defoliate the
plants and it's also has preservative
called calcium propionate, which caused
autism in animal models and is shown to
cause behavioral problems in kids. So,
ADD, all that stuff could be all the
flour. So, I'm not a big flour person,
plus it's just like sugar. So, if you
want to have have other grains if you're
not gluten sensitive, like rye or
barley, that's fine.
And then beans again, you know, lima
beans, kidney beans. If you're If Look,
75% of Americans are overweight. So,
most people should be eating a lot of
starch and that You know, you have to
eat three cups of beans to get the
equivalent of like four 6 oz of protein.
Uh so, I have this lentils and things
like that, um which are lower-starch
beans, adzuki beans, other kinds of
beans. I talk about them in my book. And
then if you're eating animal products,
you want to eat animal products that are
not
going to hurt the animals, not going to
hurt you, and not going to hurt the
environment, right? So, for
beef, it should be regeneratively
raised, ideally, which is hard to find,
but you can actually get more and more
of that around and there's ways to do it
by by looking online to get it, looking
Thrive Market is a great resource for uh
regeneratively raised beef. Um and
again, chicken should be pasture-raised,
pork and all that should be raised in
ways that are are more organic or
sustainable. Uh fish, you want to eat
fish that's sustainably harvested or,
you know, sustainably organically
uh aquacultured, uh cuz we over-harvest
the fish and then we don't want to eat
big fish that's like full of mercury and
tuna and swordfish.
Just cuz they've lived longer? Well,
what happens is the coal and all the
fossil fuels go in the ocean, go in the
algae, get stored in the algae, that the
little fish eat the algae, then the
little little bigger fish eat the little
fish, and it goes on up the food chain,
and then you got a swordfish or a tuna.
Um these are monster fish and uh they
bioaccumulated all this. And so,
you want to, you know, eat the right
animal products, you want to eat the
right grains, the right beans, the right
vegetables, the right fruits,
And so,
give me the right vegetables. Are we
just looking for color spectrum?
vegetables. If you want to cut out
nightshades and get rid of lectins,
that's fine. You know, I don't care. But
I love tomatoes, so I'm not going to do
that. And they don't make me feel bad.
Uh so, there's no point in restricting
your diet necessarily if you're not
sick, right? Talking really fast just
cuz you mentioned that you eat
nightshades, which are problematic for a
lot of people. I've heard you say that
your body is the best doctor. What do
you mean by that?
So, yeah, you listen and watch my stuff.
That's impre- I'm impressed.
Uh so, the the whole idea is that
you can listen to all the nutritional
advice you want, but pay attention to
how you feel. Your body's going to tell
you. If you go vegan
and you stop having your period, you
lose muscle, you feel tired, you're B12
deficient, you feel like crap, you
develop autoimmune diseases, you gain
weight, whatever, maybe it's not for
you, right?
Uh I mean, I literally just did a whole
analysis on a very well-known celebrity
and he's a vegan and he's massively
nutrition deficient. No omega-3s,
extremely low vitamin D, extremely low B
vitamins, extremely low zinc, selenium.
I mean, it was it was frightening to see
in a young guy how depleted he was.
Uh but other people it works really well
for. Um
and then uh see how you feel. If you get
rid of gluten and dairy, do you feel
better, right? So, I have people do a
detox, but essentially a dietary
cleanse, which is get off all the junk,
get off all the sugar, get off all the
processed food, eat whole foods, get rid
of gluten and dairy, even getting rid of
grains and beans for a while and see how
you feel.
And if you don't feel good, you know,
try to add things back. If you feel
amazing and your autoimmune disease goes
away, your digestive problems clear up,
your brain fog is clear, your migraines
are gone,
well, then that's probably a sign that
your body likes that way of eating, you
know. Walk people through really fast
your 10-day detox. Like, what does that
entail? How do they um take advantage?
of the essential, you know, therapeutic
approaches of functional medicine is
food as medicine.
And
um
in that thinking, one of the ways we
treat people is taking away the most
inflammatory foods.
So, gluten and dairy are
number one and two
for most people for a lot of reasons,
but then there's a whole host of other
ones like eggs and soy and some nuts for
people. Um so, the 10-day detox
essentially is whole foods based.
It's high-quality animal protein, lots
of veggies,
but non-starchy veggies. So, it's
extremely low glycemic, so there's not
starch and sugar and flour.
It cuts out grains, cuts out beans, cuts
out fruit except for berries.
And it's got a lot of good fats. Avocado
fruit except for berries. Just you're
trying to get
Well, the diet is designed to be like
it's not one size fits all, but it's
close cuz it's low glycemic, so it helps
you lose weight. It's anti-inflammatory.
It fixes your gut. And it's highly
nutrient-dense and has lots of fiber or
lots of phytochemicals, lots of good
fats. So, it's high fat, low starch and
sugar. So, it works for autoimmune
diseases, for gut issues, for weight
issues, for diabetes. I mean, I should
show you this picture of this woman who
literally had type 2 diabetes
for 10 years, on insulin, heart failure,
kidney failure, liver failure, high
blood pressure, tons of medications, 65
years old, on her way out.
She came into one of our group programs
at Cleveland Clinic, one of the 10-day
detoxes.
Took a basic supplements like a
multivitamin, fish oil, vitamin D, not a
lot of stuff.
And within 3 days she was off her
insulin. Woah!
In 3 months she reversed her heart
failure, her kidney failure, her liver
failure, her high high blood pressure,
got off all her medications, lost 43 lb,
and in a year she lost 116 lb and is off
everything. Wow.
And she saved $20,000 a year in co-pays
for her medications cuz insulin is so
expensive.
And And that was food. I mean, it was
you know, she was seeing so many
doctors, she was seeing the best in the
field, and they were managing her
disease, and I don't really want to
manage people's disease. I want to get
to the root of it. And for so many
people food is really the root.
What I like about that approach is that
it's a detox, right? So, it's more about
what you're removing even than what
you're adding, and and I find a lot of
times
That's interesting. I want to hear more
about that cuz what I find a lot of
times is that people want to just add
like, "Oh, if I add uh broccoli to my
Twinkie diet that I'll be fine.
So what where do you think that balance
is? Like how much of this is a removal,
how much of this is an addition? Um I
think, you know,
we we have the most inflammatory diet in
the world right now.
And all the diseases that people suffer
with, it's gut issues, diabetes, cancer,
Alzheimer's, heart disease, these are
all inflammatory diseases. So the foods
that we're eating, 60% of our diet is
considered ultra-processed food made
from corn, wheat, and soy, mostly in the
form of white flour, high fructose corn
syrup, and trans fats or soybean oil
now.
And
the people who eat the most of it are
the sickest. And the people who eat it
for every 10% of your diet that's
ultra-processed foods, your risk of
death goes up by 14%.
So we eat 60%.
And and so we have to get rid of that
stuff that's destroying our biology cuz
we're it's like literally putting poison
in our body.
And and our bodies don't die
immediately. It's a slow, long,
prolonged, painful death, right? Yeah.
So it's taking out all that stuff.
It's taking out things that are often
inflammatory. Like the wheat we eat
isn't the wheat that our ancestors ate,
right?
The dairy we eat is not the dairy that
our ancestors eat. It's been highly
altered through genetic breeding. It
changes the quality, the the fats, the
proteins, the the allergens in there. So
like we used to have heirloom cows which
were, you know, if you travel around the
world and you see these cows you're
like, "Wow, that's a weird looking cow."
You know, like cuz they're like I never
saw a cow like that cuz they're all like
these same cows in America. They're like
these white and black Holstein cows.
They're all bred by like three bulls and
they're all pretty much genetically the
same. And they have high levels of A1
casein which is super inflammatory.
Whereas heirloom cows don't. Or sheep
and goat also have A2 casein which is
less problematic. Uh wheat, same thing.
They the way they've created the dwarf
wheat, they breed the wheat for all
these properties that are drought
resistant, more starchy, and so forth.
And the guy won the Nobel Prize for
this, but the unintended consequences is
when you breed plants, it's not like
humans. You get your 23 pairs of
chromosomes, every every human has 46.
If you were a wheat plant and you have
46 chromosomes and you breed with
another wheat plant with 46, you get 90,
you get 92 chromosomes.
Right? And then, but that means is
you're making extra proteins cuz
chromosomes, genes make proteins, and
you're making way more gluten proteins
that are much more likely to cause
celiac, which is why we've seen such an
increase in celiac disease and gluten
sensitivity.
That's really interesting.
Okay, one thing I want to go back to you
is where you started and like your whole
thing around love and community and how
if you really want to make change, it's
about connection and getting other
people that are around you to change
their lifestyle as well and then it
self-reinforces. One, walk us through
like how did you end up going so deep on
Buddhist studies? What did you draw from
that?
Yeah. And then as you were having really
a near-death experience, but I mean, you
were in a risky place there the first
time you had that medical emergency.
Like the peace that you had during that
whole process, which I found very
interesting.
Yeah, well, you know, um, I was always a
weird kid. I always like didn't really
have any friends. Just read a lot of
books. Couldn't really relate to anybody
except grown-ups.
And you know, then I got to college and
I was like, "Wow." And I read I read
Walden when I was like 14, 15. And I
just like studied it like a Bible. And I
then I
What specifically is hitting you? Like
at 15 to encounter those ideas, which
would be very, run very contrary to a
standard American upbringing. But what
specifically were you like, "Wow, that
that resonates."
just, you know, I I I remember being
like free and you know, just feeling so
much love for everybody and just feeling
in a state of love all the time.
And I remember noticing how all the
grown-ups were just so weird and why
were they so disconnected and
and I always felt that sense of love and
I think when I began to understand what
Buddhism is about it was about
understanding
compassion and kindness and service and
also like wisdom, you know, how do how
do we see the world? So Buddhism isn't a
religion. It's It's It's basically
a a phenomenology of the mind. It's a
description of how our perception works,
why we suffer, and how we can break down
that you know, sort of in slow motion
like the Matrix, you know, like break
down the the
the ways in which we get into this
suffering pattern of getting attached to
our meanings we put on things and that
creates all this misery and suffering.
It's all created in our head. And I and
I really was looking for a way out of my
own
suffering as a kid and it just was
really spoke to me. And how does that
become so important as you look at
wellness and think of that as as sort of
a a critical pillar of actual wellness?
Do you talk in functional medicine when
somebody comes to see you, do you talk
at all about the need to meditate or
yeah, 100%. So what is that? What's the
connection there? What's the mind-gut
connection? Like how does this all play
out?
I said before, we're one system. So
your brain is connected to everything
else and when you're stressed, you're
dysregulating all the functions in your
body, right? It's fine if you're running
from a tiger, but if you're stressed all
the time, your gut shuts down, your
immune system doesn't work, you're
you know, you're constantly a state of
of vigilance and stress, which is just
degrades every system in your body. So
it's a huge component is both dealing
with your mindset and your way of
thinking to sort of be able to unhook
from all the meanings we attach to
things, all the the perceptions we have
that aren't really true, and the
suffering we self-generate. And then I
also peop- teach people tools and
techniques to help them reset, right? So
we're we're all stressed. Like I'm
running around in LA today, you know,
doing my TV shows and this and that, you
know, for my new book, but like I make
sure I meditate. Like I meditated this
morning, you know, soon as I'll be able
to squeeze in a yoga class, like I'll
I'll, you know,
You used to be a yoga instructor.
I was a yoga teacher before I was a
doctor. Yeah, I was kind of weird I told
you I was weird. It's it's so
interesting, man. Here's the problem
with where you're at today. Functional
medicine is no longer like this alien
notion, but the fact that you've had
your finger on this for as long as you
have is really interesting. The fact
that it was born into the mind of
somebody that was so into Eastern
philosophy does not surprise me.
a sys- it's a systems view, right?
Mhm.
And and we you know, what is what is
you know, Buddhism is sort of a
description of the laws of the mind,
right? And so functional medicine is is
a description of the laws of biology.
For we have no theory we have theories
of physics, right? We have the laws of
physics. We can we can build a bridge or
a spaceship based on the laws of
physics, right? And it works because
they're natural laws. Well, what are the
natural laws of biology? There are
natural laws. In in medicine, we've not
thought about that. We were like, well,
this hurts, so fix this, you know, it's
like a knee problem. The knee problem
might be related to your gut, right? And
and how do we think about that? So so
functional medicine attempts to describe
what are those natural laws, what are
those essential elements. So when I I
look at, you know, traditional medicine,
there's now 155,000
diseases.
Woah. If you look at your code book,
it's ridiculous.
And it used to be 12,000, and they used
to subcategorize them. So say you have
depression,
it's just the name of the disease. It
doesn't tell you the cause of the
disease. So functional medicine, what
are those natural causes? And you can
have a few natural laws that that
describe it immense number of phenomena
that you see, right? So, that's like the
laws of physics, immense number of
phenomena. So, the same thing is true in
biology.
And and functional medicine I think is
an attempt to codify what those natural
laws are, how the body actually works,
how it's connected as a web, how what
are the root causes of diseases? And
there's not many, right? It's stress,
poor diet, toxins, allergens, microbes.
And what are the things we need to
create a healthy human? It's a short
list, the right food, nutrients, balance
of hormones, light, air, water, love,
meaning, connection, purpose. Those are
the things that we need to thrive. And
you just take out the bad stuff, put in
the good stuff, and you know, miracles
happen.
Dude, that is such a powerful way to
explain all this.
Yeah. That was [ __ ] amazing. Thank
you for that.
Where can people connect with you? Uh
they can go to drhyman.com. I've got a
podcast, The Doctor's Pharmacy, which is
killing it. I don't know why, but people
love it. And uh you know, I'm
uh yeah.
Very easy to answer why people love it.
It's absolutely amazing, high quality,
as is everything that you put out there.
Dude, it's amazing. What you're doing is
really really extraordinary. I can think
of few voices that would be able to to
match yours in the space. And so, the
fact that you've stepped out front and
are doing all this is really incredible.
And just the knock-on effect with you
getting involved in
regulation and everything I think is
really
got We all got to We all got to save
ourselves here because nobody's coming
to save us. And I think we have to
understand that that our food system is
generating most of the problems we see
in the world. Chronic disease, the
burden on our economy, our $22 trillion
debt, a lot of that has to do with the
food we're eating and how it's causing
chronic disease. It's burdening our our
government, climate change that results
from it, the environmental degradation,
violence, poverty, injustice,
malnutrition. I mean, it's all It just
goes on and on.
a web.
It's all connected. That's the beautiful
thing. It's like functional medicine.
When you see how it's all connected
and not in silos, you can actually fix
one thing and everything gets better,
right? Yep.
All right, if you could have people make
one change that would have the biggest
impact on their health, what change
would you have them make?
It I It's pretty simple. I mean, eat
whole, real food. I mean,
follow the Pegan diet. Okay, my
cookbook.
I mean, it's pretty simple. I mean, I I
I kind of laugh because I get paid a lot
of money to tell people to eat real food
and I'm like,
you know, it's sort of obvious, right?
I think it is a very effective answer.
Mark, thank you so much for being on the
show today.
Thank you. Guys, go check out everything
that he does. The books, he has so many,
they're so good. You can literally pick
them almost at random, but starting with
the one that he just released, I think
is a very good start. And then, be sure
to check out his podcast, The Doctor's
Pharmacy with an F. Uh it is really
fantastic. Everything that he does, I
think is incredible and is leading
everything in the right direction. If
you haven't already, be sure to
subscribe and until next time, my
friends, be legendary. Take care.
Thank you guys so much for watching and
being a part of this community. If you
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